Clinical trials: Amlodipine
Hypertension
Irbesartan/Amlodipine in Hypertensive Patients Uncontrolled on Amlodipine 5 mg Monotherapy
Primary Objective: To demonstrate that the antihypertensive efficacy of the fixed combination irbesartan/amlodipine 150/5 mg is superior to that of amlodipine 5 mg monotherapy in lowering systolic blood pressure (SBP) as measured…
- Trial name
- I-COMBINE (NCT00956644)
- Testing
- irbesartan/amlodipine, amlodipine
- Where
- 40 sites in Brazil, Chile and 7 more
- Volunteers
- 406 people
- Sponsor
- Sanofi
Hypertension
Nifedipine GITS and Amlodipine Besylate on Recovery of Blood Pressure Rhythm and Arterial Stiffness
This trial evaluates the effects of Nifedipine GITS and Amlodipine besylate on blood pressure rhythm restoration and arterial stiffness in young and middle-aged non-dipper hypertensives.
- Trial name
- NARRAS (NCT02940548)
- Testing
- Nifedipine GITS, Amlodipine besylate
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Jing Liu
Healthy
Bioequivalence Study of Telmisartan Between Telmisartan 80 mg/Amlodipine 5 mg/Hydrochlorothiazide 12.5 mg (T80/A5/H12.5 mg) Fixed-dose Combination (FDC) Tablet and T80/H12.5 mg Tab and A5 mg (Encap A2.5 mg Tab x2) Concomitant Use
To investigate the steady state pharmacokinetics of different formulation of Telmisartan, Amlodipine, and Hydrochlorothiazide (HCTZ).
- Trial name
- NCT02129192
- Testing
- Amlodipine 5mg capsule, T80/H12.5 mg FDC tablet, T80/A5/H12.5 mg FDC tablet
- Where
- Japan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hypertension
Efficacy and Tolerability of Combination Antihypertensive Drug in Non-Responders to ARB monoTHerapy Using 24h ABPM
A majority of Korean doctors tend to add other antihypertensive rather than to titrate the same drug. However, we try to induce doctors to titrate the Sevikar than to add other antihypertensive if patients are not controlled with…
- Trial name
- EARTH (NCT01713920)
- Testing
- SEVIKAR
- Where
- 2 sites in South Korea
- Volunteers
- 68 people
- Sponsor
- Sang Hyun Ihm, MD PhD
Healthy
Study to Evaluate the Bioavailability of the Test Formulation of Amlodipine 10 mg Tablets (Torrent Pharmaceuticals Limited) Compared to a 10 mg Dose of Norvasc® (Pfizer) in 18 Fed, Healthy Adult Subjects
Objective: The objective of this study was to compare the rate and extent of absorption of the test formulation, amlodipine besylate 10 mg tablets (Torrent Pharmaceuticals Ltd.), with that of the marketed reference product…
- Trial name
- NCT00932880
- Testing
- Amlodipine Besylate, Norvasc
- Where
- United States
- Sponsor
- Torrent Pharmaceuticals Limited
Hypertension
Valsartan Versus Amlodipine Effect on Left Ventricular Multidirectional Deformation and Adipocytokines Level
Aim: To evaluate the effects of Valsartan versus Amlodipine on LV deformation in relation to plasma adiponectin and leptin levels in hypertensive individuals.
- Trial name
- NCT03990480
- Testing
- valsartan (160 mg/d), amlodipine (10 mg/d).
- Where
- Egypt
- Volunteers
- 230 people
- Sponsor
- Damanhour University
Depression
Vascular Augmentation of Late-life Unremitted Depression (VALUeD)
Depression has a high occurrence and causes other problems in older people, two thirds of these patients will not have a lessening in their condition from routine treatment medication.
- Trial name
- VALUeD (NCT01557153)
- Testing
- Amlodipine
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Gateshead Health NHS Foundation Trust
Essential Hypertension
Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension
This study is to compare the efficacy and safety of Telmisartan, Amlodipine, and Chlorthalidone Fixed-Dose Combination and Telmisartan, Amlodipine, and Hydrochlorothiazide in Elderly Patients with Essential Hypertension…
- Trial name
- NCT06041529
- Testing
- Telmisartan/Amlodipine/Chlorthalidone 40/5/12.5 mg, Telmisartan/Amlodipine/Hydrochlorothiazide 40/5/25 mg
- Where
- 15 sites in South Korea
- Volunteers
- 198 people
- Sponsor
- Yuhan Corporation
Hypertension, Hypercholesterolemia
Caduet vs Usual Care in Subjects With Hypertension and Additional Risk Factors
To investigate whether a Caduet based treatment strategy might result in greater reduction in total cardiovascular risk as compared to usual care in subjects with hypertension and additional risk factors.
- Trial name
- CRUCIAL (NCT00407537)
- Testing
- Amlodipine besylate/atorvastatin calcium single pill combination
- Where
- 125 sites in Costa Rica, Croatia and 18 more
- Volunteers
- 1,531 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypertension
Irbesartan and Amlodipine Combination in Controlling Blood Pressure
The primary objective is to compare the extent of reduction of mean Seated Diastolic Blood Pressure (SeDBP) at the end of 8 weeks between each Fixed Dose Combination (FDC), its individual constituents administered as monotherapy…
- Trial name
- I-COMBO (NCT00950066)
- Testing
- IRBESARTAN (SR47436), Amlodipine, Irbesartan / Amlodipine
- Where
- 4 sites in India, Philippines and 2 more
- Volunteers
- 270 people
- Sponsor
- Sanofi
Arterial Hypertension
Once-daily Fixed Combination of Three Antihypertensive Drugs
Randomized comparison of once-daily fixed combiNation versus free-drug combination of three antihypertensive agents in arterial hypertension
- Trial name
- ONE&ONLY (NCT02710539)
- Testing
- perindopril, indapamide , amlodipine, Tripliam (perindopril, indapamide, amlodipine)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Hypertension
Relative Bioavailability Study of One Amlodipine 10mg Tablet and One Rosuvastatin 20mg Tablet to Two Fixed Dose Combinations of Amlodipine (10mg) and Rosuvastatin (20mg) in Healthy Subjects Under Fasting Conditions
This is an open-label, single-centre, randomized, single dose, three-way crossover, six sequence study to evaluate the comparative bioavailability of two Fixed Dose Combination (FDC) tablet formulations of amlodipine and…
- Trial name
- NCT02075619
- Testing
- Amlodipine+Rosuvastatin, GSK3074477 FDC - 1, GSK3074477 FDC - 2
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Essential Hypertension
Evaluation of Effect of Combination With Telmisartan and Hydrochlorothiazide in Hypertensives Uncontrolled on Amlodipine
The purpose of this study is to compare depressor effect and safety between combination therapy with telmisartan plus low-dose hydrochlorothiazide and amlodipine in hypertensive patients.
- Trial name
- ONEAST (NCT00509470)
- Testing
- telmisartan plus hydrochlorothiazide, Amlodipine
- Where
- Japan
- Volunteers
- 75 people
- Sponsor
- Tokyo University
Frailty
Nutraceuticals and Drug Treatment in Frail Older Adults
Frailty is a multidimensional condition due to reserve loss leading to physical and cognitive impairment that is very common in older adults; in fact, its incidence increases with age.
- Trial name
- NCT04962841
- Testing
- Nutraceuticals
- Where
- Italy
- Volunteers
- 485 people
- Sponsor
- University of Campania Luigi Vanvitelli
Hypertension
A Clinical Study to Compare Long-term Efficacy and Safety of an Aliskiren Based Regimen to a Hydrochlorothiazidebased Treatment Regimen With Optional Addition of Amlodipine
This study is designed to compare the long-term efficacy and safety of an aliskiren based regimen to an HCTZ based treatment regimen with optional addition of amlodipine in patients with essential hypertension.
- Trial name
- NCT00219154
- Testing
- aliskiren
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 1,125 people
- Sponsor
- Novartis
Bioequivalence
Bioequivalence Study of Amlodipine and Norvasc Under Fasting and FED Conditions in Chinese Healthy Volunteers
This study evaluates the pharmacokinetics and bioequivalence of Amlodipine Besylate Tablets 5 mg versus Norvasc 5 mg tablets administered as 5 mg tablet in healthy volunteers with a washout period of 14 days
- Trial name
- NCT02974439
- Testing
- LANDI-Amlodipine Besylate Tablet 5mg, Norvasc Tablets 5mg
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Haini Pharmaceutical Co., Ltd.
HIV Infections, Cardiovascular Diseases
Interactions Between HIV Protease Inhibitors and Calcium Channel Blockers
Diltiazem CD and amlodipine are drugs used to treat heart disease and high blood pressure. The purpose of this study is to find out if these drugs interact with the anti-HIV drugs indinavir and ritonavir.
- Conditions
- HIV Infections, Cardiovascular Diseases, Hypertension
- Trial name
- NCT00039975
- Testing
- Indinavir sulfate, Ritonavir, Amlodipine
- Where
- 9 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sleep Apnea Syndrome, Hypertension
Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome
Obstructive sleep apnea (OSA) is a highly prevalent chronic sleep disorder that affects 3% to 7% in middle aged individuals and increases with age.
- Trial name
- NCT02408172
- Testing
- Amlodipine, metoprolol
- Where
- 2 sites in China, Hungary
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Hypertension
Telmisartan and Amlodipine Versus Monocomponent Tablets
This study will be an open-label, randomized, two-treatment, two-period, two-sequence crossover study to evaluate the bioequivalence of the amlodipine component of Boehringer Ingelheim Pharma GmbH \& Co.
- Trial name
- NCT01278797
- Testing
- Telmisartan/Amlodipine Combination Tablet, Amlodipine Monocomponent
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hypertension
Study to Evaluate the Safety and PK of LODIENT Tablet 80/2.5mg in Healthy Adult Volunteers
A randomized, open label, single dose, 2-sequence, 4-period, cross-over phase I clinical trial to compare and evaluate the safety and pharmacokinetics after oral administration of "LodienT tablet…
- Trial name
- NCT04667624
- Testing
- Twynsta, LodineT
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hanlim Pharm. Co., Ltd.