Clinical trials: Conventional therapy, completed
Esophageal Cancer
Combination Chemotherapy Followed By Chemoradiotherapy, With or Without Surgery, in Treating Patients With Resectable Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction
RATIONALE: Drugs used in chemotherapy such as paclitaxel, fluorouracil, and cisplatin use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00069953
- Testing
- filgrastim, pegfilgrastim, cisplatin
- Where
- 97 sites in United States
- Volunteers
- 43 people
- Sponsor
- Radiation Therapy Oncology Group
Mental Disorders
Exergames in Mental Health
Mental health and stress-related disorders have a growing impact on physical functioning, motivation, and participation in daily activities.
- Trial name
- PHYSIOGAME (NCT07387757)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION, Control
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- University of Salamanca
Arthritis, Rheumatoid
Efficacy and Safety of GSK3196165 (Otilimab) Versus Placebo and Sarilumab in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biological Disease-modifying Antirheumatic Drug (DMARDs) and/or Janus Kinase (JAK) Inhibitors
This study (contRAst 3 [202018: NCT04134728]) is a Phase 3, randomized, multicenter, double-blind study to assess the safety and efficacy of GSK3196165 in combination with conventional (cs) DMARD[s]) or the treatment of adult…
- Trial name
- contRAst 3 (NCT04134728)
- Testing
- GSK3196165 (Otilimab), Sarilumab, csDMARDs
- Where
- 131 sites in United States, Argentina and 13 more
- Volunteers
- 550 people
- Sponsor
- GlaxoSmithKline
Asthma
AIR Extension Study - Long-Term Safety of Alair Treated Subjects
The primary purpose of this study is to gather additional safety data for subjects who previously completed the one-year study entitled: "Multicenter Randomized Clinical Trial of the Alair System for the Bronchial Thermoplasty…
- Trial name
- AIRx (NCT00448812)
- Testing
- Bronchial Thermoplasty with the Alair System
- Where
- 5 sites in Brazil, Canada and 1 more
- Volunteers
- 69 people
- Sponsor
- Boston Scientific Corporation
Cerebral Hemorrhage
Evaluation of Minimally Invasive Subcortical Parafascicular Access for Clot Evacuation
Intracerebral hemorrhage (ICH) is the most severe form of stroke: early mortality is 40%, and 80%-of survivors are physically disabled with high rates of cognitive impairment and depression.
- Trial name
- MiSPACE (NCT02331719)
- Where
- 8 sites in United States
- Volunteers
- 16 people
- Sponsor
- Wake Forest University Health Sciences
Atrial Fibrillation, Atrial Flutter
Strategy of Early Detection and Active Management of Supraventricular Arrhythmia With Telecardiology (SETAM)
This study investigates if the early detection and treatment of supraventricular arrhythmia (SVA) may help to prevent the progression of the arrhythmia and improve the clinical outcome.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Atrial Tachycardia
- Trial name
- SETAM (NCT01108692)
- Testing
- Telecardiology
- Where
- 57 sites in France
- Volunteers
- 602 people
- Sponsor
- Biotronik France
Brain Injury, Consciousness Disorders
Early Stepping Verticalization in ICU for ABI Patients
Verticalization was reported to improve the level of arousal and awareness in patients with severe acquired brain injury (ABI) and to be safe in ICU.
- Trial name
- NCT02828371
- Testing
- stepping verticalization, conventional mobilization
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Morbid Obesity, High BMI
Efficacy Of Quadratus Lumborum II Block For Laparoscopic Sleeve Gastrectomy
The QL 2 block is a novel fascial plane block recently described by Blanco and colleagues in which local anesthetic is deposited adjacent to the antero-lateral aspect of the quadratus lumborum muscle.
- Trial name
- NCT04073056
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Stroke
A Water-based Sequential Preparatory Approach and Stroke
Many studies hypothesize that people who have suffered stroke could benefit from water-based exercises to improve their strength and ability to perform the activities of daily living.
