Clinical trials: sponsored by Icahn School of Medicine at Mount Sinai
Colorectal Cancer Screening
Evaluating the Efficacy of the eNav Toolkit to Improve Colorectal Cancer Screening
The purpose of this research study is to evaluate the efficacy of a digital navigation tool, called the eNav to improve colorectal cancer screening uptake among patients treated at federally qualified health centers (FQHC)s.
- Trial name
- NCT06184594
- Testing
- eNav, Standard of Care
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gestational Diabetes Mellitus (GDM)
Validating CGM for GDM
This is a prospective pilot study to assess the validity of using a continuous glucose monitor (CGM) in diagnosing gestational diabetes mellitus (GDM).
- Trial name
- VALID (NCT06858787)
- Testing
- Continuous glucose monitor
- Where
- 3 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Aging, Influenza Vaccine
A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults
This is a prospective, single-arm study designed to understand the mechanisms that lead to a loss of response to influenza vaccine in older adults.
- Conditions
- Aging, Influenza Vaccine, Dendritic Cell, Vaccine Response
- Trial name
- FluVax3 (NCT05518500)
- Testing
- Flu Vaccine (Year 1), Flu Vaccine (Year 2), Flu Vaccine (Year 3)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The Jackson Laboratory
Sleep Disturbances, Depression
Methodology Issues in a Tailored Light Treatment for Persons With Dementia
Tailored light treatment will increase sleep efficiency, reduce depression and reduce agitation scores in those with Alzheimer's disease and related dementia
- Trial name
- NCT01816152
- Testing
- High Active intervention, Inactive intervention, Mid Level Active Intervention
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Opiate Use Disorder
Mindfulness-Oriented Recovery Enhancement (MORE) in Heroin Addiction
In this study, neuroimaging of reward processing, drug cue reactivity and inhibitory control is used before and immediately after 8 weeks of two types of group therapy in individuals with opioid addiction; clinical outcomes will…
- Trial name
- MORE (NCT04112186)
- Testing
- Behavioral group therapy #1, Behavioral group therapy #2
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Traumatic Brain Injury, Emotion Regulation
Community-based Implementation of Online EmReg
This is a hybrid type III implementation-effectiveness trial; this study design blends elements of implementation and clinical effectiveness research, with the primary aim of determining the utility of an implementation strategy…
- Trial name
- NCT05933629
- Testing
- Online EmReg, Consultation Sessions
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Physical Activity
Molecular Transducers of Physical Activity Consortium
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA).
- Trial name
- MoTrPAC (NCT03960827)
- Testing
- EE Training, RE Training
- Where
- 11 sites in United States
- Volunteers
- 1,836 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Physical Activity
Molecular Transducers of Physical Activity Consortium (MoTrPAC) - Pediatric Protocol
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA).
- Trial name
- MoTrPAC (NCT04151199)
- Testing
- EE Training
- Where
- United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Multiple Myeloma, Light Chain Nephropathy
Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy
Objective 1: To test whether treatment with plasma exchange improves renal recovery in patients with light chain cast nephropathy Objective 2: To compare renal outcomes among patients treated with plasma exchange versus…
- Conditions
- Multiple Myeloma, Light Chain Nephropathy, Acute Kidney Injury
- Trial name
- NCT06483139
- Testing
- Plasma exchange, Daratumumab
- Where
- United States
- Volunteers
- 549 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Borderline Personality Disorder
The Effect of Oxytocin Administration on Interpersonal Cooperation in Borderline Personality Disorder Patients and Healthy Adults
The study will examine behavioral patterns and underlying neural correlates which distinguish patients with borderline personality disorder (BPD) from healthy subjects as they participate in a two-person trust game and will…
- Trial name
- NCT02225600
- Testing
- 40 IU Intranasal Oxytocin, 24 IU intranasal Oxytocin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Low Risk Prostate Cancer
Decision Making in Men With Early Stage Prostate Cancer Patients and Partners/Close Allies
The purpose of this study is to collect information on how patients and their partners/close allies make treatment decisions when they have been diagnosed with early stage prostate cancer.
- Trial name
- NCT01877070
- Testing
- assessments
- Where
- 3 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Alcohol Drinking
Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study
The purpose of this study is to investigate the behavioral and neural correlates of stress exposure. Results from this study will enrich the understanding of how sociocultural, behavioral, and neural factors combine to influence…
- Trial name
- NCT05675332
- Testing
- Task-based behavioral intervention
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetes
Circulating Biomarkers in the Development of Type 1 Diabetes
More than 100 million U.S. adults are now living with diabetes or prediabetes. Investigators still do not fully understand how diabetes develops and how the disease worsens.
- Trial name
- NCT05505669
- Testing
- One-time blood (up to 100 ml) will be drawn and the amount of blood drawn is based on weight. Saliva and urine will be collected during the blood draw visit.
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection
Defining the Basis of Fibromuscular Dysplasia (FMD)
The purpose of this study has evolved and expanded since its inception. Originally the intent was to establish the functional, molecular and genetic profile of fibroblasts from Fibromuscular Dysplasia (FMD) patients as compared…
- Conditions
- Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection, Cervical Artery Dissection
- Trial name
- DEFINE (NCT01967511)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mild Cognitive Impairment
Rhythmic Light Therapy for Alzheimer's Disease Patients
The investigator will investigate how light delivering 40 hertz (Hz) affects subjective sleep and cognition in a controlled laboratory study.
- Trial name
- NCT05015478
- Testing
- Tailored Rhythmic Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Multiple Sclerosis, Neuromyelitis Optica
Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders
In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be used to understand the natural history, underlying immunologic mechanisms, and clinical implications of central nervous system (CNS)…
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NCT05982925
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Tobacco Dependence
Assessment of Biomarkers in Children to Help Parents Quit Tobacco
This randomized controlled trial will test whether adding biomarker measurement and informed outreach for tobacco smoke exposure as part of routine practice increases identification and improves treatment, effectiveness, and…
- Trial name
- ABC Quit (NCT04832659)
- Testing
- CEASE, CEASE + BIO
- Where
- United States
- Volunteers
- 865 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Network Neurofeedback Using 7-Tesla MRI to Reduce Rumination Levels in Depression
Patients with major depressive disorder (MDD) exhibit increased levels of rumination (i.e. repetitive thinking and focus on negative mood states) which have been found to increase the risk of depressive relapse.
- Trial name
- NCT05933148
- Testing
- Siemens 7T MRI
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Caregiver Burden, Caregiver Burnout
A Study of Meaning-Centered Psychotherapy for Caregivers to People With Cancer
Participants will complete 1 set of questionnaires about 2 weeks before beginning their Meaning-Centered Psychotherapy for Caregivers/MCP-C or standard Supportive Psychotherapy for Caregivers/SP-C sessions.
- Conditions
- Caregiver Burden, Caregiver Burnout, Caregiver Stress Syndrome
- Trial name
- NCT06307535
- Testing
- Meaning-Centered Psychotherapy for Caregivers, Supportive Psychotherapy for Caregivers
- Where
- 8 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cardiometabolic Syndrome, Obesity
Impact of Yo-Yo Sleep on Cardiometabolic Health
The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance…
- Trial name
- NCT05880758
- Testing
- Intermittent Short Sleep (ISS), Social Jetlag (SJL), Sustained Adequate Sleep (SAS)
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Columbia University