Clinical trials: Esomeprazole, completed
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori Rescue Treatment
With increasing antibiotic resistance and unsatisfactory results of empiric eradication regimens, tailored therapy may be the best choice to achieve high efficacy for rescue treatment.
- Trial name
- NCT03413020
- Testing
- esomeprazole, bismuth Potassium Citrate, amoxicillin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
The Study About the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure
The patients who accepted the quadruple eradication program of the helicobacter pylori but failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication time of helicobacter pylori.
- Trial name
- NCT05173493
- Testing
- Amoxicillin,Furazolidone, Amoxicillin,Levofloxacin, Tetracycline,Furazolidone
- Where
- China
- Volunteers
- 670 people
- Sponsor
- Shandong University
Healthy
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DWP14012 After Oral Administration in Healthy Male Volunteers
This is a dose block-randomized, double-blind, placebo- and active-controlled, single and multiple dosing, dose-escalation clinical phase 1 trial to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of…
- Trial name
- NCT02757144
- Testing
- DWP14012, Esomeprazole
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Acute Coronary Syndrome, Acute Myocardial Infarction
Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease
Aspirin and clopidogrel +/- heparin or thrombolytic co-therapy is well established and effective treatment for unstable cardiac patients. However, the major complication was gastrointestinal bleeding (GIB) due to peptic ulcer.
- Trial name
- NCT00683111
- Testing
- esomeprazole 20 mg daily, famotidine 40 mg daily
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruttonjee Hospital
Gastritis, Dyspepsia
Helicobacter Rescue Therapy With High-dose Esomeprazole and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy
This study aims at evaluating efficacy and safety of high-dose esomeprazole and amoxicillin dual therapy(esomeprazole and amoxicillin) versus bismuth-containing quadruple Therapy(bismuth，esomeprazole，tetracycline and…
- Conditions
- Gastritis, Dyspepsia, Helicobacter Pylori Infection, Gastric Cancer
- Trial name
- NCT04678492
- Testing
- Esomeprazole, Amoxicillin, Bismuth
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Xijing Hospital of Digestive Diseases
NSAID Associated Gastric Ulcers
A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued in Subjects in the US Only
Nonsteroidal anti-inflammatory drugs (NSAIDS) are often associated with gastric ulcers. This study looks at the treatment of these gastric ulcers with one of the three following treatment groups for up to 8 weeks: esomeprazole 40…
- Trial name
- NCT00633412
- Testing
- Esomeprazole, Ranitidine
- Volunteers
- 400 people
- Sponsor
- AstraZeneca
Helicobacter Pylori Infection
Comparison of Two Rescue Therapies for Helicobacter Pylori Infection
From the profiles of antibiotic susceptibility data following eradication therapy, tetracycline, amoxicillin and levofloxacin are all good candidates of antibiotics used in the rescue treatment.
- Trial name
- NCT02547012
- Testing
- esomeprazole+amox+levo+tetra, esomeprazole+amox+levo
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Asthma, Lung Diseases
Study of Acid Reflux in Asthma
The purpose of this study is to determine if subjects with symptomatic asthma who are assigned to treatment with a proton pump inhibitor (PPI) drug such as Nexium have fewer asthma attacks than similar subjects assigned to…
- Conditions
- Asthma, Lung Diseases, Lung Diseases, Obstructive
- Trial name
- NCT00069823
- Testing
- Esomeprazole
- Where
- 20 sites in United States
- Volunteers
- 403 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Gastroesophageal Reflux Disease (GERD)
Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to determine the safety and efficacy of Rabeprazole extended release (ER) 50 mg versus Esomeprazole 40 mg for healing and symptomatic relief among subjects with erosive gastroesophageal reflux disease…
- Trial name
- NCT00658528
- Testing
- Rabeprazole sodium, Esomeprazole
- Where
- 88 sites in United States, Argentina and 11 more
- Volunteers
- 1,061 people
- Sponsor
- Eisai Inc.
Healthy
A Study of Food Effect and Esomeprazole on LY4064809 in Healthy Adult Participants
The purpose of this study is to evaluate the safety and effect of food on LY4064809 and the safety and effect of stomach changes by a proton pump inhibitor (PPI) esomeprazole, under fasted conditions in healthy adult…
- Trial name
- NCT06991179
- Testing
- LY4064809
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Scorpion Therapeutics, a wholly owned subsidiary of Eli Lilly and Company
Helicobacter Pylori Infection
10-day Versus 14-day Concomitant PAMC as First-line Treatment Strategy for the Eradication of H. Pylori Infection
Helicobacter pylori (H. pylori) infection is highly associated with gastrointestinal disorders, including peptic ulcer disease, gastric cancer, and gastric mucosa associated lymphoid tissue lymphoma.1 In 1994, H.
- Trial name
- NCT02959255
- Testing
- Esomeprazole
- Where
- Greece
- Volunteers
- 364 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Helicobacter Pylori Infection
15-day Sequential Therapy for Helicobacter Pylori Infection in Korea
10-day sequential therapy was not sufficient to overcome tough situation for H. pylori eradication in Korea due to high antimicrobial resistance.
- Trial name
- NCT01887249
- Testing
- Clarithromycin, metronidazole, esomeprazole
- Where
- South Korea
- Volunteers
- 287 people
- Sponsor
- Seoul National University Bundang Hospital
Nausea, Vomiting
The Effects of Nexium on the Side Effects Associated With a Colonoscopy Prep
The purpose of this study is to ascertain if the use of Nexium for 7 days prior to taking a colon prep for a colonoscopy will decrease the side effects that are associated with the colon preparation
- Conditions
- Nausea, Vomiting, Abdominal Pain
- Trial name
- NCT00225238
- Testing
- esomeprazole (PPI)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Thomas Jefferson University
Barrett Esophagus, Proton Pump Inhibitor
On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus.
On-demand PPI therapy is feasible for the long-term treatment of patients with Barrett's esophagus.
- Conditions
- Barrett Esophagus, Proton Pump Inhibitor, Symptom, Reflux
- Trial name
- NCT04329000
- Testing
- Esomeprazole 40mg, Esomeprazole
- Volunteers
- 218 people
- Sponsor
- Kaohsiung Veterans General Hospital.
GERD
Pantoprazole Magnesium 40 mg Versus Esomeprazole 40 mg in Patients With Erosive Gastroesophageal Reflux Disease
The aim of this trial is to evaluate the complete remission of erosive gastroesophageal reflux disease with pantoprazole magnesium 40 mg once daily versus esomeprazole 40 mg once daily during four-week treatment with an extension…
- Trial name
- PAMES 0109 (NCT01132638)
- Testing
- Magnesium Pantoprazole, Magnesium Esomeprazole
- Where
- 9 sites in Brazil
- Volunteers
- 713 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease
Open, Randomized, Two Way Crossover Study Comparing the Effect of Esomeprazole Adminstered Orally and iv
The purpose of this study is to examine the effects of Nexium at a dose of 20mg administered orally compared to intravenously on the maximum acid output in subjects with symptoms of Gastroesophageal reflux disease (GERD).
- Trial name
- NCT00626262
- Testing
- Esomeprazole
- Volunteers
- 60 people
- Sponsor
- AstraZeneca
Non-erosive Reflux Disease
Phase 2 Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH1885L in Patients With Non-erosive Reflux Disease(NERD)
Randomized, double-blind, active-controlled, multi-center phase 2 clinical trial to investigate the safety, tolerability and efficacy of YH1885L in patients with non-erosive reflux disease(NERD)
- Trial name
- NCT01750437
- Testing
- YH1885L(Revaprazan), Esomeprazole 20mg
- Where
- 10 sites in South Korea
- Volunteers
- 149 people
- Sponsor
- Yuhan Corporation
Non-erosive Reflux Disease
Clinical Trial to Assess the Efficacy and Safety of YYD601 in NERD Patients
Clinical Trial to Assess the Efficacy and Safety of YYD601 in NERD Patients
- Trial name
- NCT03967886
- Testing
- YYD601 20mg, Nexium 20mg
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Chronic Hepatitis B
A Study to Assess CYP3A4 Modulator, Oral Contraceptive, and pH Modifier Drug Interactions for ABI-H2158 in Healthy Adults
This study is designed to assess 1) the effect of multiple doses of itraconazole (CYP3A4 inhibitor), rifampin (CYP3A4 inducer), and esomeprazole (pH modifier) on the pharmacokinetics of a single oral dose of ABI-H2158, and 2) the…
- Trial name
- NCT04142762
- Testing
- ABI-H2158, Itraconazole, Rifampin
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assembly Biosciences
Non-erosive Reflux Disease(NERD)
Clinical Trial to Evaluate the Efficacy and Safety of EsoDuo Tab. 20/800mg
To Evaluate the Efficacy and Safety of EsoDuo Tab. 20/800mg
- Trial name
- NCT03928470
- Testing
- EsoDuo Tab. 20/800mg
- Where
- 38 sites in South Korea
- Volunteers
- 379 people
- Sponsor
- Chong Kun Dang Pharmaceutical