Clinical trials: sponsored by Unity Health Toronto
Caregiver, Caregiver Mental Health
Friends/Family of Individuals at Risk of Suicide Training Program
The Friends/Family of Individuals at Risk of Suicide Training (FIRST) program is a six-week program designed to provide knowledge and practical skills to help caregivers care for their loved one while also supporting their own…
- Conditions
- Caregiver, Caregiver Mental Health, Caregiver Stress, Suicide
- Trial name
- FIRST (NCT07902089)
- Testing
- FIRST Program
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Weaning-induced Pulmonary Edema, Mechanical Ventilation Weaning
Detecting Early Weaning-induced Pulmonary Oedema Using Lung Impedance Negative Trend During Spontaneous Breathing Trials
Critically ill patients who require a breathing machine are routinely assessed with a spontaneous breathing trial (SBT) to determine if they can safely breathe on their own.
- Conditions
- Weaning-induced Pulmonary Edema, Mechanical Ventilation Weaning, Spontaneous Breathing Trial
- Trial name
- DEWPOINT (NCT07886671)
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Sepsis
Clinical Outcomes Using Molecular Prediction in Acute Suspected Sepsis and Infection
Sepsis is a complex syndrome that affects the functioning of multiple organ systems and is caused by an uncontrolled response to infection.
- Trial name
- COMPASS-I (NCT07874698)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Healthy Volunteers
Examining the Effects of Nasal High Flow Oxygen Therapy Compared to Non-invasive Ventilation in Health Volunteers
Respiratory failure is characterized by low levels of oxygen and high levels of carbon dioxide in the blood which causes difficulty breathing.
- Trial name
- NCT03902639
- Testing
- Phase 1 and 2, Phase 3
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Treatment Resistant Depression, Depression - Major Depressive Disorder
Characterizing Synaptic Density in Treatment Resistant Depression
The purpose of this study is to better understand how certain brain systems work in people with depression, especially in those whose symptoms have not improved with antidepressant treatments.
- Trial name
- TPET (NCT03537794)
- Testing
- PET scans
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases Risk
Circulating Vascular Regenerative Cell Exhaustion in Individuals Without Type 2 Diabetes Who Are of South Asian or European Origins
ORIGINS-VRCE-2 is an observational study aimed to assess how blood vessel forming stem cells from individuals without diabetes or a history of cardiovascular disease differ between individuals of South Asian and European…
- Trial name
- ORIGINS-VRCE-2 (NCT06769347)
- Where
- 5 sites in Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
HIV, Chlamydia
National Rapid TLC: Testing and Linkage to Care
The goal of this cross-sectional study is to learn if the GeneXpert system is a practical system for HIV and STBBI testing in community-based organizations and health clinics.
- Conditions
- HIV, Chlamydia, Gonorrhea, HCV
- Trial name
- NCT07730801
- Testing
- Xpert® HIV-1 Qual XC
- Where
- 2 sites in Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Mood Disorders, Depressive Disorder
An Innovative Master Platform for Clinical Trials in Mood Disorders
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person.
- Conditions
- Mood Disorders, Depressive Disorder, Bipolar and Related Disorders
- Trial name
- ENABLE (NCT06408012)
- Where
- 9 sites in Canada
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Cardiac Conditions, Connective Tissue Diseases
The Genetics Navigator: Evaluating a Digital Platform for Genomics Health Services
Genetic testing (GT) (including targeted panels, exome and genome sequencing) is increasingly being used for patient care as it improves diagnosis and health outcomes.
