Clinical trials: Esomeprazole
Psoriasis
Proton Pump Inhibitors Use in Patients With Psoriasis
Proton pump inhibitors act in blocking acid secretion and also have antioxidant and anti-inflammatory properties. For that mechanisms possibly PPIs may have an anti-inflammatory action with improvement in skin lesions in patients…
- Trial name
- NCT02624544
- Testing
- esomeprazole, desonide
- Sponsor
- EMS
Helicobacter Pylori Infection, Traditional Chinese Medicine
Eradication of Helicobacter Pylori With Bismuth Agent Quadruple and Traditional Chinese Medicine
This study is a prospective randomized case-control study. Six hundred patients who were firstly diagnosed as Helicobacter pylori infection will be selected, and then randomly assigned into case group and control group.
- Conditions
- Helicobacter Pylori Infection, Traditional Chinese Medicine, Eradication
- Trial name
- NCT05586464
- Testing
- Ban xia xie xin Decoction and bismuth quadruplicate group, Bismuth quadruplicate group
- Volunteers
- 600 people
- Sponsor
- Liaocheng People's Hospital
Adverse Drug Events, Adverse Drug Reactions
YouScript IMPACT Registry
This multicenter observational study aims to investigate the benefits of providing pharmacogenetic testing with the YouScript Personalized Prescribing System which includes a clinical decision support tool and individualized…
- Conditions
- Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation, Drug Metabolism, Poor, CYP2D6-RELATED
- Trial name
- IMPACT (NCT02191358)
- Where
- 7 sites in United States
- Volunteers
- 800 people
- Sponsor
- Genelex Corporation
Erosive Esophagitis, GERD
Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Erosive Esophagitis
The purpose of this study is to investigate the optimal dose and administration methods of CJ-12420 in patients with erosive esophagitis by comparing the safety and efficacy of orally administered CJ-12420 to esomeprazole 40mg.
- Trial name
- NCT02028663
- Testing
- CJ-12420, Esomeprazole
- Where
- South Korea
- Volunteers
- 206 people
- Sponsor
- HK inno.N Corporation
Helicobacter Pylori Infection
Recurrence Rate Comparison Between Esomeprazole and Lansoprazole in Eradicating Helicobacter Pylori Infection Among Children
This study aims to compare the recurrence rates of Esomeprazole and Lansoprazole in triple combination therapy to eradicate H.pylori infection in children.
- Trial name
- NCT05861687
- Testing
- Esomeprazole, Lansoprazole, Amoxicillin
- Where
- 2 sites in Indonesia
- Volunteers
- 51 people
- Sponsor
- Finni Kollins
Achlorhydria
Study to Evaluate Effects of Food or Proton Pump Inhibitor on the Pharmacokinetics of Itraconazole in Healthy Volunteers
The aim of this study is to evaluate the effects of food or proton pump inhibitor on the pharmacokinetics of itraconazole in healthy volunteers.
- Trial name
- NCT04942652
- Testing
- Itraconazole 200 mg, Esomeprazole 40 mg
- Where
- South Korea
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Vonoprazan, Helicobacter Pylori Infection
A RCT of the Efficacy of Vonoprazan 20mg QD in the Treatment of Helicobacter Pylori Infection
The treatment of helicobacter pylori is very important. The routine treatment is quadruple therapy. In recent years, double therapy has appeared and the curative effect is fair.
- Conditions
- Vonoprazan, Helicobacter Pylori Infection, Proton Pump Inhibitor
- Trial name
- VATH-1 (NCT05590286)
- Testing
- Vonoprazan Tablets, Amoxicillin Capsules, Esomeprazole
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou
Helicobacter Pylori Infection
Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection
This prospective non-interventional study is being conducted as part of the EU4Health project Eurohelican. The main goal of this pilot study is to evaluate the feasibility and acceptability of implementing the proposed…
- Trial name
- NCT06216639
- Testing
- Bismuth Subcitrate, Esomeprazole, Metronidazole
- Where
- Slovenia
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Public Health, Slovenia
Healthy Volunteer, Pharmacokinetics
Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose Combination
This is a Phase 1, open-label, three-part, study in approximately 96 healthy adult participants between 18 and 55 years of age (both inclusive) (16 participants in Part 1, 20 participants in Part 2 and , and approximately 60…
- Conditions
- Healthy Volunteer, Pharmacokinetics, Safety, Drug-Drug Interaction (DDI)
- Trial name
- NCT06733675
- Testing
- Ledaborbactam etzadroxil, Ceftibuten, Ceftibuten-ledaborbactam etzadroxil
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Healthy Participants
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of INCB160058 When Administered Orally to Healthy Adult Participant
This study is being conducted to assess the Safety, Tolerability, and Pharmacokinetics of INCB160058 When Administered Orally to Healthy Adult Participants.
- Trial name
- NCT06213818
- Testing
- INCB160058, Esomeprazole, Famotidine
- Where
- Australia
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Incyte Corporation
Helicobacter Pylori Infection
High Dose of Dual Therapy Plus Metronidazole for Helicobacter Pylori RescueTreatment
Dual therapy containing high dose of proton pump inhibitor (PPI) and amoxicillin had showed excellent eradication results with Helicobacter pylori first-line treatment.
- Trial name
- NCT04024527
- Testing
- Esomeprazole, Amoxicillin, Metronidazole
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Gastroesophageal Reflux Disease
A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)
The purpose of the study is to evaluate efficacy and safety of arbaclofen placarbil (XP19986) versus placebo as adjunctive therapy in subjects with troublesome GERD symptoms despite therapy with approved doses of a Proton Pump…
- Trial name
- NCT00978016
- Testing
- arbaclofen placarbil-Cohort 1, arbaclofen placarbil-Cohort 2, arbaclofen placarbil-Cohort 3
- Where
- 64 sites in United States, Canada
- Volunteers
- 460 people
- Sponsor
- XenoPort, Inc.
Healthy, Pharmacokinetics
Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety
The objectives of this study were (a) to evaluate the pharmacokinetics and to evaluate and compare the pharmacodynamics of ilaprazole and esomeprazole following a single dose (Day 1) and once daily (QD) administration for 5…
- Conditions
- Healthy, Pharmacokinetics, Pharmacodynamics, Ilaprazole
- Trial name
- NCT01820143
- Testing
- Ilaprazole, Esomeprazole
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Treatment of Helicobacter Pylori
Quadruple Therapy for Triple Therapy Resistant Helicobacter Pylori Infection
Triple therapy, a combination of proton pump inhibitor with two antibiotics, is the gold standard for anti-Helicobacter pylori treatment.
- Trial name
- QT-Hp (NCT00520949)
- Testing
- Augmentin (Amoxicillin-clavulanic), Furoxone (furazolidone), Cebes (colloidal bismuth subcitrate)
- Where
- Pakistan
- Volunteers
- 176 people
- Sponsor
- Aga Khan University
Liver Cirrhosis
Predicting Response and Exposure Changes in Cirrhosis for Effectiveness
The goal of this clinical trial is to learn how liver cirrhosis affects the way the body processes drugs in adults with different stages of liver cirrhosis.
- Trial name
- PRECISE (NCT07750587)
- Testing
- Five-Drug CYP Probe Cocktail
- Volunteers
- 45 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Healthy
Bioequivalence Study of Torrent Pharmaceutical Ltd's Esomeprazole Magnesium Delayed Release Capsules
Subjects to compare the single dose bioavailability of Torrent's Esomeprazole Delayed Release Capsule 1 × 40 mg and Nexium 1× 40 mg of AastraZeneca LP, USA. Dosing periods of studies were separated by a washout period of 7 days.
- Trial name
- NCT02680132
- Testing
- Nexium 40 mg DR Capsules of AstraZeneca LP, USA, Torrent's Esomeprazole Magnesium DR Capsules 40 mg
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Torrent Pharmaceuticals Limited
Helicobacter Pylori Infection
Minocycline for Helicobacter Pylori Rescue Treatment
Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy.
- Trial name
- NCT06332599
- Testing
- BQT, PBM4M4, PBM3M3
- Where
- China
- Volunteers
- 823 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Peptic Ulcer
AGN 201904 Versus Esomeprazole in the Prevention of Aspirin-induced Stomach or Upper Intestinal Damage in Healthy Volunteers
AGN 201904, a proton pump inhibitor, versus esomeprazole in the prevention of stomach or upper intestinal damage following administration of high-dose aspirin in healthy volunteers
- Trial name
- NCT00325715
- Testing
- AGN 201904, esomeprazole
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Allergan
Healthy
Effect of Tegoprazan on Pharmacodynamics of Clopidogrel in Healthy Subjects
This study aims to evaluate the effects of tegoprazan or esomeprazole administered in combination with clopidogrel on the pharmacodynamics/Pharmacokinetics of clopidogrel in healthy adults
- Trial name
- NCT06164834
- Testing
- Clopidogrel 75 mg, Tegoprazan 25 mg, Esomeprazole 20mg
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Functional Dyspepsia, Peptic Ulcer
Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori
The purpose of this study is to observe the efficacy of ten day triple therapy-based, bismuth-containing quadruple therapy for H.pylori treatment.
- Conditions
- Functional Dyspepsia, Peptic Ulcer, Helicobacter Pylori
- Trial name
- NCT01667575
- Testing
- Esomeprazole, Amoxicillin, Clarithromycin
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine