Clinical trials: Clopidogrel, completed
Ischemic Stroke
Clopidogrel Versus Cilostazol in Ischemic Stroke
Along with the current clinical trial, the efficacy and safety of a 300 mg loading dose of clopidogrel administered within 24 hours of the first-ever moderate to severe ischemic stroke compared to 200 mg cilostazol were assessed…
- Trial name
- NCT06242132
- Testing
- Clopidogrel tablet, Cilostazol 100 MG
- Where
- Egypt
- Volunteers
- 870 people
- Sponsor
- Kafrelsheikh University
Acute Coronary Syndrome, Platelet Function
Sampling P2Y12 Receptor Inhibition With Prasugrel and Ticagrelor in Patients Submitted to Thrombolysis
Introduction: Platelet aggregation plays an important role in ischemic complications in patients undergoing to percutaneous coronary intervention (PCI).
- Trial name
- SAMPA (NCT02215993)
- Testing
- Prasugrel, Ticagrelor
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Hemodialysis, Chronic Renal Failure
Prasugrel Versus High Dose Clopidogrel in Clopidogrel Resistant Patients Undergoing Chronic Hemodialysis
Clopidogrel administration is essential in patients undergoing percutaneous coronary intervention, in patients with previous stroke, in patients under chronic hemodialysis via fistulae and in patients with chronic atrial…
- Trial name
- NCT01155765
- Testing
- Prasugrel, Clopidogrel
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- University of Patras
Healthy
Interaction Study of Clopidogrel 600/150 mg Given Alone or Concomitantly With Omeprazole 80 mg in Healthy Subjects
Primary objective: Assess the effects of clopidogrel (600 mg loading dose followed by 4 days 150 mg/day) on Adenosine diphosphate (ADP)-induced platelet aggregation when given concomitantly with omeprazole 80 mg/day compared to…
- Trial name
- NCT01129414
- Testing
- Clopidogrel, Omeprazole
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sanofi
Stroke
Antiplatelet vs R-tPA for Acute Mild Ischemic Stroke
Acute ischemic stroke (AIS) is one of common diseases with significant morbidity, mortality and disability. A wide array of studies confirms that intravenous thrombolytic therapy with alteplase can effectively improve the…
- Trial name
- ARAMIS (NCT03661411)
- Testing
- Aspirin, Clopidogrel 75mg, Alteplase
- Where
- China
- Volunteers
- 760 people
- Sponsor
- General Hospital of Shenyang Military Region
Type-2 Diabetes Mellitus, Coronary Artery Disease
Ticagrelor Versus Clopidogrel in Type 2 Diabetic Patients
The purpose of this study is to determine whether treatment with ticagrelor + aspirin is more effective than treatment with clopidogrel + aspirin in patients with type-2 diabetes.
- Trial name
- NCT01823510
- Testing
- Ticagrelor + Aspirin, Clopidogrel + Aspirin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Juan J Badimon
Acute Coronary Syndrome (ACS)
Prasugrel Switching Study in Patients With Acute Coronary Syndrome (ACS) Who Underwent Percutaneous Coronary Intervention (PCI)
This Phase IV, multicenter trial is designed to assess the efficacy of prasugrel in preventing the formation of blood clots in Taiwanese patients with ACS who have been treated with PCI.
- Trial name
- NCT03672097
- Testing
- Prasugrel
- Where
- 10 sites in Taiwan
- Volunteers
- 204 people
- Sponsor
- Daiichi Sankyo Taiwan Ltd., a Daiichi Sankyo Company
Chronic Thrombocytopenia, Immune Thrombocytopenia
Efficacy and Safety of Oral E5501 Plus Standard of Care for the Treatment of Thrombocytopenia in Adults With Chronic Immune Thrombocytopenia (Amendment 02)
Core Study: To demonstrate that the efficacy of avatrombopag (in addition to standard of care) is superior to placebo (in addition to standard of care) for the treatment of adult participants with chronic immune thrombocytopenia…
- Trial name
- NCT01438840
- Testing
- Avatrombopag, Standard of care
- Where
- 25 sites in Australia, Belgium and 9 more
- Volunteers
- 49 people
- Sponsor
- Eisai Inc.
Carotid Stenosis, Brain Ischemia
Correlation Between Laboratory Markers and Origin of New Brain Ischemic Lesions After Carotid Stenting
New brain ischemic lesions are detected in about 50% of patients undergoing carotid artery stenting (CAS). The aim was to assess correlation between selected laboratory markers and occurrence of new brain infarctions after CAS.
- Conditions
- Carotid Stenosis, Brain Ischemia, Laboratory Problem
- Trial name
- NCT02310191
- Testing
- Carotid stenting
- Where
- Czechia
- Volunteers
- 81 people
- Sponsor
- University Hospital Ostrava
COPD, Emphysema
Anti-Platelets in Chronic Obstructive Pulmonary Disease
This is a 6 week crossover study in current and former smokers with and without COPD to evaluate whether 2 weeks of dual antiplatelet therapy (aspirin 81mg and clopidogrel 75mg) improves pulmonary perfusion (i.e.
- Conditions
- COPD, Emphysema, Emphysema or COPD
- Trial name
- NCT05567562
- Testing
- dual anti-platelet therapy
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Acute Coronary Syndromes
Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry
The primary objective of the UPSTREAM Registry is to address the data gap regarding the course of NSTEMI (Non-ST-Elevation Myocardial Infarction)between ED (Emergency Department) arrival and diagnostic angiography in detail, by…
- Trial name
- NCT02271022
- Testing
- Non-Interventional Study
- Where
- 55 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- AstraZeneca
Coronary Artery Disease, Drug Resistance
Efficacy of Adjusted Clopidogrel Dose in Patients With Insufficient Platelet Inhibition
This study is a prospective, single-center evaluation of the efficacy of clopidogrel dose adjustment in patients with insufficient platelet inhibition after elective coronary stent implantation.
- Trial name
- NCT00302913
- Testing
- Adjustment of clopidogrel dose
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Atrial Fibrillation
Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy
The study goal is to determine the clinical benefit of percutaneous catheter-based left atrial appendage (LAA) closure in patients with non-valvular atrial fibrillation (NVAF) at high risk of stroke (CHA2DS2-VASc Score ≥2) as…
- Trial name
- CLOSURE-AF (NCT03463317)
- Testing
- CE-mark approved LAA closure devices, Acetylsalicylic acid, Clopidogrel
- Where
- 42 sites in Germany
- Volunteers
- 912 people
- Sponsor
- Charite University, Berlin, Germany
Intracranial Aneurysm
Guided Antiplatelet Therapy in Interventional Treatment of Intracranial Aneurysms
The use of intracranial stents expands the possibilities for endovascular treatment of intracranial aneurysms and improves the success rate. However, it also increases the risk of ischemic complications in patients.
- Trial name
- GATITIA (NCT05825391)
- Testing
- Adjustment of Antiplatelet Drugs
- Where
- 2 sites in China
- Volunteers
- 590 people
- Sponsor
- Beijing Tiantan Hospital
Retinal Detachment
Anticoagulant and Antiplatelet Agents in Patients Undergoing Vitreoretinal Surgery
Purpose: To establish the prevalence of anticoagulant, aspirin, and clopidogrel use in patients undergoing vitreoretinal surgery, and to compare the outcome of peribulbar anesthesia between users and non-users.
- Trial name
- NCT01020656
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Platelet Activation Testing Before/After Anti-platelet Therapy, Healthy
The Accuracy Of A Novel Platelet Activity Assay In Humans On Antiplatelet Agents: Pharmacodynamics And Comparison With Light Transmission Aggregometry
The purpose of this study is to test a novel diagnostic immunoassay of platelet function and compare it to the current gold standard platelet function assay by testing the response to aspirin and clopidogrel in a group of healthy…
- Trial name
- NCT04822363
- Testing
- Aspirin, Clopidogrel
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy
The Impact of Grapefruit Juice on the Response to Clopidogrel
This study will measure the percentage of platelet aggregation inhibition with a loading dose of clopidogrel (300 mg) using the VerifyNow Assay System in healthy volunteers who have drank 11 oz of grapefruit juice.
- Trial name
- NCT00817999
- Testing
- Grapefruit juice, Clopidogrel 75 mg/day, Clopidogrel 300 mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Creighton University
Type 2 Diabetes Mellitus, Acute Coronary Syndrome
Assessment of Thrombogenicity in Acute Coronary Syndrome
The purpose of this study is to assess platelet dependent thrombogenicity in patients after acute coronary syndrome using an ex vivo arterial injury model.
- Trial name
- NCT00728286
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Acute Coronary Syndrome, Unstable Angina
Vasoactive and Anti-inflammatory Effects of Prasugrel in Acute Coronary Syndrome
To test the vasoactive and anti-inflammatory effects of prasugrel in patients with acute coronary syndrome endothelial function -as a surrogate parameter of NO bioavailability- and different markers of inflammation, oxidative…
- Trial name
- NCT01774838
- Testing
- Prasugrel, Clopidogrel
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University of Cologne
Acute Coronary Syndrome, Myocardial Ischemia
Safety and Efficacy of Ticagrelor Versus Clopidogrel in Asian/KOREAn Patients With Acute Coronary Syndromes Intended for Invasive Management
The purpose of this study is to assess safety and efficacy of Ticagrelor versus Clopidogrel in Asian/KOREAn patients with acute coronary syndromes intended for invasive management.
- Conditions
- Acute Coronary Syndrome, Myocardial Ischemia, Heart Diseases, Cardiovascular Diseases
- Trial name
- TICA KOREA (NCT02094963)
- Testing
- Ticagrelor, Clopidogrel
- Where
- 10 sites in South Korea
- Volunteers
- 800 people
- Sponsor
- Seung-Jung Park