Clinical trials: enrolling by invitation
3D-Printed, Direct Composite
Clinical Evaluation of 3D-Printed Versus Direct Composite Restorations in Class II Cavities
The aim of this study is to clinically evaluate the performance of 3D-printed composites compared to direct conventional composite restorations in Class II cavities
- Conditions
- 3D-Printed, Direct Composite, Resin Restorations
- Trial name
- NCT07861659
- Testing
- PG4 Dentsprint 3D-printed composite resin, Filtek P60 (3M) Packable composite
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Aortic Stenosis
Deep Learning Enhanced Detection of Aortic Stenosis - The DETECT-AS-Diagnostic Study
The DETECT-AS Diagnostic Study will assess the performance of artificial intelligence (AI) risk predictions to detect aortic stenosis using results from portable electrocardiogram (ECG) and cardiac ultrasound devices.
- Trial name
- NCT06749145
- Testing
- Portable 1-lead electrocardiogram, Point-of-care ultrasound, AI-ECG risk algorithm
- Where
- 3 sites in United States
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder (AUD), Alcohol Abstinence
SER-ABS-AUD: Neuropsychosocial-Spiritual Correlates of Serene Abstinence in Adults With AUD
SER-ABS-AUD is a single-centre, non-interventional, mixed retrospective-prospective longitudinal cohort study of 70 adults aged 18-70 years with documented alcohol use disorder, at least 12 consecutive months of continuous…
- Trial name
- SER-ABS-AUD (NCT07561749)
- Where
- Romania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Cardiotoxicity, Heart Failure
Novel On-body Evaluation of Cardiac Health for Oncology
The goal of this study is to develop a wearable sensor system that can estimate left ventricular ejection fraction (LVEF), which is a measurement of the heart's function.
- Trial name
- NOECHO (NCT07158450)
- Where
- 11 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Skribe Medical
Spinal Fusion, Adolescent Idiopathic Scoliosis
Low Dose Dexmedetomidine as a Postoperative Pain Adjunct
This randomized controlled trial examines whether the addition of a low-dose dexmedetomidine infusion to our current multimodal pain management plan decreases narcotic consumption and reduces side effects in adolescent patients…
- Trial name
- NCT06067893
- Testing
- Dexmedetomidine, Normal Saline
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Nichole Doyle
Developmental Disabilities, Developmental Delay
Exploratory Trial of a Pediatric Web-Based Care Planning Guide
Infants and toddlers with developmental disabilities or delays use early intervention (EI) for rehabilitation services. Yet, poor quality of EI services is pervasive, particularly for racially and ethnically diverse and socially…
- Trial name
- PROSPECT+ (NCT06458959)
- Testing
- PEM+
- Where
- United States
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Cancer
Understanding and Enhancing Health-Related Social Needs (HRSN) Screening Among Community Oncology Practices
This study evaluates health related social needs screening processes in community oncology clinics.
- Trial name
- HRSN (NCT06412029)
- Testing
- Non-Interventional
- Where
- 38 sites in United States, Guam and 1 more
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
All Conditions, All
Measurement of Ocular Microtremor With the iTremor Device in a Diverse US Cohort
To evaluate the reliability of using the iTremor device to accurately measure Ocular Microtremor (OMT) across a diverse cohort, representative of the US population, with a view to establishing this as a standard measurement tool…
- Trial name
- NCT07858214
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Head Diagnostics
Wellbeing
Self-Help Plus Pilot Study, Colombia: Train2Care
This project will strengthen local capacity for mental health care in high-need settings in Colombia by culturally and linguistically adapting the Self-Help+ intervention and delivering participatory, supervised training.
- Trial name
- T2C (NCT07524309)
- Testing
- Self help plus
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- George Washington University
Genetics, Obesity
Inherited and Environmental Risks Acting on Body Weight
The goal of this research is to investigate genetic and environmental factors that contribute to obesity through brain inflammation.
- Trial name
- INTERACT (NCT07430852)
- Testing
- Diet modification
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Washington
Ultrasonography, Difficult Airway
Airway Ultrasound vs Clinical Predictors for Difficult Airway
This prospective observational study aims to evaluate the diagnostic value of airway ultrasonography in predicting difficult intubation in adult patients undergoing elective surgery under general anesthesia.
