Clinical trials: Amlodipine
Essential Hypertension, High Blood Pressure
Intensive Vasodilator Therapy in Patients With Essential Hypertension
The purpose of this study is to determine whether add-on of intensive vasodilator therapy can improve the coronary perfusion and reduce the total peripheral resistance in patients with ongoing treatment for essential hypertension.
- Trial name
- Vasomore (NCT01180413)
- Testing
- Amlodipine, Ramipril, Lercanidipine
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Aarhus University Hospital
Hypertension
Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome
The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels.
- Trial name
- AMORE (NCT01271374)
- Testing
- amlodipine and olmesartan, losartan and HCTZ
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- InVasc Therapeutics, Inc.
Hepatitis B, Chronic, Lipid Disorder
An Experimental Study on the Effect of Tenofovir Amibufenamide on Blood Lipid During Anti-HBV Treatment
In June 2021, Chinese Food and Drug Administration approved the launch of the self-developed new drug Tenofovir Amibufenamide(TMF). TMF is a new second generation of tenofovir(TFV) and its effect on blood lipids is unclear.
- Trial name
- NCT05398393
- Testing
- oral Tenofovir Amibufenamide 25mg each day, lipid lowering drugs (e.g. Atorvastatin and amlodipine.)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Healthy
Pharmacokinetics of Telmisartan Alone and in Combination With Amlodipine in Healthy Volunteers
Study to investigate the steady state pharmacokinetics of 80 mg telmisartan alone and in combination with repeated doses of 10 mg amlodipine
- Trial name
- NCT02259816
- Testing
- Telmisartan, Amlodipine
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hypertension
Efficacy of Losartan + Amlodipine Compared to Amlodipine Alone in the Treatment of Uncontrolled High Blood Pressure (MK-0954F-399)
This study will determine whether using losartan and amlodipine together will be non-inferior in lowering blood pressure than amlodipine alone.
- Trial name
- NCT01277822
- Testing
- Losartan (+) amlodipine, Amlodipine camsylate
- Volunteers
- 334 people
- Sponsor
- Organon and Co
Hypertension
Black Education and Treatment of Hypertension (BEAT HTN)
Clinical trials have yet to test the adequacy of HTN control in African Americans (AA) when both control and intervention groups are given free antihypertensive medications and are involved in usual versus intensive intervention…
- Trial name
- BEAT (NCT00661895)
- Testing
- Hydrochlorothiazide, Lisinopril, Lisinopril and Hydrochlorothiazide
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Creighton University
Healthy
Clinical Trial to Investigate the Efficacy and Safety of DWJ1351
The purpose of this study is to compare the safety and pharmacokinetic characteristics of combination of amlodipine, olmesartan and rosuvastatin and DWJ1351 in healthy male volunteers
- Trial name
- NCT03753477
- Testing
- DWJ1351(FDC Amlodipine/Olmesartan/Rosuvastatin), Sevikar and Crestor
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Chronic Kidney Disease
The Canadian Prevention of Renal and Cardiovascular Endpoints Trial
Advanced kidney disease with it's associated heart and blood vessel problems are becoming more frequent. These problems markedly affect length and quality of life and cost a lot to treat.
- Trial name
- CanPrevent (NCT00231803)
- Testing
- Combined CKD and CVD Prevention, Cardiovascular Disease prevention, Treatment of Chronic Kidney Disease complications
- Where
- 5 sites in Canada
- Volunteers
- 474 people
- Sponsor
- Brendan Barrett
Coronary Artery Disease
Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity
Patients with coronary artery disease (CAD) are often treated with dual antiplatelet therapy (DAT), including aspirin and clopidogrel, to prevent from recurrent atherothrombotic events.
- Trial name
- PEARL (NCT01567774)
- Testing
- Atorvastatin, Rosuvastatin
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Hypertension
Aliskiren and the Calcium Channel Blocker Amlodipine Combination as an Initial Treatment Strategy for Hypertension
This study will compare the safety and efficacy of initial combination treatment with aliskiren + amlodipine to sequential add-on treatment strategies with aliskiren or amlodipine in patients with hypertension.
- Trial name
- ACCELERATE (NCT00797862)
- Testing
- Amlodipine, hydrochlorothiazide, Aliskiren
- Where
- 10 sites in Canada, Costa Rica and 8 more
- Volunteers
- 1,254 people
- Sponsor
- Novartis
Hypertension,Essential
Management of Hypertension Utilizing Trained Community Health Worker in Rural Municipalities of Nepal
The investigators will evaluate whether a system involving Female Community Health Volunteers (FCHVs) and facility-based community health workers (FB-CHWs) of Health Post (Auxiliary Health Workers, Auxiliary Nurse Midwives and…
- Trial name
- MUTU (NCT04521582)
- Testing
- Amlodipine, Lifestyle counselling
- Where
- 2 sites in Nepal
- Volunteers
- 1,428 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Adrenal Incidentalomas
Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas
The general objective is to evaluate the consequences of surgical removal of SCSI on hypertension and cardiovascular risk factors in order to determine on an evidence-based basis if surgical excision of SCSI is preferable to an…
- Trial name
- CHIRACIC (NCT02364089)
- Testing
- Laparoscopic surgical removal of the adrenal tumor, Standardized medical treatment of hypertension by SAHR
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 78 people
- Sponsor
- University Hospital, Bordeaux
Hypertension
Efficacy and Safety of GMRx2 Compared to Dual Combinations for the Treatment of Hypertension
Recent hypertension guidelines recommend combination therapy as initial treatment for many or most patients. Several trials suggest triple low-dose combination therapy may be highly effective in terms of achieving blood pressure…
- Trial name
- GMRx2_ACT (NCT04518293)
- Testing
- Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mg, telmisartan 40 mg/amlodipine 5 mg/indapamide 2.5 mg, Telmisartan 20 mg/amlodipine 2.5 mg
- Where
- 89 sites in United States, Australia and 5 more
- Volunteers
- 1,385 people
- Sponsor
- George Medicines PTY Limited
Blood Pressure, High
INTERVENCION Trial
This trial is designed to: 1. Assess the response to montherapy with : a thiazide diuretic (HCTZ), a calcium-channel blocker (CCB, amlodipine) and an angiotensin-receptor blocker (telmisartan), among hypertensive subjects who…
- Trial name
- INTERVENCION (NCT02373163)
- Testing
- Hydrochlorothiazide, Amlodipine, Telmisartan
- Where
- Peru
- Volunteers
- 166 people
- Sponsor
- Prevencion
Carotid Artery Stenosis, Atherosclerosis
Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis
The aim of this study is to determine whether optimal medical treatment can postpone carotid endarterectomy.
- Conditions
- Carotid Artery Stenosis, Atherosclerosis, Stroke
- Trial name
- AMTEC (NCT00805311)
- Testing
- Carotid Endarterectomy, atorvastatin, aspirin, losartan, amlodipine
- Where
- 2 sites in Russia
- Volunteers
- 400 people
- Sponsor
- Russian Cardiology Research and Production Center
Hypertension
Efficacy and Safety of Amlodipine and Losartan in Patients With Essential Hypertension
The purpose of this study is to evaluate the safety and efficacy of fixed combination of amlodipine(5mg or 10mg) and losartan (50 mg or 100 mg), amlodipine and losartan alone in reducing blood pressure.
- Trial name
- NCT00942344
- Testing
- Amlodipine plus Losartan, Amlodipine, Losartan
- Where
- South Korea
- Volunteers
- 320 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Hypertension
Cozaar XQ Re-examination Study (MK-0954-349)
This survey is conducted for preparing application material for re-examination under the Pharmaceutical Affairs Law and its Enforcement Regulation; its aim is to reconfirm the clinical usefulness of COZAAR XQ through collecting…
- Trial name
- NCT01041807
- Testing
- amlodipine/losartan
- Volunteers
- 669 people
- Sponsor
- Organon and Co
Hypertension
Comparing Bisoprolol and Valsartan-Amlodipine for Hypertension
Randomized comparison of bisoprolol 2.5 mg monotherapy with fix combination drug valsartan 80 mg- amlodipine 5 mg
- Trial name
- NCT07327749
- Testing
- Bisoprolol, valsartan and amlodipine
- Where
- Iran
- Volunteers
- 59 people
- Sponsor
- Shiraz University of Medical Sciences
Ischemic Stroke, Blood Pressure
Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Stroke Patients
Elevated blood pressure (BP) consists of a major public health concern especially in low and middle income countries. Besides being a highly prevalent condition, it is also a risk factor for several major cardiovascular events…
- Conditions
- Ischemic Stroke, Blood Pressure, Cognitive Impairment, Vascular Diseases
- Trial name
- OPTIMAL Stroke (NCT04036409)
- Testing
- Intensive Control of Systolic Blood Pressure (SBP), Standard control of Systolic Blood Pressure (SBP)
- Where
- 30 sites in Brazil
- Volunteers
- 4,368 people
- Sponsor
- Hospital Israelita Albert Einstein
Healthy Volunteers
Pharmacokinetics of Irbesartan/Amlodipine High FDC and Co-administration of Irbesartan and Amlodipine High in Healthy Volunteers
The purpose of this study is to compare pharmacokinetics and safety of Irbesartan and Amlodipine High Fixed Dose Combination and coadministration of mono compounds in healthy adult volunteers
- Trial name
- NCT05688098
- Testing
- Irbesartan/Amlodipine High FDC, Irbesartan, Amlodipine High
- Where
- South Korea
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Handok Inc.