Clinical trials: Esomeprazole
ECL-cell Hyperplasia, Parietal-cell Hyperplasia
Effect of Netazepide on Omeprazole-induced Changes in Chromogranin A and Gastrin
Hypergastrinaemia induced by proton pump inhibitor (PPI) treatment is reported to cause ECL-cell and parietal-cell hyperplasia, and rebound hyperacidity and dyspepsia after PPI withdrawal.
- Conditions
- ECL-cell Hyperplasia, Parietal-cell Hyperplasia, Rebound Hyperacidity, Dyspepsia
- Trial name
- NCT02620696
- Testing
- netazepide
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Trio Medicines Ltd.
GERD
Clinical Trial to Evaluate the Safety and Efficacy of JP-1366 in Patients With Erosive Gastroesophageal Reflux Disease
Clinical trial to evaluate the safety and efficacy of JP-1366 in patients with erosive gastroesophageal reflux disease
- Trial name
- NCT04282954
- Testing
- JP-1366, Esomeprazole 40mg
- Where
- South Korea
- Volunteers
- 188 people
- Sponsor
- Onconic Therapeutics Inc.
Early Gastric Cancer, Gastric Dysplasia
Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing
Endoscopic submucosal dissection (ESD) is an established treatment for early gastric cancer and precancerous lesions. Post-ESD artificial ulcers may lead to complications including delayed bleeding (3-15%) and prolonged healing.
- Conditions
- Early Gastric Cancer, Gastric Dysplasia, Gastric Neoplasms, Peptic Ulcer With Haemorrhage
- Trial name
- NCT07312370
- Testing
- Esomeprazole (Intravenous), Esomeprazole (Oral), Sucralfate Suspension
- Where
- China
- Volunteers
- 120 people
- Sponsor
- LanZhou University
Gastric (Stomach) Cancer
Eradication of Helicobacter Pylori Subtypes at High Gastric Cancer Risk: a Cluster-randomized Controlled Trial
This study is a prospective, multicenter cluster randomized controlled trial. Additional fecal screening for high-risk SNP subtypes, in conjunction with routine Hp testing, may improve the identification of individuals at high…
- Trial name
- NCT06943794
- Testing
- recommendations for Hp eradication treatment
- Where
- China
- Volunteers
- 4,824 people, healthy volunteers welcome
- Sponsor
- Fudan University
Gastroesophageal Reflux, Heartburn
HEARD (Long Term) Study - Histology of the Esophagus in Acid-Related Disease
Determine if different levels of acid-suppression with esomeprazole for 6 months on chosen histological markers of esophageal epithelial acid-related disease in patients with upper GI symptoms.
- Conditions
- Gastroesophageal Reflux, Heartburn, Dyspepsia
- Trial name
- NCT00243724
- Testing
- Esomeprazole
- Where
- 10 sites in Canada
- Volunteers
- 350 people
- Sponsor
- AstraZeneca
Reflux, Esophagitis
The Effect of Nexium on Transmucosal Esophageal Leak
In a related study, the investigators have found evidence that patients with Barrett's esophagus have a leak for oral sucrose to leave their upper gastrointestinal tract, enter the blood, and be filtered into urine.
- Conditions
- Reflux, Esophagitis, Barrett's Esophagus
- Trial name
- NCT00216788
- Testing
- Esomeprazole (Nexium) 40 mg/day
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Main Line Health
Helicobacter Pylori Eradication
Effect of Probiotics on Helicobacter Pylori Eradication
The purpose of this clinical trial is to evaluate the clinical efficacy of Bifidobacterium quadruple live bacteria tablets (Si Lian Kang) on reducing the incidence rate of adverse reactions of Helicobacter pylori quadruple…
- Trial name
- NCT04034641
- Testing
- Bifidobacterium tetrad live bacteria tablet plus Helicobacter pylori quadruple eradication therapy
- Where
- 2 sites in China
- Volunteers
- 238 people
- Sponsor
- Hangzhou Grand Biologic Pharmaceutical, Inc.
Gastroesophageal Reflux Disease (GERD), Erosive Esophagitis
Esomeprazole for Treatment of GERD in Pediatric Patients
To look at the safety and improvement in symptoms of a once a day dosing of esomeprazole in children 1 to 11 years old with inflammation of their esophagus or food pipe ("esophagitis") caused by gastroesophageal reflux disease…
- Conditions
- Gastroesophageal Reflux Disease (GERD), Erosive Esophagitis, Non-erosive Esophagitis
- Trial name
- NCT00228527
- Testing
- Esomeprazole (Nexium)
- Where
- 36 sites in United States, Belgium and 2 more
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Helicobacter Pylori Infection
Recurrence Rate Comparison Between Esomeprazole and Lansoprazole in Eradicating Helicobacter Pylori Infection Among Children
This study aims to compare the recurrence rates of Esomeprazole and Lansoprazole in triple combination therapy to eradicate H.pylori infection in children.
- Trial name
- NCT05861687
- Testing
- Esomeprazole, Lansoprazole, Amoxicillin
- Where
- 2 sites in Indonesia
- Volunteers
- 51 people
- Sponsor
- Finni Kollins
Self Efficacy
Genotypic Resistance Guided Therapy in Helicobacter Pylori Eradication
We aimed to compare the efficacy of genotypic resistance guided sequential therapy vs. empiric therapy in the third line therapy.
- Trial name
- NCT01725906
- Testing
- empirical therapy, Genotypic resistance guided therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Gastroesophageal Reflux Disease, GERD
To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole
Administration of esomeprazole 20 mg to subjects who still had heartburn after receiving rabeprazole 10 mg once daily for at least 4 weeks will result in statistically significant improvement of heartburn after 8-week treatment.
- Conditions
- Gastroesophageal Reflux Disease, GERD, Reflux Esophagitis
- Trial name
- NCT01397084
- Testing
- esomeprazole 20 mg
- Volunteers
- 107 people
- Sponsor
- AstraZeneca
Gastrointestinal Disease, Signs and Symptoms, Digestive
Nexium Dyspepsia/AST
The aim is to evaluate if the resolution of upper abdominal symptoms (pain or burning) during an acid suppressive test trial of esomprazole given daily for 7 days predicts symptoms resolution at the end of a subsequent treatment…
- Conditions
- Gastrointestinal Disease, Signs and Symptoms, Digestive, Dyspepsia
- Trial name
- NCT00251992
- Testing
- Esomeprazole
- Where
- 183 sites in Austria, Belgium and 11 more
- Volunteers
- 1,200 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients
This study is designed to evaluate the efficacy and tolerability of ilaprazole relative to that of esomeprazole in healing erosive esophagitis and resolving accompanying symptoms of GERD.
- Trial name
- NCT01107938
- Testing
- 10 mg ilaprazole, 15 mg ilaprazole, 40 mg esomeprazole
- Volunteers
- 330 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Gastric Ulcer, Chronic Gastritis
Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy
This study aims at evaluating efficacy and safety of berberine- amoxicillin containing quadruple therapy(berberine, amoxicillin, esomeprazole and bismuth) versus tetracycline-furazolidone quadruple therapy (tetracycline…
- Conditions
- Gastric Ulcer, Chronic Gastritis, Gastric Cancer, Helicobacter Pylori Infection
- Trial name
- NCT03609892
- Testing
- Berberine, Amoxicillin, Esomeprazole
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Acute and Chronic Inflammation, Dyspepsia
Evaluation of Two Therapies for the Treatment of Osteoarticular Inflammation in Dyspeptic Patients
The purpose of this study is to evaluate the safety of an association with one anti-inflammatory and one gastroprotective agent compared to the one anti-inflammatory and one gastroprotective agent in patients with acute or…
- Trial name
- NCT01670552
- Testing
- Nimesulide + Pantoprazole, Naproxen + Esomeprazole
- Where
- Brazil
- Volunteers
- 490 people
- Sponsor
- EMS
Gastritis
A Multi-center Study for Eradication of Refractory Helicobacter Pylori
Recently studies showed that the eradication rate of H. pylori fail to exceed 80% and even falls into an unacceptable range. A major cause of treatment failure is associated with antibiotic resistance and poor patient compliance.
- Trial name
- NCT02741414
- Testing
- The result of H pylori culture based on gram staining and enzyme activity testing, The result of 13C-urea breath test after treatment based on the selection of clarithromycin, levofloxacin, metronidazole, amoxicillin，tetracycline，furazolidone and the dose of esomeprazole, The result of Amoxicillin resistance in vitro based on antibiotic susceptibility testing
- Where
- China
- Volunteers
- 4,428 people
- Sponsor
- Taizhou Hospital
Repeatedly Recurring Esophagitis, Relapsing Reflux Esophagitis
Nexium Capsules RE Maintenance Specific Clinical Experience Investigation
The purpose of this study is to collect following data in patients given Nexium capsule (Nexium) in usual post-marketing use as the maintenance therapy for repeatedly recurring/relapsing reflux oesophagitis.
- Trial name
- NCT01562639
- Where
- 46 sites in Japan
- Volunteers
- 647 people
- Sponsor
- AstraZeneca
Healthy
Safety/Tolerability and Pharmacokinetics/Pharmacodynamics of YH4808 After Oral Administration in Healthy Male Subjects
First in human study
- Trial name
- NCT01007019
- Testing
- YH4808 30mg, YH4808 50mg, YH4808 100mg
- Where
- South Korea
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Helicobacter Pylori Infection
Minocycline for Helicobacter Pylori Rescue Treatment
Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy.
- Trial name
- NCT06332599
- Testing
- BQT, PBM4M4, PBM3M3
- Where
- China
- Volunteers
- 823 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Functional Dyspepsia
Gastric Functions & Proton Pump Inhibitor( PPI) Study
Functional dyspepsia is one of the most common digestive disorders. The pathophysiology of functional dyspepsia is uncertain. Proton pump inhibitor (PPI) has been recommended as the first line treatment for functional dyspepsia.
- Trial name
- NCT00951431
- Testing
- Esomeprazole
- Where
- Hong Kong
- Volunteers
- 155 people
- Sponsor
- Chinese University of Hong Kong