Clinical trials: Bupivacaine
Chronic Pain, Cardiac Surgery
Bilateral Erector Spinae Plane Block for Postoperative Chronic Pain After Open Heart Surgery
The aim of this study is to investigate the effect of bilateral erector spinae plane (ESP) block application on postoperative chronic pain in patients undergoing on-pump open-heart surgery.
- Conditions
- Chronic Pain, Cardiac Surgery, Post Operative Pain
- Trial name
- NCT06315959
- Testing
- Bilateral ultrasound guided erector spinae plane block, morphine PCA, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people
- Sponsor
- Ondokuz Mayıs University
Spinal Bupivacaine/Morphine in Laparoscopic Surgery
Spinal Bupivacaine/Morphine in Laparoscopic Gastro-intestinal Surgery
The objective of this study is to determine if a single spinal shot of morphine can decrease post-operative opioid-use, and thereby decrease opioid side-effects and lead to a quicker recovery after surgery.
- Trial name
- Salmon (NCT02284282)
- Testing
- Spinal injection bupivacaine/morphine, subcutaneum injection lidocaine
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- Maasstad Hospital
Postoperative Pain
Effect of Quadratus Lumborum Block on Perioperative Analgesia and Inflammatory Responses in Laparoscopic Nephrectomy
Quadratus lumborum (QL) block can reduce intraoperative opioid consumption, decrease inflammation responses of IL-6, and reduce acute pain intensity in comparison with non-receiving QL block as the control group.
- Trial name
- NCT03879980
- Testing
- Bilateral QL block, Non-QL block
- Where
- Indonesia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Rotator Cuff Tear, Postoperative Pain
Liposomal Bupivacaine for Pain Control After Rotator Cuff Repair
The use of an interscalene block (ISB) is often associated with rebound pain that could be avoided through adjunctive therapy with longer duration.
- Trial name
- NCT03692546
- Testing
- Liposomal bupivacaine (LB)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Orthopaedic & Neurosurgery Specialists
Post Operative Pain
Postoperative Anelgesic Effect of Rhomboid Intercostal Nerve Block Versus Erector Spinae Plane Block
Despite of analgesic effect of intravenous analgesic medications at intraoperative and postoperative time , The regional anesthetic techniquehas more benefits suchbetter control of Acute pain and hence less chronic pain and…
- Trial name
- NCT05452369
- Testing
- Rhomboid intercostal plane block
- Where
- 2 sites in Egypt
- Volunteers
- 104 people
- Sponsor
- ghada fouad
Pain
Transversus Abdominis Plane Block in the Management of Acute Postoperative Pain Syndrome After Caesarean Section
In many countries, caesarean section (CS) rates have been increasing. The international literature is unclear regarding the analgesic efficacy of the transversus abdominis plane block (TAPB) after a CS.
- Trial name
- NCT02728323
- Testing
- Levobupivacaine, Saline
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Emiliano Petrucci
Migraine Headache
Greater Occipital Nerve Block for Migraine Prophylaxis
Migraine is a common neurological condition that can be disabling, particularly if chronic. Greater occipital nerve (GON) block has been utilized for decades for the treatment of migraine in the absence of a single randomized…
- Trial name
- NCT00915473
- Testing
- bupivicaine, normal saline, methylprednisolone
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic
Acute Pain, Opioid Use
Effect of Adding TTPB to SAPB in Breast Cancer Surgery
Breast cancer is the most common malignancy in women worldwide. Even minor breast surgery can cause significant postoperative pain (PP). PP can turn into chronic pain in 25-40% of cases.
- Trial name
- NCT06082141
- Testing
- Transversus thoracis plane block combined with serratus anterior plane block, Serratus anterior plan block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bezmialem Vakif University
Pain, Postoperative
Efficacy of Adding Dexmedetomidine as an Adjuvant to Bupivacaine in TAP Block and Caudal Block
This study compares the efficacy of Dexmedetomidine as an adjuvant to Bupivacaine in Ultrasound Guided Transversus Abdominis Plane Block versus Caudal Block for post-operative analgesia in children undergoing congenital inguinal…
- Trial name
- NCT04926454
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Inguinal Hernia, Spinal Anesthesia
The Effect of Local Anesthetic and Clonidine on the Cutaneous Silent Period During Spinal Anesthesia
The cutaneous silent period is a non-invasive technique that gives insight into the function of thin A delta fibers and as such can be a complement to conventional electrophysiological methods used to study the peripheral nerves.
