Clinical trials: Bupivacaine
Pain Management, C Section
Pain After Scheduled Cesarean Delivery: Spinal Morphine With or Without Levobupivacaine Wound Infiltration
The goal of this observational study is to learn whether injecting a numbing medicine (levobupivacaine, a local anesthetic) into the surgical wound at the end of a cesarean delivery improves pain control in women who also receive…
- Conditions
- Pain Management, C Section, Obstetric Pain, Levobupivacaine
- Trial name
- LEVO-CS (NCT07859956)
- Testing
- Levobupivacaine, Intrathecal Morphine
- Where
- Colombia
- Volunteers
- 336 people
- Sponsor
- Fundación Santa Fe de Bogota
Lower Extremities Fracture
Comparison Between Dexamethasone and Morphine as an Adjuvant to Bupivacaine for Post-operative Analgesia
The study aimed to compare the effectivity of dexamethasone 8 mg and morphine 2 mg as an adjuvant to epidural bupivacaine 0,125% 12,5mg for post-operative analgesia in lower extremities.
- Trial name
- NCT03051022
- Testing
- Dexamethasone 8 mg, Morphine 2 mg
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Universitas Indonesia
Pain, Postoperative
Efficacy and Safety of A Collagen Bupivacaine Implant in Patients After Gastrointestinal Surgery
The purpose of this study is to determine whether the CollaRx Bupivacaine Implant (bupivacaine sponge) is safe and effective in reducing the amount of narcotic pain medication needed to control pain during the first 24 hours…
- Trial name
- NCT00661466
- Testing
- Bupivacaine Collagen Sponge
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Innocoll
Postoperative Pain Management, Penile Surgery-Related Pain
Anatomical Measurements of Pudendal Nerve Block in Children
This prospective observational study aims to investigate the relationship between anatomical parameters-specifically the distance from the anus to the needle insertion point and the depth required to reach the pudendal…
- Trial name
- NCT07348029
- Testing
- Neurostimulation-Guided Pudendal Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Scoliosis Idiopathic, Scoliosis; Adolescence
Erector Spinae Plane Block in Scoliotic Adolescents
For scoliotic surgeries, Erector Spinae Plane Block (ESPB) can add to the multimodal approach for perioperative pain management with decreasing the opioids requirement, improving recovery and decreasing ICU stay.
- Conditions
- Scoliosis Idiopathic, Scoliosis; Adolescence, Erector Spinae Plane Block
- Trial name
- NCT03968146
- Testing
- Erector Spinae Plane Block, Fentanyl, additional Fentanyl
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Breast Cancer
Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in Erector Spinae Plane Blocks for Mastectomies
Perform a comparison of effective pain relief duration between liposomal bupivacaine and dexmedetomidine when added to bupivacaine in a block for mastectomy for cancer surgery.
- Trial name
- NCT06252662
- Testing
- Dexmedetomidine, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, Portsmouth
Cardiac Disease
Exparel in Minimally Invasive Cardiac Surgery
The investigators are presently using Exparel, a slow released local anesthestic, in patients undergoing minimally invasive cardiac surgery.
- Trial name
- NCT02008370
- Testing
- Exparel infiltration
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Maimonides Medical Center
Pain, Postoperative
Thoracic Paravertebral Blockade in Video Assisted Thoracoscopic Surgery (VATS)
Video-assisted thoracoscopic surgeries (VATS) include severe postoperative acute pain which is also a predictor of chronic pain.
- Trial name
- VATS (NCT02302586)
- Testing
- Thoracic paravertebral block (TPVB), Patient Controlled Analgesia (IV PCA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Migraine
Greater Occipital Nerve Block With Bupivacaine for Acute Migraine
This is a randomized, sham-controlled study of greater occipital nerve block (GONB) using bupivacaine 0.5% for emergency department patients with acute migraine.
- Trial name
- NCT02665273
- Testing
- Greater occipital nerve block, Bupivacaine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Montefiore Medical Center
Pain, Postoperative, Inguinal Hernia Unilateral
Intrathecal Morphine and Transversalis Fascia Plane Block for Analgesia After Open Inguinal Hernia Repair
Inguinal hernia is a common surgical condition, and open inguinal hernia repair may be associated with significant postoperative pain.
- Conditions
- Pain, Postoperative, Inguinal Hernia Unilateral, Intrathecal Morphine, Transversalis Fascia Plane Block
- Trial name
- NCT07826741
- Testing
- Intrathecal Morphine Group, Transversalis Fascia Plane Block Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Pectus Excavatum, Funnel Chest
Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum
Primary objective of the current study is to determine the impact of intercostal nerve cryoablation on postoperative length of hospital stay compared to standard pain management of young pectus excavatum patients (12-24 years)…
- Trial name
- ICE (NCT05731973)
- Testing
- Intercostal nerve cryoablation, Thoracic epidural analgesia (continuous infusion with sufentanyl (1 µg/ml) and bupivacaine (1.25 mg/ml)), Intercostal nerve block (single shot bupivacaine (1.25 mg/ml))
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Zuyderland Medisch Centrum
Postoperative Analgesia
Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery.
