Clinical trials: Acetaminophen, completed
Inflammatory Bowel Diseases
Efficacy of LiveSpo COLON as a Supportive Treatment for Inflammatory Bowel Disease (IBD)
Inflammatory bowel disease (IBD) is a prevalent condition, comprising two major types: (1) Crohn disease (chronic enteritis characterized by abdominal pain, stool irregularities, fatigue, weight loss, and malnutrition) and (2)…
- Trial name
- NCT06637683
- Testing
- LiveSpo COLON, Routine treatment
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Anabio R&D
Schizophrenia, Cognitive Deficits
Treatment of Cognitive and Negative Symptoms in Schizophrenia With N-acetylcysteine
The purpose of this study is to attempt to treat cognitive and negative symptoms of schizophrenia, with the nutritional supplement N-acetylcysteine (NAC).
- Conditions
- Schizophrenia, Cognitive Deficits, Schizophrenia; Negative Type
- Trial name
- NAC2 (NCT02505477)
- Testing
- N-acetylcysteine, Treatment as Usual
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of California, Los Angeles
Stroke, Cardiovascular Diseases
Kinesio Taping in Stroke Patient
Despite being nearly independent in daily life, chronic high-functioning stroke survivors still experienced mild impairments in skilled hand function.
- Conditions
- Stroke, Cardiovascular Diseases, Physical Disability
- Trial name
- Kinesio taping (NCT06188845)
- Testing
- Kinesio taping
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
Irreversible Pulpitis With Apical Periodontitis
Effect of Common Analgesia on Pulp Sensibility
his study will investigate whether commonly used analgesics - 400 mg ibuprofen and 500 mg paracetamol - influence the accuracy of pulpal sensibility tests (cold test and electric pulp test) in patients with symptomatic…
- Trial name
- NCT07125911
- Testing
- Ibuprofen 400 mg (if necessary), Paracetamol 500 mg
- Where
- Pakistan
- Volunteers
- 122 people
- Sponsor
- HITEC-Institute of Medical Sciences
Back Pain
The Safety and Efficacy of the Buprenorphine Transdermal System (BTDS) in Subjects With Chronic Back Pain.
The objective of this study is to assess the safety of the buprenorphine transdermal system (5, 10, and 20) in comparison to placebo transdermal system and immediate release oxycodone/ acetaminophen in subjects with chronic back…
- Trial name
- BP96-0604 (NCT00315445)
- Testing
- Buprenorphine transdermal patch, OXY/APAP
- Where
- 12 sites in United States
- Volunteers
- 134 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis, Type 2 Diabetes
Effects of Acetyl L-Carnitine Supplementation on Clinical, Metabolic and Inflammatory Symptoms in Obese, Diabetic, Postmenopausal Women With Osteoarthritis
OA is a degenerative bone disease more common in postmenopausal women. Diabetes and obesity are common risk factors for the development of OA.
- Conditions
- Osteoarthritis, Type 2 Diabetes, Obesity
- Trial name
- NCT07660081
- Testing
- Acetyl-l-carnitine
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Pain
Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen
Morphine is the opioid used to treat pain after surgery. Acetaminophen (called APAP) can reduce the amount of opioids needed for this. The problem is that morphine slows down digestion. That can delay pain relief from APAP pills.
- Trial name
- NCT02848729
- Testing
- Oral Acetaminophen, IV Acetaminophen, IV Morphine
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Gastric-bypass Surgery, Opioid Consumption
Transversus Abdominis Plane (TAP) Block in Laparoscopic Gastric-bypass Surgery
Laparoscopic gastric-bypass surgery (LGBS) is one of the surgical treatments for morbid obesity, which is performed under general anesthesia.
- Conditions
- Gastric-bypass Surgery, Opioid Consumption, Obesity
- Trial name
- NCT01568437
- Testing
- TAP-Block, Conventional Managment
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Acetaminophen Toxicity
Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing
A purpose of this protocol is to is to compare the metabolites of the toxic bioactivating pathway after acetaminophen alone or acetaminophen followed by Propylene Glycol (PG) and to determine if it prevents the formation of the…
- Trial name
- APAPII (NCT02322879)
- Testing
- First Treatment Period, Washout, Second Treatment Period
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Melanoma (Skin)
Combination Chemotherapy in Treating Patients With Stage III or Stage IV Melanoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003346
- Testing
- acetaminophen, acetylcysteine, carmustine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Non-Hodgkin's Lymphoma
A Study of Rituximab Alternative Dosing Rate in Patients With Previously Untreated Diffuse Large B-cell or Follicular Non-Hodgkin's Lymphoma (RATE)
This was a prospective, open-label, Phase III, multicenter, single-arm trial designed to assess the safety, pharmacokinetics, and pharmacodynamics of an alternative dosing rate of rituximab in previously untreated patients with…
- Trial name
- RATE (NCT00719472)
- Testing
- Rituximab, CHOP (cyclophosphamide, hydroxydaunorubicin [doxorubicin], Oncovin [vincristine], prednisone), CVP (cyclophosphamide, vincristine, prednisone)
- Volunteers
- 451 people
- Sponsor
- Genentech, Inc.
Outpatient Surgery, Abdominal Surgery
Pilot Trial: Postoperative Opioid-free Analgesia
North America is facing an opioid epidemic fueled by surgeons, who are the second largest subgroup of physicians involved in opioid prescribing.
- Conditions
- Outpatient Surgery, Abdominal Surgery, Breast Surgery
- Trial name
- NCT04254679
- Testing
- Opioid analgesics, Non-opioid analgesics
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Solid Tumor
Safety Study of KPT-330 (Selinexor) in Patients With Advanced or Metastatic Solid Tumor Cancer
Phase 1 study to evaluate the safety and tolerability of selinexor and determine the Recommended Phase 2 Dose (RP2D) of selinexor for advanced or metastatic solid tumor malignancies.
- Trial name
- NCT01607905
- Testing
- Selinexor, Acetaminophen
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 192 people
- Sponsor
- Karyopharm Therapeutics Inc
Septic Shock, Sepsis
Heamodynamic Effects of Paracetamol in Septic Shock Patients
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock is defined as sepsis that has circulatory, cellular, and metabolic abnormalities that are associated with a greater…
- Trial name
- NCT06076980
- Testing
- Paracetamol, Normal saline
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Ayah Mohammed Khalil
Rotator Cuff Tear Arthropathy
Does Botulinum A Toxin Help With Pain From Rotator Cuff Arthropathy?
Rotator cuff arthropathy is a cause of shoulder arthritis which is a common condition seen both in primary and secondary care. It is a painful condition, with significant disability.
- Trial name
- NCT02512536
- Testing
- Botulinum Toxin Type A
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Back Pain
The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Chronic Low Back Pain.
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (5, 10, and 20 mg) in comparison to placebo transdermal system and immediate release oxycodone/acetaminophen…
- Trial name
- NCT00315874
- Testing
- Buprenorphine transdermal delivery system
- Where
- 12 sites in United States
- Volunteers
- 225 people
- Sponsor
- Purdue Pharma LP
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Impact of Acetaminophen on Performance of Guardian™ Sensor (3) in Adults
The purpose of this study is to characterize the impact of acetaminophen ingestion on the performance of the Guardian™ Sensor (3) (i.e., C algorithm and Zeus algorithm) in subjects age 18 - 80 years.
- Trial name
- NCT04378114
- Testing
- Guardian™ Sensor (3) connected to a Guardian™ Connect Transmitter. C sensor algorithm applied retrospectively to raw sensor data., Guardian™ Sensor (3) connected to a Guardian™ Connect Transmitter. Zeus sensor algorithm applied retrospectively to raw sensor data., Acetominophen
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- Medtronic MiniMed, Inc.
Pain, Postoperative, Opioid Use
Eliminating Narcotic Prescriptions from Outpatient Minimally Invasive Gynecologic Surgery
Laparoscopic gynecologic surgeries are generally very well tolerated procedures, and patients are able to go home on the same day, with a prescription for pain control.
- Trial name
- eNARCOS (NCT04837014)
- Testing
- prescription for regular acetaminophen and naproxen, prescription for regular acetaminophen , naproxen and dilaudid
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Delirium
Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery
Investigators will assess the incidence and duration of postoperative delirium in patients ≥60 years old undergoing coronary artery bypass grafting (CABG), with/without valve surgery (aortic and/or mitral) based on different…
- Trial name
- DEXACET (NCT02546765)
- Testing
- IV acetaminophen & IV propofol, IV acetaminophen & IV dexmedetomidine
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Pain
A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine
Characterize the relative abuse liability of a short versus a long acting opioid in chronic pain patients.
- Trial name
- NCT00314340
- Testing
- Markers of Abuse Liability, Neuropsych Testing, and Cue Reactivity, ER Morphine, hydrocodone plus acetaminophen
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
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