Clinical trials: sponsored by Sun Yat-sen University
Preterm Birth, Neurodevelopmental Disorders
Guangzhou Preterm and Term Birth Cohort Study
The Guangzhou Preterm-Term Birth Cohort (GPTBC) is a prospective observational study of how early-life nutrition, environmental exposures, and family factors relate to the health and development of preterm and term infants and…
- Conditions
- Preterm Birth, Neurodevelopmental Disorders, Overweight, Obesity
- Trial name
- GPTBC (NCT07756177)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
China HEalthy Aging and Dementia Study (HEAD)
The China HEalthy Aging and Dementia (HEAD) study is a large-scale, community-based, multi-center prospective cohort study covering eastern, northern, southern, and central-western regions of China.
- Conditions
- Alzheimer Disease (AD), Mild Cognitive Impairment (MCI), Dementia, Vascular Dementia (VaD)
- Trial name
- NCT07912710
- Where
- 30 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Systemic Health Risk
AI-Assisted Systemic Health Risk Assessment in General Ophthalmology
This study will evaluate whether providing ophthalmologists with additional artificial intelligence (AI)-assisted health risk information derived from routine retinal images affects subsequent clinical care in adults attending…
- Trial name
- LifeEye-RCT (NCT07890922)
- Testing
- AI-Assisted Health Risk Information
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Upper Limb Volume Measurement
Clinical Trial of an Upper Limb Measurement Device
This clinical study evaluates an upper limb measurement device designed to measure upper limb volume. The study will compare measurements obtained using the upper limb measurement device with those obtained using the water…
- Trial name
- NCT07898410
- Testing
- Upper Limb Measurement Device
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Refractive Errors
Consistency of an Automated Subjective Refraction Program Between Personnel With Diverse Professional Backgrounds and Senior Optometrists
This study aims to evaluate the performance of automated subjective refraction performed by operators with different professional backgrounds.
- Trial name
- NCT07891884
- Testing
- Nurse-Operated Automated Subjective Refraction, Village Doctor-Operated Automated Subjective Refraction, Lay Personnel-Operated Automated Subjective Refraction
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Refractive Errors
Evaluation of the Agreement Between Automated Program-Operated Phoropter Subjective Refraction and Optometrist-Performed Subjective Refraction
This study aims to evaluate the performance of an automated subjective refraction system that operates a digital phoropter. By comparing its results with those obtained through conventional subjective refraction performed by an…
- Trial name
- NCT07891897
- Testing
- Automated Program-Controlled Subjective Refraction, Optometrist-Performed Subjective Refraction
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Prediabetes
Efficacy of Diacylglycerol Oil on Metabolic Risk Factors in Prediabetes
This study will implement a four-week dietary intervention among middle-aged and older adults with pre-diabetes. Participants assigned to the intervention arm will replace their usual cooking oil with diacylglycerol (DAG) oil…
- Trial name
- NCT07289880
- Testing
- Diacylglycerol oil, Colza Oil
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangdong Pharmaceutical University
Lung Cancer Non-small Cell, Colorectal Cancer
Multimodal Liquid-Biopsy Omics Biomarkers of Treatment Response in Breast Cancer
This single-center cohort study integrates humoral immune response profiling (Phage ImmunoPrecipitation Sequencing, PhIP-seq) with circulating cell-free DNA (cfDNA) genomic and epigenomic features, exosome transcriptomics, and…
- Conditions
- Lung Cancer Non-small Cell, Colorectal Cancer, Stomach Cancer, Hepatocellular Carcinoma
- Trial name
- NCT07880106
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
HIV Infections, Frailty
Sleep Quality and Frailty Among People Living With HIV
With effective antiretroviral therapy (ART), people living with HIV (PLWH) are living longer and are increasingly experiencing aging-related conditions such as frailty and sleep problems.
- Conditions
- HIV Infections, Frailty, Sleep Quality, Oral Frailty
- Trial name
- NCT07880054
- Testing
- No intervention (observational assessments)
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Sun Yat-sen University
Cognitive Dysfunction
Eye Movement Parameters and Cognitive Functions in Older Adults
Dementia most commonly occurs in elderly individuals, but currently there is still a lack of objective measurement methods that can detect cognitive impairment in older adults at an early stage.
- Trial name
- NCT07358598
- Where
- Taiwan
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National Sun Yat-sen University
Uterine Fibroid
Epidemiology and Risk Factors of Uterine Fibroids in China
Uterine fibroids are the most common form of benign uterine tumors in the uterine muscle layer, which had a certain rate of malignancy, but it is rare.
- Trial name
- NCT05840042
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Wenwen Wang
Chronic Hepatitis B
Impact of Functional Cure of Chronic Hepatitis B on Patient-Reported Outcomes (PROs)
This single-center comparative cross-sectional study includes a prospective longitudinal follow-up cohort. At least 400 subjects from the "Everest Project" cohort will be enrolled into four groups: clinical-cure, non-cure…
- Trial name
- NCT07855029
- Testing
- Observation-based data collection via patient-reported questionnaires
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Zhiliang Gao
Dental Anxiety
Intranasal Dexmedetomidine for Severe Dental Anxiety: a Randomized Trial
Patients with dental anxiety only develop anxiety and fear about dental treatments. Patients with severe dental anxiety have difficulty cooperating with dental treatments, and can only complete dental treatments through general…
- Trial name
- NCT05500261
- Testing
- Dexmedetomidine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Asthenopia, Visual Fatigue
Visual and Neural Responses to Naked-Eye 3-D Viewing
This multicenter study examines short-term changes in visual fatigue and eye function after glasses-free three-dimensional (3D) viewing in healthy adults.
- Conditions
- Asthenopia, Visual Fatigue, Binocular Vision Disorder
- Trial name
- NCT07848763
- Testing
- Device / Behavioral Exposure
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Dry Eye
Dry Eye Screening and Referral System
Dry eye is one of the most common ocular surface diseases. Its pathogenic factors are related to multiple etiology. Because of the complexity of the pathogenesis of dry eye, the diversity of related examinations, and the…
- Trial name
- NCT04413370
- Testing
- Dry eye diagnostic test
- Where
- China
- Volunteers
- 1,273 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Visual Fatigue, Dry Eye
A Study of Full-Spectrum Screen Lighting for Reducing Screen-Related Eye Fatigue and Dry Eye
This study will evaluate whether full-spectrum screen bar lighting can reduce eye fatigue and dry eye symptoms after a standardized screen task.
- Conditions
- Visual Fatigue, Dry Eye, Computer Vision Syndrome
- Trial name
- NCT07706231
- Testing
- Full-spectrum screen bar light, Brightness-matched screen task without screen bar lighting
- Where
- China
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Nasopharyngeal Carcinoma (NPC)
Comparison of Multi-omics Models for Early Nasopharyngeal Carcinoma Screening: cfDNA Methylation, EBV DNA, and Serological Double-antibodies Detection
This study focus on nasopharyngeal carcinoma, a cancer type with Chinese characteristics, analyze the early screening detection performance of nasopharyngeal carcinoma in the multi-cancer early screening model, and compare the…
- Trial name
- PROFOUND-NPC (NCT06763289)
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Ophthalmology, Artificial Intelligence (AI)
Detection of Systemic Diseases Such as Hepatobiliary Diseases From Ocular Images Via Deep Learning
Oculomics is an emerging interdisciplinary field that deciphers multi-dimensional, high-throughput ocular data to predict, diagnose, and monitor systemic diseases and health span.In recent years, artificial Intelligence may…
- Conditions
- Ophthalmology, Artificial Intelligence (AI), Hepatobiliary Diseases, Systemic Diseases
- Trial name
- NCT07581925
- Testing
- Systemic diseases such as Hepatobiliary Disorders
- Where
- China
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Laparoscopic Hepatectomy
The Effect of Remimazolam Versus Propofol on Postoperative Extubation Time
This clinical trial aims to help us understand how two drugs, Propofol and Remazoloam, affect when researchers remove a Participants' breathing tube after liver surgery (laparoscopic liver resection).The main research questions…
- Trial name
- NCT07611344
- Testing
- Remimazolam, propofol
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Xuyu Zhang
Nasopharyngeal Carcinoma (NPC), Screening
"Xijiang Project" Screening Cohort for NPC
The purpose of this study is to establish a comprehensive and integrated nasopharyngeal carcinoma screening cohort, which includes an epidemiological information database containing basic information, gender, age, ethnic and…
- Trial name
- NCT06787456
- Testing
- EBV antibodies test, EBV DNA test, epidemiological information survey
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Ming-Yuan Chen