Clinical trials: Botulinum toxin type A, completed
Bladder Pain Syndrome
Comparison of the Treatment of Refractory Bladder Pain Syndrome With DMSO and DMSO With Botulinum Toxin A
The purpose of this research study is to evaluate the efficacy of intravesical botulinum A toxin and DMSO in women with bladder pain syndrome who have not responded to first-line treatments.
- Trial name
- NCT03103594
- Testing
- DMSO, Botox
- Volunteers
- 2 people
- Sponsor
- University of Pennsylvania
Glabellar Frown Lines
Efficacy and Safety of DaxibotulinumtoxinA for Injection to Treat Moderate to Severe Glabellar Lines
This is a safety and efficacy study of DaxibotulinumtoxinA for Injection to treat moderate to severe frown lines.
- Trial name
- NCT03014622
- Testing
- Botulinum Toxins, Type A
- Where
- 15 sites in United States
- Volunteers
- 303 people
- Sponsor
- Revance Therapeutics, Inc.
Dystonia, Dystonic Disorder
Meditoxin® Treatment in Patients With Cervical Dystonia
To determine the efficacy and safety of Meditoxin in subjects with cervical dystonia compared with placebo (normal saline)
- Trial name
- NCT03232320
- Testing
- Meditoxin
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Medy-Tox
Neurogenic Bladder Disorder
Predictive Urodynamic Parameters for The Treatment Efficacy of Onabotulinum A Toxin in Neurogenic Lower Urinary Tract Dysfunction
Purpose: To evaluate urodynamic parameters predicting the treatment efficacy of onabotulinumtoxin A (onaBoNT-A) in patients with neurogenic lower urinary tract dysfunction (NLUTD).
- Trial name
- NCT06485453
- Testing
- Botox 200 UNT Injection
- Volunteers
- 74 people
- Sponsor
- University of Gaziantep
Scar
Early Postoperative Prevention and Treatment of Median Sternotomy Scars With Botulinum Toxin Type A Injection
Linear hypertrophic scar is a common surgical problem that can be difficult to manage, especially for the median sternotomy scar.
- Trial name
- NCT02886988
- Testing
- Botulinum toxin type A, normal saline
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Xijing Hospital
Lateral Canthal Lines, Crow's Feet
ET-01 in Subjects With Lateral Canthal Lines
This study tests an investigational drug formulation called ET-01, botulinum toxin, Type A, topical, in lateral canthal lines (LCL).
- Trial name
- NCT03326856
- Testing
- botulinum toxin, Type A, Vehicle
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Eirion Therapeutics Inc.
Urinary Incontinence, Urge
Refractory Overactive Bladder: Sacral NEuromodulation v. BoTulinum Toxin Assessment (ROSETTA)
The purpose of this randomized, open-label, active-control trial is to compare the effectiveness of intra-detrusor botulinum toxin A (Botox A®, Allergan) versus sacral neuromodulation (InterStim®, Medtronic) for the treatment of…
- Trial name
- ROSETTA (NCT01502956)
- Testing
- InterStim® device, Botox® injection
- Where
- 9 sites in United States
- Volunteers
- 386 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Shoulder Pain
The Treatment of Shoulder Pain in Hemiplegic Spastic Patients With Botulinum Toxin A
Stroke is the leading cause of disability in developed countries, and the major cause of mortality in Brazil.It is associated with low quality of life, disability, decreased muscle strength and control due to the hypertonia…
- Trial name
- dolomtox (NCT04470401)
- Testing
- AbobotulinumtoxinA, Saline
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Post-Operative Atrial Fibrillation
Botulinum Toxin Type A (AGN-151607) for the Prevention of Post-operative Atrial Fibrillation in Adult Participants Undergoing Open-chest Cardiac Surgery (NOVA)
This was a multi-center, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study to evaluate the efficacy and safety of botulinum toxin type A (AGN-151607) injections into the epicardial fat pads, foci of…
- Trial name
- NCT03779841
- Testing
- AGN-151607
- Where
- 32 sites in United States, Austria and 7 more
- Volunteers
- 323 people
- Sponsor
- AbbVie
Interstitial Cystitis
Intravesical Instillation of Liposome Encapsulated Botulinum Toxin A (Lipotoxin) in Treatment of Interstitial Cystitis
To evaluate the efficacy and safety of intravesical instillation of Lipotoxin for the treatment of IC/BPS
- Trial name
- NCT02247557
- Testing
- Liposome encapsulated BoNT-A, BOTOX 200U in normal saline, Normal saline
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Spasticity, Post-Stroke
A Phase III Study to Evaluate the Efficacy and Safety of GSK1358820 in Subjects With Post-stroke Upper Limb Spasticity
Botulinum toxin A (GSK1358820) is a sterile, purified type A botulinum neurotoxin complex. In Japan, 240 units of botulinum toxin A are approved as a maximum dose per administration for upper limb spasticity.
- Trial name
- NCT03261167
- Testing
- Botulinum toxin A (GSK1358820)
- Where
- 38 sites in Japan
- Volunteers
- 124 people
- Sponsor
- GlaxoSmithKline
Rotator Cuff Tear Arthropathy
Does Botulinum A Toxin Help With Pain From Rotator Cuff Arthropathy?
Rotator cuff arthropathy is a cause of shoulder arthritis which is a common condition seen both in primary and secondary care. It is a painful condition, with significant disability.
- Trial name
- NCT02512536
- Testing
- Botulinum Toxin Type A
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Lateral Canthal Lines
Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
The purpose of this study is to evaluate the safety and efficacy of RT001 to treat moderate to severe lateral canthal lines in adults and duration of effect.
- Trial name
- NCT00907387
- Testing
- RT001
- Where
- 9 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Hemiplegia, Spastic, Spastic
Wearable Robotic System and Robotic Mirror Therapy in Spastic Hemiplegia Post Botulinum Toxin Injection
The purpose of this project is to examine and compare the immediate and long-term effects of combined Botulinum toxin type A(BoNT-A) injection with wearable robotic hand system (RT) and Robotic mirror therapy (RMT) in patients…
- Trial name
- NCT04826900
- Testing
- BoNT-A injections, Robotic therapy (RT), Robotic mirror therapy (RMT)
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- Chang Gung Memorial Hospital
Skin Aging
Efficacy and Safety Study of Botulinum Toxin Type A to Treat Glabellar Lines
The purpose of this study is to test the hypothesis that the efficacy and safety of Meditoxin® are not inferior to Botox®'s in the treatment of glabellar lines.
- Trial name
- NCT01237977
- Testing
- Botulinum Toxin Type A(Meditoxin®), Botulinum Toxin Type A(Botox®)
- Where
- 6 sites in South Korea
- Volunteers
- 314 people
- Sponsor
- Medy-Tox
Muscle Spasticity
Muscle Selection for Botulinum Toxin A Injection in Poststroke Elbow Flexor Spasticity
Botulinum toxin A (BoNT A) has been reported to be effective in the treatment of elbow flexor spasticity. Although BoNT A is an efficacious treatment option, there is a debate in the selection of target muscle(s) for BoNT…
- Trial name
- NCT04036981
- Testing
- Botulinum toxin type A
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Izmir Katip Celebi University
Low Anterior Resection Syndrome, Rectal Cancer
The Value of Botox-A for Management of Low Anterior Resection Syndrome
Low anterior resection syndrome (LARS) is frequent after treatment for low rectal cancer. Increased bowel frequency and urgency with rectal spasms and incontinence have deleterious impacts on quality of life in a third of the…
- Trial name
- NCT01589471
- Testing
- intra-rectal Botulinum toxin A injection
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pruritus
Itch Relieving Effect of Botox: a Study in Healthy Subjects
The purpose of this study is to determine if Botox is effective in the treatment of an experimentally induced itch that mimics chronic itch in healthy volunteers.
- Trial name
- NCT02639052
- Testing
- Botox, Saline
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Temple University
Epicondylitis, Lateral Humeral
Treatment of Tennis Elbow With Botulinum Toxin
The purpose of this study is to determine whether Botulinum A toxin is effective in the treatment of tennis elbow (lateral epicondylitis).
- Trial name
- NCT00119704
- Testing
- Botulinum toxin A injection or normal saline
- Where
- 2 sites in Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Hyperhidrosis
Safety and Efficacy of Botulinum Toxin Type A Topical Gel for Primary Axillary Hyperhidrosis
This is a safety and efficacy study of botulinum toxin type A in subjects with primary axillary hyperhidrosis.
- Trial name
- NCT02565732
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Revance Therapeutics, Inc.