The aim of the study is to investigate the analgesic effects of the subcutaneous wound infiltration with tramadol, ketamine, dexamethasone, dexmedetomidine and midazolam as adjuvant to ropivacaine, compared to ropivacaine alone…
- Trial name
- NCT03809442
- Testing
- Ropivacaine + Ketamine, Ropivacaine + Tramadol, Ropivacaine + Midazolam
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Aga Khan University
Mastectomy, Pain, Postoperative
Erector Spina Plane Block vs Serratus Anterior Plane Block for Postoperative Mastectomy Pain
The aim of this study is to compare the efficiency of serratus anterior plane block and erector spina plane block on analgesic consumption, postoperative pain and patient's satisfaction and recovery quality in patients undergoing…
- Conditions
- Mastectomy, Pain, Postoperative, Recovery Period, Anesthesia
- Trial name
- NCT04296188
- Testing
- serratus anterior plane block, erector spina plane block
- Volunteers
- 60 people
- Sponsor
- Tokat Gaziosmanpasa University
Pain, Postoperative, Pruritus
Enhanced Recovery After Cesarean Section With Low Dose Intrathecal Morphine.
This study is designed to see the effect of low dose intrathecal morphine on promting enhanced recovery after cesarean delivery with early ambulation and reduction of hospital stay.
- Conditions
- Pain, Postoperative, Pruritus, Nausea, Postoperative, Vomiting, Postoperative
- Trial name
- NCT04618146
- Testing
- Morphine Sulfate, Bupivacaine Hydrochloride
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Shoulder Pain, Shoulder Injuries
Serratus Posterior Superior Intercostal Plane Block for Arthroscopic Shoulder Surgery
Postoperative pain is a significant problem in patients undergoing arthroscopic shoulder surgery. This situation disrupts the patient's comfort and affects the functional outcome after surgery by preventing early rehabilitation.
- Trial name
- NCT06866054
- Testing
- SPSIPB block, Postoperative analgesia management
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Pain
Bupivacaine Pain Pumps to Decrease Mastectomy Post-Operative Pain
This double-blind, randomized, controlled clinical trial comparing patient-reported pain and pain medication/narcotic use between patients randomized to treatment (bupivacaine) or placebo (saline) delivered via pain pump to the…
- Trial name
- NCT01494259
- Testing
- Bupivacaine, Saline
- Where
- United States
- Sponsor
- Johns Hopkins University
Pain, Acute, Nausea
Enhanced Recovery Strategies in Elective Breast Surgery
Postoperative pain, nausea, and vomiting are frustrating sequelae of elective breast surgery. Poorly managed postoperative pain can lead to increased opioid use, increased postoperative nausea and vomiting (PONV), delayed return…
- Conditions
- Pain, Acute, Nausea, Vomiting, Postoperative, Opioid Use
- Trial name
- NCT03187080
- Testing
- Paravertebral block procedure using either local anesthetic (0.25% bupivacaine) or sterile saline, Enhanced recovery after breast surgery (ERABS) strategies, Paravertebral block using local anesthetic
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Pain, Postoperative
Liposomal Bupivacaine at Cesarean Delivery to Decrease Post-operative Pain
This is a randomized controlled trial to test whether the use of liposomal bupivacaine at the time of cesarean delivery may decrease post-operative pain scores.
- Trial name
- NCT02959996
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Pain
Preoperative Gabapentin for Acute and Chronic Post-thoracotomy Analgesia
One dose of either gabapentin or placebo will be given to patients prior to thoracotomy. Patients will also receive an epidural infusion, intravenous patient-controlled analgesia with fentanyl, oral acetaminophen and intravenous…
- Trial name
- NCT00588159
- Testing
- Gabapentin, Diphenhydramine
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Michelle Kinney
Postoperative Pain, Pediatric Open Heart Surgery
A Combination of Intrathecal Fentanyl and Pecto-Intercostal Fascial Block in Paediatric Cardiac Surgery.
Cardiac surgery is commonly performed via median sternotomy. Patients undergoing cardiac surgical procedures frequently experience intense acute pain in the post-sternotomy wound, which can potentially transition into persistent…
- Trial name
- NCT06882655
- Testing
- PIFB group, Intrathecal fentanyl(IT fentanyl), IT + PIFB
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Alexandria University
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