Clinical trials: 5-FU
Tumor
Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors
This is a study to assess the combination of PXD101 and 5-Fluorouracil (5-FU)in patients with advanced solid tumors. The primary goal of the study is to understand the safety, anti-tumor activity, and how the study drug behaves…
- Trial name
- NCT00413322
- Testing
- belinostat, 5-Fluorouracil (5-FU)
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Valerio Therapeutics
Colorectal Cancer
Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003594
- Testing
- irinotecan, fluorouracil, leucovorin calcium
- Where
- 466 sites in United States, Canada and 2 more
- Volunteers
- 1,691 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Squamous Carcinoma of Esophagus, Esophagus Disorders
Perioperative Vs. Preoperative Chemotherapy With Surgery in the Squamous Carcinoma of Esophagus
To assess whether or not a perioperative therapy with surgery can improve the outcomes among patients with potentially curable squamous carcinoma of esophagus as compared to a preoperative chemotherapy followed by surgery
- Trial name
- NCT01225523
- Testing
- Paclitaxel; Cisplatin; 5-Fluorouracil, Paclitaxel; Cisplatin; 5-Fluorouracil; Capecitabine
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Intrahepatic Cholangiocarcinoma
HAIC With FOLFOX Versus Systemic Chemotherapy With GP for Unresectable ICC
The purpose of this study is to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) of oxaliplatin, 5-fluorouracil and leucovorin compared systemic chemotherapy of gemcitabine and cisplatin in…
- Trial name
- NCT04961970
- Testing
- oxaliplatin , fluorouracil, and leucovorin, gemcitabine and cisplatin
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Shi Ming
Solid Tumor
Feasibility of Switching Fluoropyrimidine Due to Cardiotoxicity Study
The purpose of the present study is to evaluate cardiotoxicity during re-challenge of a different modality of fluoropyrimidine (primary end-point S-1 and secondary any other fluoropyrimidine) after having perceived cardiotoxicity…
- Trial name
- CardioSwitch (NCT04260269)
- Testing
- Fluoropyrimidine
- Where
- 13 sites in Denmark, Finland and 5 more
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
Breast Cancer
Molecular Triaging of Newly Diagnosed Breast Cancer
The goal of this clinical research study is to learn if using "gene signatures" can be an effective way to decide the best treatment for breast cancer patients.
- Trial name
- NCT01159236
- Testing
- Paclitaxel, Fluorouracil, Doxorubicin
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
Side Effects to FOLFOXIRI + Tocotrienol/Placebo as First Line Treatment of Metastatic Colorectal Cancer
Treatment with FOLFOXIRI (5-fluorouracil, oxaliplatin, irinotecan) can be effective, but it has serious side effects, which may require hospitalization.
- Trial name
- NCT02705300
- Testing
- Irinotecan 165 mg/m2 iv, Oxaliplatin 85 mg/m2 iv, Calcium folinate 200 mg/m2 iv
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Vejle Hospital
Rectal Cancer
Chemotherapy Followed by Pelvic Reirradiation Versus Chemotherapy Alone as Pre-operative Treatment for Locally Recurrent Rectal Cancer
GRECCAR 15 is focused on Locally Recurrent Rectal Cancer (LRRC) for patients with previous pelvic radiotherapy for the primary rectal cancer.
- Trial name
- GRECCAR15 (NCT03879109)
- Testing
- Chemotherapy FOLFIRINOX, 6 cycles, Radiochemotherapy, Surgery
- Where
- 13 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Bordeaux
Breast Cancer
Weekly Docetaxel and CMF in the Adjuvant Treatment of Elderly Women With High-Risk Breast Cancer
This trial will evaluate the effectiveness of standard adjuvant treatment with CMF chemotherapy versus treatment with weekly docetaxel in patients with high-risk breast cancer who are 65 years of age and older or are poor…
- Trial name
- NCT00193011
- Testing
- Docetaxel, Cyclophosphamide, Methotrexate
- Volunteers
- 150 people
- Sponsor
- SCRI Development Innovations, LLC
Colorectal Cancer, Relapse
A Phase II Randomized Trial of Serplulimab With Second-Line Chemo/Targeted Therapy for Early Relapse Colorectal Cancer After Adjuvant Chemotherapy
Approximately 20-50% of patients with colorectal cancer (CRC) develop distant metastasis after curative surgery, and those with early relapse within one year of completing adjuvant chemotherapy (XELOX or FOLFOX) have a…
- Trial name
- NCT07604909
- Testing
- Serplulimab, Second-Line Chemo/Targeted Therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fudan University
Colorectal Cancer
Comparing Efficacy and Safety of Enlituo® Versus Erbitux® Plus FOLFOX in Locally Advanced/Metastatic Colorectal Cancer With RAS/BRAF Wild-type and MSS/pMMR Status.
