Clinical trials: Experimental
Patients Undergoing Endoscopic Submucosal Dissection
A Comparison of High-flow Nasal Oxygen and Conventional Nasal Cannula in Monitored Anesthesia Care for Endoscopic Submucosal Dissection
Sedation for endoscopic submucosal dissection places patients at risk of desaturation, and high-flow nasal oxygen may reduce the risk.
- Trial name
- NCT06688019
- Testing
- conventional oxygenation (nasal cannula), high-flow humidified oxygen-delivery system (OptiFlow THRIVE)
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Antisepsis
Pre-surgical Antisepsis Using an Alcoholic Solution of Chlorhexidine Digluconate and Potassium Sorbate
The present study evaluates the effects of bactericidal load reduction after surgical hand scrub antisepsis using the reference antiseptic product propan-ol-1 60% as control versus a surgical hand scrub antisepsis with addition…
- Trial name
- sorbectol (NCT04454619)
- Testing
- Hand antisepsis with Clorhexidine and solution
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centro Ortopedico y Quirurgico del Pie
Pleural Infection, Pleural Infections
Role of Medical Thoracoscopy in Pleural Infection (PROMPT Trial)
The PROMPT study is testing whether an early keyhole procedure called Medical Thoracoscopy, which lets doctors look inside the chest and remove infected fluid, works better than current standard treatment (medicines to break up…
- Conditions
- Pleural Infection, Pleural Infections, Pleural Infections and Inflammations
- Trial name
- PROMPT (NCT07550530)
- Testing
- medical thoracoscopy, Standard of Care
- Volunteers
- 170 people
- Sponsor
- Università Politecnica delle Marche
Allergic Conjunctivitis
Evaluation of Brimonidine Tartrate/Ketotifen Fumarate Combination for the Treatment of Allergic Conjunctivitis
To evaluate the efficacy of Combo (Drug Product Brimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Ophthalmic Solution) compared to its individual components and vehicle in a population of subjects with allergic conjunctivitis:
- Trial name
- NCT05579730
- Testing
- Brimonidine tartrate 0.025%/ketotifen fumarate 0.035%, Brimonidine Tartrate 0.025%, Ketotifen Fumarate 0.035%
- Where
- 4 sites in United States
- Volunteers
- 188 people
- Sponsor
- Bausch & Lomb Incorporated
Mayer Rokitansky Kuster Hauser Syndrome, Mullerian Aplasia
Uterus Transplantation From Live Donors and From Deceased Donors - Clinical Study
Uterus transplantation (UTx) is the only causative treatment for congenital or acquired uterus absence. Individual cases of UTx from a live donor (LD UTx) with healthy child birth performed so far showed favourable outcomes.
- Conditions
- Mayer Rokitansky Kuster Hauser Syndrome, Mullerian Aplasia, Uterus; Absence, Congenital, Infertility, Female
- Trial name
- UTxLD/DBD (NCT03277430)
- Testing
- Live donor uterus transplantation, Deceased donor uterus transplantation, Tacrolimus
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Bipolar I Disorder, Current Episode Depressed
Creatine Monohydrate as Adjuvant Therapy for Bipolar Depression
The purpose of this study is to determine whether creatine monohydrate is effective as an adjuvant treatment for bipolar depression.
- Trial name
- NCT01655030
- Testing
- creatine monohydrate
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Acute Pain
Open Label Placebo to Reduce Prescription Opioid Use
The goal of the proposed study is to examine the efficacy of using an honest placebo to relieve pain for patients with an acute pain condition.
- Trial name
- NCT05014230
- Testing
- Opioid medication as part of standard care
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Brown University
Tumor Lysis Syndrome
Febuxostat for Tumor Lysis Syndrome Prevention in Hematologic Malignancies
The purpose of this study is to determine whether febuxostat is superior to allopurinol in the prevention of tumor lysis syndrome (TLS) in patients with hematological malignancies at intermediate or high risk of TLS (according to…
- Trial name
- FLORENCE (NCT01724528)
- Testing
- Febuxostat, Allopurinol
- Volunteers
- 346 people
- Sponsor
- Menarini Group
Breast Cancer
Efficacy and Safety Of Xeloda as Sequential Adjuvant Therapy After Chemotherapy in Breast Cancer
Select 600 cases of women with breast cancer of triple negative or Her-2 positive or with more than 4 axillary lymph node metastasis. All the patients were accepted the chemotherapy of Anthracycline and/or Taxane.
- Trial name
- NCT01662128
- Testing
- Xeloda
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Tianjin Medical University
Peri-Implantitis
Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis
The purpose of the study is to evaluate if using Erbium-doped yttrium aluminium garnet laser, Erbium YAG laser (Er:YAG) laser could have adjunctive benefits to the conventional standard mechanical debridement to ablate the…
- Trial name
- NCT03127228
- Testing
- Standard mechanical debridement, Er:YAG laser-assisted debridement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Post-Activation Performance Enhancement (PAPE)
Acute Effects of Resistance Exercise-Based PAPE in Adolescent Basketball Players
This study evaluates the acute effects of resistance exercise-based post-activation performance enhancement (PAPE) on basketball-specific cognitive-motor dual-task performance in male adolescent basketball players.
- Trial name
- PAPE (NCT07851428)
- Testing
- Standardized Basketball Warm-Up, Back Squat PAPE, Deadlift PAPE
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Uludag University
Atopic Dermatitis, Eczema
Effects of an Emollient Containing Postbiotic Saccharomyces and Lactobacillus on Pediatric Atopic Dermatitis
The goal of this study is to investigate whether the use of emollients containing postbiotic Saccharomyces and Lactobacillus can significantly reduce the risk of atopic dermatitis (AD) recurrence in pediatric patients aged 0-6…
- Conditions
- Atopic Dermatitis, Eczema, Emollient
- Trial name
- NCT06474728
- Testing
- Treatment with an Emollient Containing Postbiotic Saccharomyces and Lactobacillus
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Children's Hospital of Fudan University
QT Effects in Healthy Volunteers
Effect of a Single Oral Dose of Moxidectin on the Cardiac QT Interval of Healthy Volunteers
This study will investigate the effect of a single oral dose of moxidectin on the QT interval associated with moxidectin plasma concentrations.
- Trial name
- NCT03012828
- Testing
- Moxidectin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medicines Development for Global Health
GIST
A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor
The purpose of this study is to evaluate the efficacy and safety of ponatinib in participants with metastatic and/or unresectable gastrointestinal stromal tumor (GIST) following failure of prior tyrosine kinase inhibitor (TKI)…
- Trial name
- GIST (NCT01874665)
- Testing
- Ponatinib
- Where
- 4 sites in United States
- Volunteers
- 45 people
- Sponsor
- Ariad Pharmaceuticals
Diabetic Macular Edema
Ranibizumab for Edema of the mAcula in Diabetes: Protocol 4 With Tocilizumab: The READ-4 Study
The purpose of this study is to investigate the safety, tolerability and efficacy of Ranibizumab and Tocilizumab alone and in combination in eyes with Diabetic Macular Edema.
- Trial name
- READ-4 (NCT02511067)
- Testing
- Tocilizumab, Ranibizumab
- Sponsor
- University of Nebraska
Adrenal Insufficiency
Extension Study for Patients Entered Into Study Infacort 003
A Phase 3, open-label, single-group, non-randomised, observational study of the safety and biochemical disease control of Infacort® in neonates, infants and children with adrenal insufficiency and congenital adrenal hyperplasia…
- Trial name
- NCT02733367
- Testing
- Infacort®
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Neurocrine UK Limited
Sleep Apnea Syndromes, Heart Failure
The Role of Sleep Disordered Breathing in Heart Failure Admissions
The purpose of this study is to evaluate the effect of in-hospital diagnosis and treatment of sleep disordered breathing (SDB) on post-discharge mortality and readmissions in- hospitalized patients with acute heart failure…
- Trial name
- NCT02505867
- Testing
- Adaptive Servo Ventilation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rami Khayat
Critical Limb Ischemia (CLI)
Initial Feasibility Study of the STENTiT Resorbable Fibrillated Scaffold (RFS). The RFS is Intended to Restore Lumen Patency and Blood Flow to Infrapopliteal Arteries. The RFS is a Fully Electrospun Tubular Device With a Fibrillated Microarchitecture and Designed for Transcatheter Delivery
This is the First-In-Human feasibility study of the RFS for below the knee lesions in subjects who experience critical limb ischemia due to the peripheral artery disease.
- Trial name
- VITAL-IT 1 (NCT07006467)
- Testing
- Implantation of RFS
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Stentit
Obesity, Morbid Obesity
DIT After RYGB - A Prospective Study
Bariatric surgery is the only satisfactory treatment for loss and weight maintenance in obese patients. This loss is a result of several factors that go beyond the simple anatomical abnormality of the gastrointestinal tract and…
- Conditions
- Obesity, Morbid Obesity, Bariatric Surgery
- Trial name
- DIT RYGB (NCT01759667)
- Testing
- A standard mixed Meal
- Where
- Brazil
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Silvia Leite Faria
Elderly Population, Cognitive Dysfunction
Effects of Balance Training with and Without Gaze Stability Exercises on Cognitive Function Balance and Dynamic Postural Stability in Older Adults with Mild Cognitive Impairment
The study aims to evaluate the effects of balance training, with and without gaze stability exercises, on cognitive function, balance, and postural stability in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT06672367
- Testing
- Balance training group, Balance training combined with gaze stability exercises
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Foundation University Islamabad
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