Clinical trials: Bupivacaine
Hemidiaphragmatic Paralysis
Shoulder Pericapsular Block Versus Interscalene Block in Arthroscopic Shoulder Surgery
This randomized controlled trial aims to compare the incidence of hemidiaphragmatic paralysis (HDP) following ultrasound-guided interscalene block (ISB) versus shoulder pericapsular nerve group (PENG) block in patients undergoing…
- Trial name
- NCT07486349
- Testing
- Interscalene Nerve Block, shoulder pericapsular nerve group block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Breast Neoplasm Female, Postoperative Pain Management
PECS II vs. MTP for Analgesia After MRM
This randomized controlled study aims to compare the analgesic efficacy of the ultrasound-guided modified pectoral nerve block (PECS II) and the midpoint transverse process to pleura (MTP) block in female patients undergoing…
- Trial name
- NCT06187909
- Testing
- PECS II BLOCK, MTP BLOCK
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
Pancreatic Carcinoma Metastatic, Pancreatic Adenocarcinoma
Trial Comparing EUS-guided Radiofrequency Ablation vs. EUS-guided Celiac Plexus Neurolysis
Pancreatic cancer is the second most common gastrointestinal malignancy. Abdominal discomfort is a main symptom in patients with pancreatic cancer. Approximately 75% have pain at diagnosis and over 90% in advanced stages.
- Conditions
- Pancreatic Carcinoma Metastatic, Pancreatic Adenocarcinoma, Pancreatic Neoplasms, Pancreatic Cancer
- Trial name
- NCT03152487
- Testing
- Celiac Plexus Neurolysis, Radiofrequency Ablation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- AdventHealth
Labor Pain
Epidural Neostigmine for Labor Pain
The purpose of this study is to see which dose of epidural neostigmine is the best additive to use with the numbing medication used in an epidural during labor.
- Trial name
- NCT00779467
- Testing
- Neostigmine, Bupivacaine, fentanyl
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University
Cesarean Section, Adhesions
Closure of Peritoneum at Cesarean Section and Postoperative Adhesion
Objective: To determine the effect of non-closure of the visceral and parietal peritoneum during Cesarean section on the formation of adhesions.
- Trial name
- cs adhesions (NCT01183000)
- Testing
- Closure of the peritoneum at cs
- Where
- 2 sites in Israel
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Spinal Anesthesia, Hypothermia Following Anesthesia
Effect of Prewarming On Skin Temperature Changes
In this randomized prospective single-blind study,American Society of Anesthesiologists physical status classification system ( ASA )I-II-III patients aged 50-80 years undergoing transurethral bladder resection will be randomly…
- Conditions
- Spinal Anesthesia, Hypothermia Following Anesthesia, Prewarming, Core Temperature
- Trial name
- NCT05063292
- Testing
- Patients in Group II will receive active prewarming with an air forced blanket (full body blanket) 30 minutes prior to the operation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bozyaka Training and Research Hospital
Total Knee Replacement, Optic Nerve Sheath Diameter Measurement
The Effect of Epidural Anesthesia on Optic Nerve Sheath Diameter Measurements in Total Knee Prosthesis Surgery
This study investigates the effects of epidural anesthesia on intracranial pressure (ICP) by using ultrasonographic optic nerve sheath diameter (ONSD) measurements as a non-invasive indicator.
- Conditions
- Total Knee Replacement, Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Change
- Trial name
- NCT07458321
- Testing
- Bupivacaine %0.25 (isobaric), Bupivacaine %0.5 (hyperbaric)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa City Hospital
Regional Anesthesia Morbidity
Cervical Plexus Block Combined With Translaryngeal Block for Tracheostomy
Current healthcare delivery models emphasize enhanced postoperative recovery (ERAS) with minimal morbidity and shorter hospital stays. Most tracheostomy cases are tumour patients.
- Trial name
- NCT04697836
- Testing
- ST
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Namik Kemal University
Toxicity, Drug
Observation Study of the Pharmacokinetics of Adductor Canal Block
With the aging of the population, osteoarthritis of knees and hips become major orthopedic problems worldwide. Osteoarthritis of the knees and hips is associated with a significant pain problem and functional disability.
- Trial name
- NCT04916392
- Testing
- Liposomal bupivacaine
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- The University of Hong Kong
Pregnancy Related
Enhanced Recovery After Surgery for Emergency Caesarean Deliveries
Caesarean section (CS) constitutes a large proportion of the total surgical volume in low-income countries. This rate comes with challenges including surgical complications, shortage of beds, and consequently long waiting time…
- Trial name
- ERAS-Mbarara (NCT03518463)
- Testing
- Enhanced recovery after surgery (ERAS)
- Where
- Uganda
- Volunteers
- 160 people
- Sponsor
- Mbarara University of Science and Technology
Hip Fractures
Comparison of Cryoablation of Pericapsular Nerve Group (PENG) to Fascia Iliaca Catheter in Patients With a Hip Fracture
The purpose of this study is to determine if patients with hip fractures who undergo cryoablation of the PENG have improved pain control 30 days from surgery when compared to those who have a fascia iliaca catheter.
- Trial name
- NCT06278987
- Testing
- PENG block and cryoablation, fascia iliaca compartment block
- Sponsor
- University of Minnesota
Pain, Postoperative, ACL
Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction
Liposomal bupivacaine injectable suspension (Exparel), manufactured by Pacira Pharmaceuticals, is an FDA-approved, long-lasting nonopioid analgesic that is indicated for single-dose infiltration in adults to produce postsurgical…
- Trial name
- NCT05161221
- Testing
- OxyCODONE 5 mg Oral Tablet, Naproxen 500 Mg, Tylenol Pill
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Coronary Artery Bypass Graft (CABG), Chest Tubes
Chest Tube-Delivered Bupivacaine to Decrease Postoperative Pain After Cardiac Surgery
Background: After heart surgery, patients require temporary chest tubes - plastic drains placed inside the chest to prevent fluid building up around the heart and lungs.
- Conditions
- Coronary Artery Bypass Graft (CABG), Chest Tubes, Post Operative Pain Control
- Trial name
- FREEZE-B (NCT07643506)
- Testing
- 0.5% Bupivacaine without epinephrine, 10cc injection of normal saline (0.9%)
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Abdominal Cancer
Cardio-pulmonary and Analgesic Effects of Pre-peritoneal VS Epidural Infusion of L-bupivacaine on Abd. Cancer Patients
60 Patients will be randomly assigned using computer generated randomization program (http://www.randomizer.org) into two groups, First group (Control group ,Group of continous epidural infusion [CEI]), where patients will…
- Trial name
- NCT04152564
- Testing
- levo-bupivacaine infusion via Thoracic epidural catheter, levo-bupivacaine infusion via preperitoneal catheter
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- South Egypt Cancer Institute
Thoracic
Pharmacokinetics of Single-Dose Liposomal Bupivacaine in Surgeon Performed Intercostal Nerve Blocks
Post-surgery pain management is critical for ensuring timely patient recovery and minimizing complications. Part of the multimodal approach to managing severe acute pain in the days following surgeries is the use of nerve blocks.
- Trial name
- NCT03708198
- Testing
- Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Prostatectomy, Pain
Impact of Perioperative Analgesia in Prostatectomy Patients on Early Quality of Recovery (SPITALIDO)
The rationale behind this RCT is to assess within 24 hours after surgery the quality of recovery of prostatectomy patients treated with 3 different analgesia concepts (intraoperative spinal analgesia, transversus abdominis plane…
- Trial name
- SPITALIDO (NCT03618693)
- Testing
- Spinal anesthesia, TAP Block, Standard
- Where
- Switzerland
- Volunteers
- 142 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Facet Syndrome of Lumbar Spine
Fluoroscopy Guided Lumbar Facet Joint Injection Versus Ultrasound Guided Injection in Patients With Low Back Pain Due to Facet Syndrome
The aim of this study is to compare the efficacy of fluoroscopy guided lumbar facet joint injection versus ultrasound guided injection in patients with low back pain due to facet syndrome.
- Trial name
- NCT03770585
- Testing
- Fluoroscopy guided Facet joint injection, Ultrsound guided Facet joint injection
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Postoperative Pain
The Effect of Adding Dexamethasone to Epidural Bupivacaine for Total Knee Replacement Surgery
The purpose of this study was to evaluate the efficacy of dexamethasone when added to epidural bupivacaine on the duration of postoperative analgesia in patients underwent total knee replacement surgery.
- Trial name
- NCT03231215
- Testing
- Dexamethasone
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cutaneous Sensory Blockade
Effects of Injection Volume and Site on Sensory Distribution After Rectus Sheath Block
This randomized controlled study aims to evaluate the effects of local anesthetic injection volume and injection site on cutaneous sensory distribution following ultrasound-guided rectus sheath block (RSB).
- Trial name
- RSB-SENSE (NCT07876297)
- Testing
- Ultrasound-Guided Upper Rectus Sheath Block (20 mL), Ultrasound-Guided Upper Rectus Sheath Block (30 mL), Ultrasound-Guided Middle Rectus Sheath Block (20 mL)
- Where
- Thailand
- Volunteers
- 120 people
- Sponsor
- Chiang Mai University
Total Shoulder Arthroplasty
Postoperative Pain Control in Total Shoulder Arthroplasty
A double blind, prospective, randomized trial to evaluate postoperative pain, narcotic use, patient satisfaction, and function among shoulder arthroplasty patients receiving interscalene block with and without the addition of…
- Trial name
- NCT05068960
- Testing
- Liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Scripps Clinic
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