- Trial name
- NCT04362202
- Testing
- Water-based Sequential Preparatory Approach
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Lumbar Disc Herniation With Radiculopathy
Pulsed Electromagnetic Field Therapy for Neuropathic Pain in Lumbar Disc Herniation
This randomized controlled study evaluated whether adding pulsed electromagnetic field (PEMF) therapy to conventional physical therapy provides additional benefits for neuropathic pain and disability in patients with lumbar disc…
- Trial name
- NCT07263737
- Testing
- Pulsed electromagnetic field (PEMF)
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Pain, Acute, Anxiety
Music to Reduce Patient Reported Pain During Intrauterine Device (IUD) Placement in the Office
This study seeks to determine if music reduces pain and anxiety in comparison to routine pain control measures alone during insertion of intrauterine contraceptive devices (Mirena, Paragard)
- Trial name
- MIUD (NCT05068245)
- Testing
- Preselected classical music
- Where
- 2 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Knee Osteoarthritis
Comparison of Conventional and Cooled Radiofrequency Ablation in Knee Osteoarthritis
The aim of this study was to examine and compare the effects of conventional and cooled radiofrequency ablation on pain and disability levels in patients with knee pain resistant to other treatments due to knee osteoarthritis.
- Trial name
- NCT06863181
- Testing
- Radiofrequency ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Polycystic Ovary Syndrome
SGLT2 Inhibitors in Treating Patients With PCOS
Chronic inflammation is the core of Polycystic ovary syndrome (PCOS), and obesity and overweight further exacerbate the level of inflammation in the peripheral circulation and ovarian tissue in PCOS patients.
- Trial name
- NCT05966792
- Testing
- SGLT2 inhibitors, metformin
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Shanghai 10th People's Hospital
Psychosis
COllaborative Shared Care to IMprove Psychosis Outcome
COSIMPO is a randomised controlled trial in which a collaborative shared care for psychosis implemented by complementary alternative providers (traditional and faith healers) and conventional primary health care providers (PHCP)…
- Trial name
- COSIMPO (NCT02895269)
- Testing
- Collaborative shared care
- Where
- 2 sites in Ghana, Nigeria
- Volunteers
- 307 people
- Sponsor
- University of Ibadan
Sepsis
Procalcitonin-guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients
This clinical trial is aimed to show a procalcitonin-guided treatment algorithm may shorten duration of antibiotic therapy safely and cost-effectively in sepsis patients of Korean ICU.
- Trial name
- PRODA (NCT02202941)
- Testing
- Procalcitonin guided treatment, Conventional treatment
- Where
- 4 sites in South Korea
- Volunteers
- 62 people
- Sponsor
- Seoul National University Hospital
Pudendal Neuralgia
Impact of Adding TENS to Conventional Physical Therapy Exercise on Pain Relief Among Patients With Pudendal Neuralgia.
Fifty two male participants, 30-50 years old, suffering from chronic pudendal neuralgia were randomly assigned either into experimental group (26 patients) received TENS plus the traditional physical therapy program( including…
- Trial name
- TENS (NCT04455659)
- Testing
- Trans-cutaneous Electrical Nerve Stimulation, Conventional physical therapy exercise
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Jaw, Edentulous
Conventional, Overdenture and Palateless Overdenture Oral Health Impact Comparison Study
This study will identify and enroll patients already scheduled to receive guided maxillary implant placement with palateless overdenture. Standard clinical practice will be followed for this multi-stage process.
- Trial name
- NCT02731703
- Testing
- Overdenture treatment
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Acute Respiratory Distress Syndrome (ARDS)
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome
This international multicenter, randomized, open trial will evaluate the impact of Extracorporeal Membrane Oxygenation (ECMO), instituted early after the diagnosis of acute respiratory distress syndrome (ARDS) not evolving…
- Trial name
- EOLIA (NCT01470703)
- Testing
- ECMO (Quadrox®, Jostra®, Maquet®), conventional care
- Where
- France
- Volunteers
- 249 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prostate Cancer, Radiotherapy Side Effect
Less to Hold - A Comparison of Bladder Toxicities (Side Effects) in Patients Undergoing Prostate Radiotherapy Between Patients Treated With Empty Bladder and Those on a Drinking Protocol.
Radical radiotherapy to the prostate is conventionally treated with a full bladder with the aim of minimising dose to the bladder and small bowel to prevent significant side effects.
- Trial name
- NCT03832803
- Testing
- Empty bladder, Full bladder
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Lancashire Teaching Hospitals NHS Foundation Trust
Blood Flow Restriction and Low-Intensity Resistance Training, Meniscal Injuries
Blood Flow Restriction Training After Meniscus Surgery
This study was conducted to investigate the effects of combined low-intensity resistance exercise with blood flow restriction (BFR-LIRE) on muscle strength, pain, and fear of movement in individuals who had undergone…
- Trial name
- NCT07299461
- Testing
- Traditional physical therapy exercises and physical therapy modalities, Traditional physical therapy exercises and physical therapy modalities + low-intensity resistance exercise with blood flow restriction (BFR-LIRE)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Uskudar University
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