Clinical trials: Bupivacaine
Postoperative Pain, Shoulder Arthroscopy
Magnesium Sulphate as an Adjuvant in Combined Costoclavicular Block and Suprascapular Block Versus Interscalene Block for Ambulatory Shoulder Arthroscopy
Shoulder arthroscopy is a common outpatient procedure that can cause moderate to severe pain during the first 24 to 48 hours after surgery.
- Conditions
- Postoperative Pain, Shoulder Arthroscopy, Hemidiaphragmatic Paresis
- Trial name
- NCT07918521
- Testing
- Combined Costoclavicular and Suprascapular Nerve Block with Magnesium Sulfate, Interscalene Brachial Plexus Block with Magnesium Sulfate
- Volunteers
- 60 people
- Sponsor
- Assiut University
Surgical Procedure, Unspecified
TFPB vs QLB III in Infra-umbilical Pediatric Surgeries
Regional anesthetic techniques; they reduce postoperative morbidity, provide early mobilization and provide great advantages by significantly reducing the need for narcotic analgesics.
- Trial name
- NCT05671484
- Testing
- Transversalis Fascial Plane Block, Quadratus Lumborum Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Namik Kemal University
Neuromuscular Block
Adductor Canal Block In Anterior Cruciate Ligament (ACL) Repair
Adductor canal block will provide adequate analgesia to patients undergoing arthroscopic ACL reconstruction surgery, yet result in less motor blockade than a femoral block.
- Trial name
- NCT01791036
- Testing
- Adductor Canal Block, Femoral Nerve Block
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Postoperative Pain
ESP Versus SPSIP Block for Pain Relief After Shoulder Arthroscopy
This study will compare two regional anesthesia techniques for pain relief after arthroscopic shoulder surgery: high thoracic erector spinae plane (ESP) block and serratus posterior superior intercostal plane (SPSIP) block.
- Trial name
- ESP-SPSIP (NCT07906392)
- Testing
- High Thoracic Erector Spinae Plane Block, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ferit Yetik
Femur Neck Fracture, Hip Fractures
Lumbar Erector Spinae Plane Block Versus PENG Block for Hip Fracture Surgery
The purpose of this clinical trial is to compare two different nerve block techniques-the Pericapsular Nerve Group (PENG) block and the Lumbar Erector Spinae Plane Block (L-ESPB)-for managing pain after hip fracture surgery in…
- Conditions
- Femur Neck Fracture, Hip Fractures, Postoperative Pain
- Trial name
- NCT07910487
- Testing
- Pericapsular Nerve Group Block, Lumbar Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Beni-Suef University
Postoperative Pain, Cholelithiasis
Comparative Efficacy of ESPB and EOPB for Postoperative Analgesia in Laparoscopic Cholecystectomy: A Randomized Controlled Trial (External Oblique Intercostal Plan Block (EOPB) and Erector Spina Plan Block (ESPB) )
This randomized controlled clinical trial investigates the comparative efficacy of two novel regional anesthesia techniques - the Erector Spinae Plane Block (ESPB) and the External Oblique Intercostal Plane Block (EOPB) - for…
- Conditions
- Postoperative Pain, Cholelithiasis, Acute Pain
- Trial name
- NCT07057934
- Testing
- ESPB Block, EOPB Block, Standard Systemic Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Post-operative Pain
Intrathecal Opioid Study
This is an interventional drug trail to evaluate the effect of different intrathecal opioids on post-operative pain experiences in women who have undergone caesarean section surgery.
- Trial name
- NCT02577809
- Testing
- Morphine100, Morphine50, Fentanyl
- Where
- South Africa
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Epidural, Analgesia
Epidural Analgesia and Delivery of Second Twin
Over an 8-year period, 124 twin pregnancies at gestational age ≥32 weeks with both twins presenting as a vertex and eligible for vaginal delivery were reviewed.
- Conditions
- Epidural, Analgesia, Labor Pain
- Trial name
- Epidural (NCT04608006)
- Testing
- Bupivacaine-fentanyl
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Abdelrady S Ibrahim, MD
Gynecologic Laparoscopic Surgery, Postoperative Pain
"Efficacy of Local Anesthetic for Postoperative Pain in Gynecologic Laparoscopy"
This is a randomized, double-blind, controlled clinical trial evaluating the efficacy of local anesthetic (LA) in reducing postoperative pain in patients undergoing gynecologic laparoscopic surgery.
