Clinical trials: sponsored by Laval University
Patent Foramen Ovale, Ischemic Stroke
Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke
To determine the safety of antithrombotic treatment discontinuation 12 months following successful transcatheter PFO closure.
- Conditions
- Patent Foramen Ovale, Ischemic Stroke, Bleeding Ulcer
- Trial name
- HALTI (NCT04475510)
- Testing
- Antiplatelet treatment discontinuation
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Josep Rodes-Cabau
Aortic Valve Disease, Conduction Disturbances
Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study
The purpose of this study is to determine the incidence and predictors of high degree or complete atrioventricular block (AVB) (paroxysmal or persistent) in patients with new-onset persistent left bundle branch block (NOP-LBBB)…
- Trial name
- MARE (NCT02153307)
- Testing
- Implantable loop recorders system Reveal ICM LINQ®,
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor
International PPB/DICER1 Registry
PPB has strong genetic implications, with a unique set of conditions in an individual or their family, occurring mostly in childhood and adolescence.
- Conditions
- Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma
- Trial name
- NCT03382158
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Cardiovascular (CV) Risk, Metabolic Health
Advancing Health Equity and Preventive Cardiovascular Care in Indigenous and Remote Communities: a Mobile Healthcare Unit
Indigenous people living in Canada face significant healthcare inequities, particularly in basic, primary, and secondary prevention, leading to higher rates of cardiovascular disease and mortality.
- Conditions
- Cardiovascular (CV) Risk, Metabolic Health, Primary Prevention
- Trial name
- NCT07869069
- Testing
- Cardiovascular risk screening, Follow-up of cardiovascular risk factors
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Laval University
Insulin Dependent Diabetes Mellitus, Feeding and Eating Disorders
The diabEAT Study: Insulin dElivery Technologies And eaTing Behaviours in People With Type 1 Diabetes
Type 1 diabetes is an autoimmune health condition that requires daily injections of insulin. Insulin allows the body to use energy from carbohydrates in food.
- Conditions
- Insulin Dependent Diabetes Mellitus, Feeding and Eating Disorders, Eating Behavior, Type 1 Diabetes
- Trial name
- NCT07348432
- Testing
- Automated Insulin Delivery (AID) Systems, Carbohydrate Counting Inaccuracy Percentage
- Where
- Canada
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- McGill University
Diet
Identification of Objective Metabolomics-based Biomarkers of Yogurt Consumption
Substantial evidence links yogurt consumption to a lower risk of type 2 diabetes (T2D). However, the existing evidence is derived exclusively from prospective cohort studies relying on self-reported dietary questionnaires…
- Trial name
- YOGBIO (NCT07491887)
- Testing
- Yogurt-free diet, Low-yogurt diet, Moderate-yogurt diet
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Laval University
Digital Health Intervention, Remote Consultation, Teleconsultation
Evaluation and Implementation of Digital Health Ecosystem in Academic Health Center
Mobile health technologies, such as smartwatches, wearable sensors, and digital applications, have the potential to support healthier lifestyles and improve the management of health conditions.
- Conditions
- Digital Health Intervention, Remote Consultation, Teleconsultation, Lifestyle Factors, Stress
- Trial name
- e-IDEA (NCT07831837)
- Testing
- Integrated Digital Health Ecosystem, Usual Primary Care
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Gut Microbiota, Metabolic Syndrome
Effects of Blueberry on Gut Microbiota and Metabolic Syndrome
There is growing evidence that nutritional intervention with dietary polyphenols can positively modulate the gut microbiota to improve cardiometabolic health.
- Trial name
- NCT03266055
- Testing
- 50 g of blueberry powder, taken daily for 8 weeks
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Laval University
Gut Microbiota, Metabolic Syndrome
Effect of Raspberry on Gut Microbiota and Metabolic Syndrome
There is growing evidence that nutritional intervention with dietary polyphenols can positively modulate the gut microbiota to improve cardiometabolic health.
- Trial name
- NCT03620617
- Testing
- Raspberry supplement
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Laval University
Gut Microbiota, Metabolic Syndrome
Effect of Non-nutritive Sweeteners of High Sugar Sweetened Beverages on Metabolic Health and Gut Microbiome
Increasing evidence suggest that artificial sweeteners such as saccharin, aspartame and sucralose may not be as metabolically safe as they first appeared, and it has been proposed that their consumption may be linked to important…
- Trial name
- NCT03259685
- Testing
- 710 ml of regular soft drinks, taken daily for 10 weeks, 710 ml of diet soft drinks, taken daily for 10 weeks, 710 ml of stevia-sweetened soft drinks, taken daily for 10 weeks
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Laval University
Cardiovascular Disease
Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors
The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors.
