Clinical trials: Botulinum toxin type A
Parkinson Disease
Botulinum Toxin Type A (Botox) in the Management of Levodopa-Induced Peak-Dose Dyskinesias in Parkinson's Disease
The primary objective of this study is to determine whether intramuscular injections of botulinum toxin type A (Botox®) in selected cervical muscles at antidystonic dosages can reduce levodopa-induced peak-dose dyskinesias (LID)…
- Trial name
- NCT00477802
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Cincinnati
Chronic Migraine
A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults
The purpose of this study is to understand the safety and effectiveness of the study drug, Dysport® when compared with placebo in preventing chronic migraine.
- Trial name
- C-BEOND (NCT06047444)
- Testing
- Botulinum toxin type A
- Where
- 120 sites in United States, Canada and 7 more
- Volunteers
- 759 people
- Sponsor
- Ipsen
Overactive Bladder Syndrome, Overactive Bladder
Comparing Number of Injection Sites of In-office Intravesical Onabotulinumtoxin A Treatments for Overactive Bladder: A Randomized Controlled Trial
Overactive bladder (OAB) is a syndrome characterized by urinary urgency, with or without urinary incontinence, nocturia, and urinary frequency.
- Trial name
- NCT05157295
- Testing
- OnabotulinumtoxinA
- Volunteers
- 100 people
- Sponsor
- Augusta University
Temporomandibular Disorders
Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A
The goal of this clinical trial is to investigate the effect of botulinum toxin on neurons' plasticity in the masseter muscle in humans with and without painful myogenous temporomandibular disorders (TMDM).
- Trial name
- NCT05720065
- Testing
- Botulinum toxin type A, Isotonic saline 0,9%
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Cosmetic Treatment Wish
Quality of Life After Cosmetic Treatments
Prospective cohort study, investigating the pre-post treatment effect of cosmetic injectable and surgical treatments on quality of life (primary outcome measure: FACE-Q Psychological, secondary outcome measure: FACE-Q Social)…
- Trial name
- NCT07687030
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Parkinson Disease, Depression
Trial of OnabotulinumtoxinA for Depression in Parkinson Disease
This study evaluates the efficacy of onabotulinumtoxinA (BOTOX®) in the treatment of depression associated with Idiopathic Parkinson Disease in adults.
- Trial name
- NCT03069911
- Testing
- OnabotulinumtoxinA, Control
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Johns Hopkins University
Obstructed Defecation, Anismus
Comparative Study Between Surgical and Non Surgical Treatment of Anismus in Patients
Comparative study between surgical and non surgical treatment of anismus in patients with symptoms of obstructed defecation. Anismus is a significant cause of chronic constipation.
- Conditions
- Obstructed Defecation, Anismus, Constipation
- Trial name
- NCT00735605
- Testing
- BFD, PDPR, BTX A
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Chronic Disease, Nasal Polyposis
Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Chronic Rhinosinusitis With Nasal Polyposis
Chronic rhinosinusitis (CRS) with nasal polyps is a particularly challenging form of chronic rhinosinusitis in several ways. Patients have significantly more severe symptom burden and worse quality of life than patients with…
- Conditions
- Chronic Disease, Nasal Polyposis, Rhinitis
- Trial name
- NCT02784262
- Testing
- botox injection Multiguide
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Norwegian University of Science and Technology
Cerebral Palsy (CP), Cerebral Palsy, Hemiplegic
Effect of Whirlpool Therapy Combined With Botulinum Toxin in Children With Cerebral Palsy
This study aims to investigate the effects of adding whirlpool therapy to standard rehabilitation in children with cerebral palsy who recently received botulinum toxin-A injections.
- Trial name
- NCT07690722
- Testing
- Conventional Rehabilitation, Whirlpool Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Ankara Etlik City Hospital
Myofascial Pain Syndrome, Myofascial Trigger Point Pain
Clinical Performance of Therapeutic Use of BTX for Bruxism
The goal of this clinical trial is to learn about the performance of botulinum toxin (BTX) injections for bruxism. Participants were divided into two groups according to the duration of the symptoms.
- Conditions
- Myofascial Pain Syndrome, Myofascial Trigger Point Pain, Bruxism, Pain
- Trial name
- BTX (NCT06258070)
- Testing
- Abobotulinumtoxin A injection for bruxism
- Where
- Tunisia
- Volunteers
- 67 people
- Sponsor
- Mohamed Tahar Maamouri University Hospital
Base-of-thumb Osteoarthritis, Osteoarthritis
Efficacy of Two Ultrasound-guided Intra-articular Injections of Botox® Combined With Custom-made Rigid Splinting in Painful Base-of-thumb Osteoarthritis.
The main objective of this study will be to compare the effects of 2 intra-articular injections of onabotulinumtoxinA with those of 1 intra-articular injection of onabotulinumtoxinA and 1 of normal saline and those of 2…
- Trial name
- RHIBOTII (NCT06902805)
- Testing
- OnabotulinumtoxinA
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Migraine
Extension Study of ABP-20001 to Evaluate Safety and Efficacy of Repeat Treatments of ABP-450 for Migraine Prevention
This Phase 2 Extension trial will evaluate the efficacy and safety of ABP-450 for migraine prevention in adults who suffer from six or more migraine days per month.
- Trial name
- NCT05016661
- Testing
- ABP-450
- Where
- 55 sites in United States, Australia and 1 more
- Volunteers
- 466 people
- Sponsor
- AEON Biopharma, Inc.
Healthy
Safety and Efficacy of NT 201, Free of Complexing Proteins, in the Treatment of Glabellar Frown Lines
NT 201 is a Botulinum toxin type A preparation free of complexing proteins. Injected into the muscle, NT 201 causes a reversible local relaxation of the injected muscle.
- Trial name
- NCT00694148
- Testing
- NT 201
- Where
- Germany
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Migraine Headaches
Prospective, Multi-Center Evaluation of the Efficacy of Peripheral Trigger Decompression Surgery for Migraine Headaches
According to the peripheral trigger theory of migraine headaches, nociceptive inputs from irritated or compressed cranial nerve branches can lead to neurovascular changes in the brain that cause migraine headaches.
- Trial name
- NCT02351544
- Testing
- Botulinum Toxin Type A, Surgery, Daily headache diary
- Where
- 6 sites in United States
- Volunteers
- 44 people
- Sponsor
- Ohio State University
Epicondylitis, Lateral Humeral, Tennis Elbow
Botulinum Toxin Versus Active Strength Training in the Treatment of Lateral Epicondylitis
The purpose of this study is to compare efficacy, feasibility and cost effectiveness of botulinum toxin type A injections to active nine weeks strength training and stretching program in the treatment of the chronic lateral…
- Trial name
- BooST (NCT00930709)
- Testing
- Botulinum toxin type A (Botox®, Allergan), Active strength training and stretching
- Where
- Finland
- Volunteers
- 103 people
- Sponsor
- Seinajoki Central Hospital
Obesity
Endoscopic Gastric Reduction for Weight Management
The proposed study is a prospective, pilot study to assess the feasibility of a novel endoscopic suturing system to reduce gastric volume by changing the shape of the stomach for the primary treatment of obesity.
- Trial name
- NCT01682733
- Testing
- Botulinum toxin, Overstitch Endoscopic Suturing System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Dyssynergic Defaecation, Evacuation Disorder
Infracoccygeal Botox for Dyssynergia
Background: Constipation is a common problem, affecting up to 20% of the population during their lifetime. Some patients respond poorly to standard treatments such as laxatives.
- Conditions
- Dyssynergic Defaecation, Evacuation Disorder, Anismus, Defecation Disorder
- Trial name
- NCT04879524
- Testing
- Percutaneous infracoccygeal Botulinum toxin injection to puborectalis
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Queen Mary University of London
Lower Limb Spasticity
RELIEF Study: Lower Limb Pain Relief After Injection Cycles in Adults Suffering From Lower Limb Spasticity Following Stroke
The objective of this study is to demonstrate the effect of intramuscular BoNT-A injections in relieving pain, in a broad population of patients who suffer pain as the primary problem associated with spasticity.
- Trial name
- RELIEF (NCT02020980)
- Testing
- Botulinum toxin type A
- Where
- 28 sites in Spain
- Volunteers
- 186 people
- Sponsor
- Ipsen
Glabellar Lines
A Study to Evaluate Sequential Administration of AGN-151586 and OnabotulinumtoxinA (BOTOX) Injections in Adult Participants for Treatment of Glabellar Lines
Facial lines that develop from repeated facial expression, such as glabellar lines (GL), are typically treated by selectively weakening specific muscles with small quantities of botulinum toxin.
- Trial name
- NCT05496335
- Testing
- AGN-151586, BOTOX
- Where
- 10 sites in United States
- Volunteers
- 90 people
- Sponsor
- AbbVie
Obstructed Defaecation Syndrome
Biofeedback Therapy Versus Botox Injection in Treatment of Dyssynergic Defecation.
assessment the Improvement symptoms of obstructed defecation after biofeedback training versus botulinum toxin injection
- Trial name
- NCT06724250
- Testing
- Biofeedback therapy, Botulinum Toxin A (Botox )
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Mansoura University
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