Clinical trials: CPAP, open to volunteers
Acute Viral Bronchiolitis
Respiratory Physiotherapy and Hospitalization in Infants With Bronchiolitis
Acute Viral Bronchiolitis (AVB) is one of the leading causes of respiratory illness and hospitalization among infants during the first year of life, generating a substantial burden on healthcare services and public health…
- Trial name
- BVA-RESP (NCT07682844)
- Testing
- Outpatient Respiratory Physiotherapy
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea (OSA)
Boosting CPAP Use in Adults With Severe Sleep Apnea: Role of Motivation and Psychological Factors
The goal of this randomized prospective clinical trial is to examine whether phenotypic traits, psychological characteristics, assessed by STAI (engl. The State-Trait Anxiety Inventory) and IPIP50S (engl.
- Trial name
- NCT06994247
- Testing
- Motivational Telephone Call
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University of Split, School of Medicine
Postural Orthostatic Tachycardia Syndrome, Postural Tachycardia Syndrome
Autoimmune Basis for Postural Tachycardia Syndrome
The purpose of this study is to see if some people with postural tachycardia syndrome (POTS) have higher levels of immune proteins (autoantibodies) directed against receptors of the autonomic nervous system, and if these…
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Postural Tachycardia Syndrome, Tachycardia, Arrhythmias, Cardiac
- Trial name
- NCT02725060
- Testing
- phenylephrine, isoproterenol, 25 micro-Ci of radiation
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obstructive Sleep Apnea
Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.
To date, there has been no head to head comparison of Upper Airway Stimulation (UAS) and Continuous Positive Airway Pressure (CPAP) utilizing a full night polysomnographic evaluation.
- Trial name
- NCT04191512
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Sleep Apnea, Obstructive, Type 1 Diabetes (T1D)
Type 1 Diabetes and Obstructive Sleep Apnea
The purpose of the study is to investigate the role of sleep apnea in glycemic dysregulation in adults with Type 1 diabetes.
- Trial name
- T1D and OSA (NCT06915831)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
High-altitude Polycythemia, HAPC
High-Altitude Polycythemia Study
This study aims to evaluate the clinical efficacy of non-invasive ventilation (NIV) in treating patients with high-altitude polycythemia (HAPC).
- Trial name
- NIV-HAPC (NCT07600086)
- Testing
- Non-invasive ventilator
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- Tibet Autonomous Region People's Hospital
Neonatal Respiratory Failure
Flow and Grow - The Ideal Time to Wean CPAP Off In Extremely Low Birth Weight Infants
Preterm neonates born at less than 30 weeks' gestation are commonly maintained on invasive or non-invasive respiratory support to facilitate gas exchange.
- Trial name
- Flow&Grow (NCT06123143)
- Testing
- Standardized/structured CPAP weaning protocol
- Where
- 5 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of California, San Diego
Sleep Apnea, Sleep Apnea, Obstructive
Benefits of Oxytocin in Obstructive Sleep Apnea (OSA) Patients Using Continuous Positive Airway Pressure (CPAP) Machine
This study will investigate if an intra-nasal nose spray of the drug oxytocin can decrease the amount of pressure needed from the automatic Continuous Positive Airway Pressure (CPAP) device while sleeping decreasing some of the…
- Trial name
- NCT03860233
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vivek Jain
Desaturation, Hypoxemia
Prevention of Desaturations Using Positive Airway Pressure or Capnometry During ERCP
Although sedation during endoscopy is sufficiently safe, desaturations are among the most common side effects of endoscopic retrograde cholangiopancreatography (ERCP) procedures, occurring in approximately 20-30% of cases.
- Conditions
- Desaturation, Hypoxemia, ERCP
- Trial name
- PrePAP-ERCP (NCT07056075)
- Testing
- Nasal PAP Ventilation System, Low Flow Oxygen, Capnometry
- Where
- 2 sites in Austria
- Volunteers
- 288 people
- Sponsor
- Karl Landsteiner University of Health Sciences
Respiratory Distress Syndrome (Neonatal), Intubation Complication
InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated…
- Conditions
- Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
- Trial name
- Aero-05 (NCT05960929)
- Testing
- Infasurf Aero™
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- ONY
Acute Respiratory Failure, Pneumonia
Practice of Oxygenation and Respiratory Support During Fiberoptic Bronchoscopy
The current practice of oxygenation and/or ventilation supports in patients undergoing Fiberoptic Bronchoscopy is very heterogeneous among studies published in the literature; in addition, clear outcomes advantages of one…
- Conditions
- Acute Respiratory Failure, Pneumonia, Lung Cancer, Fibrosis Lung
- Trial name
- NCT05681962
- Testing
- Bronchoscopy
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University Magna Graecia
Obstructive Sleep Apnea
KPAP Adherence Crossover Study
A device able to provide less positive airway pressure (PAP) for the entire duration of inspiration and roughly half the duration of expiration, designated KPAP, is being developed by SleepRes for the treatment of obstructive…
- Trial name
- NCT06413134
- Testing
- KPAP, APAP
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- SleepRes Inc.
Respiratory Disease of A Newborn
Swaddling and Facilitated Tucking During Nasal CPAP Application
This study was planned to determine the effects of fetal position and swaddling during nasal CPAP application on pain, stress level, comfort and physiological parameters of the newborn.
- Trial name
- NCT07077148
- Testing
- Facilitated tucking, Swaddling
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Recep Tayyip Erdogan University
Preterm, Ventilator Lung; Newborn
Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound
This study aims to evaluate the effect of non-invasive ventilation (nIPPV) , (nCPAP), and nasal high flow cannula (NHFC) as a primary mode of ventilation in preterm neonates <37 gestational week with moderate to severe RD using…
- Trial name
- NCT06550219
- Testing
- Nasal humidified heated high flow cannula (NHHHC), Nasal intermittent positive pressure ventilation (NIPPV), Nasal continuous positive airway pressure NCPAP
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Acute Hypoxemic Respiratory Failure
Bag CPAP vs Standard Oxygen Therapy in Acute Hypoxemic Respiratory Failure
Acute Hypoxemic Respiratory Failure (AHRF) is one of the prevalent causes of admission around the world and is associated with high mortality in resource-limited settings.
- Trial name
- BAGCPAP-R (NCT07460427)
- Testing
- Bag CPAP, Standard oxygen
- Where
- Rwanda
- Volunteers
- 250 people
- Sponsor
- Prof RWABIHAMA Jean Paul
Neonatal Disorder
Impact of Tactile Kinesthetic Stimulation and Soft Tissue Manipulation on Cortisol in Preterm
Effect of Soft tissue Therapy in managing Procedural Pain among neonates admitted to the neonatal intensive care unit. This study focuses on procedural pain management with the help of Soft tissue manipulation, which includes…
- Trial name
- NCT06845137
- Testing
- Tactile-Kinesthetic Stimulation (TKS) and Soft Tissue Manipulation (STM), Standard Therapy
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- faizan kashoo, PT
Aherence, Physical Symptoms
The Effectiveness of Augmented Reality to Enhance CPAP Therapy in OSA Patients
The goal of this clinical trial is to exam if artificial reality works to improve continuous positive airway pressure (CPAP) adherence in obstructive sleep apnea (OSA) patients.
- Conditions
- Aherence, Physical Symptoms, Mental Health, Quality of Life
- Trial name
- CPAP OSA (NCT06520592)
- Testing
- With AR guided CPAP therapy
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Acute Respiratory Failure (ARF)
The Effects of Different Non-invasive Respiratory Support
Patients with acute hypoxemic respiratory failure (AHRF) typically present with pathophysiological alterations characterized by the coexistence of respiratory dysfunction and hypoxemia.
- Trial name
- NCT07247318
- Testing
- Continuous Positive Airway Pressure, Non-invasive ventilation, High-flow nasal oxygen
- Volunteers
- 60 people
- Sponsor
- Southeast University, China
Obstructive Sleep Apnea, Down Syndrome
Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome
The goal of this observational study is to learn about the use of non-invasive ventilation for treatment of obstructive sleep apnoea syndrome in children with Down Syndrome.
- Conditions
- Obstructive Sleep Apnea, Down Syndrome, Quality of Life, Behavior
- Trial name
- REFRESHED (NCT06030349)
- Testing
- Non-invasive ventilation
- Where
- 6 sites in Ireland, United Kingdom
- Volunteers
- 200 people
- Sponsor
- Children's Health Ireland
Preterm Infants, Respiratory Distress Syndrome (Neonatal)
Pressure Targeting During High Flow Therapy in Premature Infants
The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants.
- Conditions
- Preterm Infants, Respiratory Distress Syndrome (Neonatal), BPD - Bronchopulmonary Dysplasia
- Trial name
- NeoMATCH (NCT07418502)
- Testing
- Pressure Targeted High Flow, CPAP
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Texas at Austin