This is a randomized, double-blind, phase III clinical trial. The study aims to demonstrate that the treatment regimen of Enlituo® plus FOLFOX is equivalent to that of Erbitux® plus FOLFOX in participants with RAS/BRAF wild-type…
- Trial name
- NCT07595276
- Testing
- Enlituo®, Erbitux®
- Where
- China
- Volunteers
- 608 people
- Sponsor
- Taizhou Mabtech Pharmaceutical Co.,Ltd
Ectropion, Skin Neoplasms
5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts
Full thickness skin grafts are an essential tool in surgery around the eyelids for reconstruction or rehabilitation following injury or surgery.
- Trial name
- NCT02705352
- Testing
- 5-Fluorouracil, Normal saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Pancreas Ductal Adenocarcinoma
Short-course Versus Long-course Pre-operative Chemotherapy With mFOLFIRINOX or PAXG (CASSANDRA TRIAL)
The main aim of this study is to compare the efficacy of short-course versus long-course pre-operative chemotherapy with PAXG or mFOLFIRINOX in patients who receive a diagnosis of pancreatic ductal adenocarcinoma (PDAC)…
- Trial name
- CASSANDRA (NCT04793932)
- Testing
- PAXG, mFOLFIRINOX, short-course chemotherapy
- Where
- 22 sites in Italy
- Volunteers
- 261 people
- Sponsor
- Associazione Italiana per lo Studio del Pancreas
Vitiligo
5-fluorouracil for Treatment of Stable Vitiligo
Vitiligo, a significant dermatologic challenge affecting 0.5 to 2% of the global population. Despite various existing medical approaches, current vitiligo treatments are still far from optimal.
- Trial name
- NCT06209138
- Testing
- 5 fluorouracil, Saline
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Colorectal Cancer
Radiation Therapy With or Without Chemotherapy Before Surgery in Treating Patients With Stage II or Stage III Rectal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as fluorouracil and leucovorin, work in different ways to stop the growth of tumor cells, either by killing the cells or…
- Trial name
- NCT00296608
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Volunteers
- 762 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Biliary Tract Cancer
Trial of Infusional FOLFIRINOX in First Line Treatment of Advanced Biliary Tract Cancers
This study is to evaluate the response rate and toxicity profile of infusional 5 fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFIRINOX) in first-line treatment of advanced biliary tract cancers and also to assess…
- Trial name
- FBI-TRAC (NCT03291899)
- Testing
- FOLFIRINOX
- Where
- Saudi Arabia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- King Faisal Specialist Hospital & Research Center
Rectal Cancer
KORTUC (KRC-01) Plus Radiotherapy for Organ Preservation in Rectal Cancer
This phase II clinical trial is evaluating whether adding KRC-01 injections to standard chemoradiotherapy may improve treatment outcomes in patients with locally advanced rectal cancer without metastases.
- Trial name
- K-BOOST (NCT07622017)
- Testing
- KRC-01 (KORTUC), Radiotherapy, Capecitabine
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Colorectal Cancer, Peritoneal Metastases
Intraperitoneal Irinotecan With Concomitant FOLFOX and Bevacizumab
The rationale of the current study is that the addition of intraperitoneal irinotecan (75 mg) to palliative systemic therapy is feasible and safe, and might result in an increased overall and progression free survival in patients…
- Trial name
- INTERACT-II (NCT06003998)
- Testing
- Irinotecan, FOLFOX regimen, Bevacizumab
- Where
- 2 sites in Netherlands
- Volunteers
- 85 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Pancreatic Cancer, Unresectable Pancreatic Cancer
Study of Sotorasib Combined With Chemotherapy for Second Line Treatment of Pancreas Cancer
This is a multicenter, non-randomized, open-label, phase Ib/II study to evaluate the safety, tolerability and efficacy of sotorasib in combination with chemotherapy for patients with advanced KRAS p.G12C mutant pancreatic cancer…
- Conditions
- Pancreatic Cancer, Unresectable Pancreatic Cancer, Metastatic Pancreatic Cancer, KRAS P.G12C
- Trial name
- NCT05251038
- Testing
- Sotorasib, Liposomal Irinotecan (nal-IRI), 5 Fluorouracil (5FU)
- Where
- United States
- Sponsor
- Devalingam Mahalingam
Advanced Hepatocellular Carcinoma
A Study of TAE+HAIC Combined With Camrelizumab and Apatinib in the Treatment of Advanced Hepatocellular Carcinoma
To evaluate the efficacy and safety of TAE+HAIC combined with camrelizumab and apatinib in the treatment of advanced liver cancer with high tumor load
- Trial name
- NCT06363825
- Testing
- camrelizumab
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Fujian Medical University
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