Clinical trials: Celecoxib, completed
Acute Kidney Injury
Acute Kidney Injury After Elective Total Joint Arthroplasty
Total joint arthroplasty (TJA) is a common orthopedic procedure to treat patients with end-stage knee arthritis. Over 4,000 TJA were performed in the Hong Kong public hospitals in the past 12 months (July 2020 - June 2021) and…
- Trial name
- NCT05595694
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 1,077 people
- Sponsor
- The University of Hong Kong
Breast Cancer
European Celecoxib Trial in Primary Breast Cancer
It has been found that the chemical changes that take place in a patient's body during the development of inflammation may provide an environment which stimulates cancer cells.
- Trial name
- REACT (NCT02429427)
- Testing
- Celecoxib
- Volunteers
- 2,639 people
- Sponsor
- Imperial College London
Locally Advanced Rectal Cancer
Trial of Celecoxib With Preoperative Chemo- Radiation for Locally Advanced Rectal Cancer
This is a single arm phase II trial with combined celecoxib, tegafur-uracil, folinate and preoperative radiotherapy for patients with locally advanced rectal cancer.
- Trial name
- NCT00931203
- Testing
- Celecoxib
- Where
- Taiwan
- Volunteers
- 55 people
- Sponsor
- National Health Research Institutes, Taiwan
Cancer, Cachexia
A Feasibility Study of Multimodal Exercise/Nutrition/Anti-inflammatory Treatment for Cachexia - the Pre-MENAC Study
A multicentre, open, randomized phase II study comparing a multimodal intervention (oral nutritional supplements, celecoxib and physical exercise) for cachexia versus standard cancer care.
- Trial name
- NCT01419145
- Testing
- Multimodal intervention, Standard care
- Where
- 3 sites in Norway, United Kingdom
- Volunteers
- 46 people
- Sponsor
- Norwegian University of Science and Technology
Dental Pain
A Study of ARRY-371797 in Subjects Undergoing Third Molar Extraction
This is a Phase 2 study designed to test the ability of investigational study drug ARRY-371797 to reduce pain in a postoperative pain model (third molar extraction), and to further evaluate the drug's safety.
- Trial name
- NCT00663767
- Testing
- ARRY-371797, p38 inhibitor; oral, Celecoxib, COX-2 inhibitor; oral
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Pfizer
Breast Cancer
Celecoxib and Trastuzumab in Treating Women With Metastatic Breast Cancer
RATIONALE: Celecoxib may be effective in preventing the further development of cancer. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without…
- Trial name
- NCT00006381
- Testing
- trastuzumab, celecoxib
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Healthy
GRC 27864 First in Man, Single Ascending Dose Study in Healthy Volunteers
A Single Dose Study of GRC 27864 in Healthy Volunteers.
- Trial name
- NCT02179645
- Testing
- GRC 27864, Celecoxib
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Hip Pain Chronic
Efficacy of Multimodal Analgesia Following Hip Arthroscopy
The purpose of the full study is to determine whether multimodal analgesia for hip arthroscopy will reduce post-operative pain scores, narcotic consumption and hospital length-of-stay.
- Trial name
- NCT03351439
- Testing
- Zopiclone, Gabapentin, Celebrex
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Western University, Canada
Knee Osteoarthritis, Arthroplasty Complications
Pre vs Post Block in Total Knee Arthroplasty (TKA)
The purpose of this project is to determine if a change in patient reported pain, nausea and vomiting after total knee arthroplasty can be observed with the substitution of a post operative adductor canal block for a preoperative…
- Conditions
- Knee Osteoarthritis, Arthroplasty Complications, Postoperative Pain
- Trial name
- NCT05974501
- Testing
- Dexamethasone, Acetaminophen, Lyrica
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Miami
Knee Osteoarthritis
Metformin as Adjuvant Therapy in Obese Knee Osteoarthritis Patients
This study aims to evaluate the possible efficacy and safety of addition of metformin to celecoxib in patients with knee osteoarthritis.
- Trial name
- NCT05638893
- Testing
- Metformin Hcl 500Mg Tab
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Breast Cancer
Study on the Neoadjuvant Use of Chemotherapy and Celecoxib Therapy in Patients With Invasive Breast Cancer
This study will investigate whether cyclooxygenase inhibition with celecoxib will add any benefit to preoperative chemotherapy alone for breast cancer patients.
- Trial name
- NCT00135018
- Testing
- celecoxib and chemotherapy
- Where
- Hong Kong
- Sponsor
- Organisation for Oncology and Translational Research
Head and Neck Cancer
Celecoxib in Treating Patients With Progressive Metastatic Differentiated Thyroid Cancer
RATIONALE: Celecoxib may stop the growth of thyroid cancer by stopping blood flow to the tumor and by blocking the enzymes necessary for tumor cell growth.
- Trial name
- NCT00061906
- Testing
- celecoxib
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Lumbar Spinal Stenosis
Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)
BACKGROUND: Lumbar spinal stenosis - known by patients as "arthritis of the spine" - is a condition that is very common; found in about 30% of older adults.
- Trial name
- NCT01943435
- Testing
- NSAIDs; adjunctive analgesics; adjunctive anti-depressants, Lumbar epidural injection, Joint Mobilizations (spine, sacroiliac, hip)
- Where
- United States
- Volunteers
- 259 people
- Sponsor
- Michael Schneider, DC, PhD
Osteoarthritis, Hip
Celecoxib Versus Diclofenac In The Treatment Of Osteoarthritis Of The Hip
To determine if celecoxib 200 mg once daily is as effective as diclofenac 50 mg three times daily in the treatment of pain symptoms associated with osteoarthritis of the hip
- Trial name
- NCT00174317
- Testing
- Celecoxib, Diclofenac
- Where
- 44 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
Safety and Efficacy of Celecoxib Versus Naproxen in the 6-month Treatment of Knee Osteoarthritis
To compare the safety and efficacy of celecoxib versus naproxen for the treatment of knee osteoarthritis
- Trial name
- CLOAK (NCT00643799)
- Testing
- Celecoxib, Naproxen
- Where
- 51 sites in United States
- Volunteers
- 586 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Anterior Cruciate Ligament Injury
Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction
This is a randomized, single blinded, standard of care controlled clinical trial. This project aims to compare postoperative pain control in patients in two treatment arms of anterior cruciate ligament reconstruction: a treatment…
- Trial name
- NCT03818932
- Testing
- Celecoxib, Hydrocodone-Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Prostate Cancer
Celecoxib (Celebrex) Versus Placebo in Men With Recurrent Prostate Cancer
The purpose of this study is to learn the effects (both good and bad) that celecoxib has on prostate cancer and patients with prostate cancer.
- Trial name
- NCT00136487
- Testing
- Celecoxib
- Where
- 9 sites in United States
- Volunteers
- 85 people
- Sponsor
- Dana-Farber Cancer Institute
Drug Interaction Potentiation
Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Naproxen, Aceclofenac, Celecoxib and Ilaprazole
This study evaluate the pharmacokinetic drug interactions and safety after co-administration of ilaprazole and NSAID in healthy adults.
- Trial name
- NCT05237297
- Testing
- Ilaprazole, Naproxen, Aceclofenac
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Healthy
Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Food Effect and DDI of Ascending Doses of the MEK Inhibitor Zapnometinib
The purpose of this study is to evaluate the safety and tolerability of ascending doses of the MEK-inhibitor zapnometinib (ATR-002) given as single doses (SAD Part) and as multiple doses for 7 days (MAD Part) in healthy subjects.
- Trial name
- NCT05555823
- Testing
- ATR-002, Repaglinide, Celecoxib
- Where
- Germany
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Atriva Therapeutics GmbH
Postoperative Pain, Total Knee Arthroplasty
Peri-Articular-Multimodal Drug and Oral Celecoxib in Management of Postoperative Pain of Total Knee Arthroplasty
This study is a randomized-clinical-trial on 146 patients candidate for total knee arthroplasty (TKA) who were randomly allocated to three treatment groups, including 1) a cocktail consisting of bupivacaine, morphine…
- Trial name
- NCT05324995
- Testing
- Multimodal Drug, epinephrine, celecoxib
- Where
- Iran
- Volunteers
- 146 people
- Sponsor
- Isfahan University of Medical Sciences