Clinical trials: Enoxaparin
Left Ventricular Thrombus, Acute Myocardial Infarction
Treatment With Apixaban Versus Warfarin in Patients With Left Ventricular Thrombus After Acute Myocardial Infarction
The optimal anticoagulant for the treatment of left ventricular (LV) thrombus following acute myocardial infarction (AMI) is unclear.
- Trial name
- RESOLVE-AMI (NCT06515730)
- Testing
- Apixaban, Warfarin
- Where
- 16 sites in Sweden
- Volunteers
- 212 people
- Sponsor
- Karolinska Institutet
Deep Vein Thrombosis, Pulmonary Embolism
Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery
The purpose of this study is to learn if apixaban can prevent blood clots in the leg (deep vein Thrombosis [DVT]) and lung (pulmonary embolism [PE]) that sometimes occur after knee replacement surgery and to learn how apixaban…
- Trial name
- NCT00371683
- Where
- 107 sites in United States, Argentina and 11 more
- Volunteers
- 3,608 people
- Sponsor
- Bristol-Myers Squibb
Venous Thromboembolism
Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Knee Replacement Surgery
The purpose of this study is to examine the superiority of YM150 to the placebo and to evaluate the dose-dependent response of YM150 in patients undergoing elective total knee replacement surgery.
- Trial name
- NCT00917254
- Testing
- YM150, Enoxaparin
- Where
- 13 sites in Japan, Taiwan and 1 more
- Volunteers
- 369 people
- Sponsor
- Astellas Pharma Inc
Cervical Artery Dissection, Carotid Artery Dissection
To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection
This is a feasibility study to determine if a sufficient number of patients can be recruited throughout the United Kingdom and whether sufficient endpoints can be generated for a full scale therapeutic trial of anticoagulants…
- Conditions
- Cervical Artery Dissection, Carotid Artery Dissection, Vertebral Artery Dissection, Stroke
- Trial name
- CADISS (NCT00238667)
- Testing
- Antiplatelet (Aspirin, Dipyridamole, clopidogrel), Anticoagulant (Unfractionated Heparin, LMW Heparin, Warfarin)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- St George's, University of London
COVID, Coronavirus Infection
A Pragmatic Randomized Controlled Trial of Therapeutic Anticoagulation Versus Standard Care as a Rapid Response to (SARS-CoV-2) COVID-19 Pandemic
Coagulopathy of COVID-19 afflicts approximately 20% of patients with severe COVID-19 and is associated with need for critical care and death.
- Conditions
- COVID, Coronavirus Infection, Severe Acute Respiratory Syndrome, Thromboembolism, Venous
- Trial name
- RAPID-BRAZIL (NCT04444700)
- Testing
- Therapeutic anticoagulation
- Where
- Brazil
- Volunteers
- 465 people
- Sponsor
- University of Sao Paulo General Hospital
Pregnancy, Prosthetic Heart Valve
Optimizing Anticoagulation in Pregnancies With Mechanical Heart Valves
The purpose of this pilot study is to collect data on pregnancies with mechanical heart valves to see if using a blood thinner called low molecular weight heparin (LMWH) and low dose aspirin (LDA) is comparable to…
- Conditions
- Pregnancy, Prosthetic Heart Valve, Anticoagulant Therapy
- Trial name
- NCT07658989
- Testing
- LMWH and LDA, Vitamin K antagonists (e.g warfarin)+/- LDA, Sequential therapy +/- LDA
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Mount Sinai Hospital, Canada
Pancreas Cancer, Pancreas Neoplasm
Pre- Vs. Postoperative Thromboprophylaxis in Pancreatic Surgery
Thromboprophylaxis for pancreatic surgery can be commenced either preoperatively or postoperatively. Despite a clear trade-off between thrombosis and bleeding in pancreatic surgery patients, there is no international consensus…
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Surgery, Thrombosis
- Trial name
- PREPOSTEROUS2 (NCT05245877)
- Testing
- enoxaparin/tinzaparin/dalteparin
- Where
- 5 sites in Canada, Finland and 1 more
- Volunteers
- 800 people
- Sponsor
- Helsinki University Central Hospital
Infertility, Female, Thrombophilia
Effect of Prophylatic Use of Enoxaparin in Women Undergoing in Vitro Fertilization Treatment
Retrospective study designed to evaluate outcomes in patients undergoing assisted reproduction. Some of them had thrombophilia, and part of them was treated with enoxaparin, started on the day of embryo transfer, and the other…
- Conditions
- Infertility, Female, Thrombophilia, Fertilization in Vitro
- Trial name
- NCT05225155
- Testing
- Enoxaparin
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Faculdade de Medicina do ABC
Venous Thromboembolism
A Comparison of Extended Versus Conventional Duration of Enoxaparin Prophylaxis (i.e., Preventive Treatment) for Venous Thromboembolism (VTE, i.e., Blood Clots in the Veins) and Bleeding Event Risk in a Population With Acute Medical Illness
Venous Thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is associated with an increase in risk of mortality and long-term disability and is a major contributor to global disease burden.
- Trial name
- NCT05819112
- Where
- United States
- Volunteers
- 14,799 people
- Sponsor
- Sanofi
Deep Vein Thrombosis (DVT), Blood Clots
Below Knee DVT Study
Hospitalized patients are at risk of developing blood clots in the legs (Deep Vein Thrombosis or DVT), which can lead to death if those clots break off and migrate to the lungs.
- Trial name
- NCT03805672
- Testing
- Low Dose Enoxaparin, High Dose Enoxaparin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Oregon Health and Science University
Deep Vein Thrombosis
The Effect of Enoxaparin Sodium on the Incidence of Deep Vein Thrombosis Following Electrophysiology Studies and Radiofrequency Ablation.
The purpose of this study is to assess the effect of the anticoagulant(blood thinner) Clexane on the development of leg clots following electrophysiology studies (EPS) and or radiofrequency ablation (RFA).
- Trial name
- NCT00232271
- Testing
- Clexane
- Where
- Australia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Melbourne Health
Coagulation
Evaluation of the Accuracy of the INRatio Prothrombin Time (PT) Monitoring System With a New Test Strip for the Oral Anticoagulation Therapy Patient in the Presence of Heparin and Low Molecular Weight Heparin (e.g., Enoxaparin or Dalteparin)
This is a multi-center study designed to evaluate the heparin insensitivity of the INRatio Prothrombin Time (PT) Monitoring System, utilizing an INRatio test strip additionally modified for low sample volume.
- Trial name
- ECLIPSE 03 (NCT00933738)
- Where
- 12 sites in United States
- Volunteers
- 150 people
- Sponsor
- Abbott RDx Cardiometabolic
Nephrotic Syndrome, Hypoalbuminemia
Edoxaban Steady-State PK/PD in Adults With Nephrotic Syndrome
A study to evaluate the impact of nephrotic syndrome on the steady state pharmacokinetics and pharmacodynamics of edoxaban compared to health volunteers, and whether edoxaban can provide an equivalent anticoagulant effect to…
- Trial name
- NCT07116239
- Testing
- Edoxaban 60 mg, Enoxaparin 40 mg
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Arthroplasty, Replacement, Knee
A Study of JNJ-70033093 (BMS-986177) Versus Subcutaneous Enoxaparin in Participants Undergoing Elective Total Knee Replacement Surgery
The purpose of this study is to determine the efficacy of JNJ-70033093 in preventing total venous thromboembolism (VTE) events (proximal and/or distal deep vein thrombosis [DVT] [asymptomatic confirmed by venography assessment or…
- Trial name
- AXIOMATIC-TKR (NCT03891524)
- Testing
- JNJ-70033093 25 mg, JNJ-70033093 50 mg, JNJ-70033093 100 mg
- Where
- 117 sites in United States, Argentina and 16 more
- Volunteers
- 1,242 people
- Sponsor
- Janssen Research & Development, LLC
Non-small Cell Lung Cancer
Taxotere-Enoxaparin-(ENOXA)-Study
Taxotere-Enoxaparin-(ENOXA)-Study: 1st-Line Docetaxel-Platin Chemotherapy as single therapy or in combination with Enoxaparin in patients aged older than 18 years with locally advanced or metastatic non-small cell lung cancer…
- Trial name
- NCT01058759
- Testing
- Enoxaparin, No Enoxaparin
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- Hannover Medical School
Healthy
Bioequivalence Study of a Generic Enoxaparin Sodium to Clexane® After Single Subcutaneous Dose in Healthy Human Subjects
This is a single-dose, randomized, double-blind, two-period, two-treatment, two-sequence, crossover, balanced, pharmacodynamic (PD) study with 7 days wash-out period.
- Trial name
- NCT05265676
- Testing
- Enoxaparin Sodium (Venus Remedies Limited), Enoxaparin Sodium (Sanofi)
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Venus Remedies Limited
Deep Vein Thrombosis
Reduction to Preventive Doses of Enoxaparin After 3 to 6 Months of Treatment With Blood Thinners for Cancer-associated Blood Clots
Background: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular disorder after myocardial infarction and stroke.
- Trial name
- STEP-CAT (NCT02752607)
- Where
- 7 sites in Canada
- Volunteers
- 52 people
- Sponsor
- Dr. Vicky Tagalakis
Coronary Artery Disease
Anticoagulant Treatments and Percutaneous Coronary Angioplasty
The purpose of this study is to determine whether adjunction of intravenous anticoagulant therapy (enoxaparin, HNF, bivalirudin) to antiaggregation with clopidogrel and aspirin improves in-hospital results of percutaneous…
- Trial name
- TACA (NCT00669149)
- Testing
- clopidogrel + aspirin, heparin + clopidogrel + aspirin, enoxaparin + clopidogrel + aspirin
- Where
- France
- Volunteers
- 99 people
- Sponsor
- Centre Hospitalier de PAU
COVID-19
Safety and Efficacy of Maraviroc and/or Favipiravir With Standard Therapy in Severe COVID-19 Adults
Phase 2, randomized, open-label study to evaluate the safety and efficacy of maraviroc, favipiravir, and both drugs administered along with currently used therapy in hospitalized patients with pulmonary SARS-CoV-2 (Severe Acute…
- Trial name
- COMVIVIR (NCT04475991)
- Testing
- Maraviroc + Currently used therapy, Curently used therapy for COVID-19 non-critical patients, Favipiravir + Currently used therapy
- Where
- Mexico
- Volunteers
- 19 people
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Deep Venous Thrombosis
Study to Assess Safety, Tolerability, and Efficacy of GMI-1271 in Patients With Calf-level Deep Venous Thrombosis (DVT)
This study will evaluate the safety profile of GMI-1271 and its effect on thrombus resolution in patients with distal calf vein Deep Venous Thrombosis (DVT).
- Trial name
- NCT02744833
- Testing
- GMI-1271, Enoxaparin Sodium (Lovenox®)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- GlycoMimetics Incorporated