Clinical trials: Esomeprazole
GERD
Gastroesophageal Reflux Disease (GERD)/Nighttime Heartburn and Driving Performance
The implications of sleep as it relates to the physiology and pathogenesis of a number of diseases has until recently been ignored.
- Trial name
- NCT01079884
- Testing
- esomeprazole 40 mg
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- David A. Johnson, MD
Helicobacter Pylori Infection
A Pilot Study of a 14-day Modified Sequential Therapy for Helicobacter Pylori Infection
The purpose of this study is to assess efficacy of a new 14-day sequential therapy for the rescue treatment of refractory Helicobacter pylori infection, and whether it is safe while maintaining an ideal eradication rates.
- Trial name
- NCT03658733
- Testing
- esomeprazole, amoxicillin, tetracycline, furazolidone (only for the first 7 days), colloidal bismuth pectin (for the second 7 days), rabeprazole, amoxicillin, tetracycline, furazolidone (only for the first 7 days), colloidal bismuth pectin (for the second 7 days)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shandong University
Vasomotor Rhinitis
Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial
The purpose of this study was to see if high dose esomeprazole (40mg bid) was effective in treating non-allergic rhinitis
- Trial name
- NCT00745849
- Testing
- esomeprazole
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Texas Southwestern Medical Center
Peptic Ulcer Hemorrhage
Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients
The purpose of this study is to determine whether a long-term prophylactic use of esomeprazole 20 mg twice daily or once daily has prevention effectiveness in reducing the recurrence of peptic ulcer bleeding after ulcer healed…
- Trial name
- Eso_1y_R6PUB (NCT02456012)
- Testing
- oral esomeprazole 20 mg twice daily, oral esomeprazole 20 mg once daily
- Where
- Taiwan
- Volunteers
- 268 people
- Sponsor
- Hsiu-Chi Cheng
Helicobacter Pylori Infection
The Effect of Time Intervals for Rescue Treatment on Eradication Effect of Helicobacter Pylori Infection
The researchers collect patients who accepted eradication program of the helicobacter pylori but failed to eradicate helicobacter pylor from the outpatient clinic.
- Trial name
- NCT05620602
- Testing
- Remedial treatment within 3 months, Remedial treatment within 3 to 6 months, Remedial treatment within 6 to 12 months
- Where
- China
- Volunteers
- 628 people
- Sponsor
- Shandong University
Response to Levodopa, Motor Outcomes
Effects of Helicobacter Pylori Infection Eradication in Patients With Parkinson's Disease
A higher prevalence of Helicobacter pylori infection rate has been demonstrated among PD patients compared to controls. As H. pylori infection is known to interfere with levodopa absorption, we embarked on this is a study to…
- Conditions
- Response to Levodopa, Motor Outcomes, Quality of Life Outcomes
- Trial name
- NCT02112812
- Testing
- Eradication therapy for H.pylori infection, Eradication of Helcobacter Pylori, Eradication therapy for Helicobacter pylori
- Where
- Malaysia
- Volunteers
- 82 people
- Sponsor
- National University of Malaysia
Helicobacter Pylori
The Study on the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure
The patients who accepted the quadruple eradication program of the helicobacter pylori but failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication time of helicobacter pylori.
- Trial name
- NCT04810793
- Testing
- Amoxicillin , Levofloxacin and Esomeprazole, Amoxicillin , Furazolidone and Esomeprazole, Tetracycline , Furazolidone and Esomeprazole
- Where
- China
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Optimized Bismuth Quadruple Therapy vs Triple Standard Therapy for Helicobacter Pylori Eradication
This study have as primary aim "To compare the H. pylori eradication rate between the quadruple bismuth therapy versus the standard triple therapy recommended by the AUGE Clinical Guidelines for Helicobacter pylori eradication…
- Trial name
- NCT05664685
- Testing
- Optimized bismuth quadruple therapy, Control
- Where
- 2 sites in Chile
- Volunteers
- 127 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Peptic Ulcer
A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers
Esomeprazole plus aspirin compared with esomeprazole alone for the treatment of aspirin-related peptic ulcers.
- Trial name
- NCT01353144
- Testing
- aspirin
- Where
- 3 sites in Taiwan
- Volunteers
- 178 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Bioequivalence
Bioequivalence Study of Esomeprazole in Healthy Adult Subjects Under Fasting Condition
The current study is conducted to evaluate and compare the relative bioavailability for Esomeprazole in two different products containing 40 mg Esomeprazole after a single oral dose administration under fasting conditions.
- Trial name
- NCT05235217
- Testing
- Test product (T) 40 mg Hard Gelatin Capsules, Reference product (R) 40 mg Hard Gelatin Capsules
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Gastroesophageal Reflux Disease
Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients
This study is designed to evaluate the efficacy and tolerability of ilaprazole relative to that of esomeprazole in healing erosive esophagitis and resolving accompanying symptoms of GERD.
- Trial name
- NCT01107938
- Testing
- 10 mg ilaprazole, 15 mg ilaprazole, 40 mg esomeprazole
- Volunteers
- 330 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Treatment Effectiveness
Vonoprazan for Helicobacter Pylori Eradication in Adolescents
The trial tends to evaluate the efficacy of vonoprazan-based triple therapy in eradicating H. Pylori infection in adolescent patients in Egypt, in comparison to standard treatment regimens to determine if it offers superior…
- Trial name
- NCT06162949
- Testing
- Vonoprazan, Amoxicillin, Clarithromycin
- Where
- Egypt
- Volunteers
- 242 people
- Sponsor
- Alexandria University
Dyspepsia, Gastroesophageal Reflux
BRAVO Study for Functional Dyspepsia
Background: Functional dyspepsia is one of the commonest digestive disorders. The pathophysiology of functional dyspepsia is uncertain.
- Trial name
- BD (NCT01349413)
- Testing
- Esomeprazole 20mg
- Where
- Hong Kong
- Volunteers
- 130 people
- Sponsor
- Chinese University of Hong Kong
Helicobacter Pylori Infection
The Efficacy of Susceptibility Test -Driven Sequential Therapy as the Third Line Therapy for Refractory Helicobacter Pylori Infection
Background: Helicobacter pylori infection has been shown to be associated with the development of gastric cancer and peptic ulcer diseases. Eradication of H.
- Trial name
- NCT01032655
- Testing
- susceptibility test guided sequential therapy
- Where
- Taiwan
- Volunteers
- 134 people
- Sponsor
- National Taiwan University Hospital
GERD
Heartburn, Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a condition caused by the reflux of stomach contents into the esophagus, presenting with typical symptoms such as heartburn and acid regurgitation.
- Trial name
- GERD (NCT07268820)
- Testing
- Zastaprazan, Esomeprazole
- Where
- 10 sites in South Korea
- Volunteers
- 160 people
- Sponsor
- Incheon St.Mary's Hospital
Efficacy, Gastric Microbiota
The Effects Probiotic Has on Gastromicroecology and Combined With Quadruple Regimen for H Pylori Infection
This study assesses the efficacy and safety of treatment with two-week probiotics followed by a 10-day tetracycline- and furazolidone-containing quadruple regimen as rescue treatment for H. pylori infection.
- Conditions
- Efficacy, Gastric Microbiota, Safety
- Trial name
- NCT03377933
- Testing
- Compound Lactobacillus acidophilus
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yiqi Du
Gastroesophageal Reflux Disease (GERD)
Rabeprazole Extended-Release, 50 mg, Versus Esomeprazole, 40 mg, for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to investigate the efficacy (ie, healing and symptom relief) and safety of Rabeprazole Extended-Release (RAB ER) 50 mg versus Esomeprazole (ESO) 40 mg for the treatment of moderate to severe erosive…
- Trial name
- NCT00658775
- Testing
- Rabeprazole sodium, Esomeprazole
- Where
- 83 sites in United States, Argentina and 12 more
- Volunteers
- 1,069 people
- Sponsor
- Eisai Inc.
Bleeding
Potassium-competitive Acid Blocker Versus Double Dose Proton Pump Inhibitors in High High-risk Peptic Ulcer Bleeding
This randomized clinical trial will enroll patients at National Cheng Kung University Hospital who have upper gastrointestinal ulcer bleeding, have undergone endoscopic hemostasis, and have a Rockall score of 6 or higher.
- Trial name
- NCT07772700
- Testing
- Vonoprazon, Esomeprazole
- Volunteers
- 108 people
- Sponsor
- National Cheng-Kung University Hospital
GERD
Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
This study was a multicentre, double-blind, randomised, placebo-controlled parallel group study consisting of 4 visits over a period of 6 months.
- Trial name
- NCT00241514
- Testing
- Esomeprazole
- Where
- 113 sites in United States, Belgium and 4 more
- Volunteers
- 334 people
- Sponsor
- AstraZeneca
Helicobacter Pylori Eradication
Effect of Probiotics on Helicobacter Pylori Eradication
The purpose of this clinical trial is to evaluate the clinical efficacy of Bifidobacterium quadruple live bacteria tablets (Si Lian Kang) on reducing the incidence rate of adverse reactions of Helicobacter pylori quadruple…
- Trial name
- NCT04034641
- Testing
- Bifidobacterium tetrad live bacteria tablet plus Helicobacter pylori quadruple eradication therapy
- Where
- 2 sites in China
- Volunteers
- 238 people
- Sponsor
- Hangzhou Grand Biologic Pharmaceutical, Inc.