Clinical trials: Conventional therapy
Early Mobilization, Critically Ill
Effect of Early Extracorporeal Diaphragm Pacing Combined With Tilt Table in Ventilated Patients.
The aim of this study is to test the effect of 1week of extracorporeal diaphragm pacing (EDP) combined either with or without tilt table verticalization (TTV) on diaphragm function in patients with mechanical ventilation compared…
- Conditions
- Early Mobilization, Critically Ill, Mechanical Ventilation, Diaphragm Dysfunction
- Trial name
- NCT05953649
- Testing
- Extracorporeal Diaphragm Pacing, Tilt Table Verticalization, Conventional Physiotherapy
- Volunteers
- 90 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Complication
Surgical Innovations in Treatment of Clavicle Fractures
Surgical incision for plate osteosynthesis of midshaft fractures of the clavicle averages 7 to 8 centimeters in the literature. It is hypothesized, that depending on the invasiveness of this incision secondary problems like…
- Trial name
- ClavFrac (NCT02247778)
- Testing
- conventional plate osteosynthesis, mini-incision-type osteosynthesis
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Stroke, Dysphagia
Effects of ITBS Combined with NMES on Dysphagia After Stroke
In recent years, research on intermittent Theta Burst Stimulation (iTBS), as a special high-frequency （repetitive transcranial magnetic stimulation，rTMS） stimulation paradigm, has focused on exploring the effects in healthy…
- Conditions
- Stroke, Dysphagia, Intermittent Theta Burst Stimulation, Neuromuscular Electrical Stimulation
- Trial name
- NCT06464835
- Testing
- Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 45 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Adult Giant Cell Glioblastoma, Adult Glioblastoma
Neoadjuvant and Adjuvant Fenretinide Compared With Adjuvant Fenretinide Alone in Treating Patients Who Are Undergoing Surgical Resection For Recurrent Glioblastoma Multiforme
This randomized phase II trial is studying how well neoadjuvant and adjuvant fenretinide works compared to adjuvant fenretinide alone in treating patients who are undergoing surgical resection for recurrent glioblastoma…
- Conditions
- Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Tumor
- Trial name
- NCT00075491
- Testing
- fenretinide, therapeutic conventional surgery, pharmacological study
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Cancer Institute (NCI)
NSCLC
High Throughput Screening Device Based on 3D Nano-matrices and 3D Tumors With Functional Vascularization
Almost 85% of new therapeutic molecules are abandoned before the clinical trial stage. Most of these failures currently concern cancer therapies.
- Trial name
- TUMOVASC (NCT04826913)
- Testing
- Organoids
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Kidney Disease
Supplemented Very Low Protein Diet and the Progression of Chronic Kidney Disease
This is a prospective single center randomized controlled trial with a total duration of 18 months aiming to evaluate the effectiveness and the safety of a very low protein diet supplemented with ketoanalogues of essential…
- Trial name
- KETOPROG (NCT02031224)
- Testing
- Conventional low protein diet, Very low protein diet supplemented with Ketosteril
- Where
- Romania
- Volunteers
- 250 people
- Sponsor
- Anemia Working Group Romania
Lateral Epicondylitis
Active Release Technique and Graston Technique in Patients With Lateral Epicondylitis
This study will be a randomized control trial and will be conducted in Pakistan Railway Hospital Rawalpindi. A sample of 36 participants will be taken. Patients will be divided into two groups by sealed envelop method.
- Trial name
- NCT05070559
- Testing
- Active Release Technique, Graston Technique Group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Infections
Reduction of Groin Wound Infections After Vascular Surgery by Using an Incision Management System (IMS)
Comparison of the Prevena™ IMS with the standard wound management method of sterile plaster in vascular surgery patients.
- Trial name
- IMS (NCT02395159)
- Testing
- Prevena™ IMS, sterile plaster dressings
- Where
- 2 sites in Germany
- Volunteers
- 204 people
- Sponsor
- RWTH Aachen University
Breast Cancer, Brain Metastasis
Evaluation of the Efficacy of Hippocampal Avoidance on the Cognitive Toxicity of Whole-Brain Radiation Therapy After Surgical Resection of Single Brain Metastasis of Breast Cancer
The incidence of brain metastases (BM) in metastatic breast cancer is increasing, due to the improvement in the control of systemic disease, and due to an improved detection through imagery.
