Clinical trials: Esomeprazole, active
Laryngopharyngeal Reflux Disease
Comparative Effectiveness of Alginate, Magaldrate, Sucralfate, Proton Pump Inhibitors, and Diet in Laryngopharyngeal Reflux Disease
The goal of this randomized controlled trial is to compare the effectiveness of different treatments for laryngopharyngeal reflux disease (LPRD) in adult patients with confirmed symptoms and signs of the condition.
- Trial name
- NCT07611162
- Testing
- Alginate, Magaldrate, Sucralfate
- Where
- Belgium
- Volunteers
- 800 people
- Sponsor
- University of Mons
MALT Lymphoma of Stomach
Prospective Study of Frontline Antibiotics Therapy in the Treatment of Early-stage HP-negative Gastric MALT Lymphoma
We hypothesized that a proportion of patients with localized Helicobacter pylori-negative gastric MALT lymphoma may well respond to frontline Helicobacter pylori eradication therapy (HPE) and remain lymphoma-free for the long…
- Trial name
- GastricMALToma (NCT07144657)
- Testing
- Esomeprazole, Bismuth tripotassium dicitrate, Tetracycline, and Metronidazole
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Doxycycline for Helicobacter Pylori Rescue Treatment
Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy.
- Trial name
- NCT05874570
- Testing
- Esomeprazole, Bismuth Potassium Citrate, Tetracycline
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
GERD
Heartburn, Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a condition caused by the reflux of stomach contents into the esophagus, presenting with typical symptoms such as heartburn and acid regurgitation.
- Trial name
- GERD (NCT07268820)
- Testing
- Zastaprazan, Esomeprazole
- Where
- 10 sites in South Korea
- Volunteers
- 160 people
- Sponsor
- Incheon St.Mary's Hospital
Helicobacter Pylori Infection
Vonoprazan Evaluation Compared to Standard Triple Therapy in Helicobacter Pylori eRadication
Helicobacter pylori (H Pylori) infection is associated with functional dyspepsia, peptic ulcer disease, atrophy and gastric cancer. The bacterium has been classified as grade I carcinogen by the WHO in 1994(1).
- Trial name
- NCT06959368
- Testing
- Vonoprazan 20mg, Esomeprazole 40 mg, Amoxicillin 1 g, Clarithromycin 500 mg
- Where
- India
- Volunteers
- 484 people
- Sponsor
- Asian Institute of Gastroenterology, India
Malignant Gastric Outlet Obstruction
Prophylactic PPI Use After EUS-GE Procedure
This study aims to compare the 6-month cumulative incidence of mucosal erosion or ulcer involving the anastomosis and LAMS flange in patients with and without 6-month prophylactic PPI treatment following EUS-GE, and to assess…
- Trial name
- NCT07896577
- Testing
- Esomeprazole
- Volunteers
- 273 people
- Sponsor
- Changhai Hospital
Helicobacter Pylori Gastritis, Helicobacter Eradication
Clinical Evaluation of a 14day Modified Bismuth Quadruple Therapy for the Eradication of Helicobacter Pylori in a High Clarithromycin and Metronidazole Resistance Area Regarding Patients With Peptic Ulcer and Non Ulcer Dyspepsia
The goal of this clinical trial is to learn if a modified bismuth-containing therapy for the treatment of helicobacter pylori infection works to treat chronic helicobacter pylori related gastritis in adults treated either for…
- Trial name
- MBISQ4HP (NCT07146594)
- Testing
- Modified bismuth-containing eradication treatment
- Volunteers
- 150 people
- Sponsor
- Athens Medical Center
Autism, Autism Spectrum Disorder
A Study of Esomeprazole in Children With Autism
Autism is a pervasive developmental disorder characterized by core deficits in social behavior and communication and the presence of repetitive/stereotyped behaviors.
- Trial name
- NCT03866668
- Testing
- Esomeprazole
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Non-Erosive Gastroesophageal Reflux Disease (NERD)
Mirgeal® Gel as Add-on Therapy to Esomeprazole in Adults With Non-Erosive Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a common condition that can cause symptoms including heartburn, acid regurgitation, sour taste and other upper gastrointestinal complaints.
- Trial name
- NCT07790549
- Testing
- Esomeprazole 20mg, Mirgeal® Gel (manufacturer: PharmExtracta S.p.A.)
- Where
- 2 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Gastritis, Dyspepsia
Saccharomyces Boulardii Combined With Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment
This study aims at evaluating efficacy and safety of Saccharomyces boulardii combined with bismuth-containing quadruple Therapy versus bismuth-containing quadruple Therapy(bismuth#esomeprazole#tetracycline and furazolidone) in H.
- Conditions
- Gastritis, Dyspepsia, Helicobacter Pylori Infection, Gastric Cancer
- Trial name
- NCT07139366
- Testing
- Bismuth, Esomeprazole, Tetracycline
- Where
- China
- Volunteers
- 1,248 people
- Sponsor
- Yongquan Shi
Radiation Esophagitis, Locally Advanced Lung Carcinoma
Esomeprazole and Radiation Induced Esophagitis
Thoracic radiation therapy combined with chemotherapy (with or without immunotherapy) is the cornerstone of management in patients with locally advanced non-small cell lung cancer (NSCLC).
- Trial name
- EERENs (NCT06120803)
- Testing
- Esomeprazole 40 mg
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Rush University Medical Center
Breast Cancer Stage III, Breast Cancer Stage II
The Efficacy and Safety of CDK4/6 Inhibitors in Combination with Endocrine Therapy in the Neoadjuvant Treatment
To explore the efficacy and safety of CDK4/6 inhibitors combined with endocrine neoadjuvant therapy for stage II-III HR-positive/HER2-negative breast cancer.
- Trial name
- NCT06810492
- Testing
- Ribociclib; abemaciclib; palbociclib; Dalpiciclib
- Volunteers
- 40 people
- Sponsor
- Hongmei Zheng, PhD
Proton Pump Inhibitors, Human Gastrointestinal Tract
Intestinal Microbiota After PPI Treatment
This clinical study aims to investigate the effects of short-term treatment with proton pump inhibitors (PPIs) on the gut microbiota of pediatric patients.
- Conditions
- Proton Pump Inhibitors, Human Gastrointestinal Tract, Gastroesophageal Reflux Disease
- Trial name
- PPI (NCT07036627)
- Testing
- study of microbiota
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Bari
Laryngomalacia
Assessing the Role of Proton Pump Inhibitors in Reducing Aspiration Incidence in Pediatric Laryngomalacia Cases
Laryngomalacia is the most common congenital laryngeal anomaly in children and is frequently associated with aspiration. This randomized controlled study aims to assess the role of proton pump inhibitor (PPI) therapy in reducing…
- Trial name
- NCT07750379
- Testing
- PPI, vitamin D, feeding instruction
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Ulcers, Gastric
Efficacy and Safety of Vonorasan Versus Esomeprazole in the Treatment of Ulcers After Endoscopic Submucosal Dissection
The purpose of this clinical trial is to find out the effectiveness of voronasan in combination with aluminum phosphate gel in the treatment of post-operative ESD ulcers.
- Trial name
- NCT06526455
- Testing
- Vonoprazan, Esomeprazole
- Where
- 5 sites in China
- Volunteers
- 196 people
- Sponsor
- Shicai Ye
Helicobacter Pylori Infection, Peptic Ulcer Disease
Vonoprazan High-Dose Dual VS Levofloxacin Concomitant
This is a randomized controlled trial comparing the efficacy and safety of two vonoprazan-based regimens: high-dose dual therapy (vonoprazan plus a single antibiotic) versus triple therapy (vonoprazan plus two antibiotics) for…
- Conditions
- Helicobacter Pylori Infection, Peptic Ulcer Disease, Gastritis
- Trial name
- NCT07624422
- Testing
- Vonoprazan, Levofloxacin 500mg
- Where
- Syria
- Volunteers
- 150 people
- Sponsor
- Damascus Hospital
Obesity, Gastric Reflux
The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass
The objective of this study is to investigate the effect of Esomeprazol administered in tablets (Esomeprazol MUT Sandoz® 40mg) or in solution (Esomeprazol MUT Sandoz® 40mg in 10ml tap water) on acid production in the gastric…
- Conditions
- Obesity, Gastric Reflux, Ulcer, Gastric
- Trial name
- NCT05320796
- Testing
- upper endoscopy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Prof Urs Zingg
Hypovitaminosis b 12
This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week
This randomized, clinical trial evaluates the efficacy of oral versus sublingual vitamin B12 supplementation in correcting early-onset vitamin B12 deficiency in adult patients using proton pump inhibitors (PPIs).
- Trial name
- NCT06966856
- Testing
- Cyanocobalamin 1000 Mcg Oral Tablet, Cyanocobalamin 1000 Mcg Sublingual Tablet, Proton Pump Inhibitor therapy only
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Tanta University
Reflux Esophagitis (RE)
A Phase III Clinical Trial for Efficacy and Safety Evaluation of JP-1366 Tablets on Reflux Esophagitis
To evaluate the efficacy and safety of JP-1366 tablets and Nexium® (Esomeprazole magnesium enteric-coated tablets) in subjects with reflux esophagitis.
- Trial name
- NCT06850480
- Testing
- JP-1366 simulation tablets, Esomeprazole Magnesium (Nexium) simulation tablets
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Upper Gastrointestinal Hemorrhage
Efficacy of Proton Pump Inhibitors in Cirrhotic Patients With Acute Variceal Bleeding
Acute Variceal Bleeding (AVB) in patients with liver cirrhosis is a common clinical critical disease. There is little evidence for the effect of proton pump inhibitor (PPI) use in patients with AVB, and there is no study on the…
- Trial name
- NCT05624229
- Testing
- Proton Pump Inhibitors, No Proton Pump Inhibitors
- Volunteers
- 672 people
- Sponsor
- West China Hospital