Clinical trials: enrolling by invitation
Aortic Stenosis
ECG-based AI Screening for Cases of Undiagnosed Moderate-to-Severe Aortic Stenosis in the Primary Care Setting
The goal of this observational study is to learn whether AccurKardia's AK-AVS algorithm can help identify moderate-to-severe aortic stenosis (AS), a narrowing of the heart's aortic valve, in older adults who have not yet been…
- Trial name
- NCT07827105
- Testing
- AK-AVS
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- AccurKardia, Inc.
Maternal Health
RESTORE - Phase II
The study will apply the principles of Community Based Participatory Research to evaluate implementation strategies, designed to assist in the delivery of an evidence-based lifestyle counseling intervention for pregnant…
- Trial name
- NCT06349070
- Testing
- Low Touch - Text Messaging Implementation Strategy, High Touch - Community Health Worker (CHW) Implementation Strategy
- Where
- 2 sites in United States
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Sexually Transmitted Infection
Characterization of Doxycycline Pharmacokinetics and Adherence
The purpose of this study is to evaluate the effect of body changes on doxycycline concentrations for different dosing schedules. This study will involve a single dose phase and a multiple dose phase.
- Trial name
- NCT07755618
- Testing
- Single-Dose PK Phase - DR Group, Single-Dose PK Phase - IR Group, Multi-Dose PK Phase - Daily Group
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- HIV Prevention Trials Network
Tooth Extraction Site Healing, Alveolar Ridge Preservation
Biomaterials Exposed to Oral Environment: Which One is the Appropriate Option?
After tooth extraction, bone loss can compromise future dental implant treatment. Dentists often use biomaterials to preserve bone, but in many cases these materials are left exposed to the oral environment, where saliva and…
- Trial name
- NCT07589751
- Testing
- Alveolar Ridge Reconstruction
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Multiple Sclerosis, Inflammatory Demyelinating Disease
A Study of Imaging in Demyelinating Diseases
This purpose of this study is research the usefulness of MRI with PET/CT imaging for measuring brain inflammation and its relation to Multiple Sclerosis (MS).
- Trial name
- NCT05805839
- Testing
- C-11 ER176 Radiotracer, C11 Pittsburgh Compound B, PET/CT scan
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypertrophy, Muscle Strength
Reliability and Performance Analysis of the Use of Tissue Flossing for Blood Flow Restriction.
Blood flow restriction (RFS) is a widely studied technique that combines low-intensity exercise with vascular occlusion, resulting in muscular benefits.
- Trial name
- NCT06075901
- Testing
- Tissue Flossing, Blood Flow Restriction Cuff, Training Protocol
- Where
- Brazil
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Paulista University
Muscle Strength, Hypertrophy
Effect of Cross-Education in Blood Flow Restriction Resistance Training on Lower Limbs in Older Women
Unilateral resistance training has been shown to promote strength adaptations in the directly trained limb and also improve strength in the contralateral limb, a phenomenon known as cross-education (CE), with more pronounced…
- Trial name
- NCT07155967
- Testing
- Blood Flow Restriction Cuff
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Paulista University
Elective Surgery, General Anesthesia
Comparison of Tracheal Intubation in Ramp vs Sniffing Position Using Customized vs Fixed Pillow
The goal of this clinical trial is to find out whether the ramp position or sniffing position is better for endo tracheal intubation which provides better hemodynamic stability and short intubation time and good laryngoscopic…
- Trial name
- NCT07506655
- Testing
- Group A - Fixed Pillow, Group B - Customized Pillow
- Where
- Pakistan
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma
HSCT, Lung Transplant Recipient
Technical Development of Xe MRI
The goal of this study is to develop and optimize new proton (1H; conventional MRI) and Xe gas MRI techniques to assess regional cardiopulmonary structure and function in the clinical setting.
- Trial name
- NCT07823010
- Testing
- Hyperpolarized 129 Xenon
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hearing, Healthy
Understanding Speech in Background Noise
The goal of this clinical trial is to establish how speech understanding is affected by background noise in people with normal hearing.
- Conditions
- Hearing, Healthy, Speech Perception
- Trial name
- NCT07822802
- Testing
- Speech filtering, Speech with background noise
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Emotion Regulation Disorders
Virtual Reality Exposure Therapy for Emotion Regulation Difficulties in Adolescent Inpatients
The goal of this clinical trial is to evaluate whether a therapist-guided virtual reality (VR)-based intervention can improve emotion regulation in adolescents receiving inpatient psychiatric treatment.
- Trial name
- VRsafe (NCT07709468)
- Testing
- Virtual Reality Exposure Therapy
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Intervention (Training) Condition, Waitlist Control Group
Online Socio-emotional Dyad Training for School Teachers' Well-being and Social Skills
The Edu:Social School Study 2 is a randomized controlled trial designed to evaluate the effects of an 8-week socio-emotional, partner-based empathy-compassion Dyad training program (EmCo) compared with a mindfulness-based…
- Trial name
- EduSocSchool2 (NCT07637409)
- Testing
- Empathy- and compassion-based socio-emotional mental training (EmCo), Mindfulness-based Training (MBT), Waitlist Control Group (WCL)
- Where
- Germany
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Max Planck Social Neuroscience Lab
Universal Behavioral Supports
Social and Emotional Learning in Norwegian Kindergarten
This project evaluates the effectiveness of the Norwegian version of Second Step Early Learning (Småsteg), a program of 28 weeks that emphasizes learning, friendship skills, and managing several strong feelings (e.g., scared…
- Trial name
- NCT06975267
- Testing
- Norwegian version of Second Step Early Learning, Free play
- Where
- Norway
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Ostfold University College
Intervention Condition, Control Condition
Online Socio-emotional Dyad Training for Healthcare Professionals' Well-being and Social Skills, Phase II.
Edu:Social Health Care Project Phase II is a non-randomized waitlist-controlled trial with sequential recruitment of the intervention and waitlist control groups (nrWLC), designed to evaluate the effects of a partner-based…
- Trial name
- EduSocHealth2 (NCT07637422)
- Testing
- Empathy- and compassion-based socio-emotional mental training (EmCo), Non-randomized waitlist control group (nrWLC)
- Where
- Germany
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Max Planck Social Neuroscience Lab
Parenting Stress, Parent Child Relationship
A Male Caregiver Adaptation Study of the Connecting and Reflecting Experience Parenting Program
Male caregivers play a critical role in children's emotional development, yet they are often underrepresented in parenting interventions and may experience unique barriers to emotional engagement and support.
- Conditions
- Parenting Stress, Parent Child Relationship, Father-Child Relations, Emotional Regulation
- Trial name
- Male-CARE (NCT07419308)
- Testing
- Connecting and Reflecting Experience (CARE) Program
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
Developing Microbiome and Dietary Strategies Based on Chrono-nutrition for Targeting ADHD
Study objectives This project seeks to understand how an intervention based on time-restricted eating (ChronoFeeding or CF) can improve quality of life, behavior, sleep, and gut health in adults with ADHD (Attention Deficit…
- Trial name
- CronoNutriBiom (NCT07821060)
- Testing
- Circadian fasting
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Spanish National Research Council
Healthy Adult
Optical Imaging of Retinal Vascular Metrics Under Different Dietary Conditions
In a typical clinical setting, patient eating habits are not controlled when performing optical coherence tomography (OCT) imaging for retinal diagnostics.
- Trial name
- NCT07818239
- Testing
- Consumption of a high fat meal, Consumption of a high carbohydrate meal
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Antimicrobial Resistance (AMR), ESBL
One Health Determinants of Rectal Colonization by ESBL-Producing Enterobacterales in the Community
This multicenter cross-sectional observational study aims to determine the prevalence of rectal colonization by extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales among community-dwelling adults in Argentina and…
- Conditions
- Antimicrobial Resistance (AMR), ESBL, Gut Microbiota Dysbiosis, Environmental Exposure
- Trial name
- NCT07818109
- Where
- Argentina
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
SARS-CoV Infection, Covid19
KIDney Injury in Times of COVID-19 (KIDCOV)
There is an unmet need to evaluate the impact of sub-clinical/mild COVID19 disease in the outpatient setting on prevalent and incident renal injury, as this data is currently unavailable.
- Conditions
- SARS-CoV Infection, Covid19, Corona Virus Infection, Acute Kidney Injury
- Trial name
- KIDCOV (NCT04705766)
- Testing
- Urine Collection
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy, Chronic Kidney Diseases
A Study of Renal Microvessel Imaging for Chronic Kidney Disease
The purpose of this research is to study the efficacy of ultrasound microvessel imaging for evaluation of Chronic Kidney Disease.
- Trial name
- NCT05764642
- Testing
- Definity, Super-resolution ultrasound imaging
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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