Clinical trials: Caffeine
Laryngopharyngeal Reflux Disease
Comparative Effectiveness of Alginate, Magaldrate, Sucralfate, Proton Pump Inhibitors, and Diet in Laryngopharyngeal Reflux Disease
The goal of this randomized controlled trial is to compare the effectiveness of different treatments for laryngopharyngeal reflux disease (LPRD) in adult patients with confirmed symptoms and signs of the condition.
- Trial name
- NCT07611162
- Testing
- Alginate, Magaldrate, Sucralfate
- Where
- Belgium
- Volunteers
- 800 people
- Sponsor
- University of Mons
Male Infertility, Sperm DNA Fragmentation
Nordic Sperm DNA Study
Introduction The goal of this prospective observational study with an embedded randomized controlled trial (RCT) is to investigate the prevalence and clinical significance of sperm DNA fragmentation (damage to the genetic…
- Conditions
- Male Infertility, Sperm DNA Fragmentation, Lifestyle Intervention
- Trial name
- NCT07779954
- Testing
- Lifestyle change
- Volunteers
- 800 people
- Sponsor
- Regionshospitalet Viborg, Skive
Sleep Disturbance, Sleep Deprivation
Impact of Bed Provision and Sleep Education
Investigators will recruit up to 100 families (children aged 8-12 years and their primary caregivers) from the Philadelphia-area Beds for Kids charity program, which provides beds, bedding, and sleep education to…
- Conditions
- Sleep Disturbance, Sleep Deprivation, Sleep, Insomnia
- Trial name
- NCT04536766
- Testing
- Enhanced Sleep Health Education, Beds for Kids Standard Program
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Saint Joseph's University, Philadelphia
Respiratory Distress Syndrome in Premature Infant
Respiratory Effect of the LISA Method With Sedation by Propofol Versus Absence of Sedation.
The investigators propose to evaluate premedication with Propofol compared to a control strategy including a placebo with a possible rescue treatment with ketamine to ensure pain control before LISA Procedure .
- Trial name
- PROLISA (NCT04016246)
- Testing
- Propofol-Lipuro
- Where
- 13 sites in France
- Volunteers
- 233 people
- Sponsor
- University Hospital, Grenoble
Operation, Cesarean Section
Effect of Coffee Consumption on Pain and Intestinal Motility After Caesarean Section:
Objective The aim of this study was to investigate whether postoperative coffee intake affects pain levels and bowel motility in women undergoing cesarean delivery.
- Trial name
- NCT06359223
- Testing
- coffee consumption, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Fall, Fall Injury
A Clinical Decision Support System and Patient Portal for Preventing Medication-related Falls in Older Patients
Falls in older adults represents a growing public health challenge. The use of certain medication is recognized as an important modifiable risk factor for falls.
- Conditions
- Fall, Fall Injury, Fall Patients, Accidental Fall
- Trial name
- ADFICE_IT (NCT05449470)
- Testing
- CDSS, Patient Portal
- Where
- 10 sites in Netherlands
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
HIV Disease Progression
Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)
A double blinded, placebo-controlled, multicenter trial to evaluate effectiveness of azithromycin prophylaxis on mortality in advanced HIV.
- Trial name
- REVIVE (NCT05580666)
- Testing
- Azithromycin Oral Tablet
- Where
- 52 sites in Côte d’Ivoire, Ethiopia and 9 more
- Volunteers
- 8,000 people
- Sponsor
- Population Health Research Institute
Out of Hospital Cardiac Arrest
Dispatcher-Activated Neighborhood Access Defibrillation and Cardiopulmonary Resuscitation
The hypothesis of this study is Dispatcher-Activated Neighborhood Access Defibrillation and Cardiopulmonary Resuscitation (NAD-CPR) would improve survival of out-of-hospital cardiac arrest (OHCA).
- Trial name
- NCT02010151
- Testing
- NAD-CPR
- Where
- South Korea
- Volunteers
- 3,194 people
- Sponsor
- Seoul National University Hospital
Healthy
Pre-Workout on Exercise Performance and Cognition
The purpose of this study is to determine the effects of four different pre-workout beverages as compared to placebo on muscular strength and endurance, perceived energy and cognitive performance in healthy adult males.
- Trial name
- NCT02255201
- Testing
- Master Performance Blend Dose 1, Master Performance Blend Dose 2, Performance Energy Blend
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Miami Research Associates
Dietary Supplement
Influence of the Time of Day in the Effect of Caffeine on Maximal Fat Oxidation During Exercise in Women
Caffeine is a natural stimulant with well-recognized metabolic benefits, however, there is a lack of studies investigating the time-of-day caffeine influence to enhance fat oxidation in women.
- Trial name
- CIRCAF_WOM (NCT05880186)
- Testing
- Acute caffeine supplementation
- Where
- Spain
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Blood Pressure
Evaluation of Effects of Green Coffee Bean Extract (GCE) on Physiological and Psychological Variables
Coffee as one of the most favorite worldwide beverages comprises a variety of chemicals with health benefits. Most investigations have so far focused on the beneficial effects of caffeine but knowledge about non-caffeine coffee…
- Trial name
- NCT02388672
- Testing
- decaffeinated coffee, chlorogenic acid, green coffee bean extract supplement
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Pulmonary Tuberculoses, Other Specified Pulmonary Tuberculosis
BTZ-043 - Multiple Ascending Dose (MAD) to Evaluate Safety, Tolerability and Early Bactericidal Activity (EBA)
This is a prospective, open label, two-centre, randomized, controlled, two-stage, phase Ib/IIa study to evaluate the safety, tolerability, PK, drug-drug interaction and bactericidal activity of BTZ-043 administered orally once…
- Trial name
- NCT04044001
- Testing
- BTZ-043, Rifafour e-275®, Probe Drug Cocktail
- Where
- 2 sites in South Africa
- Volunteers
- 78 people
- Sponsor
- Michael Hoelscher
Apnea of Prematurity
Caffeine for Apnea of Prematurity (CAP)
At least 5 of every 1000 live-born babies are very premature and weigh only 500 to 1250 grams at birth. Approximately 30-40% of these high-risk infants either die or survive with lasting disabilities.
- Trial name
- NCT00182312
- Testing
- Caffeine citrate injection
- Where
- 34 sites in United States, Australia and 7 more
- Volunteers
- 2,000 people
- Sponsor
- McMaster University
Breast Feeding, Exclusive
Supplemental Nursing System Compared to Bottle Supplementation
This is a randomized controlled trial comparing the SNS to bottle feeding. This study will compare exclusive breastfeeding rates and breast milk feeding rates at discharge, day of life 14, and day of life 28 between neonates…
- Trial name
- NCT04638075
- Testing
- Supplemental Nursing System
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Surfactant Deficiency Syndrome Neonatal
Premedication for Less Invasive Surfactant Administration
Early respiratory management of preterm infants immediately after birth should be as gentle as possible. With this so-called developmental approach, unnecessary invasive methods can be avoided or at least postponed.
- Trial name
- LISA-Med (NCT03735563)
- Testing
- Ketamine, Fentanyl
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- University of Oulu
Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy
PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia
A phase 1 study investigating the tolerability and pharmacokinetics of caffeine citrate in neonates with hypoxic ischemic encephalopathy receiving therapeutic hypothermia.
- Conditions
- Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy, Caffeine
- Trial name
- NCT05295784
- Testing
- Caffeine citrate
- Where
- 2 sites in United States
- Sponsor
- University of Arkansas
Healthy
How Does Altering the Timing of Pre-exercise Low-dose Caffeine Ingestion Affect Endurance Exercise Performance
Investigate how manipulating the time between caffeine ingestion and exercise may alter exercise performance and cognition
- Trial name
- NCT02985606
- Testing
- Caffeine powder -60, Caffeine powder -30, Caffeine powder 0
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Caffeine
The Effects of Caffeine on Heart Rate and Heart Rate Variability
In previous research we have shown that an acute caffeine dose of 5 mg/kg body mass reduces heart rate at rest and during low intensity exercise, with the effect dissipating as exercise intensity increases.
- Trial name
- NCT05521386
- Testing
- Caffeine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Prematurity, Respiratory Failure
Non-invasive Neurally Adjusted Ventilatory Assist Versus Nasal Intermittent Positive Pressure Ventilation for Preterm Infants After Extubation
Non-invasive respiratory support has been emerging in the management of respiratory distress syndrome (RDS) in preterm infants to minimise the risk of lung injury.
- Conditions
- Prematurity, Respiratory Failure, Ventilator Lung; Newborn
- Trial name
- NCT03388437
- Testing
- NI-NAVA, NIPPV
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Fahad Armed Forces Hospital
Healthy Volunteers
A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants
The purpose of this study is to assess the effect of BMS-986419 on the pharmacokinetics (PK) of single doses of caffeine (CYP1A2 substrate), bupropion (CYP2B6 substrate), midazolam (CYP3A4 substrate), flurbiprofen (CYP2C9…
- Trial name
- NCT05932277
- Testing
- BMS-986419, Caffeine, Bupropion
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
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