Clinical trials: Acetaminophen, completed
Fever
Comparison of the Efficacy of Intravenous Paracetamol and Ibuprofen in the Treatment of Fever Due to Upper Respiratory Tract Infection
Currently, paracetamol, ibuprofen and nonsteroidal antiinflammatory drugs are widely used by emergency physicians in Turkey for the treatment of fever .
- Trial name
- NCT03918135
- Testing
- Paracetamol, Ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Pamukkale University
Healthy
Influence of Medication Taste on Pediatric Prescribers' Prescribing Habits
The purpose of this study is to see if a medication taste test influences the prescribing habits of pediatric prescribers at Mayo Clinic.
- Trial name
- NCT01734759
- Testing
- Taste Test
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pain Management
Effect of Over-the-counter Analgesics on Postoperative Pain
In 2011, a randomized controlled trial compared acetaminophen, acetaminophen + ibuprofen, and acetaminophen + codeine for post-operative pain relief after Mohs surgery.
- Trial name
- NCT06948513
- Testing
- Naproxen, Acetaminophen (Standard of Care), ibuprofen
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zitelli & Brodland Skin Cancer Center
Postoperative Pain
Assessing the Efficacy of Intravenous Acetaminophen Versus the Oral Formulation for Perioperative Pain Treatment
To compare oral (PO) to intravenous (IV) acetaminophen with postoperative pain scores, and consumptions of opiates, among orthopedic surgery patients undergoing total knee replacement with spinal anesthesia.
- Trial name
- NCT02216682
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Massachusetts General Hospital
Inflammatory Diseases
Safety and Tolerability of Single and Multiple Doses of ISIS 353512 in Healthy Volunteers
The purpose of this study is to evaluate the safety and tolerability of single and multiple doses of ISIS 353512, to evaluate the blood concentration and rate elimination of ISIS 353512 from the blood, and to evaluate the…
- Trial name
- NCT00734240
- Testing
- ISIS 353512
- Where
- Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Osteoarthritis
Proof-of-concept Study to Assess the Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients With Painful Osteoarthritis of the Knee
Primary Objective: To assess the efficacy of a single intraarticular dose of GZ389988 compared to placebo for relief of knee pain in patients with osteoarthritis (OA) of the knee.
- Trial name
- NCT02845271
- Testing
- GZ389988, acetaminophen or paracetamol, fixed combination of paracetamol + codeine
- Where
- 2 sites in Germany
- Volunteers
- 104 people
- Sponsor
- Genzyme, a Sanofi Company
Sepsis, Acetaminophen
Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients
This is a randomized double-blind controlled study with the primary aim of scientifically evaluating the potential effects of paracetamol and ibuprofen in the management of sepsis by comparing their fever-reducing efficacy in…
- Conditions
- Sepsis, Acetaminophen, Fever, Ibuprofen
- Trial name
- NCT06061575
- Testing
- Acetaminophen, Ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- Ankara City Hospital Bilkent
Kidney Transplant
Effects of Inhibiting Early Inflammation in Kidney Transplant Patients
During transplant surgery, there is a period of time when a donated kidney is removed from a donor's body and stored until the time of the transplant surgery.
- Trial name
- NCT02495077
- Testing
- Infliximab, Methylprednisolone, Mycophenolate Mofetil
- Where
- 15 sites in United States, Canada
- Volunteers
- 290 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pain, Fever
Evaluation of Efficacy and Safety of Subcutaneous Acetaminophen
Subcutaneous perfusion is an underused technique, the effectiveness of which has been demonstrated. A number of drugs of different therapeutic classes, including morphine, have a good level of scientific evidence for use by this…
- Conditions
- Pain, Fever, Drug Effect, Drug Reaction
- Trial name
- APAPSubQ (NCT03635684)
- Testing
- Acetaminophen
- Where
- Lebanon
- Volunteers
- 31 people
- Sponsor
- Saint-Joseph University
Pain, Unspecified Adult Solid Tumor, Protocol Specific
Oxycodone or Standard Pain Therapy in Treating Patients With Cancer Pain
RATIONALE: Oxycodone helps lessen pain caused by cancer and may improve quality of life. It is not yet known whether oxycodone works better and is more cost effective than standard therapy in treating patients with cancer pain.
- Trial name
- NCT00378937
- Testing
- acetaminophen, codeine phosphate, dextropropoxyphene hydrochloride
- Volunteers
- 30 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Healthy
The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers
Aspirin is a medication commonly used to relieve minor pains. Aspirin has also been used to prevent heart attacks and strokes. Aspirin, however, can also cause damage to the stomach and/or intestinal lining leading to the…
- Trial name
- NCT00594867
- Testing
- Acetaminophen 4 gram per day + Aspirin 325 mg per day
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Analgesia, Postoperative Pain
Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery
To test if multimodal analgesia with different analgesic medication offer better pain relief, lesser side effects and is safe compared to conventionel opiod analgesia after cardiac surgery.
- Trial name
- NCT01966172
- Testing
- Ibuprofen, Gabapentin, Morphine
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Pain
Intravenous Acetaminophen in Craniotomy
The purpose of this study is to assess the use of intravenous Acetaminophen (OFIRMEV) as an effective adjunct therapeutic agent in patients undergoing craniotomy.
- Trial name
- NCT01598701
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pain and Discomfort, Orthodontic Appliance Complication
The Role of Paracetamol-caffeine and Laser Irradiation on Controlling Pain and Discomfort During Orthodontic Treatment
Patients with class I malocclusion who have mild to moderate crowding will be treated in this study. The efficacy of low level laser therapy and Panadol-extra® in relieving pain due to orthodontic treatment will be assessed.
- Trial name
- NCT03400111
- Testing
- low-level laser therapy, Panadol-extra
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Damascus University
Overweight or Obesity
The Effect of AMG 133 on Gastric Emptying
The primary objective of the trial is to evaluate the effect of AMG 133 versus placebo on acetaminophen pharmacokinetics (PK), a marker for gastric emptying, in participants living with overweight or obesity.
- Trial name
- NCT07429032
- Testing
- AMG 133, Acetaminophen
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Amgen
Pain
A Study of Extended-Release Hydrocodone/Acetaminophen (Vicodin CR®) in Subjects With Acute Pain Following Bunionectomy
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of Extended-Release Hydrocodone/Acetaminophen compared to placebo over a 48 hour dosing period in patients who…
- Trial name
- NCT00402792
- Testing
- Hydrocodone/Acetaminophen Extended-Release, Hydrocodone/Acetaminophen Extended Release
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Abbott
Post Cesarean Pain Management
To Compare the Efficacy and Patients' Satisfaction for the Treatment of Post Cesarean Pain of Two Protocols: Oral Medications in Fixed Time Interval Administration Versus Spinal Morphine
Cesarean deliveries are prevalent. Unlike other operations, quick recovery is required for the mother to nurture the newborn child and establishing an appropriate mother-child bonding.
- Trial name
- NCT02440399
- Testing
- Tramadol hydrochloride, Morphine, Paracetamol
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- HaEmek Medical Center, Israel
Common Cold, Pharyngitis
Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold
The purpose of this study is to determine the efficacy and safety of 1000 mg Aspirin (study medication) by comparing 1000 mg Paracetamol (study medication) in treating the symptoms of sore throat associated with a common cold.
- Conditions
- Common Cold, Pharyngitis, Tonsillitis
- Trial name
- NCT01465009
- Testing
- Acetylsalicylic acid (Aspirin, BAYE4465), Paracetamol
- Where
- 8 sites in United Kingdom
- Volunteers
- 508 people
- Sponsor
- Bayer
Pain
Pain Management Following Dental Treatment Under General Anesthesia
The main goal of this study is to test the efficacy of postoperative pain management for cases undergoing extractions of primary teeth under GA using a validated measure.
- Trial name
- NCT06574516
- Testing
- Ibuprofen 200 mg, paracetamol
- Where
- Jordan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Adverse Anesthesia Outcome
Preemptive Analgesia Using Intravenous Paracetamol
Dental treatment for children should be done in a calm atmosphere and without pain. Oral Propacetamol has been shown to be effective in a variety of postsurgical pain models.
- Trial name
- NCT02884921
- Testing
- Paracetamol
- Volunteers
- 87 people
- Sponsor
- Bnai Zion Medical Center
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