Clinical trials: Esomeprazole
Chronic Cough Caused by Gastroesophageal Reflux
Efficacy of Proton Pump Inhibitor for Chronic Cough Caused by Gastroesophageal Reflux; Double-blind, Placebo-controlled, Randomized Clinical Trial
Efficacy of proton pump inhibitor for chronic cough caused by gastroesophageal reflux; double-blind, placebo-controlled, randomized clinical trial
- Trial name
- NCT01888549
- Testing
- High-dose PPI, standard PPI
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yonsei University
Gram-Negative Bacterial Infections, Helicobacter Infections
Efficacy and Safety Study of Finafloxacin Used in Helicobacter Pylori Infected Patients
The primary objective of this study is to compare the H. pylori eradication rates with Finafloxacin in combination with Amoxicillin or Esomeprazole.
- Conditions
- Gram-Negative Bacterial Infections, Helicobacter Infections, Dyspepsia
- Trial name
- FLASH (NCT00723502)
- Testing
- Finafloxacin + Amoxicillin, Finafloxacin + Esomeprazole
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- MerLion Pharmaceuticals GmbH
GERD
Twenty-Four Hour Combined Multi-Channel Impedance and pH Ambulatory Monitoring: Impedance Reflux Episodes of Patients On and Off Proton Pump Inhibitor Therapy
The purpose of this study is to determine the effects of proton pump inhibitors (PPIs) on the total number of reflux episodes in the distal esophagus measured by impedance in patients with and without gastroesophageal reflux…
- Trial name
- NCT01710800
- Testing
- Esomeprazole
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
GERD
Open, Randomized, Two Way Crossover 40mg, Orally and Intravenously
This study looks at the effect on basal and pentagastrin-stimulated acid output of 40 mg Esomeprazole (Nexium) administered orally and intravenously as a 15-minute infusion to people with symptoms of Gastroesophageal Reflux…
- Trial name
- NCT00635414
- Testing
- Esomeprazole
- Volunteers
- 60 people
- Sponsor
- AstraZeneca
Helicobacter Infection
The Efficacy of the 7 Days Tailored Therapy as the 1st Eradication of H. Pylori Infection
To compare the eradication success rate between 10-days sequential therapy and 7-days tailored therapy based on H. pylori culture and antimicrobial susceptibility testing.
- Trial name
- NCT02373280
- Testing
- 10 day sequential therapy (Esomeprazole, amoxicillin, clarithromycin, metronidazole), 7 day tailored PPI triple therapy (clarithromycin-containing triple therapy), 7 day moxifloxacin based triple therapy [Esomeprazole, Moxifloxacin, Amoxicillin]
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Helicobacter Eradication
Bismuth Quadruple Therapy Versus Modified Bismuth Therapy for Helicobacter Pylori
The primary objective of the study is to compare the efficacy of 2 different regimens of treatment of gastric bacteria (H pylori) these are: quadruple bismuth therapy and clarithromycin triple therapy with add-on bismuth, in…
- Trial name
- NCT07810985
- Testing
- Bismuth added on triple therapy, Quadruple therapy
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Reham Abdelkader Elkhouly
Helicobacter Infection
Comparison of Daily Single Dose Triple and Conventional Triple Therapies for Helicobacter Pylori Infection
This study is conducted to investigate whether the efficacy of single-dose triple therapy (Esomeprazole 40 mg, Tinidazole 1 g, and Levofluxacine 500 mg) for 14 days is superior to double-dose lansoprazole 30 mg, amoxicillin 1 g…
- Trial name
- NCT02711176
- Testing
- Nexium, Tinafas, Tavanex
- Where
- Iran
- Volunteers
- 212 people
- Sponsor
- Zahra Vahdat Shariatpanahi
Helicobacter Pylori
Optimized-dose Amoxicillin Versus Standard-dose Amoxicillin for Quadruple Therapy in Helicobacter Pylori Eradication
The goal of this prospective randomized clinical trial is to compare the rate of Helicobacter Pylori (HP) eradication after standard or dose-optimized amoxicillin quadritherapy in patients naïve to any anti-HP treatment and with…
- Trial name
- Helicomatri (NCT05635942)
- Testing
- optimized quadruple therapy, standard quadruple therapy
- Where
- Tunisia
- Volunteers
- 88 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Upper Gastrointestinal Bleeding
A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy
A bleeding peptic ulcer remains a serious medical problem with significant morbidity and mortality. Endoscopic therapy significantly reduces further bleeding, surgery, and mortality in patients with bleeding peptic ulcers and is…
- Trial name
- NCT01275937
- Testing
- Esomeprazole
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Taipei Medical University
Healthy
Study Evaluating Effect of Esomeprazole, Omeprazole or Lansoprazole on the Pharmacodynamics (PD) and Pharmacokinetics (PK) of Clopidogrel
The aim of this study is to determine if there is a pharmacological interaction between clopidogrel and different types of proton pump inhibitors (PPIs), and if the extent of this possible interaction would change over time.
- Trial name
- NCT01147588
- Testing
- lansoprazole, omeprazole, esomeprazole
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Gastroesophageal Reflux
Validation of RDQ Questionnaire
The primary objective of this study is to determine the accuracy of the Reflux Disease Questionnaire (RDQ) as a diagnostic test for gastroesophageal reflux disease.
- Trial name
- NCT00291746
- Testing
- Esomeprazole, Bravo technique
- Where
- 30 sites in Canada, Denmark and 4 more
- Volunteers
- 350 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Local Phase IV, Gastroesophageal Reflux Disease (GERD) Sleep Study US
The purpose of this research study is to compare the safety and effectiveness (how well the medicine works) of esomeprazole (study drug) to placebo (a capsule that does not contain any medication) taken daily in relieving…
- Trial name
- NCT00660660
- Testing
- Esomeprazole
- Where
- 45 sites in United States
- Volunteers
- 276 people
- Sponsor
- AstraZeneca
Helicobacter Pylori Infection
High Dose of Dual Therapy Plus Metronidazole for Helicobacter Pylori RescueTreatment
Dual therapy containing high dose of proton pump inhibitor (PPI) and amoxicillin had showed excellent eradication results with Helicobacter pylori first-line treatment.
- Trial name
- NCT04024527
- Testing
- Esomeprazole, Amoxicillin, Metronidazole
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Healthy
A Study in Healthy Men to Test Whether Esomeprazole Influences the Amount of BI 3000202 in the Blood
The main objective of this trial is to investigate the effect of the proton pump inhibitor esomeprazole on the pharmacokinetics of BI 3000202 in plasma.
- Trial name
- NCT06419660
- Testing
- BI 300202, esomeprazole
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Total Knee Replacement, Manipulation
Efficacy and Safety of Chuna Manual Treatment as an Adjunctive Therapy After Total Knee Arthroplasty: A Study Protocol for a Single-Center, Randomized, Assessor Blind, Parallel-Group Clinical Trial
Evaluate the efficacy and safety of Chuna treatment as an adjunctive therapy in patients with moderate pain following total knee replacement.
- Trial name
- NCT03625050
- Testing
- Chuna + Usual care(Celecoxib and esomeprazole), Usual care(Celecoxib and esomeprazole)
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Gachon University Gil Oriental Medical Hospital
Healthy
A Study of the Effects of Multiple Doses of Dexlansoprazole, Lansoprazole, Omeprazole or Esomeprazole on the Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Participants.
The purpose of this study is to assess the potential effect and safety of multiple oral doses of dexlansoprazole, lansoprazole, omeprazole or esomeprazole, once daily (QD), on the steady-state pharmacokinetics and…
- Trial name
- NCT00942175
- Testing
- Clopidogrel, Clopidogrel and Lansoprazole, Clopidogrel and Dexlansoprazole
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Takeda
Healthy
A Study to Evaluate the Effects of Food and Esomeprazole on the Pharmacokinetics of Crizotinib in a Coated Microsphere Formulation.
This study will estimate the effect of food and the proton pump inhibitor, esomeprazole on the pharmacokinetics of crizotinib in a coated microsphere formulation.
- Trial name
- NCT03137134
- Testing
- Crizotinib, Esomeprazole
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Reflux Esophagitis, Gastric Ulcer
A Study of Esomeplazole (D961H) in Japanese Paediatric Patients With Reflux Esophagitis, Gastric Ulcer or Duodenal Ulcer
This is an open label, parallel group, multi-centre, phase III study to assess the safety and efficacy of D961H in maintenance therapy following initial healing therapy in Japanese paediatric patients with reflux esophagitis, and…
- Conditions
- Reflux Esophagitis, Gastric Ulcer, Duodenal Ulcer
- Trial name
- NCT03553563
- Testing
- D961H capsule 10mg, D961H sachet 10mg
- Where
- 15 sites in Japan
- Volunteers
- 50 people
- Sponsor
- AstraZeneca
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes
A Study to Learn How a Proton Pump Inhibitor Affects the Way Elinzanetant (BAY 3427080) Moves Into, Through and Out of the Body, and How Much of it Gets Absorbed by the Body When Taken as a Single and Small Radioactive Dose in Healthy Adults
Researchers are looking for a better way to treat people who have vasomotor symptoms (VMS). VMS such as hot flashes are caused by hormonal changes occurring during menopausal transition when women may have also changes in their…
- Trial name
- NCT05061563
- Testing
- Elinzanetant (BAY3427080), Esomeprazole
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bayer
Arthritis
A Pharmacokinetic (PK) Study Evaluating Naproxen and Esomeprazole Plasma Levels
A pharmacokinetic study evaluating naproxen and esomeprazole blood levels in 4 treatments, each containing one or both components.
- Trial name
- NCT00749385
- Testing
- PN 400, EC naproxen plus EC esomeprazole, EC naproxen
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- POZEN