- Conditions
- Ultrasonography, Difficult Airway, Preoperative Evaluation
- Trial name
- NCT07243106
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Healthy Volunteers
A Study of [13C]Pyruvate as an Imaging Agent for Magnetic Resonance Imaging in Healthy Volunteers
The purpose of the study is to learn about the use of [13C]pyruvate as an imaging agent for MRI scans. In past studies, researchers have seen that [13C]pyruvate can improve imaging with MRI scans.
- Trial name
- NCT05041166
- Testing
- Hyperpolarized [13C] Pyruvate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obese, Healthy
Dietary Sugar Absorptive Phenotype for Prediction of Weight Loss Outcome
This study is trying to determine whether the success of bariatric surgery can be predicted by evaluating the dietary sugar absorptive characteristics in the small intestine and if there is any gene expression change on the…
- Conditions
- Obese, Healthy, Bariatric Surgery Candidate
- Trial name
- NCT05408728
- Testing
- Endoscopic biopsy
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pain, Postoperative
Screen Addiction and Postoperative Pain
Excessive or problematic smartphone use has become increasingly common and has been associated with various psychological and physical health consequences, including anxiety, depressive symptoms, reduced sleep quality…
- Trial name
- NCT07242872
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Health Literacy
Development and Reliability and Validity Testing of a Health Literacy Assessment Scale for Nursing Assistants
The goal of this observational study is to develop and evaluate a health literacy assessment scale for caregivers (nursing assistants) working in medical institutions, based on their job characteristics and caregiving needs.
- Trial name
- NCT07853820
- Testing
- Health Literacy Questionnaire for Nursing Assistants
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Air Force Medical University
Burnout, Caregiver
Evaluation of the CBSM Program Online and in Person to Reduce Caregiver Burnout
Professional burnout is a common syndrome among healthcare workers, impacting both their well-being and the quality of care provided .
- Trial name
- Caregiver-CBSM (NCT06626061)
- Testing
- Cognitive Behavioral Stress management in in person group Format, Cognitive Behavioral Stress management Hybrid Format
- Where
- 2 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Breast Cancer, Ovarian Cancer
Tissue Acquisition and Genomics Analysis of Breast Cancer and Other Gynecologic Malignancies
Background: A person s blood, tissue, and other samples contain DNA. Cancer is a disease of cells that are not working properly. It is caused by changes in DNA that build up.
- Conditions
- Breast Cancer, Ovarian Cancer, Uterine Cancer
- Trial name
- NCT03762733
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Extraction Socket Healing
Assessment of Topical Application of Chitosan 0.2% Chlorhexidine Gel on Wound Healing in Diabetic Patients
Despite efforts to prevent postoperative discomfort, immediate side effects of surgical extraction of lower molars include bleeding at the site of extraction, inflammation, pain, and alveolar osteitis especially in diabetic…
- Trial name
- NCT07429812
- Testing
- Surgical extraction of the offending tooth will be performed under local anesthesia using inferior alveolar nerve block technique with buccal mucosa infiltration, make an incision on the gingival tis
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Health Services, Mental Health
Telephone-Based Care Coordination for Services Addressing Childhood Adversity
The goal of this study is to learn how telephone-based screening and care coordination impacts children experiencing adverse childhood events (ACEs). The main questions are: 1.
- Conditions
- Health Services, Mental Health, Well-being
- Trial name
- CARE (NCT07686614)
- Testing
- Telephone-based Screening and Care Coordination
- Where
- United States
- Volunteers
- 778 people, healthy volunteers welcome
- Sponsor
- Paul Chung
Pressure Injury Prevention
Evaluation of Commercially Available Heel Pads for the Prevention of Pressure Ulcers: An Observational Study of Incidence and Usability in Adult Surgical Patients.
This study will evaluate the incidence of heel pressure ulcers in adult patients undergoing elective surgery while using the Oasis Elite Heel Pad (EL130) as part of routine pressure ulcer prevention.
- Trial name
- NCT07852897
- Testing
- Oasis Elite Heel Pad (EL130)
- Where
- Ireland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Trulife