Clinical trials: sponsored by Hoffmann-La Roche
Angelman Syndrome
A Study To Assess Distribution Of RO7248824 In The Central Nervous System Following Single Intrathecal Doses Of [89zr] Labeled RO7248824 In Healthy Male Participants
The aim of Study BP41660 is to quantify the amount and concentration of [89Zr]DFO-RO7248824 in the brain with positron emission tomography (PET) following a single sub-pharmacological dose of RO7248824 and [89Zr]DFO-RO7248824…
- Trial name
- NCT04863794
- Testing
- RO7248824
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Autism Spectrum Disorder
A Study to Evaluate Scales for Repetitive and Restricted Behaviors in Children, Adolescents, and Adults With Autism Spectrum Disorder (ASD)
This is a non-drug study seeking to characterize different scales to measure repetitive and restrictive behaviors in different ASD sub-populations over time. This study will also explore the use of digital biomarkers.
- Trial name
- NCT03611075
- Testing
- No Intervention
- Where
- 18 sites in United States, Canada and 1 more
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Alzheimer Disease, Progressive Supranuclear Palsy
Tau Protein and SV2a Imaging in Patients With Tau Protein-related Diseases
Tau protein has been identified as one of the key pathological features of Tau proteinopathies, such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), frontotemporal dementia (FTD).
- Conditions
- Alzheimer Disease, Progressive Supranuclear Palsy, Frontotemporal Dementia
- Trial name
- NCT05260151
- Where
- China
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Healthy Volunteers Study
Drug-drug Interaction Study of Digoxin and AT-527 (R07496998)
Drug-drug interaction study of Digoxin and AT-527 (R07496998)
- Trial name
- NCT05137626
- Testing
- AT-527 + digoxin
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Healthy Volunteer Study
Study of AT-527 in Healthy Subjects (R07496998)
This study will assess the safety, tolerability and pharmacokinetics (PK) of AT-527 in healthy subjects.
- Trial name
- NCT04711187
- Testing
- AT-527 Formulation 1, AT-527 Formulation 2
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Healthy Volunteer Study
Bronchopulmonary PK of AT-527 (R07496998)
This study will assess the safety, tolerability and bronchopulmonary pharmacokinetics (PK) of AT-527 (R07496998)
- Trial name
- NCT04877769
- Testing
- AT-527
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Healthy Volunteer Study
Mass Balance Study of AT-527 in Healthy Adult Male Subjects (R07496998)
Mass balance study of AT-527 in Healthy Male Subjects.
- Trial name
- NCT05004415
- Testing
- AT-527 (R07496998)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Healthy Volunteer Study
Drug-drug Interaction Study of Rosuvastatin and AT-527 (R07496998)
Drug-drug interaction study of rosuvastatin and AT-527 (R07496998)
- Trial name
- NCT05154123
- Testing
- Drug: AT-527 + rosuvastatin, AT-527 + rosuvastatin
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Autism Spectrum Disorder
The Effect of Hepatic Impairment on the Pharmacokinetics of Balovaptan
This is a multi-center, non-randomized, open-label, parallel group, multiple-dose study to assess the pharmacokinetic, safety, and tolerability of balovaptan in male and female subjects with moderate hepatic impairment compared…
- Trial name
- NCT03912350
- Testing
- Balovaptan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Myelin Integrity
Scan-rescan Reproducibility of Myelin Sensitive MRI Techniques
This study is to assess the variation in the measurements of myelin sensitive MRI techniques in both white and grey matter in the brain.
- Trial name
- NCT04673734
- Testing
- myelin sensitive MRI scan
- Where
- Switzerland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Alzheimers Disease
A Single Ascending Dose Study to Investigate the Safety, Tolerability, Immunogenicity and Pharmacokinetics of Intravenously Administered RO7126209 in Healthy Participants
Study BP41192 is a randomized, adaptive, placebo-controlled parallel group study to investigate the safety, tolerability, immunogenicity and pharmacokinetics of single-ascending intravenous (IV) doses of RO7126209 in healthy…
- Trial name
- NCT04023994
- Testing
- RO7126209
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Healthy Volunteer Study
Effect of Cyclosporine on the Pharmacokinetics (PK) of AT-527 (R07496998)
This study will determine the effect of cyclosporine on the PK of AT-527 (R07496998) in healthy male subjects
- Trial name
- NCT04849299
- Testing
- AT-527 550 mg + cyclosporine
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Healthy Volunteer Study
Effect of Carbamazepine on the Pharmacokinetics (PK) of AT-527
This study will determine the effect of carbamazepine on the PK of AT-527 (RO7496998) in healthy adult subjects.
- Trial name
- NCT04784000
- Testing
- Period 1: AT-527 550 mg, Period 2: carbamazepine, Period 3: AT-527 550 mg + carbamazepine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Healthy Volunteer Study
Drug-drug Interaction Study of Midazolam and AT-527 (R07496998)
Drug-drug interaction study of midazolam and AT-527 (R07496998)
- Trial name
- NCT04865445
- Testing
- AT-527 550 mg + midazolam
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Hepatitis B Virus Infection
A Study of RO7239958 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers and Participants With Chronic Hepatitis B Virus Infection
This study is designed to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single and multiple ascending doses in healthy volunteers (HV) and participants diagnosed with chronic hepatitis B…
- Trial name
- NCT03762681
- Testing
- RO7239958
- Where
- 14 sites in Bulgaria, Hong Kong and 5 more
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Autism Spectrum Disorder
A Study to Investigate the Effect of Esomeprazole and the Effect of Food on the Pharmacokinetics of Balovaptan in Healthy Volunteers
This study will investigate the effect of food and the effect of esomeprazole on the pharmacokinetics (PK) of a single dose of balovaptan in healthy volunteers.
- Trial name
- NCT04156646
- Testing
- Balovaptan, Esomeprazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Muscular Atrophy, Spinal
A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function
This is a multi-center, open-label, non-randomized, parallel-group, 2-part study to evaluate the effect of hepatic impairment on the PK and safety and tolerability of a single oral dose of risdiplam compared to matched healthy…
- Trial name
- NCT03920865
- Testing
- Risdiplam
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Chronic Hepatitis B
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of RO7062931in Healthy Volunteers and Subjects With Chronic Hepatitis B
This randomized study will be conducted in two parts to evaluate the safety, tolerability, pharmacodynamics, and pharmacokinetics of subcutaneous administration of RO7062931.
- Trial name
- NCT03038113
- Testing
- RO7062931, Immune Modulator
- Where
- 19 sites in Australia, Hong Kong and 5 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Spinal Muscular Atrophy
A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants
This will be a Phase I, 2-part, open-label, non-randomized study to investigate the safety, tolerability, and pharmacokinetics (PK) of a multiple-dosing regimen of risdiplam (Part 1) and the effect of risdiplam on the PK of…
- Trial name
- NCT03988907
- Testing
- Risdiplam, Midazolam
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Healthy Volunteer
Study to Assess the Pharmacokinetics, Safety and Tolerability of Baloxavir Marboxil in Healthy Chinese Participants
This study will evaluate the pharmacokinetics, safety and tolerability of a single oral dose of baloxavir marboxil (40 mg or 80 mg) in healthy Chinese participants.
- Trial name
- NCT03959332
- Testing
- Baloxavir Marboxil
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche