Clinical trials: CPAP
Morbid Obesity
Effect of Boussignac CPAP Ventilation on PaO2 and PaO2/FiO2 Ratio in Morbidly Obese Patients Undergoing Bariatric Surgery
The purpose of this study is to determine if the application of Boussignac continuous positive airway pressure (CPAP) immediately after extubation improves PaO2 and PaO2/FiO2 ratio in morbidly obese patients undergoing gastric…
- Trial name
- NCT02297828
- Testing
- Boussignac CPAP, Venturi face mask
- Where
- Portugal
- Volunteers
- 24 people
- Sponsor
- Centro Hospitalar do Porto
Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
"Continuous Positive Airway Pressure on Venovenous extracorporeaL Membrane Oxygenation for Acute respIratory Distress syndrOme"
The CALMDOWN trial is a prospective, open-label, multicenter, comparative, controlled trial randomizing patients who received near apneic ventilation vs usual care on ECMO (ultra-protective lung ventilation).
- Trial name
- CALMDOWN (NCT06814340)
- Testing
- ECMO + near apneic ventilation, ECMO + ultra-protective lung ventilation
- Where
- 11 sites in France
- Volunteers
- 280 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea, Dementia
The Effect of OSA on Brain Waste Clearance
Recent ground-breaking research has shown that clearance of toxic neuro-metabolites from the brain including the proteins β-Amyloid (Aβ) and tau that form dementia causing plaques and tangles is markedly impaired when sleep is…
- Conditions
- Obstructive Sleep Apnea, Dementia, Cognitive Impairment
- Trial name
- NCT05606991
- Testing
- CPAP Withdrawal
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Pregnancy, Sleep-disordered Breathing
Effect of CPAP Treatment on Glycemic Control in Gestational Diabetes: A Pilot Randomized-Controlled Trial
Clinical trial on effects of continuous positive airway pressure (CPAP) on glucose levels in pregnant patients with sleep-disordered breathing and gestational diabetes
- Conditions
- Pregnancy, Sleep-disordered Breathing, Gestational Diabetes
- Trial name
- NCT02245659
- Testing
- CPAP, Nasal dilator strip
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Obstructive Sleep Apnea, Excessive Daytime Sleepiness
BF2.649 in Patients With OSA and Treated by CPAP But Still Complaining of EDS
Multicenter randomized double blind study versus placebo during 12 weeks with at first, an escalating dose period followed by stable dose period at the selected dose.
- Trial name
- HAROSA1 (NCT01071876)
- Testing
- BF2.649
- Where
- France
- Volunteers
- 244 people
- Sponsor
- Bioprojet
Obstructive Sleep Apnea of Adult
Effect of Inspiratory Muscle Training in Obstructive Sleep Apnea Syndrome.
Sleep apnea-hypopnea syndrome is a sleep-related respiratory disorder characterized by partial or total interruptions in breathing during sleep.
- Trial name
- NOCTURNE (NCT06117579)
- Testing
- Inspiratory muscle training
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Diabetic Retinopathy, Sleep Apnea
CPAP Effect on the Progression of Diabetic Retinopathy in Patients With Sleep Apnea
Objectives: Main objective: To compare the percentage of patients with new microaneurysm or hard exudates after 12 months between the CPAP group and the control group.
- Trial name
- RetinAS (NCT02874313)
- Testing
- Continuous positive airway pressure, Pharmacological treatment, Conventional anti-diabetic diet recommendations
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- Hospital Universitario La Paz
Sleep Apnea, Chronic Pain Syndrome
Sleep and Pain Sensitivity
This project will assess patients with diagnosed obstructive sleep apnea, to investigate the impact of poor sleep on central pain mechanisms.
- Trial name
- NCT04246294
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Aalborg University
Neonatal Disorder
Impact of Tactile Kinesthetic Stimulation and Soft Tissue Manipulation on Cortisol in Preterm
Effect of Soft tissue Therapy in managing Procedural Pain among neonates admitted to the neonatal intensive care unit. This study focuses on procedural pain management with the help of Soft tissue manipulation, which includes…
- Trial name
- NCT06845137
- Testing
- Tactile-Kinesthetic Stimulation (TKS) and Soft Tissue Manipulation (STM), Standard Therapy
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- faizan kashoo, PT
Lung Injury, Lung Inflammation
The Effects of Different Ventilation Modes on Patients With Pulmonary Lobe Resection
The objective of this study was to discuss the effects of different ventilation modes on patients with plasma inflammatory factor and respiratory function in patients with pulmonary removal.
- Trial name
- NCT06514729
- Testing
- Adopting different ventilation modes during the operation
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Mao Enting
Acute Respiratory Distress Syndrome
Stepwise Positive End Expiratory Pressure Elevation For Lung Recruitment in Acute Respiratory Distress Syndrome (ARDS)
Acute respiratory distress syndrome is a severe lung disease caused by a variety of direct and indirect issues. It is characterized by inflammation of the lung parenchyma leading to impaired gas exchange and persistent hypoxemia.
- Trial name
- NCT01373905
- Testing
- Recruitment maneuver
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- University of Alexandria
Obstructive Sleep Apnea
Transcend Auto vs Commercially Available Device Clinical Evaluation for Treatment of Obstructive Sleep Apnea (OSA)
The purpose of this study is to determine whether the Transcend Auto is as effective in treating obstructive sleep apnea as another device that is already on the market.
- Trial name
- NCT01799265
- Testing
- Somnetics Transcend Auto, Respironics REMstar Auto with C-Flex
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Somnetics International, Inc.
RDS of Prematurity
NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome)
The purpose of this study is to determine whether two different strategies of Non Invasive Ventilation (NIV) have different effect on length and failure of NIV support in preterm infants with respiratory distress syndrome (RDS).
- Trial name
- NIV (NCT02259400)
- Testing
- NSIPPV, BiPAP
- Volunteers
- 280 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Obstructive Sleep Apnoea, Obesity
Obstructive Sleep Apnoea and Adipose Tissue Dysfunction
Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea.
- Conditions
- Obstructive Sleep Apnoea, Obesity, Hypoxia
- Trial name
- NCT02518633
- Testing
- Continuous positive airway pressure devices
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Lung Diseases, Sleep Apnea Syndromes
Continuous Positive Airway Pressure to Improve Milder Obstructive Sleep Apnea
The purpose of this study is to determine whether functional status improves in individuals with milder obstructive sleep apnea (OSA) following continuous positive airway pressure (CPAP) treatment.
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Hypertension
- Trial name
- CATNAP (NCT00089752)
- Testing
- Continuous Positive Airway Pressure (CPAP) Treatment
- Where
- 5 sites in United States, Canada
- Volunteers
- 281 people
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea, Down Syndrome
Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome
The goal of this observational study is to learn about the use of non-invasive ventilation for treatment of obstructive sleep apnoea syndrome in children with Down Syndrome.
- Conditions
- Obstructive Sleep Apnea, Down Syndrome, Quality of Life, Behavior
- Trial name
- REFRESHED (NCT06030349)
- Testing
- Non-invasive ventilation
- Where
- 6 sites in Ireland, United Kingdom
- Volunteers
- 200 people
- Sponsor
- Children's Health Ireland
Obstructive Sleep Apnoea
Comparison of Two Continuous Positive Airway Pressure Systems
Randomised crossover trial of a novel and traditional Continuous Positive Airway Pressure (CPAP) system in Obstructive Sleep Apnoea patients.
- Trial name
- NCT02535234
- Testing
- Novel System, Traditional System
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- ResMed
Hypertension, Obstructive Sleep Apnea
Impact of Sleep-Disordered Breathing Management in Systemic Hypertension Control: METASLEEP Project
Hypertension is a frequent condition affecting 11M Spanish citizens and is the leading modifiable contributor to cardiovascular disease and death.
- Trial name
- NCT05986487
- Testing
- CPAP or usual practice, Monitoring and intervention in follow-up
- Where
- Spain
- Volunteers
- 1,523 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Obstructive Sleep Apnoea
Effect of Continuous Positive Airway Pressure (CPAP) on Systemic Blood Pressure, Coagulability and Carotid Intima-media Thickness in Patients With Sleep Apnea
Sleep-disordered breathing (SDB) briefly means cessation of breathing during sleep at least 5 times per hour. Sleep-disordered breathing affects 9 to 24% of the middle-aged and overall 4% of the middle-aged males suffers from…
- Trial name
- NCT00300599
- Testing
- Continuous Positive Airway pressure
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Autonomic Dysfunction
Autonomic Regulation in Prader-Willi Syndrome
To evaluate autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing.
- Trial name
- NCT04118816
- Testing
- Polysomnography, Multiple sleep latency test, Continuous positive airway pressure
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
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