Clinical trials: CPAP
Obstructive Sleep Apnea
Obstructive Sleep Apnea Treatment With CPAP With and Without the Use of Expiratory Pressure Relief Technology
Expiratory pressure relief (EPR) is a technology designed to improve patient comfort during continous positive airway pressure (CPAP) treatment for obstructive sleep apnea (OSA).
- Trial name
- OSAEPR (NCT05219591)
- Testing
- EPR
- Where
- Brazil
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Respiratory Insufficiency in Children, Newborn Rds
Diaphragmatic Work During HFNC and CPAP Support
The goal of this randomised controlled, cross-over clinical trial is to compare High Flow Nasal Cannulas (HFNC) and Continuous Positive Airways Pressure (CPAP) in neonates over 34 weeks' amenorrhoea (SA) up to children weighing…
- Conditions
- Respiratory Insufficiency in Children, Newborn Rds, Nasal Cannula, CPAP Ventilation
- Trial name
- DiaWorkHFNC (NCT06249009)
- Testing
- Non invasive ventilation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infant, Newborn, Disease, Hypoxia
CPAP Or Nasal Cannula Oxygen for Preterm Infants: A Randomized Controlled Trial
The purpose of this study is to determine if in preterm infants < 34 weeks' gestation at birth receiving respiratory support with continuous positive airway pressure (CPAP) or nasal cannula (NC), CPAP compared with NC will…
- Conditions
- Infant, Newborn, Disease, Hypoxia, Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
- Trial name
- COCO (NCT04792099)
- Testing
- Continuous positive airway pressure, Nasal Cannula
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Alabama at Birmingham
Healthy
Non Invasive Ventilation Comfort Study
Patients who are suffering from a variety of respiratory conditions benefit from continuous positive airway pressure (CPAP) which is a form of Non-Invasive Ventilation (NIV).
- Trial name
- NCT02473068
- Testing
- CPAP
- Where
- New Zealand
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Weight Gain After CPAP Treatment in Patients With Obstructive Sleep Apnea
The purpose of this trial is to investigate the mechanisms leading to weight gain during CPAP treatment for obstructive sleep apnea (OSA).
- Trial name
- OSA (NCT03567317)
- Testing
- CPAP withdrawal
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Acute Respiratory Failure
Physiological Effects of a New Interface on Lung Ventilation and Gas Distribution
Hypoxemic Acute Respiratory Failure (hARF) is a common reason of admission to Intensive Care. Different modalities can be used to administer oxygen, which is the first supportive treatment in these patients.
- Trial name
- NCT04619641
- Testing
- High Flow Nasal Cannula (HFNC), Continuous Positive Airway Pressure (CPAP)
- Volunteers
- 15 people
- Sponsor
- University Magna Graecia
Sleep Disordered Breathing
Contribution of an Educational Game for Continuous Positive Pressure/Non-invasive Ventilation Therapeutic Education in Children
A growing number of children with obstructive sleep apnea syndrome (OSAS) or nocturnal alveolar hypoventilation syndrome are treated with continuous positive airway pressure (CPAP) or nocturnal non-invasive ventilation (NIV)…
- Trial name
- YAPOUNI (NCT04660994)
- Testing
- Educational game
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome (Neonatal), Intubation Complication
InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated…
- Conditions
- Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
- Trial name
- Aero-05 (NCT05960929)
- Testing
- Infasurf Aero™
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- ONY
Obstructive Sleep Apnea
The Effect of Mandibular Advancement Devices on Markers of Cardiovascular Health in Obstructive Sleep Apnea Patients
Obstructive sleep apnea (OSA) is a type of disordered breathing defined by the repetitive obstruction of airflow during sleep due to upper airway collapse. Each obstructive event contributes to decreased blood oxygen, or hypoxia.
- Trial name
- NCT05387122
- Testing
- mandibular advancement device (MAD)
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta
Adherence
CPAP (Continuous Positive Airway Pressure) Study Educational Materials and Usage Feedback to Promote CPAP Adherence
The study hypothesis: in groups receiving tailored education and feedback in a style that matches their psychological profile, will show a higher CPAP adherence rates than groups receiving mismatched tailored education /…
- Trial name
- NCT02195531
- Testing
- Education and feedback
- Where
- 6 sites in United States
- Volunteers
- 169 people
- Sponsor
- Philips Respironics
Preterm Infants, Respiratory Distress Syndrome (Neonatal)
Pressure Targeting During High Flow Therapy in Premature Infants
The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants.
- Conditions
- Preterm Infants, Respiratory Distress Syndrome (Neonatal), BPD - Bronchopulmonary Dysplasia
- Trial name
- NeoMATCH (NCT07418502)
- Testing
- Pressure Targeted High Flow, CPAP
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Texas at Austin
Apnea of Prematurity, Prematurity
Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants
This trial analyzes the effect of an olfactory stimulation with vanilla or strawberry aroma compared to placebo on desaturations and bradycardia in preterm infants with apnea of prematurity.
- Conditions
- Apnea of Prematurity, Prematurity, Infant, Premature, Diseases
- Trial name
- NOSE (NCT05878925)
- Testing
- Aroma
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Respiration; Insufficient or Poor, Newborn, Infant, Premature, Diseases
Comparison Of Respiratory Support After Delivery on Infants Born Before 28 Weeks Gestational Age
Trial purpose: For infants born <28 weeks of age, can initial respiratory resuscitation with new system (low imposed work of breathing and prongs) reduce the frequency of delivery room intubations compared to standard treatment…
- Trial name
- CORSAD (NCT02563717)
- Testing
- T-piece used for respiratory support (several manufacturers), New system used for respiratory support
- Where
- 6 sites in Iceland, Lithuania and 3 more
- Volunteers
- 250 people
- Sponsor
- Baldvin Jonsson
Acute Hypoxemic Respiratory Failure
Helmet CPAP vs Venturi O2 to Treat Early ALI/ARDS
Mechanical ventilation through an endotracheal tube is a lifesaving procedure for acute respiratory failure. However endotracheal intubation increases patient's discomfort and stress, and represents one of the most important…
- Trial name
- HelmetCPAP (NCT00342368)
- Testing
- CPAP delivered by an Helmet
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Catholic University of the Sacred Heart
Academic Underachievement Disorder
Type D Personality and the Compliance for CPAP Therapy and Cardiovascular Complications in OSA.
Type D personality is characterized by negative affectivity and social inhibition and is assessed with the DS-14 questionnaire. This type of personality was initially described in patients with coronary heart disease and…
- Trial name
- NCT04114409
- Volunteers
- 600 people
- Sponsor
- Universitair Ziekenhuis Brussel
Sleep Apnea Syndrome, Coronary Artery Disease
Evolution of Oxidative Stress in Coronary Patients With Moderate Sleep Apnea Syndrome After Treatment With Continuous Positive Airway Pressure
Published data indicate that obstructive sleep apnea syndrome (OSAS) worse the prognosis of coronary artery disease (CAD) and that oxidative stress can link this 2 diseases.
- Trial name
- CardioX SAS (NCT02893865)
- Testing
- Continuous positive airway pressure
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Montpellier
Respiratory Distress Syndrome in Premature Infant, Surfactant
Clinical RD (Respiratory Distress) Score for Objective Decision Making for Surfactant Therapy
To develop a comprehensive 'Clinical RD score' for decision making for administration of Surfactant in respiratory distress syndrome in preterm infants with gestation of 26 0/7 - 34 6/7 weeks and to assess the validity of this…
- Conditions
- Respiratory Distress Syndrome in Premature Infant, Surfactant, CPAP
- Trial name
- NCT03273764
- Where
- India
- Volunteers
- 209 people
- Sponsor
- Lady Hardinge Medical College
Obstructive Sleep Apnea
An Investigation to Test the Efficacy of the High Flow (HF) Continuous Positive Airway Pressure (CPAP) in Patients With Obstructive Sleep Apnea (OSA)
Phase One: High Flow (HF) CPAP (HF-CPAP) Titration: Participants will attend the sleep lab to undergo a comprehensive split-night respiratory PSG.
- Trial name
- NCT01025440
- Testing
- Continuous Positive Airway Pressure
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea, Mild Cognitive Impairment
Sleep Apnea, Neurocognitive Decline and Brain Imaging in Patients With Subjective or Mild Cognitive Impairment
Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and potentially lead to cardiometabolic and…
- Conditions
- Obstructive Sleep Apnea, Mild Cognitive Impairment, Subjective Cognitive Impairment
- Trial name
- NCT06150352
- Testing
- Continuous Positive Airway Pressure or other management for OSA per clinical indications.
- Where
- Hong Kong
- Volunteers
- 180 people
- Sponsor
- The University of Hong Kong
Sleep Apnea Syndromes, Hypertension
CPAP in SAHS Patients With Hypertension
Study objective: To assess the nocturnal changes in mechanosensitivity and chemosensitivity in hypertensive sleep apnea-hypopnea syndrome (SAHS) patients and in SAHS patients with isolated nocturnal hypertension.
- Trial name
- SAHS2-3 (NCT02398032)
- Testing
- CPAP nasal
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Hospital Universitario La Paz
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