Clinical trials: CPAP
Obstructive Sleep Apnea
Ambulatory Blood Pressure Control and Cognition in Patients With Obstructive Sleep Apnea (AMPLE)
To compare the blood pressure control and cognitive responses of three groups of patients: those diagnosed with Obstructive Sleep Apnea (OSA) and treated with Continuous Positive Airway Pressure (CPAP) for at least six months…
- Trial name
- AMPLE (NCT06463002)
- Testing
- Ambulatory blood pressure monitoring and Montreal Cognitive Assessment
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Sleep Apnea
Effect of High Flow Nasal Cannula Versus Continues Positive Airway Pressure in Adults With Obstructive Sleep Apnea
The participants whom undergo Polysomnography study (Sleep study) and are found to have mild, moderate or severe Obstructive Sleep Apnea (OSA) will have two consecutive titration nights.
- Trial name
- NCT05475119
- Testing
- Continuous Positive Airway Pressure (CPAP), High Flow Nasal Cannula (HFNC)
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- King Abdulaziz University
Obstructive Sleep Apnea
Dual Obstructive Sleep Apnea Therapy
Continuous positive airway pressure (CPAP) is considered the gold standard therapy for obstructive sleep apnea (OSA). However, CPAP users sometimes experience pressure-related discomfort.
- Trial name
- DOT (NCT03435731)
- Testing
- Dual Therapy
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
ARDS (Acute Respiratory Distress Syndrome)
Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
The goal of this clinical trial is to learn how low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV) affect lung tissue mechanics in adults with ARDS.
- Trial name
- NCT06790875
- Testing
- Airway Pressure Release Ventilation (APRV)
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Respiratory Distress Syndrome
Comparing Weaning of Nasal Continuous Positive Airway Pressure (CPAP) From Preterm Infants
To compare the 2 methods of weaning of nasal continuous positive airway pressure (CPAP) in premature babies born between 26 and 32 weeks
- Trial name
- NCT02126501
- Testing
- Gradual pressure wean
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Maimonides Medical Center
Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea
Effect of CPAP on Abnormal Gastroesophageal Reflux and Lung Inflammation in IPF
This study will evaluate the effect of CPAP therapy on esophageal pH and lung inflammation in patients with idiopathic pulmonary fibrosis (IPF) and sleep apnea.
- Conditions
- Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea, Gastro Esophageal Reflux
- Trial name
- NCT05359965
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Healthy, Respiratory Disease
A New Portable Device for Non-invasive Ventilatory Support
Acute respiratory failure is a medical emergency rapidly leading to death, if not timely treated. Prompt Continuous Positive Airway Pressure (CPAP) improves patient outcomes.
- Trial name
- PREVENT (NCT06716502)
- Testing
- Portable CPAP efficacy, Portable CPAP usability assessment
- Where
- 3 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
COVID-19, COVID
Early CPAP in COVID-19 Confirmed or Suspected Patients
There is surge in COVID infected patients in New York City with a shortage of hospital beds, ICU beds and ventilators. Strategies to reduce the need for all of the above are immediately needed.
- Conditions
- COVID-19, COVID, Coronavirus
- Trial name
- PAP-COVID (NCT04390191)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Covid19, Acute Respiratory Failure
Noninvasive Respiratory Support in COVID-19 (CATCOVID-AIR)
COVID-19 pneumonia can cause severe acute hypoxemic respiratory failure. The usefulness of noninvasive respiratory support (NIRS), by means of nasal high-flow oxygen (NHFO), continuous positive airway pressure (CPAP), or…
- Conditions
- Covid19, Acute Respiratory Failure, Corona Virus Infection
- Trial name
- CATCOVID-AIR (NCT04668196)
- Testing
- High-flow nasal cannula treatment, Continuous positive airway pressure (CPAP) treatment, Noninvasive ventilation treatment
- Where
- 10 sites in Spain
- Volunteers
- 367 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Sleep Apnea, Overweight and Obesity
CPAP, Nutrition & Exercise Against Sleep Apnea
This study evaluates the addition of a comprehensive lifestyle program including dietary management and exercise to continuous positive airway pressure (CPAP) therapy in overweighted adults with obstructive sleep apnea.
- Trial name
- TINE (NCT03959280)
- Testing
- Tailored intervention, Control
- Where
- 2 sites in France, Switzerland
- Volunteers
- 120 people
- Sponsor
- Raphael Heinzer
Preoxygenation, Anesthesia
High-Flow Nasal Cannula (HFNC) Preoxygenation in Obese Patients Undergoing General Anesthesia
This study aims to evaluate the effectiveness of the High Flow Nasal Cannula (HFNC) for the preoxygenation of obese patients undergoing a general anesthesia.
- Conditions
- Preoxygenation, Anesthesia, Obesity
- Trial name
- NCT03615417
- Testing
- High Flow Nasal Cannula (HFNC), Standard anesthesia FaceMask (FM)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Erasme University Hospital
Pneumonia
Effectiveness of OLE Airway Clearance Therapy in ICU Patients With Pulmonary Infections
This study aims to explore the application of Electrical Impedance Tomography (EIT) in evaluating the effectiveness of OLE (Oscillatory Lung Expansion) airway clearance therapy for ICU patients with pulmonary infections.
- Trial name
- NCT07395297
- Testing
- Oscillatory Lung Expansion (OLE) Therapy
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Chinese PLA General Hospital
Respiratory Distress Syndrome, Lower Respiratory Tract Infection
A Low-Resource Oxygen Blender Prototype for Use in Modified Bubble CPAP Circuits
Purpose: Using a novel oxygen blender prototype with modified bCPAP to manage children 1 month to 5 years of age hospitalized with respiratory distress due to lower respiratory tract infection (LRTI) in low-resource settings is…
- Trial name
- NCT04311320
- Testing
- Low-Resource Oxygen Blender
- Where
- Cambodia
- Volunteers
- 33 people
- Sponsor
- University of Minnesota
Sleep Apnea, Obstructive
Drug-Induced Sleep Endoscopy in Guiding Non-CPAP Therapy in Obstructive Sleep Apnea
Continuous positive airway pressure (CPAP) remains the gold standard treatment for obstructive sleep apnea (OSA). However, many patients decline or fail CPAP therapy.
- Trial name
- NCT07422402
- Testing
- Drug induced sleep endoscopy
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Mansoura University
Obstructive Sleep Apnea
Anxiety and Depression In Patients With Obstructive Sleep Apnoea Before and After Continuous Positive Airway Pressure
Continuous positive airway pressure (CPAP) is the gold-standard treatment for obstructive sleep apnoea (OSA), the most common sleep-disordered breathing in the overall population.
- Trial name
- ADIPOSA (NCT04104880)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Granada
Massage, Stress
Massage for Newborns Receiving Nasal CPAP
One of the most frequently required treatments for respiratory distress in neonatal intensive care is continuous positive airway pressure (NCPAP) support through the nose.
- Conditions
- Massage, Stress, Newborn, Comfort
- Trial name
- NCT06360159
- Testing
- Intervention
- Volunteers
- 36 people
- Sponsor
- Sultan Besiktas
Obstructive Sleep Apnea
Effects of Physical Activity on OSA Severity Based on the Level of Fluid Shift
Obstructive sleep apnea (OSA) is characterized by complete or partial upper-airway collapse during sleep associated with sleepiness.
- Trial name
- AP-FLUID (NCT04623463)
- Testing
- Physical activity intervention
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Grenoble
Sars-CoV2
The Prone Position in Covid-19 Affected Patients
The prone position during mechanical ventilation in patients with Acute Respiratory Distress Syndrome (ARDS) is able to improve oxygenation and thus reduce mortality.
- Trial name
- PRON-COVID (NCT04365959)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Milano Bicocca
Asthma
Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients With Asthma (CPAP)
The CPAP trial is a 3-arm parallel design randomized sham-controlled trial. Participants are randomly assigned in equal allocation to one of three treatments: CPAP 10 cm water (H₂O) (high) vs. CPAP 5 cm H₂O (medium) vs.
- Trial name
- CPAP (NCT01629823)
- Testing
- Continuous Positive Airway Pressure device (Resmed, Swift, Mirage)
- Where
- 18 sites in United States
- Volunteers
- 209 people
- Sponsor
- American Lung Association Asthma Clinical Research Centers
Apnea, Sleep, Chronic Fatigue Syndrome
Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment
The purpose of this study is to determine any sleep disordered breathing in veterans with Gulf War Syndrome (GWS) and compare it to healthy normal asymptomatic Gulf War veterans.
- Trial name
- NCT00252629
- Testing
- Nasal CPAP treatment during sleep
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- US Department of Veterans Affairs
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