Clinical trials: sponsored by Vanda Pharmaceuticals
Nausea and Vomiting, Obesity
A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use
The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one…
- Trial name
- NCT07446439
- Testing
- Tradipitant
- Where
- 10 sites in United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Healthy
Food Effect Study of VHX-896 in Healthy Volunteers
A single center, two-period, randomized study to evaluate the food effect of VHX-896 tablets in healthy volunteers
- Trial name
- NCT06803290
- Testing
- VHX-896
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Healthy Volunteer
Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Volunteers
To evaluate the effects of tradipitant relative to placebo on satiation, gastric volume, gastric accommodation, and gastric emptying in healthy volunteers.
- Trial name
- NCT04849559
- Testing
- Tradipitant
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Healthy
Bioequivalence Study Between Tasimelteon Capsule Formulation and Liquid Suspension Formulation in Healthy Volunteers
This is a single center, two-period, randomized study to evaluate the bioequivalence of a single dose of tasimelteon capsule formulation relative to a single dose of liquid suspension formation in healthy volunteers.
- Trial name
- NCT05572281
- Testing
- Tasimelteon Oral Capsule, Tasimelteon Oral Suspension
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Healthy Volunteers
Evaluation of Next-Day Residual Effects of Tasimelteon Compared With Placebo and Active Control in Healthy Subjects
The aim of this study is to investigate next-day residual effects of tasimelteon compared with placebo and active control in healthy subjects.
- Trial name
- NCT06323655
- Testing
- Tasimelteon, Active Control
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Performance Anxiety
Evaluating the Effects of VQW-765 vs. Placebo in Performance Anxiety
This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of a single oral dose of VQW-765 compared to placebo in male and female participants with performance anxiety.
- Trial name
- NCT04800237
- Testing
- VQW-765
- Where
- 15 sites in United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Jet Lag Type Insomnia
Evaluating the Effects of Tasimelteon vs. Placebo on Jet Lag Type Insomnia
The aim of this study is to investigate tasimelteon vs. placebo on sleep in healthy individuals after a phase advance in jet lag type insomnia.
- Trial name
- NCT03373201
- Testing
- Tasimelteon
- Where
- 12 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Healthy
Bioequivalence Study Between VHX-896 Tablets and Iloperidone Tablets in Healthy Volunteers
This is a single center, two-period, randomized study to evaluate the Bioequivalence of VHX-896 Tablets Relative to Iloperidone Tablets in Healthy Volunteers
- Trial name
- NCT04969211
- Testing
- VHX-896 and iloperidone, Iloperidone and VHX-896
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Jet Lag Disorder
A Proof of Concept Study to Evaluate the Effects of Tasimelteon and Placebo in Travelers With Jet Lag Disorder
A Proof of Concept Study to Evaluate the Effects of Tasimelteon and Placebo in Travelers With Jet Lag Disorder
- Trial name
- NCT03291041
- Testing
- Tasimelteon
- Where
- 3 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Jet Lag Disorder
An Observational Study to Investigate the Effects of Rapid Transmeridian Travel
Observational study to investigate circadian rhythm patterns
- Trial name
- NCT02560103
- Testing
- Transmeridian travel across multiple time zones
- Where
- 2 sites in United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Non-24-Hour-Sleep-Wake Disorder
Open Label Study to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZ™)
Hetlioz™ (tasimelteon) is used in the treatment of Non-24-Hour-Sleep-Wake Disorder (Non-24). Non-24 is very common in people who are totally blind because light can not reset their body clock.
- Trial name
- NCT02130999
- Testing
- tasimelteon 20 mg capsule, tasimelteon 2 mg I.V.
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Healthy Volunteers
Study to Assess the Effect of Multiple Doses of Tradipitant on CYP3A4 Using Midazolam as a Substrate in Healthy Subjects
This study is designed to evaluate the potential effect of administration of tradipitant on CYP3A4 using midazolam pharmacokinetics as markers. The study will also further characterize the pharmacokinetics of tradipitant.
- Trial name
- NCT02621385
- Testing
- tradipitant, Midazolam
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Pruritus
Study of Itch Control by VLY-686 in Healthy Volunteers After Intradermal Injections of Substance P
The purpose of this study is to test whether VLY-686 can prevent or reduce the itch and dermatological reaction observed after healthy volunteers are injected with Substance P in comparison with placebo.
- Trial name
- NCT01919944
- Testing
- VLY-686
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Insomnia
VEC-162 Study in Healthy Adult Volunteers in a Model of Insomnia
The purpose of this study is to determine the safety and efficacy of VEC-162 compared to placebo to improve sleep parameters in a model of insomnia.
- Trial name
- NCT00291187
- Testing
- 20 mg VEC-162, 50 mg VEC-162, 100 mg VEC-162
- Where
- 19 sites in United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Circadian Rhythm Sleep Disorders
Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers
The purpose of this study is to assess the safety and efficacy of VEC-162 compared to matching placebo on circadian phase shift and sleep parameters.
- Trial name
- NCT00490945
- Testing
- VEC-162
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Healthy Volunteers
A Study to Assess the Effect Tasimelteon on the Cytochrome P450 3A4 and 2C8 Enzymes in Healthy Subjects
The purpose of this research study is to understand whether there is any difference in the amount of midazolam (including its breakdown product) in the blood when midazolam is given with tasimelteon, and whether there is any…
- Trial name
- NCT01402076
- Testing
- Tasimelteon, Rosiglitazone, Midazolam
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Healthy Volunteers
Effects of Smoking, Age and Body Size on Pharmacokinetics, Safety and Tolerability on Tasimelteon in Healthy Subjects
The purpose of this research study is to understand whether there is any difference in the amount of tasimelteon in the blood in smokers versus non-smokers.
- Trial name
- NCT01477619
- Testing
- Tasimelteon
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Hepatic Impairment
Pharmacokinetics of Tasimelteon in Subjects With Mild or Moderate Hepatic Impairment
The purpose of this research study is to understand whether there is any difference in the amount of tasimelteon (including its breakdown products) in the blood in individuals with mild or moderate liver disease compared to…
- Trial name
- NCT01271387
- Testing
- tasimelteon
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Healthy Volunteers
Pharmacokinetics of Tasimelteon Alone and in Combination With CYP1A2 Inhibitor, Fluvoxamine
The purpose of this research study is to evaluate whether administration of a CYP1A2 inhibitor affects the single-dose pharmacokinetics of tasimelteon and its metabolites.
- Trial name
- NCT01540500
- Testing
- Tasimelteon, Fluvoxamine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Renal Impairment
Pharmacokinetics of Tasimelteon in Subjects With Renal Impairment and Matched Control Subjects With Relatively Normal Renal Function
The purpose of this research study is to understand whether there is any difference in the amount of tasimelteon (including its breakdown products) in the blood of individuals with severe renal impairment compared to individuals…
- Trial name
- NCT01526746
- Testing
- Tasimelteon
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals