Clinical trials: sponsored by University Hospital Heidelberg
Right Ventricular Dysfunction, Cardiopulmonary Diseases
Right Heart and Lung Blood Flow During Exercise (RIGHT-NET 2.0)
RIGHT-NET 2.0 is a multicenter observational study with a retrospective-prospective design that builds on the original RIGHT-NET study.
- Conditions
- Right Ventricular Dysfunction, Cardiopulmonary Diseases, Pulmonary Hypertension
- Trial name
- RIGHT-NET 2 (NCT07851610)
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- IRCCS SYNLAB SDN
Hereditary Spastic Paraplegia, Spastic Ataxia
TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias
Ataxias, hereditary spastic paraplegias (HSP), and spastic ataxias (collectively referred to as SPAX diseases) are rare neurological conditions that cause progressive problems with walking, balance, coordination, and daily…
- Trial name
- TreatHSP (NCT07798674)
- Where
- 30 sites in Austria, Czechia and 7 more
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Hospital Emergency and Operations Planning, Pediatric Hospital
State of In-hospital Disaster Protection at Children's Hospitals in Germany
Catastrophic situations demand a heigh preparedness from hospitals. In Germany, all hospitals are required to maintain an emergency and response plan for such situations. However, these plans are often insufficient.
- Trial name
- NCT07766941
- Where
- Germany
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Mental Health, Well-being
A Mentalization Based Prevention Program to Foster Well-Being and Mental Health in Pre-Adolescent Children and Their Families
The FLOW project involves the implementation and rigorous evaluation of an evidence-based, multi-level mentalization prevention program targeting social and psychological determinants of well-being in four European countries…
- Trial name
- FLOW (NCT07494929)
- Testing
- Lighthouse Program, Mentalization Based Skills Training, Lighthouse program parenting guidebook
- Where
- 4 sites in Germany, Lithuania and 2 more
- Volunteers
- 15,200 people, healthy volunteers welcome
- Sponsor
- Svenja Taubner
Occupational Health, Stress
Implementation of the ASCEND Training for Supervisors in Dutch Small and Medium-sized Enterprises (SMEs)
This cluster randomized controlled trial (cRCT) aims to evaluate the effectiveness of the Dutch adaptation of an in-person group intervention for workplace supervisors - Advancing Supervisors' Capacity for Mental Health at Work…
- Conditions
- Occupational Health, Stress, Burnout, Mental Health Conditions
- Trial name
- NCT06989398
- Testing
- Advancing Supervisors' Capacity for Mental Health at Work (ASCEND)
- Where
- Netherlands
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam
High Altitude
HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men
Randomized clinical trial evaluating the effect of acetazolamide on pulmonary artery pressure in women compared to men travelling to 3600 m.
- Trial name
- NCT06498505
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Mountain Sickness
HighCycle Study: Effect of High Altitude on Acute Mountain Sickness in Women Related to Their Menstrual Cycle Phase
Prospective cohort study investigating the menstrual cycle phase (MCP)-dependent incidence of acute mountain sickness (AMS) in women travelling to 3600 m.
- Trial name
- NCT06499714
- Testing
- Exposure to 3600 m
- Where
- Kyrgyzstan
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sleep-Disordered Breathing
HighCycle Study: Effect of High Altitude on Sleep Disordered Breathing in Women Related to Their Menstrual Cycle Phase
Prospective cohort study investigating the menstrual cycle phase (MCP) dependent sleep disordered breathing (SDB) in women travelling to 3600 m.
- Trial name
- NCT06498544
- Testing
- Exposure to 3600 m
- Where
- Kyrgyzstan
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sleep-Disordered Breathing
HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men
Randomized clinical trial evaluating the effect of acetazolamide on sleep disordered breathing in women compared to men travelling to 3600 m.
- Trial name
- NCT06498531
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Periodontitis, Adult, Periodontitis (Stage 3)
Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy
Periodontitis is a prevalent chronic inflammatory disease driven by a dysbiotic oral biofilm and a dysregulated host immune response.
- Conditions
- Periodontitis, Adult, Periodontitis (Stage 3), Periodontitis Stage IV
- Trial name
- PROPARO (NCT07443410)
- Testing
- Non-surgical periodontal therapy (NSPT) and supportive periodontal therapy (SPT), Probiotic lozenge (Limosilactobacillus reuteri; GUM® PerioBalance®), Vitamin B12 drops (natural elements)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Metabolic Dysfunction-Associated Steatotic Liver Disease
Using Digital Twin Technology and Clinical Decision Support Systems to Improve the Early Detection, Personalised Treatment, and Long-term Monitoring of Patients Across the Full Spectrum of Metabolic-associated Fatty Liver Disease (MAFLD).
The goal of this observational study is to create a detailed virtual model to better understand how Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) develops.
- Trial name
- ARTEMIS (NCT07430501)
- Testing
- Data recollection
- Where
- Spain
- Volunteers
- 7,720 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Mountain Sickness
HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
Millions of people travel to high altitude for work or leisure activities and are exposed to reduced inspiratory oxygen partial pressure and hypoxemia that may lead to altitude illness, among which the most common form is acute…
- Trial name
- NCT06499727
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
HPV
PANHPVAX, Study of a New HPV Vaccine in Healthy Volunteers
First-in-human, phase I, single-center, open-label, dose-escalation trial in healthy volunteers. Investigation of safety and tolerability of ascending doses of PANHPVAX, a vaccine against human papilloma L2 antigens formulated…
- Trial name
- PANHPVAX (NCT05208710)
- Testing
- Vaccination with PANHPVAX 10µg, Vaccination with PANHPVAX 40µg, Vaccination with PANHPVAX 100µg
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center
Cognitive Change, Well-Being, Psychological
Impact of GPT Use on Essay Writing Performance and Cognitive Abilities
The goal of this randomized controlled lab experiment is to examine if using generated artificial intelligence (AI) technology will affect people's academic performance and cognitive abilities in the context of analytical writing…
- Trial name
- NCT06511102
- Testing
- GPT Support
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Stroke
Guideline-recommended Basic Parameter Adherence in Neurocritical Care Patients
The aim of the planned study project is to assess the current situation regarding the treatment of patients with severe stroke at the neuro-critical care unit.
- Trial name
- NORMONICU (NCT06367543)
- Testing
- Time in therapeutic range of vital parameters
- Where
- Germany
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Pulmonary Hypertension, Global Health
PVRI GoDeep Global Deep Phenotyping Meta-Registry for Pulmonary Hypertension
PVRI-GoDeep is a PH Meta-Registry, run under the umbrella of the Pulmonary Vascular Research Institute (PVRI). It merges anonymized PH patient related data from various local registries around the world run under the…
- Trial name
- PVRI GoDeep (NCT05329714)
- Where
- Germany
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Chronic Kidney Diseases, Healthy
Multiparametric MRI in Healthy Volunteers and CKD Patients
Chronic kidney disease (CKD) is a global health concern because more than 10% of the world's population have it, its prevalence is increasing, and CKD is an important contributor to morbidity and mortality for this population.
- Trial name
- RESPECT (NCT05229263)
- Testing
- Non- contrast Enhanced Multiparametric Renal Magnetic Resonance
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Peripheral Nerve Disease
The Development of Diagnosis and Prognosis Predictive Model for Peripheral Nerve Disease
This is a retrospective observational cohort study (MRN-PND), aiming to explore the utility of contrast-enhanced MRN (ceMRN) compared to plain MRN in diagnosing peripheral nerve diseases and predicting the prognosis of patients…
- Trial name
- NCT06843642
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Cancer, Exercise
Multi-professional Care Pathway and Network for the Promotion of Needs-oriented, Resident-oriented Exercise Therapy for Oncological Patients
MOVE-ONKO is developing and implementing a guideline-based, multi-professional care pathway for the promotion and therapy of exercise for cancer patients.
- Conditions
- Cancer, Exercise, Implementation
- Trial name
- MOVE-ONKO (NCT06185777)
- Testing
- Exercise oncology counseling and referal
- Where
- 7 sites in Germany
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Non-small Cell Lung Cancer
Tumor-specific T Cells in Lung Cancer
Non-small cell lung cancer is characterized by aggressive growth and treatment resistance. New approaches include immunotherapeutic strategies but spontaneous immune responses against tumor antigens remain unclear.
- Trial name
- NCT02515760
- Testing
- Bone marrow aspiration from the iliac crest, Illinois bone marrow aspiration neddle
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg