Clinical trials: CPAP
Obstructive Sleep Apnea (OSA)
Intermittent-Hypoxia Inhibits Neutrophil Extracellular Traps Formation: Role of Cathelicidins
The study will enroll 80 moderate-to-severe Obstructive sleep apnea (OSA) patients (40 obese) and 40 age-, gender-, and body mass index-matched controls.
- Trial name
- NCT07129486
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kun-Ta Chou
Obstructive Sleep Apnea, Sleep Disorder
Multidimensional Evaluation of Patients' Affected by Obstructive Apnea Syndrome (OSAS) Before and After Ventilotherapy
This observational study aims to evaluate multiple dimensions of health in patients with Obstructive Sleep Apnea Syndrome (OSAS), before and after three weeks of ventilotherapy.
- Conditions
- Obstructive Sleep Apnea, Sleep Disorder, Well-Being, Psychological, Cognitive Impairment
- Trial name
- MULTI-OSAS (NCT06312956)
- Testing
- Continuous Positive Airway Pressure Ventilotherapy
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Istituto Auxologico Italiano
Respiratory Distress Syndrome, Newborn
"Effectiveness of Delivery Room Bubble CPAP in Preterm Infants With Respiratory Distress
Background When babies are born too early (preterm), their lungs are often not fully developed. They may have trouble breathing because their airways and chest are not strong enough, and their lungs don't make enough surfactant…
- Trial name
- NCT07162285
- Testing
- Delivery Room Bubble CPAP, Delivery Room Supplemental Oxygen
- Where
- Bangladesh
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
COPD Exacerbation, Oxygen Toxicity
Influence of FreeO2 on Percentage of Time Within Oxygen Saturation Target Using Noninvasive Ventilation (NIV) and Continuous Positive Airway Pressure (CPAP) for Patients Admitted for AECOPD or Bariatric Surgery
The main objective is to evaluate the FreeO2 device combined with noninvasive respiratory support technique for COPD patients and postoperative bariatric surgery patients.
- Conditions
- COPD Exacerbation, Oxygen Toxicity, Abdominal Obesity, Surgery
- Trial name
- NCT04136717
- Testing
- Washout period, NIV - FreeO2, Nasal High flow Oxygen therapy - FreeO2
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- François Lellouche
Neonatal, Premature Birth
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function
This is a study to see if an extra 2 weeks of continuous positive airway pressure (CPAP) in stable preterm infants in the neonatal intensive care unit (NICU) can cause increased lung growth and lung function in the infants as…
- Conditions
- Neonatal, Premature Birth, Respiratory Distress Syndrome
- Trial name
- NCT04295564
- Testing
- Additional 2 weeks of CPAP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cynthia McEvoy
Acute Respiratory Failure With Hypoxia, Acute Respiratory Distress Syndrome
The Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) Study
The dearth of Intensive care units in low resource settings portends for poor outcomes amongst patients with acute hypoxemic respiratory failure (AHRF) .
- Conditions
- Acute Respiratory Failure With Hypoxia, Acute Respiratory Distress Syndrome, Acute Lung Injury
- Trial name
- ARISE-AFRICA (NCT04693403)
- Testing
- HFNC, CPAP, Standard Oxygen
- Where
- 17 sites in Uganda
- Volunteers
- 705 people
- Sponsor
- Makerere University
Personality, Patient Compliance
Distribution of Mood and Personality Characteristics and Their Influence on Treatment Compliance
This study intends to investigate the personality and psychological characteristics of OSA patients using classical standard scales and obtain treatment information and adherence data through prospective follow-up to summarize…
- Conditions
- Personality, Patient Compliance, Anxiety, Depression
- Trial name
- NCT07101796
- Testing
- continous positive airway pressure (CPAP)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Acute Respiratory Failure
Continous Positive Airway Pressure (CPAP) Support for Acute Hypoxemic Respiratory Failure in Burkina Faso
Acute respiratory failure (ARF) is a frequent medical emergency, involving high costs for health organizations and patients who often require intensive care and respiratory assistance.
- Trial name
- NCT06912360
- Testing
- CPAP
- Where
- 4 sites in Burkina Faso
- Volunteers
- 240 people
- Sponsor
- Université NAZI BONI
Sleep Apnea, Obstructive, Bariatric Surgery
Effect of CPAP Versus APAP in Patients With Obesity Undergoing Bariatric Surgery Protocol
Introduction Obstructive sleep apnea (OSA) is a common disorder in obese patients, especially those undergoing bariatric surgery.
- Conditions
- Sleep Apnea, Obstructive, Bariatric Surgery, Obesity, Treatment Adherence and Compliance
- Trial name
- ObesAOS (NCT07001215)
- Testing
- In the intervention group, patients will be treated with auto-adjusting APAP, providing variable pressures throughout the sleep hours., CPAP
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Hospital Universitario Ramon y Cajal
COPD
Effects of Manual Positive End Expiratory Pressure and Non-invasive Continuous Positive Air Pressure in COPD Patients
This randomized clinical trial aims to compare the effectiveness of Manual Positive End Expiratory Pressure (PEEP) and Non-Invasive Continuous Positive Airway Pressure (CPAP) in patients with Chronic Obstructive Pulmonary Disease…
- Trial name
- NCT07079527
- Testing
- Manual Positive End Expiratory Pressure (PEEP) Therapy, Non-Invasive CPAP Therapy
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Excessive Daytime Sleepiness, Obstructive Sleep Apnea (OSA)
Validating a Novel Driving Simulation-based MWT Against the Standard MWT in an OSA-cohort Challenged by CPAP-withdrawal
In brief, the proposed study will evaluate a recently proposed naturalistic, driving simulation test to identify and measure sleepiness behind the wheel, one of the most underestimated causes of road accidents.
- Conditions
- Excessive Daytime Sleepiness, Obstructive Sleep Apnea (OSA), CPAP Treatment, Driving Simulator Performance
- Trial name
- DS-MWT2 (NCT06872593)
- Testing
- CPAP-withdrawal, Test Sequence
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Stefan Lakämper
Obstructive Sleep Apnea (OSA)
Assessment of Circuit Rebreathing During CPAP Therapy
The goal of this research is to better understand how different CPAP mask designs affect airflow and rebreathing of exhaled carbon dioxide (CO₂) during sleep in individuals with obstructive sleep apnea (OSA).
- Trial name
- NCT07062770
- Testing
- Continuous positive airway pressure (CPAP), Mask exhaust port flow
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Brigham and Women's Hospital
Ischemic Stroke, Obstructive Sleep Apnea
Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke
The study aims to evaluate whether early treatment of obstructive sleep apnea with continuous positive airway pressure in ischemic stroke patients has a favorable effect on functional recovery.
- Trial name
- ATACS (NCT07044830)
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 425 people
- Sponsor
- Hospital das Clínicas de Ribeirão Preto
Obstructive Sleep Apnea, Dementia
The Effect of OSA on Brain Waste Clearance
Recent ground-breaking research has shown that clearance of toxic neuro-metabolites from the brain including the proteins β-Amyloid (Aβ) and tau that form dementia causing plaques and tangles is markedly impaired when sleep is…
- Conditions
- Obstructive Sleep Apnea, Dementia, Cognitive Impairment
- Trial name
- NCT05606991
- Testing
- CPAP Withdrawal
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Obstructive Sleep Apnea (OSA), Ischemic Optic Neuropathy/Optic Nerve Stroke
Optic Nerve Injury in Obstructive Sleep Apnea Patients
Ischemic optic neuropathy (ION) is damage to the optic nerve caused by ischemia and hypoxia of the optic nerve due to an impairment of the blood supply to the optic nerve from the arteries.
- Trial name
- NCT06748703
- Testing
- CPAP Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanjing Medical University
Acute Respiratory Failure, Acute on Chronic Respiratory Failure
Treatment of Dyspnea in Do-not-intubate Patients
Patients with severe chronic diseases are often admitted to the hospital complaining of shortness of breath. Some of these patients decide that they do not want placement of a breathing tube in the windpipe to assist their…
- Conditions
- Acute Respiratory Failure, Acute on Chronic Respiratory Failure, Dyspnea
- Trial name
- NCT02114944
- Testing
- NIV, CPAP, Standard oxygen
- Where
- 2 sites in United States, Italy
- Volunteers
- 400 people
- Sponsor
- Tufts Medical Center
Respiratory Distress Syndrome (RDS)
Comparison of Continuous Positive Airway Pressure (CPAP) and Non-Invasive Positive Pressure Ventilation (NIPPV) in Preterm Newborns With Respiratory Distress Syndrome.
Primary objective: to evaluate safety and efficacy of two different non-invasive respiratory support modalities in preterm neonatal patients with respiratory distress syndrome.
- Trial name
- NC3 (NCT06966752)
- Testing
- NIPPV, CPAP
- Where
- Lithuania
- Volunteers
- 150 people
- Sponsor
- Vilnius University
Obstructive Sleep Apnea, Erectile Dysfunction
Changing Lifestyle in OSA Males Who Suffer Metabolic Syndrome and Impotence: Is There a Response?
The problems like metabolic syndrome and sexual impotence in males with obstructive sleep apnea are common. continuous passive airway pressure (CPAP) is an authorized treatment for this type of apnea but still the recommendations…
- Conditions
- Obstructive Sleep Apnea, Erectile Dysfunction, Metabolic Syndrome
- Trial name
- NCT06960746
- Testing
- lifestyle changing plus CPAP, CPAP
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
OSA - Obstructive Sleep Apnea
SMARTPHONE APPLICATION HOME-BASED EXERCISES IN OBSTRUCTIVE SLEEP APNEA IN JEDDAH
The study aim is to explore the effects of a home-based exercise training smartphone application on sleep quality, fatigue, functional capacity, and quality of life among obstructive sleep apnea (OSA) patients in Jeddah city…
- Trial name
- NCT06954974
- Testing
- CPAP device, CPAP device and exercise, Exercise
- Volunteers
- 60 people
- Sponsor
- King Abdulaziz University
Obstructive Sleep Apnea
Obstructive Sleep Apnea in World Trade Center Responders
The goal of the study is to examine the possible underlying causes of sleep apnea (a disorder in which there are problems with breathing during sleep) in World Trade Center Responders.
- Trial name
- NCT01753999
- Testing
- Standard CPAP, CPAP - Flex
- Where
- 3 sites in United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey