Clinical trials: Esomeprazole
Obesity
The ESG Integrity Study: Effect of Proton Pump Inhibitors on the Structural Integrity of Endoscopic Sleeve Gastroplasty
The study is a single center randomized, open-label, phase IV clinical trial. Obese patients who have indication to Endoscopic sleeve gastroplasty (ESG) for clinical reasons are included and ESG is performed as per clinical…
- Trial name
- ESGIS (NCT06283381)
- Testing
- Esomeprazole
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Helicobacter Pylori Infection
Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection
This prospective non-interventional study is being conducted as part of the EU4Health project Eurohelican. The main goal of this pilot study is to evaluate the feasibility and acceptability of implementing the proposed…
- Trial name
- NCT06216639
- Testing
- Bismuth Subcitrate, Esomeprazole, Metronidazole
- Where
- Slovenia
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Public Health, Slovenia
Gastrointestinal Diseases
Bioequivalence Study of Esomeprazole 20 Milligram (mg) Delayed-Release Capsules in Healthy Adult Participants
The purpose of this study is to evaluate bioequivalence parameters of esomeprazole capsules 20 mg (test product) vs. esomeprazole capsules 20 mg (reference product) under fasted conditions.
- Trial name
- NCT05265247
- Testing
- Esomeprazole 20 mg Delayed-Release Capsules, Esomeprazole 20 mg Delayed-Release Capsules (Nexium 24HR)
- Where
- Canada
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- HALEON
Healthy Subjects
Esomeprazole Magnesium Dihydrate 40 mg Tablets Relative to Nexium 40 mg Tablets Under Fasting Condition
The study is to compare the rate and extent of absorption of a generic formulation with that of a reference for mulation when given as equal labeled dose.
- Trial name
- NCT06233097
- Testing
- Esomeprazole magnesium dihydrate-Test product, Esomeprazole magnesium dihydrate-Reference product
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bio-innova Co., Ltd
Healthy Subjects
Esomeprazole Magnesium Dihydrate 40 mg Tablets Relative to Nexium 40 mg Tablets Under Fed Condition
The study is to compare the rate and extent of absorption of a generic formulation with that of a reference for mulation when given as equal labeled dose.
- Trial name
- NCT06233149
- Testing
- Esomeprazole magnesium dihydrate-Test product, Esomeprazole magnesium dihydrate-Reference product
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bio-innova Co., Ltd
Sepsis, Septic Shock
Esomeprazole to Reduce Organ Failure in Sepsis
Sepsis is a severe disease with a high mortality rate and lack of efficacious therapies. Proton pump inhibitors (PPI) are drugs widely used to inhibit acid secretion by gastric cells and with a high safety profile.
- Trial name
- PPI-SEPSIS (NCT03452865)
- Testing
- Esomeprazole
- Where
- 17 sites in Italy, Kazakhstan and 1 more
- Volunteers
- 300 people
- Sponsor
- Università Vita-Salute San Raffaele
Healthy
A Study Comparing Different Formulations of LY3410738 in Healthy Adult Participants
The main purpose of study is to compare different formulations of LY3410738 under fasting condition by looking at the amount of the study drug, LY3410738, that gets into the blood stream and how long it takes the body to get rid…
- Trial name
- NCT06181084
- Testing
- LY3410738, Esomeprazole
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy
Effect of Tegoprazan on Pharmacodynamics of Clopidogrel in Healthy Subjects
This study aims to evaluate the effects of tegoprazan or esomeprazole administered in combination with clopidogrel on the pharmacodynamics/Pharmacokinetics of clopidogrel in healthy adults
- Trial name
- NCT06164834
- Testing
- Clopidogrel 75 mg, Tegoprazan 25 mg, Esomeprazole 20mg
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Helicobacter Pylori Infection
Efficacies of Two Bismuth Quadruple Therapies in the Second-line Treatment of H Pylori Infection
From the profiles of antibiotic susceptibility data following eradication therapy, tetracycline, amoxicillin and levofloxacin are all good candidates of antibiotics used in the rescue treatment.
- Trial name
- NCT03779087
- Testing
- 10d TL quadruple therapy, 10d AL quadruple therapy
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Ping-I (William) Hsu, M.D.
Helicobacter Pylori Eradication
Potassium Copetitive Acid Blockers Efficacy in H.Pylori Eradication
This trial assessed the efficacy of potassium competetor acid blocker (P-CAB) in the eradication of H.pylori
- Trial name
- P-CABs (NCT06101420)
- Testing
- Vonoprazan
- Where
- Egypt
- Volunteers
- 232 people
- Sponsor
- Ain Shams University
Healthy Subjects
A Study of IBI351 in Healthy Subjects
This is a randomized, open-label, two-cycle clinical study to evaluate the drug interaction, food effect and pharmacokinetics of IBI351 and esomeprazole in healthy subjects.
- Trial name
- NCT05688124
- Testing
- IBI351, Esomeprazole
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Helicobacter Pylori Infection, Helicobacter Pylori Eradication
Efficacy of Amoxicillin-Esomeprazole HDDT Compared to Levofloxacin Triple Therapy for H. Pylori Eradication: A RCT
The goal of this clinical trial is to compare the efficacy of two different therapeutic regimen for the treatment of Helicobacter pylori infected dyspeptic patients. The aim is - 1. To identify the percentage of H.
- Trial name
- NCT06088316
- Testing
- group A : Amoxicillin Esomeprazole HDDT, group-B : Levofloxacin triple therapy
- Where
- Bangladesh
- Volunteers
- 70 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Helicobacter Pylori Infection
Levofloxacin Concomitant Versus Levofloxacin Sequential
The goal of this trial is to determine the efficacy of levofloxacin based sequential treatment regimen or concomitant levofloxacin based regimens as empirical first-line therapy in the Syrian population
- Trial name
- NCT06065267
- Testing
- sequential, Levofloxacin 500Mg Oral Tablet
- Where
- Syria
- Volunteers
- 150 people
- Sponsor
- Damascus Hospital
Upper Gastrointestinal Hemorrhage
Efficacy of Proton Pump Inhibitors in Cirrhotic Patients With Acute Variceal Bleeding
Acute Variceal Bleeding (AVB) in patients with liver cirrhosis is a common clinical critical disease. There is little evidence for the effect of proton pump inhibitor (PPI) use in patients with AVB, and there is no study on the…
- Trial name
- NCT05624229
- Testing
- Proton Pump Inhibitors, No Proton Pump Inhibitors
- Volunteers
- 672 people
- Sponsor
- West China Hospital
Helicobacter Pylori
A Study to Evaluate the Efficacy and Safety of Bismuth-Containing Quadruple Therapy With Oral Vonoprazan (TAK-438) 20 mg Compared to Esomeprazole 20 mg Twice Daily in Paticipants With Helicobacter Pylori Infection
The purpose of this study is to evaluate the efficacy of helicobacter pylori (HP) eradication with bismuth-containing quadruple therapy with vonoprazan versus esomeprazole in all HP-positive participants.
- Trial name
- NCT04198363
- Testing
- Vonoprazan, Amoxicillin, Clarithromycin
- Where
- 29 sites in China
- Volunteers
- 510 people
- Sponsor
- Takeda
Helicobacter Pylori
A Study of Vonoprazan in Adults With Helicobacter Pylori
Helicobacter Pylori (H Pylori) is a bug found in the digestive system. It can cause soreness and redness in the stomach (gastritis). It can also cause ulcers in the stomach and other parts of the digestive system.
- Trial name
- NCT04753437
- Testing
- Clarithromycin, Amoxicillin, Bismuth potassium citrate
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Takeda
Healthy Volunteers
A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy Participants
The primary purpose of this study is to assess the effects of rifampin on the PK of brensocatib in Part 1 of the study and to assess the effects of esomeprazole on the PK of brensocatib in Part 2 of the study.
- Trial name
- NCT05826574
- Testing
- Brensocatib, Rifampin, Esomeprazole
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Insmed Incorporated
Gastroesophageal Reflux Disease
A Study to Evaluate the Efficacy and Safety of Tegoprazan in GERD Patients With Nighttime Heartburn
This study aims to compare the nighttime heartburn improvement effect of Tegoprazan 50mg and Esomeprazole 40mg(or 20mg) in patients with GERD.
- Trial name
- NCT05701540
- Testing
- Tegoprazan, Esomeprazole
- Where
- South Korea
- Volunteers
- 338 people
- Sponsor
- HK inno.N Corporation
Helicobacter Pylori Infection
Comparison of Two Dual Therapies in the First-line Treatment of Helicobacter Pylori Infection （SHARE2301）
Helicobacter pylori (H. pylori) infection is a common global infectious disease of the gastrointestinal tract. Helicobacter pylori eradication can effectively prevent the development of stomach cancer.
- Trial name
- NCT05870683
- Testing
- Tegoprazan, Amoxicillin, Esomeprazole
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Yanqing Li
Stomach Diseases
PROGRESSive Withdrawal Esomeprazole and Acid-related Symptoms
Rebound acid hypersecretion (RAHS), defined as an increase in gastric acid secretion above pre-treatment levels after PPIs therapy is observed within two weeks after withdrawal of treatment and could theoretically lead to…
- Trial name
- PROGRESS (NCT02476097)
- Testing
- Esomeprazole: Nexium® 20mg, Astra Zeneca, CYP2C19 phenotypical analysis
- Where
- 2 sites in Switzerland
- Volunteers
- 58 people
- Sponsor
- Victoria Rollason