Clinical trials: Esomeprazole
Gastric Ulcer
Efficacy and Safety Study of Esomeprazole 20mg qd vs Ranitidine 150mg Bid in Patients With an NSAID-induced Gastric Ulcer
The purpose of this study is to assess the efficacy of esomeprazole 20 mg dosed once daily and ranitidine 150 mg dosed twice daily through 4 weeks of treatment for the healing of gastric ulcers in patients receiving daily…
- Trial name
- NCT00401752
- Testing
- Esomeprazole, Ranitidine
- Where
- 9 sites in China, Hong Kong
- Volunteers
- 397 people
- Sponsor
- AstraZeneca
Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant, Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant
Pharmacogenetic and Pharmacokinetics of Naproxen and Associated Naproxen-esomeprazole
The family of cytochrome P450 (CYP) is the most important drug metabolizing enzymes which contributes to the metabolism of a large proportion of drugs in humans.
- Trial name
- NCT03092193
- Testing
- Naproxen, Naproxen-esomeprazole
- Where
- Brazil
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes
A Study to Learn How a Proton Pump Inhibitor Affects the Way Elinzanetant (BAY 3427080) Moves Into, Through and Out of the Body, and How Much of it Gets Absorbed by the Body When Taken as a Single and Small Radioactive Dose in Healthy Adults
Researchers are looking for a better way to treat people who have vasomotor symptoms (VMS). VMS such as hot flashes are caused by hormonal changes occurring during menopausal transition when women may have also changes in their…
- Trial name
- NCT05061563
- Testing
- Elinzanetant (BAY3427080), Esomeprazole
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bayer
Hospitalized Cases of Angioneurotic Oedema, Pneumonia
Drug Utilization and Safety Events Among Children Using Esomeprazole, Other Proton Pump Inhibitors or H2-receptor Antagonists
The purpose of this study is 1. To describe patient characteristics and drug usage among children that are prescribed esomeprazole for the first time and to compare them with patients who are prescribed other proton pump…
- Conditions
- Hospitalized Cases of Angioneurotic Oedema, Pneumonia, Gastroenteritis, Failure to Thrive
- Trial name
- NCT01338363
- Where
- Netherlands
- Volunteers
- 23,470 people
- Sponsor
- AstraZeneca
Healthy Volunteers, Bioequivalence
A Bioequivalence Study to Compare VIMOVO Manufactured at AstraZenca AB to VIMOVO Manufactured by Patheon Pharmaceuticals and Marketed Enteric-coated Naproxen Formulation
The primary purpose is to demonstrate the bioequivalence of naproxen administered as VIMOVO manufactured at a new facility in Sweden (AstraZeneca) to that of naproxen administered as VIMOVO manufactured in the USA (Patheon) and…
- Trial name
- NCT01331993
- Testing
- VIMOVO (AstraZeneca), VIMOVO (Patheon), Marketed enteric-coated naproxen formulation
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Aspirin, Dyspepsia
Esomeprazole or Famotidine in the Management of Aspirin Related Non-Ulcer Dyspepsia
Aspirin can prevent ischemic vascular disease but is commonly complicated by dyspepsia in 30% of patients. Patients, who have aspirin related dyspepsia, commonly underwent upper endoscopy to exclude peptic ulcer disease or…
- Trial name
- NCT00978159
- Testing
- esomeprazole, Famotidine
- Where
- 2 sites in China
- Volunteers
- 128 people
- Sponsor
- Ruttonjee Hospital
Helicobacter Pylori Infection
Bismuth Based Quadruple Therapy 10 Days in Children
Helicobacter pylori infection causes chronic gastritis, peptic ulcer disease and is involved in the development of gastric cancer.
- Trial name
- NCT03299725
- Testing
- colloidal bismuth sub-citrate
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Queen Fabiola Children's University Hospital
Gastroesophageal Reflux Disease (GERD)
Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected Patients
The primary objective of this study is to investigate whether eradication treatment of Helicobacter pylori followed by therapy with esomeprazole for a total of 8 weeks extends the time to relapse in patients with gastroesophageal…
- Trial name
- NCT00574925
- Testing
- Esomeprazole
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Dyspepsia
Rebamipide in Combination With Esomeprazole in the Management of Asian Patients With Functional Dyspepsia
This is a multi-Asian-centre randomised controlled trial of Rebamipide alone vs Rebamipide with Esomeprazole in the treatment of adult patients with Functional Dyspepsia.
- Trial name
- NCT02134405
- Testing
- Rebamipide, Esomeprazole
- Where
- Malaysia
- Volunteers
- 200 people
- Sponsor
- University of Malaya
Pain, Other Surgical Procedures
Comparison of the Clinical Efficacy of Naproxen, Associated or Not With Esomeprazol, in Lower Third Molar Removal
The present clinical trial randomized compared the clinical efficacy of the naproxen associated or not with esomeprazol, for the removal of lower third molars.
- Conditions
- Pain, Other Surgical Procedures, Impacted Third Molar Tooth
- Trial name
- NCT02494856
- Testing
- Surgery with Naproxen, Surgery with Naproxen and Esomeprazole
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Giovana Maria Weckwerth
Barrett's Esophagus
An Open Label pH Comparison of Esomeprazole and Lansoprazole in Barrett's Esophagus Patients
The purpose of the study is to compare the treatment of esomeprazole 40 mg once daily and lansoprazole 30 mg once daily in controlling intragastric pH in Barrett's Esophagus patients
- Trial name
- NCT00352261
- Testing
- Esomeprazole, Lansoprazole
- Where
- 12 sites in United States
- Volunteers
- 80 people
- Sponsor
- AstraZeneca
Stress Ulcer Bleeding
A Multi-center, Double-blinding, Parallel and Positive-controlled Phase III Clinical Trial for Efficacy and Safety Evaluation of Ilaprazole Sodium for Injection on Prevention of Stress Ulcer Bleeding
The purpose of this study is to evaluate the efficacy of the study drug (Ilaprazole Sodium for Injection) for potential effect on preventing stress ulcer bleeding in vulnerable population by comparing the radio of upper…
- Trial name
- NCT05841394
- Testing
- Esomeprazole 40mg, Ilaprazole Sodium
- Where
- 2 sites in China
- Volunteers
- 449 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Cancer
A Phase I Study of BMS-275183 (Oral Taxane) Given on a Daily Schedule in Combination With Esomeprazole (Nexium) in Patients With Advanced Cancer
The purpose of this study is to determine what effects Esomeprazole (Nexium) has on increasing or decreasing the amount of oral taxane in the blood, and to determine the safety of oral taxane and effect of oral taxane on the…
- Trial name
- NCT00332748
- Testing
- Oral Taxane
- Where
- 4 sites in United States, Netherlands
- Volunteers
- 36 people
- Sponsor
- Bristol-Myers Squibb
Reflux Esophagitis
Reflux Esophagitis Phase III Study (Maintenance Treatment)
The primary objective of this study is to evaluate the efficacy of esomeprazole 20 mg once daily for 24 weeks on maintenance of Reflux Esophagitis in patients with healed reflux esophagitis in comparison with omeprazole 10 mg…
- Trial name
- NCT00634114
- Testing
- Esomeprazole, Omeprazole
- Where
- 44 sites in Japan
- Volunteers
- 540 people
- Sponsor
- AstraZeneca
Helicobacter Pylori Infection, Chronic Gastritis
Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication
The purpose of this study was to evaluate the efficacy and safety of the triple therapy of berberine hydrochloride, vonorasan and amoxicillin for the primary eradication of Helicobacter pylori.It is hypothesized that berberine…
- Trial name
- NCT06514274
- Testing
- Berberine, Vonoprazan, Amoxicillin
- Where
- China
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori Rescue Treatment
With increasing antibiotic resistance and unsatisfactory results of empiric eradication regimens, tailored therapy may be the best choice to achieve high efficacy for rescue treatment.
- Trial name
- NCT03413020
- Testing
- esomeprazole, bismuth Potassium Citrate, amoxicillin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection, Helicobacter Pylori Eradication
Efficacy of Amoxicillin-Esomeprazole HDDT Compared to Levofloxacin Triple Therapy for H. Pylori Eradication: A RCT
The goal of this clinical trial is to compare the efficacy of two different therapeutic regimen for the treatment of Helicobacter pylori infected dyspeptic patients. The aim is - 1. To identify the percentage of H.
- Trial name
- NCT06088316
- Testing
- group A : Amoxicillin Esomeprazole HDDT, group-B : Levofloxacin triple therapy
- Where
- Bangladesh
- Volunteers
- 70 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Pharmacokinetics, Voriconazole
Development of Voriconazole Pharmacokinetics and Metabolism in Children and Adolescents
The death rate in children from the invasive fungal infection called aspergillosis is more than 50%. Voriconazole is the first-line therapy for this infection.
- Trial name
- NCT01976078
- Testing
- Midazolam/Ranitidine/Esomeprazole
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Children's Hospital Los Angeles
GERD
A New System for GERD Diagnosis and Treatment
This is a pilot study measuring a new diagnosis and treatment system "EAISMLP" in adult patients with gastroesophageal reflux disease (GERD).
- Trial name
- EAISMLP (NCT03600974)
- Testing
- Stretta, Laparoscopic Nissen fundoplication, Probiotic Agent
- Volunteers
- 200 people
- Sponsor
- Capital Medical University
Proton Pump Inhibitor Adverse Reaction
Is Long-Term Proton Pump Inhibitor Use a Cause of Leaky Gut Syndrome
Our study aims to investigate the effect of bacterial overgrowth induced by long-term PPI use on zonulin levels.
- Trial name
- NCT06268834
- Testing
- Blood for zonulin level was drawn from the group.
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital