Clinical trials: Experimental
Parental/Patient Satisfaction
The Impact Of Physician Communication On Family Inpatient Experience
Patient satisfaction is affected by physician communication styles and communication at the bedside. The investigators are conducting a randomized controlled trial involving both providers and families to determine if providers…
- Trial name
- NCT01298791
- Testing
- Sitting, Standing
- Where
- United States
- Sponsor
- Boston Medical Center
Heel Pain Syndrome
Effectiveness Of DN and STM Combined With Self-Stretching for Management of Calf and Heel Pain
To determine the effectiveness of dry needling and soft tissue mobilization with self-stretching for the management of calf and heel pain. In our topic pain and physical dysfunction are our variables
- Trial name
- NCT05810818
- Testing
- Dry Needling, Self Stretching
- Volunteers
- 54 people
- Sponsor
- Superior University
Influenza
Seasonal Influenza DNA Vaccine Prime With Trivalent Inactivated Vaccine (TIV) Boost Compared to TIV Alone
This is a Phase 1b, randomized study in healthy younger (18-50 years) and older (51-70 years) adults to evaluate the safety, tolerability, and immunogenicity of a prime-boost vaccination regimen with an investigational plasmid…
- Trial name
- NCT01498718
- Testing
- DNA vaccine, TIV
- Where
- 4 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anal Fistula, Complex Perianal Fistula
Evaluating an rhPDGF-BB-enhanced Collagen Plug for Perianal Fistula Healing
The average success rate for healing and remission of complex perianal fistulas, idiopathic or Crohn's-related, is approximately 50%.
- Trial name
- NCT06632418
- Testing
- RhPDGF-BB
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Alexander Hawkins
Small Cell Lung Cancer Recurrent
S1 Plus Anlotinib in Treating Patients With Refractory or Relapsed Small-cell Lung Cancer
The purpose of this study is to assess the efficacy and safety of S1 combination with Anlotinib in patients with small cell lung cancer whose cancer has progression or recurrence after at least one standard chemotherapy.
- Trial name
- NCT03823118
- Testing
- S1/Anlotinib
- Where
- 3 sites in China
- Volunteers
- 48 people
- Sponsor
- Taizhou Hospital
Malignant Glioma, Recurrent Glioma
Personalized Vaccine for Patients With Recurrent Malignant Glioma
A single-arm, single-center, open-labeled study will be conducted with an aim to investigate the feasibility, safety, and efficacy of the personalized vaccine for patients with recurrent malignant glioma.
- Trial name
- NCT04943718
- Testing
- personalized vaccine
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Sickle Cell Anemia
Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Pediatric and Young Adult Patients With Sickle Cell Anemia
The study assesses the efficacy, safety and tolerability of ACZ885 (canakinumab) in pediatric and young adult patients with sickle cell anemia (SCA).
- Trial name
- NCT02961218
- Testing
- ACZ885
- Where
- 15 sites in United States, Canada and 5 more
- Volunteers
- 49 people
- Sponsor
- Novartis Pharmaceuticals
Healthy
Study to Assess the Concentration of Avibactam and Ceftazidime in Epithelial Lining Fluid and Plasma
This is an open-label study divided in 2 parts and 3 cohorts to determine the concentration of Avibactam and Ceftazidime in the lining of the lungs and the blood.
- Trial name
- NCT01395420
- Testing
- CAZ104
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pfizer
Drug Drug Interaction, Healthy
Pharmacokinetics of Omeprazole and Midazolam When Co-administered With ACT-1014-6470
A study on whether ACT-1014-6470 has an effect on how the body takes up, distributes and gets rid of omeprazole and midazolam in healthy male subjects
- Trial name
- NCT05123820
- Testing
- Treatment period A, Treatment period B
- Where
- Czechia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Sickle Cell Disease
Observational Prospective Study Measuring the Impact of the Use of a Hypnotic Script Associated With Virtual Reality on the Pain of the Child's Sickle Cell During a Vaso-occlusive Crisis
The purpose of this study is to evaluate the effect of Virtual Reality induced Hypnosis on patients' pain scores, anxiety and the use of analgesics during a vaso-occlusive crisis
- Trial name
- DREPAReV (NCT04917120)
- Testing
- Virtual Reality
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gingival Recession
Platelet Rich Fibrin in the Treatment of Multiple Gingival Recessions
The aim of this randomized controlled clinical study is to evaluate and compare the effectiveness of platelet rich fibrin (PRF) and connective tissue grafts in the treatment of multiple gingival recessions.
- Trial name
- NCT02018120
- Testing
- connective tissue graft, platelet rich fibrin
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ege University
Postoperative Pain
Postoperative Pain Following Restoration With Composite Resin Versus Sonic Fill
The aim of this study is to assess the postoperative pain following restoration with composite resin versus sonic fill in children with deep carious first permanent molar.
- Trial name
- NCT04307420
- Testing
- Sonic Fill Restoration, Composite Resin Restoration
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Parents
New Programme for Antenatal Preparation for Early Parenthood
Becoming a parent is a challenging stage in life, which provokes feelings of both excitement and insecurity; parents strive to develop confidence in their parenting role.
- Trial name
- NCT03679520
- Testing
- New programme, Regular programme
- Where
- 7 sites in Sweden
- Volunteers
- 71 people
- Sponsor
- Region Skane
Kidney Transplantation
Benefit of Early Protocol Biopsy and Treatment of Subclinical Rejection
This multicentre randomized, controlled trial (RCT) compared renal allograft histology and function in subjects treated with Tacrolimus + MMF + prednisone undergoing early protocol biopsies and treatment of subclinical rejection…
- Trial name
- NCT00885820
- Testing
- Tacrolimus, MMF, Corticosteroids (Prednisone)
- Where
- 12 sites in United States, Canada
- Volunteers
- 240 people
- Sponsor
- Astellas Pharma Inc
Cognitive Dysfunction, Acquired Brain Injury
Fareon Open Label Device Clinical Trial
The purpose of this study is to assess the safety and feasibility of an at-home MMT treatment in patients with cognitive dysfunction related to acquired brain injury, Long COVID, traumatic brain injury, myalgic encephalomyelitis…
- Conditions
- Cognitive Dysfunction, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- NCT07600320
- Testing
- Fareon device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pregnancy, Pain
The Effect of Affirmation During Non-Stress Test on Pain, Anxiety, Fear, and Stress
This study will examine whether positive affirmations used during the Non-Stress Test (NST) can help reduce pain, anxiety, fear, and stress in pregnant women.
- Conditions
- Pregnancy, Pain, Anxiety, Fear
- Trial name
- NST-AFFIRMATIO (NCT07667920)
- Testing
- Affirmation Practice During Non-Stress Test
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Bipolar Disorder
A Double-Blind Placebo Controlled Trial of Riluzole in Bipolar Depression
The Johns Hopkins Department of Psychiatry is conducting a research study to examine the effectiveness of riluzole in treating the depressed phase of bipolar disorder.
- Trial name
- NCT00376220
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Johns Hopkins University
Infertility
Fresh Vs Frozen Surgical Sperm in IVF
The primary objective of this study is to determine if the use of frozen surgical testicular sperm specimens for ICSI lead to different IVF outcomes when compared with the use of fresh surgical testicular sperm for ICSI.
- Trial name
- NCT03361982
- Testing
- Slow Freezing and Thawing
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Atrial Fibrillation, Deep Vein Thrombosis
Randomized Trial of Interventions to Improve Warfarin Adherence
The purpose of this research study is to see if a lottery which provides the opportunity to win money, a reminder system using a "Med-eMonitor", or the combination of both might be useful in helping patients to achieve better…
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Dilated Cardiomyopathies
- Trial name
- WIN3 (NCT00904982)
- Testing
- Financial Incentive and Med-eMonitor, 2Med-eMonitor
- Where
- 2 sites in United States
- Volunteers
- 268 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder
Treating Major Depressive Disorder With Music and Low-frequency Rhythmic Sensory Stimulation
Major depressive disorder (MDD) is a highly prevalent and disabling disorder associated with persistent low mood, loss of the capacity to experience pleasure (i.e.
- Trial name
- NCT02685982
- Testing
- Rhythmic Sensory Stimulation
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
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