- Conditions
- Gynecologic Laparoscopic Surgery, Postoperative Pain, Recovery Outcomes, Pain Management
- Trial name
- NCT07030647
- Testing
- Bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Usama Ahmed Elsaeed Salem, MD
Postoperative Pain
Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair
The aim of the study is to determine wether continuous wound infusion with local anaesthetic plus a single dose intravenous morphine is non-inferior to postoperative analgesia provided with continuous thoracic epidural infusion…
- Trial name
- APERIVIP (NCT02677532)
- Testing
- Paracetamol, Levobupivacaine wound infiltration, Levobupivacaine epidural bolus
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- University of Genova
Chronic Pancreatitis
Intraductal Liposomal Bupivacaine for Chronic Pancreatitis
The major clinical features of chronic pancreatitis include glandular (exocrine and endocrine) failure and pain. Pain has remained a major clinical challenge and is present in up to 90% of patients and is the primary cause of…
- Trial name
- NCT04611958
- Testing
- ERCP with Bupivacaine infusion
- Where
- United States
- Sponsor
- Johns Hopkins University
Malignant Neoplasm of Breast
Analgesic Effects of Ultrasound Guided PEC Blocks on Analgesic Opioid Consumption of Cancer Surgery Patients
Examining the analgesic effect of ultrasound guided Pectoral Blocks on analgesic opioid consumption after surgical removal of breast tissue.
- Trial name
- NCT02495363
- Testing
- PECS Block, Bupivacaine 0.25-0.5%
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Open Abdominal Surgery
Intrathecal Morphine for Quality of Recovery After Open Abdominal Surgery Within an Enhanced Recovery Pathway
Pain management after open abdominal surgery still faces severe challenges, with the incidence of moderate to severe pain after surgery as high as 50 - 90%.
- Trial name
- NCT07575321
- Testing
- Intrathecal Morphine, Intrathecal saline injection, TAPB
- Volunteers
- 756 people
- Sponsor
- Sun Yat-sen University
Post Thoracic Surgery
Intrapleural Bupivacaine for Ipsilateral Shoulder Pain After Thoracotomy
While thoracic epidural could control incisional pain after thoracotomy, an excruciating ipsilateral shoulder pain happens post thoracotomy and could affect up to 85% of thoracotomy patients.
- Trial name
- NCT03862404
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Breast Cancer
Compare Analgesia Between MTP Block And ESPB in MRM
This study is conducted to compare the analgesic efficacy between ultrasound guided Erector Spinae Plane block Vs midpoint transverse process to Pleura block in modified radical mastectomy surgeries
- Trial name
- NCT06888258
- Testing
- Ultrasound guided Erector Spinae Plane block, Ultrasound guided Mid-point to Pleura block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Hand Injury, Wrist Injury
Comparing Two Injection Sites of Local Anesthetic for Hand Surgery
The purpose of this study is to compare two different injection sites for local anesthesia in patients having hand surgery. The hypothesis is that subjects receiving injections around the three nerves of the forearm will provide…
- Conditions
- Hand Injury, Wrist Injury, Finger Injury
- Trial name
- NCT02112006
- Testing
- 0.5% bupivacaine injected in the forearm, 20-30ml of 0.5% bupivacaine.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD
Post Operative Analgesia
Dexmedetomidine and Bupivacaine Intra-articular for Postoperative Analgesia After Knee Arthroscopic Surgery
The aim of this study to compare the analgesic effects of intraarticular dexmedetomidine added to bupivacaine with those of bupivacaine alone after knee arthroscopy
- Trial name
- DEXMED (NCT06665438)
- Testing
- Bupivacaine 0.25%, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 75 people
- Sponsor
- Al-Azhar University
Vaginal Laceration During Delivery
The PAIN (Pelvic Area Injection for Numbness) Study
Postpartum pain can interfere with patient's ability to care for themselves, and their newborn, and untreated pain is associated with risk of greater opioid use, postpartum depression, and development of persistent pain.
- Trial name
- PAIN (NCT05972681)
- Testing
- Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Inflammation, Inflammatory Response
Effects of Multimodal Analgesia on Serum MCP-1, BDNF, and MiRNA-124 in Hysterectomy Surgery
The inflammatory process is the main mechanism in the occurrence of acute postoperative pain. It is also the main risk for the development of acute pain into persistent pain.
- Conditions
- Inflammation, Inflammatory Response, Acute Pain, Chronic Pain
- Trial name
- NCT05069311
- Testing
- Multimodal analgesia, Conventional intravenous analgesia
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Udayana University
Postoperative Pain
Intrathecal Pethidine Plus Dexamethasone for Distal Lower Orthopedic Surgeries
Bupivacaine is commonly used as a sole agent for spinal anesthesia unlike pethidine. Pethidine (meperidine) is a unique opioid. In addition to its analgesic activity, it also has significant local anesthetic activity.
- Trial name
- NCT05303311
- Testing
- Bupivacaine Hydrochloride, Pethidine plus Dexamethasone
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Zagazig University
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