Clinical trials: Conventional therapy
Postural Kyphosis, Cervicothoracic Region
Effect of Mulligan Snag and Diaphragmatic Release on Thoracic Kyphosis
the aim of this study is to investigate the efficacy of mulligan snag mobilisation and diaphragmatic release on upper crossed syndrome
- Trial name
- NCT05458206
- Testing
- mulligan snag mobilization and diaphragmatic release
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Irreversible Pulpitis With Apical Periodontitis
Full Pulpotomy in Permanent Teeth With Irreversible Pulpitis and Apical Periodontitis
This study will evaluate whether full pulpotomy can successfully treat mature permanent teeth with irreversible pulp inflammation and a periapical lesion.
- Trial name
- NCT07768852
- Testing
- Full pulpotomy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Dental Caries
An in Vitro Evaluation of Antimicrobial Photodynamic Therapy on Deciduous Carious Dentin
Despite of the decline of dental caries, this disease is still common in polarized groups affecting children. Therefore, the aim of this randomized blind in vivo study was to compare the antimicrobial effect of two antimicrobial…
- Trial name
- NCT02479958
- Testing
- Rubber dam isolation, Tooth drying, Dentin wash with chlorhexidine 2%
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Head and Neck Cancer, Oral Complications
Paclitaxel and Radiation Therapy Plus Chemoprotection With Amifostine in Treating Patients With Stage III or Stage IV Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003193
- Testing
- amifostine trihydrate, paclitaxel, conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Contaminated Medical or Biological Substances, Environmental-Pollution-Related Condition
Potential Risk for Bacterial Contamination in Ventilator Systems
Background: Few studies have investigated the difference of bacterial contamination between conventional reused ventilator systems and disposable closed ventilator-suction systems.
- Trial name
- NCT03359148
- Testing
- Disposable ventilator system, Conventional reused ventilator system
- Volunteers
- 27 people
- Sponsor
- Chang Gung University
Locally Advanced, Urothelial Carcinoma Ureter
Combined Postoperative Radiotherapy With Kidney Sparing Surgery for Locally Advanced High-risk Ureteral Cancer
In this study, we propose to conduct an ambispective study to analyze the safety of preserved renal unit surgery combined with postoperative adjuvant radiotherapy in patients with limited stage ureteral cancer with high risk…
- Trial name
- NCT06120387
- Testing
- Radical surgery, Kidney sparing surgery+Postoperative radiotheray
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- Xuesong Li
Abdominal Compartment Syndrome, Pancreatitis,Acute Necrotizing
Fasciotens to Treat an Open Abdomen - a Prospective Cohort Study
The open abdomen can occur as a result of various diseases. After infections of the abdomen, compartment syndromes or traumata, it is essential for survival (1). This condition of the open abdomen lasts from days to months.
- Conditions
- Abdominal Compartment Syndrome, Pancreatitis,Acute Necrotizing, Intraabdominal Hypertension, Peritonitis
- Trial name
- Fasciotens (NCT04033614)
- Testing
- Fasciotens-Abdomen
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- RWTH Aachen University
Primary Dental Caries
Evaluation of Hall Technique and Atraumatic Restorative Treatment for Management of Caries in the Primary Dentition
The aim of the present study is to evaluate both Hall technique and atraumatic restorative technique in comparison to the conventional restorative technique in the management of carious lesions in primary molars.
- Trial name
- NCT04367649
- Testing
- Hall technique, Atraumatic restorative treatment, Conventional Stainless Steel Crown Restoration
- Where
- Egypt
- Volunteers
- 155 people
- Sponsor
- Nourhan M.Aly
Multiple Myeloma in Relapse, Multiple Myeloma Progression
Anti-CD19/BCMA Bispecific CAR-T Cell Therapy for R/R MM
The goal of this clinical trial is to study the feasibility and efficacy of anti-CD19/BCMA bispecific chimeric antigen receptors (CARs) T cell therapy for relapsed and refractory multiple myeloma.
- Trial name
- NCT03706547
- Testing
- anti-CD19/BCMA CAR-T cells, Fludarabine, Cyclophosphamide
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peng Liu
Accuracy of Tissue Diagnosis, Bile Duct Stricture
Accuracy of Spybite Forceps When Compared to Conventional Sampling Methods
The investigators are evaluating the use of a SpyBite biopsy forceps for tissue diagnosis when compared to standard biopsy techniques.
- Conditions
- Accuracy of Tissue Diagnosis, Bile Duct Stricture, Pancreatic Duct Stricture
- Trial name
- NCT01227382
- Testing
- ERCP with cholangiopancreatoscopy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Florida
Rehabilitation, Physical Fitness
The Effect of Baduanjin on Physical Fitness and Bone Density in Maintenance Hemodialysis Patients
The aim of this study is to examine the effect of 18-month Baduanjin exercise on physical fitness and bone density in maintenance hemodialysis (MHD) patients.
- Conditions
- Rehabilitation, Physical Fitness, Bone Density, Hemodialysis Complication
- Trial name
- NCT06346379
- Testing
- Baduanjin exercise
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Affiliated Hospital of Nantong University
Pit Viper Bite, Coagulopathy
Thrombelastography for Coagulopathy in Chinese Snakebites
This study aims to evaluate the coagulation disorders caused by pit viper bites in patients from Zhanjiang and surrounding areas.
- Conditions
- Pit Viper Bite, Coagulopathy, Thromboelastography (TEG), Venom-induced Consumptive Coagulopathy
- Trial name
- NCT06860503
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hansung University
Nasopharyngeal Carcinoma
Reduced-dose Radiotherapy for Stage III Nasopharyngeal Carcinoma Based on the Treatment Response
This is an Open Label, Non-Inferiority, Multicenter, Randomized Phase 3 Trial aimed to investigate the impact of reduced-dose radiotherapy in combination with chemotherapy and immunotherapy on patients' prognosis and complication…
- Trial name
- NCT06239727
- Testing
- PD-1 blocking antibody, Gemcitabine, Cisplatin (80 mg/m2)
- Where
- 26 sites in China
- Volunteers
- 593 people
- Sponsor
- Sun Yat-sen University
PRETEXT I Hepatoblastoma, PRETEXT II Hepatoblastoma
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer
This phase III trial studies the side effects and how well risk-based therapy works in treating younger patients with newly diagnosed liver cancer.
- Conditions
- PRETEXT I Hepatoblastoma, PRETEXT II Hepatoblastoma, PRETEXT III Hepatoblastoma, PRETEXT IV Hepatoblastoma
- Trial name
- NCT00980460
- Testing
- Cisplatin, Dexrazoxane, Doxorubicin Hydrochloride
- Where
- 209 sites in United States, Australia and 4 more
- Volunteers
- 236 people
- Sponsor
- National Cancer Institute (NCI)
Depressive Disorder, Treatment-Resistant
Personalized rTMS for Resistant Depression
The investigators hypothesize that personalizing the rTMS targets using functional MRI will increase its efficacy. The most dysfunctional regions or the most dysfunctional network will be stimulated homogeneously.
- Trial name
- NCT02863380
- Testing
- Functional magnetic resonance imaging used to individualize rTMS protocol, Individualized rTMS (transcranial magnetic stimulation), Classical rTMS (transcranial magnetic stimulation)
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Obstructive Pulmonary Disease
The Effect of Reflective Breathing Therapy Compared With Conventional Breathing Therapy in Patients With Chronic Obstructive Pulmonary Disease (COPD) III-IV
The purpose of this study is to determine whether different types of breathing therapies in patients with COPD III-IV decrease dyspnea and increase activity.
- Trial name
- NCT01478646
- Testing
- conventional breathing therapy, reflectory breathing therapy
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Malocclusion
FM Technique in Orthodontic Clear Aligner Therapy: A Single-Arm Clinical Study
This trial tests whether a new method (FM) for moving back teeth can shorten clear-aligner treatment. All participants use FM, which moves the canine and first molar back together instead of one tooth at a time like the standard…
- Trial name
- NCT07896369
- Testing
- Clear aligners with FM (Fluid Move) design
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Interstitial Lung Disease (ILD)
Nasal High-flow Oxygen Therapy During Rehabilitive Exercise Training in ILD
Although uncommon, interstitial lung diseases (ILDs), and particularly idiopathic pulmonary fibrosis (IPF), are progressive, irreversible, and ultimately fatal without treatment.
- Trial name
- PID-OX (NCT07679854)
- Testing
- Pulmonary rehabilitation with NHFO2, Pulmonary rehabiltation with conventional oxygen therapy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Frédéric Hérengt
Surgical Wound Infection
Prophylactic Negative Wound Pressure Therapy (PICO-7) Following Groin Incisions in Vascular Surgery (PICO-Vasc Study)
Comparison between waterproof sterile dressing OPSITE Post-Op Visible, Smith \& Nephew, UK and PICO-7, Smith \& Nephew, UK in terms of inguinal surgical wound infection and complications after lower limb revascularization.
- Trial name
- PICO-Vasc (NCT04840576)
- Testing
- Regular waterproof sterile dressing., Prophylactic Negative Pressure Dressing
- Where
- Spain
- Volunteers
- 132 people
- Sponsor
- Corporacion Parc Tauli
Type 1 Diabetes Mellitus
Closing the Loop in Adults With Type 1 Diabetes in the Home Setting
The main study objective is to compare real-time continuous subcutaneous glucose monitoring (CGM) combined with overnight automated closed-loop glucose control, and real-time CGM alone in the home setting.
- Trial name
- NCT01440140
- Testing
- Closed-loop, Conventional insulin pump delivery
- Where
- 3 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Cambridge
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