- Trial name
- NCT01942980
- Testing
- Radiation therapy Brain metastasis in breast cancer
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Institut Paoli-Calmettes
Myo-inositol, Post Varicocelectomy
Comparative Study of Post-Varicocelectomy Myo-inositol vs. Antioxidants vs. Surgery Alone in Infertile Men
The purpose of this open-label, 3-arm randomized controlled trial is to compare the clinical efficacy and safety of adding oral myo-inositol versus conventional oral antioxidants (vitamin C, L-carnitine, and zinc) versus surgery…
- Conditions
- Myo-inositol, Post Varicocelectomy, Infertile Men, Varicocele
- Trial name
- MYO-VAR (NCT07915388)
- Testing
- Experimental Arm Intervention: Myo-inositol, Conventional Antioxidants, Group C (Control)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Fayoum University Hospital
Diabetes Mellitus Type 2 (T2DM), Artificial Intelligence (AI)
Therapeutic Efficacy and Safety Evaluation of AI in the Management of Diabetes: A RCT Trial
Purpose: To evaluate the efficacy of artificial intelligence (AI)-based decision-making technology in managing glycated hemoglobin (HbA1c) and blood glucose levels compared to the control group.
- Trial name
- NCT06957093
- Testing
- artificial intelligence, Routine diagnosis and treatment group for diabetes
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The First Hospital of Jilin University
Positive Regulation of Oxidative Stress Process
A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus
This study was performed to assess the efficacy of systemic lycopene (8 mgms Daily for two months) as an adjunct to scaling and root planing in chronic periodontitis patients with type 2 diabetes mellitus.
- Trial name
- "SLSRPD" (NCT02263352)
- Testing
- Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day, Scaling and root planing
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Operation Site Inflammation, Pain, Postoperative
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar
Clinical and preclinical studies have demonstrated encouraging results of non-steroidal anti-inflammatory drug (NSAID) chronotherapy in the management and treatment of inflammatory diseases such as rheumatoid arthritis.
- Conditions
- Operation Site Inflammation, Pain, Postoperative, Teeth, Impacted
- Trial name
- NCT03789058
- Testing
- Ibuprofen 400 mg
- Where
- Jordan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Subacromial Impingement Syndrome
Mulligan Mobilization Versus PNF Technique in SIS
To investigate the differences between adding Mulligan mobilization and PNF to the conventional physical therapy program on shoulder pain, function, shoulder muscles strength, glenohumeral flexion, abduction, external rotation…
- Trial name
- NCT07675655
- Testing
- Standard conventional program, Proprioceptive neuromuscular facilitation (PNF) +Standard program, MWM +Standard program
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Cairo University
Sarcoma
Combination Chemotherapy and Dexrazoxane Followed by Surgery and Radiation Therapy in Treating Patients With Advanced Soft Tissue Sarcoma or Recurrent Bone Sarcoma
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, ifosfamide, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00544778
- Testing
- filgrastim, dexrazoxane hydrochloride, doxorubicin hydrochloride
- Volunteers
- 7 people
- Sponsor
- City of Hope Medical Center
Respiratory Distress Syndrome in Premature Infant
nHFOV Versus Invasive Conventional Ventilation for Preterm Neonates With Respiratory Distress Syndrome
Preterm neonates usually develop respiratory distress syndrome (RDS) for which they need respiratory support, which may be invasive and non-invasive depend on the availability and individual need.
- Trial name
- nHFOV (NCT04914715)
- Testing
- Non-invasive High Frequency Oscillatory Ventilation, Conventional Invasive Ventilation
- Where
- Pakistan
- Sponsor
- Indus Hospital and Health Network
Carotid Artery Stenosis
Prospective Trial of IVL for Calcified Carotid Lesions(CREATE Trial)
Clinical Trial Summary Trial Title:** CREATE Trial: Safety and Efficacy of IVL for Carotid Calcified Lesions Sponsor:** Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
- Trial name
- CREATE (NCT06936176)
- Testing
- Neurovascular Intravascular Shockwave Catheter
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
Sacroiliac Joint Dysfunction
Gluteus Maximus Versus Gluteus Medius Strength On Back Muscles Performance In Patients With Sacroiliac Dysfunction
This study will be conducted to compare between the effect of glutes maximus and glutes medius muscles strength on back muscle performance in patients with Sacroiliac joint dysfunction.
- Trial name
- NCT05809206
- Testing
- Glutes maximus strength protocol, Gluteus medius strength program, Corrective Exercises
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Classical Hodgkin Lymphoma, Classical Hodgkin Lymphoma Recurrent
Changing Paragidms In The Prognostic Assessment Of Hodgkin Lymphoma
Classical Hodgkin's Lymphoma (cHL) is a rare but highly treatable malignancy of the immune system, primarily affecting young adults.
- Conditions
- Classical Hodgkin Lymphoma, Classical Hodgkin Lymphoma Recurrent, Classical Hodgkin Lymphoma Refractory
- Trial name
- LH_BIO (NCT06822855)
- Where
- 12 sites in Italy
- Volunteers
- 755 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Pain, Fibromyalgia
Real-time Pain Monitoring in Fibromyalgia Patients
This study aims to examine whether the pain of fibromyalgia patients can be reduced with utilization of real-time pain monitoring system (PAAS).
- Trial name
- NCT03571009
- Testing
- utilization of PAAS
- Volunteers
- 25 people
- Sponsor
- Ji Hyeon Ju
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