- Trial name
- FAS (NCT01343342)
- Testing
- n-3 PUFA supplementation
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Laval University
Abdominal Obesity
Effects of a Polyphenol-rich Cranberry Extract on Cardiometabolic and Neurocognitive Health
The objective of this double-blind, parallel, randomized placebo-controlled clinical trial is to evaluate the effects of consumption of polyphenol-rich cranberry extract standardized in PACs (36 mg PACs/capsule) on…
- Trial name
- Neurocan (NCT05062954)
- Testing
- Polyphenol-rich cranberry extract supplement standardized in proanthocyanidins
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Laval University
Conduction Disturbances, Transcatheter Aortic Valve Replacement
Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following TAVR
The high incidence and variety of conduction disturbances post-TAVR represents a major challenge in the periprocedural management of TAVR recipients.
- Conditions
- Conduction Disturbances, Transcatheter Aortic Valve Replacement, Permanent Pacemaker Implantation
- Trial name
- PROMOTE (NCT04139616)
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Obesity and Obesity-related Medical Conditions
Egg Intake, Metabolic Outcomes and Choline Levels
The purpose of this research is to determine the effect of additional daily egg intake on metabolic phenotypes and metabolism in the context of obesity.
- Trial name
- NCT06687122
- Testing
- 3 whole eggs
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Body Composition Changes, Body Weight Change
Effect of Dairy Protein Yogourt vs Plant-based Yogourt on Body Weight, Body Composition, Bone Health and Gut Microbiota
The consumption of an adequate quantity of protein in the diet is essential to maintain a healthy body composition and functioning.
- Conditions
- Body Composition Changes, Body Weight Change, Metabolic Health, Bone Metabolism
- Trial name
- PROYO (NCT07578103)
- Testing
- Dairy yogurt, Plant based yogurt, No yogurt
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Laval University
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Novel MRI Biomarkers for Monitoring Disease Progression in ALS
Routine MRI is normal in motor neuron diseases such as ALS. However, advanced MRI techniques can provide an objective measure of degeneration (a "biomarker") by examining brain structure, wiring, chemistry, and function.
- Trial name
- NCT03362658
- Where
- 7 sites in United States, Canada
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Autosomal Recessive Disorder (Genetic Carriers of PKU)
Phe for Me? The Effects of L-Phe on PKU Carriers and Non-carriers
This is a clinical intervention study of PKU carriers (cases) and non-carriers (controls). Upon completing the informed consent process, participants will complete baseline measures of chronic mental health prior to the…
- Trial name
- Phe for Me (NCT06119048)
- Testing
- L-Phenylalanine
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS
CAPTURE ALS is a long-term data and biorepository platform that will facilitate future ALS research. CAPTURE ALS will provide the standardized systems and tools necessary to collect, store, and analyze vast amounts of multimodal…
- Conditions
- Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy, Frontotemporal Degeneration
- Trial name
- CAPTURE ALS (NCT05204017)
- Where
- 4 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Left Atrial Appendage Closure, Thrombosis
Short-Term Anticoagulation Versus Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure
The objective of the study is to compare short-term (8 weeks) anticoagulation therapy (DOAC) vs. antiplatelet therapy for the prevention of device thrombosis following transcatheter LAAC.
- Conditions
- Left Atrial Appendage Closure, Thrombosis, Stroke, TIA
- Trial name
- ANDES (NCT03568890)
- Testing
- Rivaroxaban, dabigatran, apixaban, or edoxaban, Clopidogrel -75 mg/day, Low dose aspirin -80 to 125 mg/day-
- Where
- Canada
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Overweight/Obesity, Metabolic Syndrome
Effects of Cranberry on Gut and Metabolic Health
The consumption of plant-based foods, particularly berries, has been associated with improved health due to their high content of bioactive compounds.
- Conditions
- Overweight/Obesity, Metabolic Syndrome, Insulin Resistance, Microbiota
- Trial name
- CRANOS (NCT07460856)
- Testing
- Cranberry beverage
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Laval University