Clinical trials: Esomeprazole
Osteoarthritis
Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis
Naxozol is a combination product of naproxen, a non-steroidal anti-inflammatory drug (NSAID) and esomeprazole, a proton pump inhibitor which is designed to improve symptoms and reduce risk of gastric ulcers in patients at risk of…
- Trial name
- NCT02355236
- Testing
- Naproxen/Esomeprazol 500/20mg, Celecoxib 200mg
- Where
- 10 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- Severance Hospital
Gastroesophageal Reflux
Comparison of Vonoprazan to Esomeprazole in Participants With Symptomatic GERD Who Responded Partially to a High Dose of Proton Pump Inhibitor (PPI)
The purpose of this study is to determine the effect of vonoprazan compared to esomeprazole for preventing heartburn symptoms over a 4-week treatment period in participants who have a partial response to treatment with…
- Trial name
- NCT02743949
- Testing
- Vonoprazan, Esomeprazole
- Where
- 39 sites in Belgium, Bulgaria and 4 more
- Volunteers
- 256 people
- Sponsor
- Takeda
Acute Coronary Syndrome, Acute Myocardial Infarction
Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease
Aspirin and clopidogrel +/- heparin or thrombolytic co-therapy is well established and effective treatment for unstable cardiac patients. However, the major complication was gastrointestinal bleeding (GIB) due to peptic ulcer.
- Trial name
- NCT00683111
- Testing
- esomeprazole 20 mg daily, famotidine 40 mg daily
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruttonjee Hospital
Chest Pain, Gastroesophageal Reflux
Chest Pain Pilot Study
The purpose of this study is to compare the efficacy of Nexium® with placebo in relief of acid related pain or discomfort in the chest.
- Trial name
- NCT00251901
- Testing
- Esomeprazole
- Where
- 80 sites in Canada, Denmark and 4 more
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Non-steroidal Anti-inflammatory Drug Adverse Reaction
Research for Prevention and Treatment of NSAIDs Related Gastrointestinal Side Effects
We aim to evaluate the protective effects of eradication of HP and continue using Geranylgeranylacetone (GGA) on NSAIDs related gastroenterological lesions.
- Trial name
- NCT01547559
- Testing
- part1:teprenone, part1:EAC-T, part1:EA-EMC-T
- Where
- 2 sites in China
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Reflux Esophagitis (RE)
A Phase III Clinical Trial for Efficacy and Safety Evaluation of JP-1366 Tablets on Reflux Esophagitis
To evaluate the efficacy and safety of JP-1366 tablets and Nexium® (Esomeprazole magnesium enteric-coated tablets) in subjects with reflux esophagitis.
- Trial name
- NCT06850480
- Testing
- JP-1366 simulation tablets, Esomeprazole Magnesium (Nexium) simulation tablets
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Helicobacter Pylori
Keverprazan Combined With Amoxicillin for the Treatment of Helicobacter Pylori
The objective of this clinical trial is to determine whether the interventional behavioral drug Keverprazan in combined with amoxicillin, is effective in treating initial Helicobacter pylori infections in adults and to assess the…
- Trial name
- NCT06851468
- Testing
- Keverprazan, Esomeprazole, Amoxicillin
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Key Laboratory for Gastrointestinal Diseases of Gansu Province
Osteoporosis
The Effect of Protein on Calcium Absorption and Gastric Acid Production
We have established that dietary protein is an important regulator of intestinal calcium absorption in humans. However, we do not understand the mechanism by which dietary protein is affecting calcium absorption.
- Trial name
- NCT00719160
- Testing
- esomeprazole
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Yale University
Helicobacter Pylori Infection
Community-based Helicobacter Pylori Eradication
Based on a universal eradication of H. pylori in an offshore island (Matsu) with a high prevalence of gastric cancer as well as premalignant gastric lesion, we first examined the infection rate of H. pylori.
- Trial name
- NCT00155389
- Testing
- Helicobacter pylori eradication
- Where
- 2 sites in Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy
YH4808 Postprandial PK/PD Study in Healthy Subjects
A clinical Study to evaluate the safety and pharmacokinetics/pharmacodynamics(PK/PD) of YH4808 after repeated Oral administration and Postprandial state in healthy volunteers
- Trial name
- NCT01761513
- Testing
- YH4808
- Where
- South Korea
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Arthritis, Cardiovascular Diseases
Celecoxib Versus Naproxen for Prevention of Recurrent Ulcer Bleeding in Arthritis Patients
The aim of this study is to compare celecoxib plus a PPI (esomeprazole) versus naproxen plus a PPI (esomeprazole) in preventing recurrent ulcer bleeding in arthritis patients with a history of ulcer bleeding who require…
- Conditions
- Arthritis, Cardiovascular Diseases, Cerebrovascular Disorders
- Trial name
- NCT00153660
- Testing
- Celecoxib(drug), Naproxen(drug)
- Where
- China
- Volunteers
- 514 people
- Sponsor
- Chinese University of Hong Kong
Hiatal Hernia, Hiatal Hernia With Gastroesophageal Reflux Disease
Complications of Laparoscopic Hiatal Hernia Repair Complicated by Gastroesophageal Reflux Disease Using the ERAS Protocol
Nissen fundoplication with cruroraphy performed according to ERAS protocols in patients with HH complicated by GERD.
- Trial name
- hiatal hernia (NCT07138235)
- Testing
- laparoscopic hiatal hernia repair
- Volunteers
- 106 people
- Sponsor
- Osh State University
NSAID Induced Gastropathy
Randomized Double-Blind Clinical Trial of Rebamipide vs Esomeprazole in the Treatment of NSAID-induced Gastropathy
Primary objective: To determine the levels of malondialdehyde (MDA) and immunohistochemistry surrogate of inflammation in patients with NSAID-induced gastric mucosal injury treated with Rebamipide 3x a day vs Esomeprazole 40mg…
- Trial name
- NCT00641004
- Testing
- Rebamipide and Esomeprazole
- Where
- 4 sites in Philippines
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical, Inc., Philippines
Neoplasms, Breast
A Study to Examine the Effects of Esomeprazole on the Pharmacokinetics of Orally Administered Lapatinib in Subjects With Metastatic ErbB2 Positive Breast Cancer
This study will characterize the effect of elevated gastric pH mediated by the proton-pump inhibitor, esomeprazole, on the relative bioavailability of lapatinib in subjects with metastatic ErbB2 positive breast cancer.
- Trial name
- NCT00849329
- Testing
- lapatinib, lapatinib plus esomeprazole
- Where
- 4 sites in United States, South Korea and 1 more
- Volunteers
- 12 people
- Sponsor
- GlaxoSmithKline
Dysphagia, GERD
Whether Proton Pump Inhibitors, Administered Prior to or After Surgery, Can Reduce the Incidence and/or Severity of Difficulty Swallowing Foods and/or Liquids,Following Anterior Cervical Surgery
The researchers wish to investigate whether proton pump inhibitors, administered prior to or after surgery, can reduce the incidence and/or severity of difficulty swallowing foods and/or liquids,following anterior cervical…
- Conditions
- Dysphagia, GERD, Degenerative Joint Disease
- Trial name
- NCT03488147
- Testing
- Esomeprazole
- Where
- 2 sites in United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Helicobacter Pylori Infection Chronic Gastrit
Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial Treatment
The purpose of this study was to evaluate the efficacy and safety of tegoprazan and minocycline dual therapy for Helicobacter pylori initial treatment.
- Trial name
- NCT06523764
- Testing
- tegoprazan, Minocycline, bismuth potassium citrate
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Xijing Hospital of Digestive Diseases
GERD
Gastroesophageal Reflux Disease (GERD)/Nighttime Heartburn and Driving Performance
The implications of sleep as it relates to the physiology and pathogenesis of a number of diseases has until recently been ignored.
- Trial name
- NCT01079884
- Testing
- esomeprazole 40 mg
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- David A. Johnson, MD
Healthy
Study of Intragastric pH Profile After 5 Days Pantoprazole 40 mg iv Followed by Oral Esomeprazole 40 mg po or Oral Pantoprazole 40 mg po
This Phase IV study is intended to compare intragastric acid suppression of oral esomeprazole (NEXIUM ® Delayed-Release Capsules) with that of oral pantoprazole (PROTONIX ® Delayed Release Tablets ), in subjects who continue to…
- Trial name
- NCT00206050
- Testing
- Esomeprazole, pantoprazole
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Helicobacter Pylori Infection
Efficacies of Two Bismuth Quadruple Therapies in the Second-line Treatment of H Pylori Infection
From the profiles of antibiotic susceptibility data following eradication therapy, tetracycline, amoxicillin and levofloxacin are all good candidates of antibiotics used in the rescue treatment.
- Trial name
- NCT03779087
- Testing
- 10d TL quadruple therapy, 10d AL quadruple therapy
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Ping-I (William) Hsu, M.D.
Obesity, Gastric Reflux
The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass
The objective of this study is to investigate the effect of Esomeprazol administered in tablets (Esomeprazol MUT Sandoz® 40mg) or in solution (Esomeprazol MUT Sandoz® 40mg in 10ml tap water) on acid production in the gastric…
- Conditions
- Obesity, Gastric Reflux, Ulcer, Gastric
- Trial name
- NCT05320796
- Testing
- upper endoscopy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Prof Urs Zingg