Clinical trials: Caffeine
Healthy Nutrition
Study of the Neurophysiological Response to Foodstuffs
The goal of this clinical trial is to investigate the effect of perception of sensory attributes of different foodstuffs on physiological and neurophysiological response in health adults.
- Trial name
- NCT06051175
- Testing
- Bitter taste perception, Salty taste perception, Sweet taste perception
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Healthy
A Study to Investigate the Efficacy of Pain Bloc-R in Healthy Participants With Non-pathological Aches and Discomfort
A randomized, double-blind, placebo-controlled, cross-over pilot study to investigate the efficacy of Pain Bloc-R in healthy participants with non-pathological aches and discomfort. The study will have 3 study periods.
- Trial name
- NCT03965819
- Testing
- Pain Bloc-R, Active Comparator - Acetaminophen
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- LifeSeasons Inc.
Pain, Postoperative
Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed
The researchers in this study wanted to find out the optimal dose of Caffeine in the combination tablet of Naproxen Sodium and Caffeine that works in patients experiencing moderate to severe pain after having wisdom teeth…
- Trial name
- NCT04132336
- Testing
- Naproxen sodium/Caffeine (BAY2880376), Naproxen sodium (Aleve), Caffeine
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- Bayer
Juçara Supplementatios After Muscle Damage
Juçara (Euterpe Edulis Martius) Supplementation Effect in Muscle Protection, Performance and Soreness in Lower Limbs After Exercise-Induced Muscle Damage
The purpose of this study is to find out if taking a natural supplement made from the Juçara fruit (a Brazilian berry rich in antioxidants called anthocyanins) can help the body recover faster after damage caused by exercise.
- Trial name
- NCT07584460
- Testing
- Juçara
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Universidade Federal de Santa Maria
Sleep Apnea
Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea
The purpose of this research study is to determine the effect of chronic nighttime low oxygen saturations on selected body systems (liver) that break down drugs in children with obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT00310323
- Testing
- Dextromethorphan, Caffeine
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Virginia Commonwealth University
Caffeine
Genetic Determinants of Cardiovascular Response to Coffee Drinking
Cardiovascular and neuropsychologic effects of coffee are still debated. The precise mechanism underlying the actions of caffeine on the cardiovascular and neuropsychologic systems is incompletely understood and a considerable…
- Trial name
- NCT01330680
- Testing
- Coffee, Decaffeinated coffee
- Where
- Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Hepatocellular Carcinoma (HCC)
Lenvatinib or Regorafenib for Advanced Hepatocellular Carcinoma After Immunotherapy (REVIVE)
The goal of this clinical trial is to learn if lenvatinib or regorafenib can help treat people with advanced liver cancer (hepatocellular carcinoma, HCC) that cannot be removed with surgery after first treatment with…
- Trial name
- REVIVE (NCT07495579)
- Testing
- Lenvatinib, regorafenib
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Asan Medical Center
Depression
Drug Metabolism and Antidepressant
We propose here to explore systematically the association between drug-metabolizing enzymes activity assessed by a phenotypical approach and antidepressant plasma concentration, efficacy and tolerance in the clinical setting.
- Trial name
- METADEP (NCT02438072)
- Testing
- Omeprazole (10 mg, A02BC01)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Apnea Neonatal, Apnea of Prematurity
The Role of Electroencephalography in Caffeine Discontinuation Timing in Premature Infants
The aim of this observational study is to investigate whether functional maturation assessment by electroencephalography in preterm infants can provide reliable data for the safe discontinuation of caffeine therapy without…
- Trial name
- NCT07324941
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Uludag University
Male Infertility, Sperm DNA Fragmentation
Nordic Sperm DNA Study
Introduction The goal of this prospective observational study with an embedded randomized controlled trial (RCT) is to investigate the prevalence and clinical significance of sperm DNA fragmentation (damage to the genetic…
- Conditions
- Male Infertility, Sperm DNA Fragmentation, Lifestyle Intervention
- Trial name
- NCT07779954
- Testing
- Lifestyle change
- Volunteers
- 800 people
- Sponsor
- Regionshospitalet Viborg, Skive
Vascular Function
Effect of Black Tea on Vascular Function
Epidemiological studies indicate that regular consumption of three cups of black tea per day reduces the risk of stroke or myocardial infarction.
- Trial name
- Heraclitus (NCT01945970)
- Testing
- Black tea extract, Positive control
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Atopic Dermatitis
Open Label, Drug-Drug Interaction (DDI) Study of Dupilumab (REGN668/SAR231893) in Patients With Moderate to Severe Atopic Dermatitis (AD)
This is an open-label, single-sequence DDI study designed to examine the effects of dupilumab on the pharmacokinetics of selected cytochrome P450 substrates in adult patients with moderate to severe AD.
- Trial name
- NCT02647086
- Testing
- Dupilumab, Midazolam, Omeprazole
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- Regeneron Pharmaceuticals
Obesity
Thermogenic Properties of Zantrex-3
Background: Zantrex-3® is a popular dietary supplement for weight control, which consists of a combination of yerba mate, guarana, caffeine and damiana.
- Trial name
- ZANTREX (NCT01622101)
- Testing
- Thermogenic properties of Zantrex-3®
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Migraine in Adults
Study of Sumatriptan Naproxen Sodium Succinate Tablets for the Treatment of Acute Migraine Attacks
A multicenter, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of sumatriptan naproxen sodium succinate tablets in the treatment of acute migraine attacks.
- Trial name
- NCT04948164
- Testing
- sumatriptan 85mg and naproxen sodium 500mg
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University Third Hospital
Drug Interaction
A Trial to Evaluate the Impact of C21 on the Exposure of 4 Substrates in Healthy Volunteers
This is a single-centre, open-label, fixed-sequence trial to evaluate the impact of C21 on the exposure of CYP1A2, CYP2C9, CYP3A4 and P-gp substrates in healthy volunteers.
- Trial name
- NCT05830799
- Testing
- Drug Drug Interaction
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vicore Pharma AB
Spinal Cord Injuries, Mindfulness Meditation
Spinal Cord Injury Mental Health Functional Outcomes Improved by Mindfulness
Recovery from injury is an immune function but also involves stress. Spinal cord injury (SCI) patients are one population with a difficult recovery journey.
- Conditions
- Spinal Cord Injuries, Mindfulness Meditation, Mental Health Wellness 1
- Trial name
- NCT04972773
- Testing
- Mindfulness meditation (MM)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Queen's University
Cancer-related Fatigue, Breast Cancer
Guaraná Supplementation for Cancer-Related Fatigue
Cancer-related fatigue is one of the most common and distressing symptoms experienced by patients during and after cancer treatment, and current options to manage it are limited.
- Conditions
- Cancer-related Fatigue, Breast Cancer, Lung Cancer, Colorectal Cancer
- Trial name
- GUARANA-CRF (NCT07816263)
- Testing
- Guaraná (Paullinia cupana)
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Hemorrhagic Shock, Trauma
REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam
The purpose of this study is to demonstrate safety, effectiveness and benefit-risk profile of ResQFoam for the inhospital treatment of exsanguinating, intraabdominal haemorrhage due to trauma in patients where emergent laparotomy…
- Conditions
- Hemorrhagic Shock, Trauma, Exsanguinating Hemorrhage, Shock; Traumatic
- Trial name
- REVIVE (NCT02880163)
- Testing
- ResQFoam
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Arsenal Medical, Inc.
Caffeine, Caffeine Withdrawal
Consumption Status of Caffeine and Adverse Effects Experience Among Anesthetists
High-caffeine consumption has been increasing in physicians, frequently causing the most common symptoms such as tremor, insomnia, anxiety, and nervousness and rarely leading to serious adverse effects like seizure, acute mania…
- Conditions
- Caffeine, Caffeine Withdrawal, Caffeine Dependence
- Trial name
- NCT05323578
- Testing
- Survey
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Ain Shams University
Scalp Health, Hair Condition
Scalp Care Efficacy Evaluation for Premium Revitalizing Elixir
The study aims to evaluate the efficacy of the Premium Revitalizing Elixir on human scalp skin. A total of 60 healthy adults, aged 18 to 60 with alopecia, baldness, or self-identified with symptoms of hair thinning will be…
- Conditions
- Scalp Health, Hair Condition, Hair Loss, Alopecia
- Trial name
- NCT07271212
- Testing
- Base formula only, Base formula plus IGF-1 and FGF-7, Base formula plus Centella asiatica and ginger extracellular vesicles
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hungkuang University
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