Clinical trials: Caffeine
Healthy
A Study to Evaluate the Effect of Oral Doses of JNJ-54175446 on the Inhibition of Cytochrome P450 CYP3A4, CYP2C9, CYP1A2 and CYP2D6 Activity and the Induction of CYP2B6 and CYP2C19 Activity Using a Multiple Probe Substrate Cocktail in Healthy Subjects
The main purpose of this study is to determine the potential inhibitory/inducing effects of JNJ-54175446 after single and repeated dosing on the single-dose pharmacokinetics (PK) of a cocktail, containing selective probes of…
- Trial name
- NCT03058419
- Testing
- JNJ-54175446 150 mg, JNJ-54175446 600 mg, Midazolam 2 mg
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Dysphagia
Impact of Glossopharyngeal Nerve Block on Swallowing Difficulties Caused by Gastroesophageal Reflux Disease
The goal of this clinical trial is to explore Clinical Effect of Glossopharyngeal Nerve Block on Pharyngeal Dysphagia Induced by Gastroesophageal Reflux Disease.
- Trial name
- NCT06328205
- Testing
- Rehabilitation therapy, Glossopharyngeal Nerve Block, Lidocaine Hydrochloride
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
Stability of Attentional Networks Over Multiple Sessions of Computerized Task
Assessment of Stability of Behavioral and Neural Measures of Attention Networks Across Multiple Sessions
The purpose of this research study is to learn more about the stability over multiple recording sessions of brainwave activity during a computerized task that measures different types of attention.
- Trial name
- NCT04033731
- Testing
- Attention Network Task
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sleep Initiation and Maintenance Disorders, Insomnia
Mindfulness Meditation for Insomnia
The investigators will conduct a 3-arm, pilot RCT where participants (N=30) will be randomized in a 1:1:1 design to 4 weeks of instructed bedtime MM practice at night (n=10) vs. uninstructed MM (n=10) vs.
- Conditions
- Sleep Initiation and Maintenance Disorders, Insomnia, Insomnia Chronic, Mindfulness
- Trial name
- NCT06972303
- Testing
- Instructed bedtime app-guided mindfulness meditation, Uninstructed app-guided mindfulness meditation, Sleep hygiene education
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Exercise Performance Impairment, Cognitive Function Decline
Effects of Energy Drink on Repeated Sprint Performance and Cognitive Function in Athletes
Energy drinks are often used by athletes before competitions to enhance their performance. Recent research has pointed out that the performance effects of select ingredients have been studied individually but not in combination…
- Conditions
- Exercise Performance Impairment, Cognitive Function Decline, Fatigue
- Trial name
- NCT07104188
- Testing
- Caffeine, Energy Drink
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Chien-Wen Hou
Chronic Insomnia, Depression Disorders
Effect of WBT for CI With Depression
This randomized controlled trial aims to explore the therapeutic effects of Well-Being Therapy (WBT) on patients with Chronic Insomnia accompanied by depressive symptoms.
- Trial name
- NCT06968013
- Testing
- Well-Being Therapy, Sleep Hygiene Education
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Xuanwu Hospital, Beijing
Bipolar Disorder
Smartphone-based Ambulatory Assessment of Early Warning Signs
Bipolar disorders are severe chronic disorders, marked by recurrent episodes of depression and (hypo)mania. The disorder usually emerges in early adulthood and tends to have a highly unpredictable course.
- Trial name
- BipoLife_A3 (NCT02782910)
- Testing
- Smartphone-Based Ambulatory Assessment, Feedback via physician
- Where
- Germany
- Volunteers
- 148 people
- Sponsor
- Technische Universität Dresden
Caffeine
Effects of Caffeine on EEG Theta/Beta Ratio and Cognitive Control
Cognitive control driven by the prefrontal cortex (PFC) of the brain is thought to be important for goal-directed control over stimulus-driven processes.
- Trial name
- NCT02940808
- Testing
- Caffeine (200mg)
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Caffeine, Placebo
Acute Caffeine Ingestion on Futsal Performance
Caffeine supplementation has been recognized such as an useful strategy for improving performance in intermittent sports, however caffeine ingestion in futsal has been barely studied.
- Trial name
- CAFFFUTSAL (NCT04852315)
- Testing
- Caffeine
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Mitral Valve Insufficiency, Coronary Artery Disease
REvascularization and Valve Intervention for Ischemic Valve diseasE: REVIVE Trial
Ischemic mitral regurgitation (MR) and coronary artery disease is common and associated with significant morbidity and mortality.
- Trial name
- REVIVE (NCT04822675)
- Testing
- Percutaneous mitral valve repair, Surgical mitral valve repair/replacement
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Cancer, Breast, Cancer, Ovarian
Family History App in Personalized Medicine
A complete family history (FH) may identify persons at high risk for certain conditions. They can be offered genetic testing and life-saving screening and treatment.
- Conditions
- Cancer, Breast, Cancer, Ovarian, Cancer, Colorectal, Cancer, Prostate
- Trial name
- FHAMe (NCT04726319)
- Testing
- FHAMe Intervention
- Where
- Canada
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Physical Activity
Effect of Energy Drink on Sport Performance and Psycho-Physiological Responses.
This work aimed to examine the effects of drinking an "energy drink" upon (i) short-term maximal performance, (ii) reaction times and (iii) psychological factors (i.e., mood state, ratings of perceived exertion (RPE) and…
- Trial name
- NCT03936712
- Testing
- Energy Drink
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Higher Institute of Sport and Physical Education of Sfax
Cognitive Function
Effect of Sprint Interval Training and Intermittent Fasting on Cognitive Function
Several lifestyle modifications, such as manipulating diet and exercise, have been shown to enhance cognitive function. This study aims to determine if a combination of Sprint Interval Training (SIT) and Time Restricted Eating…
- Trial name
- NCT05152719
- Testing
- Cognitive Performance
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Post-traumatic Stress Disorder
Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance
The purpose of this study is to compare the effectiveness of two cognitive behavioral group psychotherapy interventions in controlling the subjective sleep disturbance in veterans with Post-traumatic Stress Disorder.
- Trial name
- NCT00108628
- Testing
- Imagery Rehearsal, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- US Department of Veterans Affairs
Diabetes Mellitus
Caffeine Consumption and Mortality in Diabetes
Previous studies suggested an inverse relationship between coffee consumption and mortality in the general population. Furthermore, an inverse association between coffee consumption and serum biomarkers of inflammation and…
- Trial name
- NCT03367806
- Volunteers
- 3,052 people
- Sponsor
- João Sérgio Neves
Sportive Performance, Caffeine
Effects of Caffeine on Upper Extremity Performance
It was aimed to apply caffeine supplement to elite basketball players and to investigate the effects of this supplement on upper extremity performance, lactic acid level and fatigue.
- Trial name
- NCT05916352
- Testing
- Caffeine Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cyprus International University
Primary Dysmenorrhea
Effect of Progressive Relaxation Versus Isometric Exercises in Management of Primary Dysmenorrhea
This study will be conducted to compare the effect of progressive relaxation and isometric exercises in management of primary dysmenorrhea.
- Trial name
- PD (NCT07525102)
- Testing
- Progressive Relaxation Exercises, Isometric Exercises, Lifestyle modification advices
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Stroke
Drug-Drug Interaction Study of MLC1501 Using Cocktail of Drugs Acting as Sensitive Clinical Probes/Substrates of Cytochrome P450 Isoenzymes and Transporters in Healthy Subjects
This is a single-centre phase I study to assess the Drug-Drug Interaction potential of MLC1501 with a cocktail of drugs acting as sensitive clinical probe substrates of Cytochrome P450 isoenzymes and Transporters in healthy…
- Trial name
- NCT04233437
- Testing
- MLC1501, CYP Cocktail, Transporter Cocktail
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Moleac Pte Ltd.
Caffeine
The Effects of Caffeine on Heart Rate and Heart Rate Variability
In previous research we have shown that an acute caffeine dose of 5 mg/kg body mass reduces heart rate at rest and during low intensity exercise, with the effect dissipating as exercise intensity increases.
- Trial name
- NCT05521386
- Testing
- Caffeine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Sleep Disorders, Obese Pregnant Women
A Nurse-Led Sleep Hygiene and Progressive Muscle Relaxation Intervention on Sleep Quality Among Obese Pregnant Women
Sleep is essential for maternal and fetal health, with adequate sleep being crucial for energy, fetal development, and overall pregnancy well-being.
- Trial name
- NCT06890910
- Testing
- evidence based intervention
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
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