Clinical trials: Dexamethasone, open to volunteers
Vitiligo, Child
Oral Tacrolimus vs Dexamethasone Micro-pulse Therapy in Pediatric Rapidly Progressing Vitiligo: A Multicenter RCT
This clinical study aims to compare the safety and effectiveness of two treatments-oral Tacrolimus capsules and Dexamethasone micro-pulse therapy-in children aged 4-12 years with rapidly progressing vitiligo.
- Conditions
- Vitiligo, Child, Progressive Disease
- Trial name
- NCT06900777
- Testing
- Tacrolimus, Dexamethasone
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Non-specific Low Back Pain (NSLBP)
Erector Spinae Plane Block for Acute Low Back Pain
Non-Specific low back pain (NSLB) is an important public health problem with a major economic and social impact. It is defined by the location of pain, between the lower rib margins and the lumbar vertebrae.
- Trial name
- ESP-BACK (NCT07434024)
- Testing
- Erector Spinae Plane Block with isotonic saline, Erector Spinae Plane Block with local anesthetic
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Relapsed Cancer, Refractory Multiple Myeloma
Isatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple Myeloma
The main goal of this phase II study is to evaluate the overall response rate of isatuximab, belantamab mafodotin, pomalidomide, and dexamethasone in relapsed and refractory multiple myeloma.
- Conditions
- Relapsed Cancer, Refractory Multiple Myeloma, Multiple Myeloma
- Trial name
- ISABELA (NCT05922501)
- Testing
- Isatuximab, Belantamab mafodotin, Pomalidomide
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Postoperative Nausea and Vomiting, Dexamethasone Palmitate
Dexamethasone Palmitate for PONV After Open Surgery
Dexamethasone is almost one of the most commonly used drugs for postoperative nausea and vomiting (PONV) prevention. However, PONV is still a complex problem to be solved; for example, even with preoperative dexamethasone…
- Conditions
- Postoperative Nausea and Vomiting, Dexamethasone Palmitate, Open Surgery
- Trial name
- NCT06997419
- Testing
- Dexamethasone Palmitate, Dexamethasone
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
Breast Cancer, Interstitial Lung Disease (ILD)
Premedication With Dexamethasone for Preventing Interstitial Lung Disease in Patients With Breast Cancer Treated With Trastuzumab Deruxtecan
Trastuzumab deruxtecan (T-DXd) has recently received approval as an antibody-drug conjugate for treating patients with metastatic breast cancer (BC) who have HER-2 protein expression as determined by immunohistochemistry…
- Trial name
- MARGARET (NCT07828054)
- Testing
- Dexamethasone, antiemetic premedication, T-DXd
- Volunteers
- 244 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Postoperative Pain, Lumbar Spine Surgery
Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery
This study aims to compare two different pain management methods in patients undergoing elective lumbar spine surgery. Patients are randomly assigned to receive either an ultrasound-guided erector spinae plane block (ESPB) or…
- Trial name
- SPINE-ANI (NCT07455565)
- Testing
- Erector Spinae Plane Block, Intravenous Multimodal Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Akdeniz University Hospital
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication
Platform of Randomized Adaptive Clinical Trials in Critical Illness
PRACTICAL is a randomized multifactorial adaptive platform trial for acute hypoxemic respiratory failure (AHRF). This platform trial will evaluate novel interventions for patients with AHRF across a range of severity states…
- Conditions
- Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
- Trial name
- PRACTICAL (NCT05440851)
- Testing
- Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL)
- Where
- 103 sites in United States, Australia and 8 more
- Volunteers
- 6,250 people
- Sponsor
- University Health Network, Toronto
Migraine
Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?
For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief.
- Trial name
- NCT06016465
- Testing
- Dexamethasone Oral
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Acute Leukemia of Ambiguous Lineage
Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage
In this prospective, single arm, open label, clinical trial, a total of 50 acute leukemia of ambiguous lineage patients will be enrolled.
- Trial name
- NCT04440267
- Testing
- vincristine, daunorubicin, cyclophosphamide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Brachial Plexus Blocks
Perineural Dexamethasone, Dexmedetomidine, or Their Combination to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block
Dexmedetomidine, an α2 adrenoceptor agonist, and dexamethasone, a potent anti-inflammatory steroid, are commonly used, effective, and safe adjuvants to peripheral nerve block (PNB).
- Trial name
- NCT07299877
- Testing
- Group A (Dexamethasone), Group B (Dexmedetomidine), Group C (Dexamethasone + Dexmedetomidine)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Al-Azhar University
Multiple Myeloma, Triple Negative Breast Cancer
Systemic Anti-Cancer Therapy Dose Modifications for Individuals With Duffy Null Phenotype
This study is comprised of a main study, an observational study, and optional survey studies. The main study is being done to see whether using Duffy null specific treatment dosing guidelines can reduce or delay dose…
- Conditions
- Multiple Myeloma, Triple Negative Breast Cancer, Duffy Blood Group, Chemokine Receptor Gene Mutation, Duffy Blood Group, Chemokine Receptor Gene C.-67T>C
- Trial name
- NCT07341867
- Testing
- Dexamethasone, Bortezomib, LENALIDOMIDE
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Andrew Hantel, MD
Mastectomy, Pain, Acute
Stellate Ganglion Block for Prevention of Post Mastectomy Depression
Complications after mastectomy include chronic pain and depression.
- Conditions
- Mastectomy, Pain, Acute, Pain, Chronic
- Trial name
- SGB (NCT06263907)
- Testing
- Stellate gangalion block
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Mansoura University
Post Operative Pain
Analgesic Efficacy of Different Nerve Blocks in Postoperative Cesarean Section
comparing analgesic efficacy of different nerve blocks on post operative cesarean sections.
- Trial name
- NCT06088420
- Testing
- Intrathcal Morphine Group, Quadratus Lumborum nerve block(QL) group, Erector Spinae nerve block (ESP)group
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Myeloma Multiple
A Study of the Efficacy and Safety of BCD-248 in Combination With Daratumumab in Patients With Relapsed or Refractory Multiple Myeloma (AMMADINA)
The aim of the study is to assess the efficacy and safety of the BCD-248 in combination with daratumumab versus the combination of daratumumab, pomalidomide, and dexamethasone in the treatment of relapsed or refractory multiple…
- Trial name
- AMMADINA (NCT07742215)
- Testing
- BCD-248 + daratumumab, Daratumumab + pomalidomide + dexamethasone
- Where
- 16 sites in Belarus, Russia
- Volunteers
- 390 people
- Sponsor
- Biocad
Prostate Cancer
Laparoscopic TAP Block During Robotic Assisted Laparoscopic Radical Prostatectomy for Improvement in Postoperative Pain
Determine the impact of a laparoscopic-guided transversus abdominis plane (TAP) block timing (at initiation or conclusion of procedure) on the postoperative pain experience in patients following robot assisted laparoscopic…
- Trial name
- TAPBlock (NCT05753046)
- Testing
- Early TAP Block, Late TAP Block
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Corewell Health East
Acute Lymphoblastic Leukemia
BEBT-908 Plus Chemotherapy Treatment for CR MRD-Positive MEF2D-Rearranged and Pre-B Acute Lymphoblastic Leukemia Patients
This investigator-initiated, prospective, single-arm, multicenter clinical trial aims to evaluate the efficacy and safety of BEBT-908 (a HDAC/PI3Kα inhibitor provided by BeBetter Med Inc ,Guangzhou, China) combined with…
- Trial name
- NCT07301138
- Testing
- BEBT-908, Cyclophosphamide, Vincristine
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Ruijin Hospital
Osteoarthritis, Unicompartmental Knee Arthroplasty
Post-op Prednisone and Glucose Monitoring in TKA
This study compares the efficacy of a 5-day post-operative oral prednisone regimen (40 mg daily) with the standard intraoperative steroid regimen, focusing on pain, swelling, range of motion, opioid use, and glucose levels…
- Conditions
- Osteoarthritis, Unicompartmental Knee Arthroplasty, Total Hip Arthroplasty (THA)
- Trial name
- NCT07630896
- Testing
- Prednisone, Continuous Glucose Monitor, InkWell Health Tattoos
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Columbia University
Acute Lymphoblastic Leukemia, Adult
Pediatric-Inspired Regimen Combined With Venetoclax and Immunotherapy for Adult Ph-Negative Acute Lymphoblastic Leukemia
This is a prospective, open-label, non-randomized cohort study evaluating the efficacy and safety of a pediatric-inspired chemotherapy regimen (IH-2014 based) combined with venetoclax and immunotherapy in adult patients with…
- Trial name
- NCT07495631
- Testing
- VDCLP+V, 2VIP, Consolidation Therapy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Myeloid Malignancies
A Phase I/II Study of CAR.70-Engineered IL15-Transduced Cord Blood-Derived NK Cells With TGF-beta Receptor 2 (TGFBR2) Knock Out in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapsed/Refractory Myeloid Malignancies
The goal of this clinical research study is to find the recommended safe dose of TGFBR2 KO CAR27/IL-15 NK cells that can be given to patients with relapsed/refractory disease.
- Trial name
- NCT06930651
- Testing
- Dexamethasone, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- M.D. Anderson Cancer Center
Amyloidosis; Systemic, AL Amyloidosis
Optimize First-line Treatment for AL Amyloidosis With t (11; 14)
Achievement of complete hematologic response (CHR) is vital for systemic AL amyloidosis. Currently, the CHR rate of daratumumab, bortezomib, and dexamethasone (DBD) is close to 60%.
- Trial name
- NCT06192979
- Testing
- Daratumumab, Bortezomib, Dexamethasone
- Where
- 7 sites in China
- Volunteers
- 41 people
- Sponsor
- Jin Lu, MD