Clinical trials: Doxycycline, completed
Type 2 Diabetes, Obesity
Examination of the Anti-inflammatory and Insulin Sensitizing Properties of Doxycycline in Humans
Obesity is a heightened state of inflammation in which production of cytokines and matrix metalloproteinases (MMPs) result in loss of function of insulin receptors and insulin resistance.
- Trial name
- DOXY (NCT01375491)
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Nephrolithiasis, Urinary Tract Infection (UTI)
Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2
This study will be a multi-institutional randomized clinical trial of a short course of pre-operative antibiotic prophylaxis in addition to perioperative antibiotics prior to undergoing percutaneous nephrolithotomy.
- Conditions
- Nephrolithiasis, Urinary Tract Infection (UTI), Sepsis
- Trial name
- PNLABXPART2 (NCT02829060)
- Testing
- Nitrofurantoin 100 MG, 7d, Gentamicin, 5mg/kg, Ampicillin 2g
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of California, San Diego
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients
This study investigates if long term use of the antibiotic doxycycline can reduce exacerbations in COPD patients. Half of the patients will receive doxycycline which the other half will receive a placebo.
- Trial name
- NCT02305940
- Testing
- Doxycycline
- Where
- 3 sites in United Kingdom
- Volunteers
- 222 people
- Sponsor
- Imperial College London
Urogential Chlamydia Trachomatis Infection
Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin
Evaluate the clinical efficacy and safety of WC2031 200 mg tablets taken orally once a day for 7 days versus Vibramycin (doxycycline) 100 mg capsules taken orally twice a day for 7 days, for the treatment of uncomplicated…
- Trial name
- NCT01113931
- Testing
- Doxycyline Hyclate tablet, Vibramycin (doxycyline hyclate) capsule
- Where
- 43 sites in United States
- Volunteers
- 495 people
- Sponsor
- Warner Chilcott
Helicobacter Pylori Eradication
Potassium Copetitive Acid Blockers Efficacy in H.Pylori Eradication
This trial assessed the efficacy of potassium competetor acid blocker (P-CAB) in the eradication of H.pylori
- Trial name
- P-CABs (NCT06101420)
- Testing
- Vonoprazan
- Where
- Egypt
- Volunteers
- 232 people
- Sponsor
- Ain Shams University
Umbilical Granuloma
Comparison Of Doxycycline And Common Salt For Treatment Of Umbilical Granuloma: A Randomised Control Trial
it is the study for the disease called umbilical granuloma to look for the better treatment option which can be performed by healthcare physicians and local nurses and even parents
- Trial name
- NCT05545462
- Testing
- Doxycyclin, COMMON SALT
- Where
- Pakistan
- Volunteers
- 196 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Diabetes Mellitus With Periodontal Disease
The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus
Aim: The purpose of this study is to investigate the effect of nonsurgical periodontal therapy plus doxycycline on glycemic control in type 2 diabetes mellitus (type 2 DM) patients who have periodontitis.
- Trial name
- NCT02845024
- Testing
- Doxycycline Group
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Prosthetic Joint Infection
Tedizolid Prolonged Treatment for Prosthetic Joint Infections
Pilot study the aim of which is to obtain reliable data on the tolerance, compliance and efficacy of Tedizolid used as prolonged (≥ 6 weeks) monotherapy or in combination therapy for the treatment of patients with orthopedic…
- Trial name
- TEDIZOAM (NCT03378427)
- Testing
- Tedizolid Phosphate 200 MG [Sivextro]
- Where
- 2 sites in France
- Volunteers
- 35 people
- Sponsor
- Tourcoing Hospital
Colitis, Ulcerative
Antibiotics for the Treatment of Ulcerative Colitis
Ulcerative colitis (UC) is an acute and chronic inflammatory bowel disease, whose cause is unknown. However, it is widely accepted that bacteria living in the large bowel are essential for the development of the disease.
- Trial name
- NCT00355602
- Testing
- Cefuroxime, Ciprofloxacin, Clarithromycin
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Dundee
Pelvic Inflammatory Disease
The Importance of Anti-anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID)
This study is a randomized placebo-controlled trial comparing two antibiotic treatment regimens for acute PID. Women with acute PID will be randomized to one of two treatment regimens: 1) a single intramuscular dose of…
- Trial name
- NCT01160640
- Testing
- Ceftriaxone, Doxycycline, Metronidazole
- Where
- 3 sites in United States
- Volunteers
- 233 people
- Sponsor
- Harold Wiesenfeld
Cetuximab-induced Papulopustular (Acneiform) Rash Who Have, Metastatic Colorectal Cancer or Head and Neck Squamous Cell Carcinoma
Study of Prophylactic Topical Dapsone 5% Gel Versus Moisturizer for Cetuximab-induced Papulopustular (Acneiform) Rash in Patients With mCRC or HNSCC Without Previous or Concurrent RT
The purpose of this study is to see if the investigators can prevent or reduce the severity of the Cetuximab-related acne rash. Two different topical agents will be applied to the skin.
- Trial name
- NCT01931150
- Testing
- Topical Dapsone 5% Gel, Moisturizer, oral antibiotics
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Papulopustular Rosacea
Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea
Subjects with moderate papulopustular rosacea will be treated either with azelaic acid 15% gel topically plus an anti-inflammatory dose of doxycyline (40mg) daily or with metronidazole 1% gel topically once daily plus an…
- Trial name
- NCT00855595
- Testing
- Azelaic acid (Finacea, BAY39-6251), Metronidazole (Metrogel), Doxycycline (Oracea)
- Where
- 17 sites in United States
- Volunteers
- 207 people
- Sponsor
- LEO Pharma
HIV, STI
Parrying the Pitfalls of PrEP: Project PEACH
The study is a prospective cohort of young MSM who are followed for 2 years either in-person at the PRISM Health Research Clinic and/or virtually with telehealth study visits.
- Trial name
- NCT05072093
- Testing
- PrEP discontinuation intervention, Offering of on-demand oral PrEP, Offering of STI PEP
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Emory University
Syphilis
Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM
This pilot study will investigate the feasibility of conducting a large, randomized trial comparing a structural intervention to contingency management to reduce incident syphilis infections in an especially high risk group: HIV+…
- Trial name
- DPMSM (NCT02257658)
- Testing
- Doxycycyline, Incentive
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Los Angeles LGBT Center
Traumatic Brain Injury
Doxycycline in Acute Traumatic Brain Injury
evaluate the impact of Doxycycline on both clinical outcome and blood levels of NSE in patients with TBI.
- Trial name
- NCT04239755
- Testing
- Doxycycline 100 MG Oral Tablet
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Damanhour University
Helicobacter Pylori Infection
Comparison Between Quadruple Regimens for Helicobacter Pylori Infection in Egypt
The overall prevalence of H. Pylori in the developing countries is 50.8%, with the highest one presented in Africa (79.1%). Hybrid therapy is supposed to be more effective as a first-line regimen for Helicobacter pylori infection…
- Trial name
- NCT04039412
- Testing
- Hybrid regimen, Reverse hybrid regimen, Levofloxacin quadruple regimen
- Where
- Egypt
- Volunteers
- 330 people
- Sponsor
- Ayman Magd Eldin Mohammad Sadek
Scrub Typhus
Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus
New antibiotics are required to have not only the antibacterial activity against doxycyline-resistant O. tsutsugamushi but also lower risk for resistance or any cross-resistance to others.
- Trial name
- NCT00568711
- Testing
- doxycycline, rifampin
- Where
- South Korea
- Volunteers
- 476 people
- Sponsor
- Dong-Min Kim
Aortic Aneurysm
Adjunctive Treatment With Doxycycline to Enhance the Durability of Endovascular Aortic Aneurysm Repair
The durability of endovascular aneurysm repair (EVAR) has been limited by development of endoleaks which may be secondary to progressive aortic degeneration by matrix metalloproteases (MMP).
- Trial name
- NCT00126204
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The Foundation for Barnes-Jewish Hospital
To Determine Bioequivalence Under Fed Conditions
Bioavailability Study of Doxycycline Monohydrate Capsules and Monodox Under Fasting and Fed Conditions
To compare the rate and extent of absorption of doxycycline monohydrate capsules equivalent to 100 mg doxycycline (Par) versus Monodox (Oclassen Pharmaceuticals)
- Trial name
- NCT00652704
- Testing
- Doxycycline monohydrate, Monodox
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Dry Eye Syndromes, Meibomian Gland Dysfunction
Effect of Topical Azithromycin on Tear Film Thickness in Patients With Meibomian Gland Dysfunction
Meibomian gland dysfunction (MGD) is among the leading causes for dry eye syndrome (DES), affecting millions of people worldwide.
- Trial name
- NCT03162497
- Testing
- Azithromycin, Doxycycline
- Where
- Austria
- Volunteers
- 23 people
- Sponsor
- Medical University of Vienna