Clinical trials: Best Practice, open to volunteers
Hand Hygiene Compliance
Tailor VHA HH Bundle for Acute Mental Health Care
Mental health settings are particularly vulnerable to outbreaks and transmission due to infectious pathogens like norovirus. This occurs since access to soap and water (sinks) is limited for safety reasons and alcohol hand rub is…
- Trial name
- NCT07607145
- Testing
- Tailored Hand Hygiene Bundle, Non-Alcohol Based Hand Sanitizer
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Glioma, Glioneuronal Tumor
Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification
Every new classification depends on its prognostic power and on the type of treatment given. With the rapid evolution of diagnostic methods and the advance in new treatments, there is much less reliable information available on…
- Conditions
- Glioma, Glioneuronal Tumor, Choroid Plexus Tumor, Pineal Tumors
- Trial name
- NCT05259605
- Testing
- Observational
- Where
- 42 sites in Austria, Belgium and 10 more
- Volunteers
- 1,650 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Heart Failure With Reduced Ejection Fraction
Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure
An increasing number of guideline-directed medical therapies (GDMT) have been developed for patients with chronic heart failure with reduced ejection fraction (HFrEF).
- Trial name
- IICAPTAIN-HF (NCT06526988)
- Testing
- EPIC-HF Patient-facing Tool, PROMPT-HF Clinician-facing Alert
- Where
- 5 sites in United States
- Volunteers
- 2,200 people
- Sponsor
- University of Colorado, Denver
Malignant Solid Neoplasm
Testing an Educational Program to Improve Goals of Care Conversations Between Patients and Their Care Teams
This clinical trial evaluates an educational program called Algorithm-Enabled Patients Activated in Cancer Care Through Teams (A-PACT) for reducing unplanned hospital visits and improving goals of care conversations with…
- Trial name
- NCT07278739
- Testing
- Best Practice, Educational Intervention, Electronic Health Record Review
- Where
- 7 sites in United States
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Hereditary Cancer Syndrome
Implementation of Population Cancer Genetic Services in Federally Qualified Health Centers (FQHC)
The goal of this clinical trial is for researchers to compare the effectiveness of a mainstreamed model of genetic testing (MGT) with an enhanced standard of care model (SOC+) on the uptake of genetic testing among at-risk…
- Trial name
- TestMiGenes (NCT05664867)
- Testing
- Mainstream Genetic Testing Model, Enhanced Standard of Care Model
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Illinois Chicago
Hematopoietic and Lymphatic System Neoplasm
Patient Navigation and the Planning Advance Care Together Website to Improve Goals of Care Conversations in Hematopoietic Cell Transplant Survivors, IMPACT-HCT Trial
This clinical trial evaluates the impact of patient navigation and the Planning Advance Care Together (PACT) website, either alone or in combination with one another, on advanced care planning (ACP) in patients with blood cancers…
- Trial name
- NCT07052630
- Testing
- Internet-Based Intervention, Patient Navigation, Best Practice
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Fred Hutchinson Cancer Center
Mechanical Ventilation Complication, Hypoxemia
Trial of Venovenous ECMO to De-Sedate, Extubate and Mobilise in Hypoxic Respiratory Failure
To determine whether a strategy of adding venovenous ECMO to mechanical ventilation, as compared to mechanical ventilation alone, increases the number of intensive care free days at day 60, in patients with moderate to severe…
- Conditions
- Mechanical Ventilation Complication, Hypoxemia, Acute Respiratory Distress Syndrome Due to COVID-19, COVID-19 Respiratory Infection
- Trial name
- REDEEM (NCT05562505)
- Testing
- Venovenous ECMO
- Where
- 7 sites in Australia, Germany
- Volunteers
- 140 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Amyotrophic Lateral Sclerosis ALS7
The Importance of Positive Expiratory Pressure Associated With the In-exsufflator in ALS Patients
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that impairs motor neurons, with a life expectancy of 2 to 7 years after diagnosis.
- Trial name
- PEPINEX (NCT06249412)
- Testing
- MI-E with PEP function activated during the pause, MI-E without PEP function activated during the pause
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Groupe Hospitalier du Havre
Acute Ichemic Stroke
ELATE Study: Evaluating Large-vessel Acute Thrombectomy in Extended Time Window
The ELATE study is a prospective, observational study designed to evaluate the clinical outcomes and safety profile of endovascular thrombectomy compared with best medical treatment alone in patients presenting with acute…
- Trial name
- ELATE (NCT07922317)
- Testing
- Endovascular treatment
- Where
- Vietnam
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- 115 People's Hospital
Uncontrolled Hypertension
Implementation of Effective Hypertension Management Approaches: OSF HealthCare
The goal of this observational pragmatic study is to learn about how evidence-based interventions and best practices for management of uncontrolled hypertension can be integrated across a large healthcare system through the use…
- Trial name
- NCT07450222
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Colleen J Klein
Metastatic Bladder Urothelial Carcinoma, Metastatic Renal Pelvis and Ureter Urothelial Carcinoma
Therapeutic Plasma Exchange With Enfortumab Vedotin and Pembrolizumab for Treatment of Bladder Cancers
This phase II trial compares therapeutic plasma exchange followed by enfortumab vedotin and pembrolizumab to standard of care next-line therapy for the treatment of patients with bladder or upper urinary tract cancers that have…
- Conditions
- Metastatic Bladder Urothelial Carcinoma, Metastatic Renal Pelvis and Ureter Urothelial Carcinoma, Refractory Bladder Urothelial Carcinoma, Refractory Renal Pelvis and Ureter Urothelial Carcinoma
- Trial name
- RECIPE-B1 (NCT07087860)
- Testing
- Best Practice, Biospecimen Collection, Central Venous Cannula Insertion
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic
Stroke Rehabilitation
Mirror Therapy Preceding Augmented Reality in Stroke Rehabilitation
This proposed research is in line with the National Health Research Institutes (NHRI) Innovative Research Grant priority to address innovative treatment strategies for neurological disorders that are in desperate need of…
- Trial name
- NCT05467813
- Testing
- mirror therapy, augmented reality (AR), control therapy
- Where
- 5 sites in Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
SCHIZOPHRENIA 1 (Disorder), Alcohol Use Disorder
Snoezelen Therapy in Adults With Alcohol Dependence and Adults With Schizophrenia
The purpose of the study: obtaining knowledge about the impact of Snoezelen® therapy on the health of adults suffering from schizophrenia and requiring permanent institutional care, adults suffering from schizophrenia and adults…
- Conditions
- SCHIZOPHRENIA 1 (Disorder), Alcohol Use Disorder, Alcohol Dependence (Primary Condition)
- Trial name
- NCT07748078
- Testing
- Snoezelen® therapy for 6 weeks, Snoezelen® therapy for 12 weeks
- Where
- 2 sites in Poland
- Volunteers
- 140 people
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
A Navigation Program to Improve Survivorship Support Service Participation Among Non-metastatic Breast Cancer Survivors
This clinical trial studies whether a navigation program improves survivorship support service participation among survivors of breast cancer that has not spread from where it first started (primary site) to other places in the…
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- NCT07699991
- Testing
- Best Practice, Patient Navigation, Referral
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Behavioral Symptoms, Community Health Workers
Health Equity and Rural Education (HERE!) Clinical Trial
The goal of this community-engaged research is two-fold. The first goal is to gather stakeholder feedback to inform a school-based community health worker intervention with youth with poor school attendance and an enhanced usual…
- Conditions
- Behavioral Symptoms, Community Health Workers, Social Determinants of Health, Educational Problems
- Trial name
- HERE (NCT06460116)
- Testing
- School-Based Community Health Worker (SB-CHW) intervention, Enhanced Usual Care (EUC) Methods
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Skin Carcinoma
A Disposable Negative Pressure Wound Therapy Device (SNaP) to Promote Wound Healing in the Lower Limbs Following Mohs Micrographic Surgery for Non-melanoma Skin Cancer
This clinical trial studies whether a disposable negative pressure wound therapy (dNPWT) device, SNaP Wound Care System (Ultraportable Mechanically Powered Negative Pressure Wound Therapy) (SNaP), promotes wound healing in the…
- Trial name
- NCT07032701
- Testing
- Best Practice, Educational Intervention, Electronic Health Record Review
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Foot Injury
From Opinion to Evidence: Multi-site Evaluation of Custom Dynamic Orthosis Best Practices
This study is designed to support evidence-based practice and optimal care by evaluating how different configurations of two types of carbon fiber custom dynamic orthoses (CDOs) influences outcomes following traumatic lower…
- Trial name
- AFOSVA (NCT06352788)
- Testing
- Modular Carbon Fiber Custom Dynamic Orthosis (CDO), Mono Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- Jason Wilken
Spinal Cord Injuries
Epidural Stimulation to Restore Voluntary Movement Following Spinal Cord Injury
This proof-of-concept case series will prospectively use magnetic resonance imaging (MRI) evidence of spared spinal cord neural fibers to guide the selection of 2 research participants to receive a surgically implanted epidural…
- Trial name
- NCT05966896
- Testing
- implanted epidural stimulator
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Chronic Disease
ECHO for Diabetes and Multiple Chronic Conditions Study
Diabetes mellitus is a chronic condition that affects the body's ability to process sugar effectively, which over time can increase the risk of heart disease, high blood pressure, and kidney damage.
- Trial name
- E4DMMC (NCT06451458)
- Testing
- ECHO program for DMMC, Usual care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of New Mexico
Hearing Loss, Hearing Aids
Innovations in Hearing Accessibility and Technology (IHAT) Study
The research will explore outcomes of different service delivery models of over-the-counter (OTC) hearing aids by comparing them to prescription hearing aids fitted by specialists in individuals with mild to moderate hearing…
- Conditions
- Hearing Loss, Hearing Aids, OTC Hearing Aids
- Trial name
- IHAT (NCT06689865)
- Testing
- HA-HCP, OTC-HCP, OTC-R
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- University of Colorado, Denver