- Conditions
- Cardiac Conditions, Connective Tissue Diseases, Retinal Disease, Epilepsy in Children
- Trial name
- NCT06455384
- Testing
- Genetics Navigator, Standard Care with Genetics Professionals
- Where
- 3 sites in Canada
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Pre-exposure Prophylaxis, HIV Infections
Project Phakama: Testing Support Strategies to Empower Young Women on PrEP in South Africa
The goal of this trial is to understand which strategies work best to support pre-exposure prophylaxis (PrEP) use among female sex workers (FSW) and adolescent girls and youth women (AGYW) in uMgungundlovu, KwaZulu-Natal, South…
- Trial name
- NCT06274060
- Testing
- Case management, Food vouchers, PrEP support buddy
- Where
- South Africa
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Major Depressive Disorder
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
This is a study that will test a predictive biomarker algorithm based on results from a previous study. The goal of this study is to integrate clinical, imaging, EEG, and molecular data across 8 sites to predict treatment outcome…
- Trial name
- CAN-BIND-17 (NCT05017311)
- Testing
- Escitalopram, Brexpiprazole
- Where
- 10 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Wellness, Burnout, Caregiver
Evaluating the Impact of Resource Navigators to Support LTC and RH Staff During and Beyond COVID-19
The goal of this clinical trial is to test how well resource navigators help long-term care and retirement home staff access the various health and wellness resources available to them and the effects that this has on their…
- Conditions
- Wellness, Burnout, Caregiver, Burnout, Professional, COVID-19
- Trial name
- NCT05677997
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Homelessness, Youth
Transitioning Youth Out of Homelessness 2.0 (TYOH 2.0)
Introduction: This 12-month pilot randomized controlled trial (RCT) built on previous community-engaged work and explored whether portable rent subsidies and an intervention targeting identity capital (purpose, control…
- Trial name
- NCT05781503
- Testing
- Identity Capital Intervention (Coach + Co-designed Leadership Guide), Monthly Rent Subsidies
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Antimicrobial Stewardship, Antimicrobial Drug Resistance
Peer Comparison Feedback As An Antimicrobial Prescribing Intervention To General Medicine Specialists
The purpose of this study is to evaluate the effect of a peer comparison feedback report, combined with a best practices toolkit, on the volume of antimicrobial use by general medicine physicians.
- Trial name
- PEER AIMS (NCT07189364)
- Testing
- Peer Comparison Feedback Report
- Where
- Canada
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Fahad Razak
Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission
Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression (PACt-MD)
This 7-year randomized controlled trial will compare the efficacy of non-invasive brain stimulation (trans-cranial Direct Current Stimulation - tDCS) combined with cognitive remediation (CR) versus sham ("placebo") tDCS combined…
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission, Major Depressive Disorder, Single Episode, in Full Remission
- Trial name
- PACt-MD (NCT02386670)
- Testing
- tDCS + CR
- Where
- 5 sites in Canada
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cardiovascular Diseases, Cardiovascular Risk Factor
Using Big Data to Conduct Innovative Cardiovascular Clinical Trials
Traditional randomized clinical trials (RCTs) have provided extremely valuable information on medical therapies and procedures that have changed the way heart diseases are treated.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Dyslipidemias
- Trial name
- NCT04067297
- Testing
- Lipid management toolbox
- Where
- Canada
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical Evaluative Sciences
Major Depressive Disorder, Suicide
Pain, Reward, Attention and Neurocircuitry: Biomarkers of Suicidality
The ultimate aim of this study is to identify a biomarker of suicide risk in MDD by measuring the "hedonic spectrum" (pain and reward responsivity), attention and its associated brain structures using brain scans (fMRI and DTI)…
- Conditions
- Major Depressive Disorder, Suicide, Suicidal Ideation
- Trial name
- NCT02811198
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Major Depressive Disorder, Suicide
Identifying the Neural Basis of Capability for Suicide
Since capability for suicide involves overriding potential pain, and the opioid system plays a strong role in controlling pain perception, it follows that capability for suicide may be impacted by the opioid system.
- Conditions
- Major Depressive Disorder, Suicide, Suicidal Ideation, Psychiatric Illness
- Trial name
- NCT03327129
- Testing
- fMRI
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HIV Infection, Syphilis Infection
Multiplo Tp/HIV Self-Test
To help reach the undiagnosed living with HIV and/or syphilis in Canada, self-tests for HIV and Syphilis may have substantial utility for increased identification of infected individuals through their relative ease of use and…
- Trial name
- NCT06716450
- Testing
- Multiplo TP/HIV Antibody Test
- Where
- 3 sites in Canada
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Non-anemic Iron Deficiency
Iron Treatment for Young Children With Non-anemic Iron Deficiency
The pre-school years are critical years for children to acquire early learning skills such as language, fine motor and social skills; this is termed early child development.
- Trial name
- OptEC (NCT01481766)
- Testing
- Ferrous Sulfate, Dietary counseling
- Where
- 2 sites in Canada
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children