- Trial name
- NCT03121261
- Testing
- levobupivacaine, clonidine
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Dubrava
Postoperative Pain Following Knee Arthroplasty, Total Knee Arthroplasty
Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty
This prospective randomized controlled study aims to evaluate the effect of ultrasound-guided Biceps Femoris Short Head (BiFeS) block combined with adductor canal block on postoperative opioid consumption and pain control in…
- Trial name
- BiFeS Adductor (NCT07577869)
- Testing
- Procedure: Biceps Femoris Short Head Block, Procedure: Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ömer Kayar
Total Knee Arthroplasty, Post-operative Pain Control
Adductor Canal Block Versus Liposomal Bupivacaine in TKA
This is a randomized prospective study of 60 patients undergoing total knee arthroplasty evaluating the clinical outcomes of liposomal bupivacaine periarticular injections (PAI) when compared to single shot adductor canal block…
- Trial name
- NCT04086186
- Testing
- Liposomal Bupivacaine Peri-articular Injection, Adductor canal block
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Good Samaritan Regional Medical Center, Oregon
Brain Tumor Adult, Cerebrovascular Disease
The Analgesic Effect of Scalp Nerve Block Using Bupivacaine Liposomes for Postoperative Pain Relief After Craniotomy
After undergoing craniotomy, 60% to 84% of neurosurgery patients experience moderate to severe acute pain, primarily in the first 48 hours. This pain is mostly superficial, affecting the muscles and soft tissues around the skull.
- Trial name
- NCT07049094
- Testing
- scalp nerve block with 0.25% hydrochloride bupivacaine and 0.67% bupivacaine liposome solution, scalp nerve block with 0.50% hydrochloride bupivacaine
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Zhejiang University
Radiculopathy Lumbar, Disc Disease Lumbar
Ultrasound-Guided Microendoscopic Versus Fluoroscopic-Guided Lumbar Transforaminal Epidural Steroid Injections
The purpose of this study is to compare the Microendoscopic combined with ultrasound technique to the standard routinely used X-ray guided transforaminal steroid injection technique.
- Trial name
- NCT05729022
- Testing
- Ultrasound microendoscopic technique, Fluoroscopy
- Where
- Lebanon
- Volunteers
- 124 people
- Sponsor
- American University of Beirut Medical Center
Post Operative Pain, Regional Block
Dual Injection ESPB Versus Single Injection ESPB for Laparotomies
To evaluate and compare the efficacy of single level injection erector spinae plane block versus double level injection Erector spinae plane block in laparotomies
- Trial name
- NCT05633329
- Testing
- single level, dual level
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Postoperative Pain, Breast Cancer
Comparison of Erector Spinae Plane Block With Serratus Anterior Plane Block for Breast Surgery
Breast cancer is by far the world's most common cancer among women and the most common cause of female death from cancer worldwide. It's worldwide incidence is 43.4 in 100.000 while in Egypt is 48.8 in 100.000.
- Trial name
- NCT03579524
- Testing
- Erector Spinae Plane Block, Serratus Anterior Plane Block
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Fayoum University Hospital
Labor Pain
Tetracaine Combined Spinal Epidural (CSE) Versus Bupivacaine CSE
The investigators hypothesis is that spinal tetracaine with fentanyl and epinephrine used for CSE labor analgesia volume will last a significantly longer period of time that that of spinal bupivacaine with fentanyl.
- Trial name
- NCT01005459
- Testing
- Tetracaine, Bupivacaine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Wake Forest University
Pain
Pain Management in Response to Exparel vs. Standard Bupivicaine
This study is looking to evaluate the efficacy of liposomal bupivicaine (Exparel) on decreasing the amount of consumed pain medications.
- Trial name
- VATS Exparel (NCT02499159)
- Testing
- Liposomal Bupivicaine, 0.25% standard bupivicaine
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Inova Health Care Services
Postoperative Pain Management
The Efficacy of Combined Intrathecal Morphine and PENG Block on Postoperative Pain in Hip Arthroplasty
This study aims to compare the postoperative 48-hour period in terms of morphine consumption, postoperative pain, and quality of recovery scores by combining the Pericapsular Nerve Group (PENG) block with low-dose intrathecal…
- Trial name
- PENG (NCT06298370)
- Testing
- Pericapsular nerve group block plus intrathecal bupivacaine, Intrathecal bupivacaine and morphine, Pericapsular nerve group block plus intrathecal bupivacaine and morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people
- Sponsor
- Bezmialem Vakif University
Pain, Postoperative
Perineural Versus IV Dexmedetomidine as Adjuvant to Quadratus Lamborum Block for Pediatrics Undergoing Pyeloplasty
this prospective parallel group double blinded study will be conducted over 50 pediatric patients ASA (American Association of Anesthesiologists) I and II between the age of 8-13 years old,who will be scheduled for laparoscopic…
- Trial name
- NCT03885804
- Testing
- Quadratus lamborum dexmedetomidine intravenous, Quadratus lamborum dexmedetomidine perineural group(
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
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