Clinical trials: Experimental
Abdominal Aortic Aneurysm, Endoleak
EndoVascular Aortic Repair With Sac Embolization for the Prevention of Type II Endoleaks (the EVAR-SE Study)
Beyond a certain threshold diameter, Abdominal aortic aneurysms (AAA) are treated by open surgical repair or, more often by endovascular aortic aneurysm repair (EVAR).
- Trial name
- EVAR-SE (NCT05665101)
- Testing
- Coil embolization of aneurysm sac
- Where
- Germany
- Volunteers
- 101 people
- Sponsor
- Univ.-Prof. Dr. Dr. med. Daniela Branzan
Bronchoscopy
Effects of Different Ventilatory Strategy During Bronchoscopy
The execution of diagnostic-therapeutic investigations by bronchial endoscopy can expose the patient to hypoxemia. For this reason, oxygen therapy is administered at low or high flows during the course of bronchoscopic…
- Trial name
- NCT05956301
- Testing
- Conventional Oxygen Therapy, High-flow nasal oxygen, Supraglottic jet oxygenation and ventilation
- Volunteers
- 150 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Spinal Cord Injuries, Self-Management
Improving Self-Management Skills Among People With Spinal Cord Injury
The goal of our study is to evaluate the use of a self-management application ("app") that the investigators have developed to help facilitate self-management among individuals with SCI who live in the community.
- Conditions
- Spinal Cord Injuries, Self-Management, Mobile Application
- Trial name
- MobileApp (NCT03140501)
- Testing
- Mobile application ("app")
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Liver Disease and Cirrhosis, Frailty
Role of Exercise in Chronic Liver Disease Patients Undergoing Liver Transplantation
The goal of this randomised clinical trial (open label) is to test the effect of supervised aerobic and resistance exercises in chronic liver disease patients being planned for living donor liver transplantation (LDLT).
- Trial name
- NCT06163001
- Testing
- Supervised aerobic and resistance exercises, Dietary supplementation
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Breast Carcinoma, Healthy Subject
Photoacoustic Imaging in Diagnosing Changes in Tumors in Participants With Breast Cancer, Sarcoma, Skin Cancer, or Soft Tissue Malignancy and Healthy Volunteers
This pilot trial studies how well photoacoustic imaging works in diagnosing changes in tumors in participants with breast cancer, sarcoma, skin cancer, or soft tissue malignancy and healthy volunteers.
- Conditions
- Breast Carcinoma, Healthy Subject, Malignant Soft Tissue Neoplasm, Sarcoma
- Trial name
- NCT03630601
- Testing
- Photoacoustic Imaging
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Inflammatory Response, Metabolic Disturbance
Cranberry Ingestion and Cycling Related Immunity and Inflammation
This is a randomized, crossover clinical trial with 25 male and female cyclists. Study participants will ingest polyphenol-rich cranberry juice or placebo juice for 4 weeks under double-blinded procedures, and then crossover to…
- Conditions
- Inflammatory Response, Metabolic Disturbance, Immune Suppression
- Trial name
- NCT05407701
- Testing
- Cranberry Juice
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Hepatocellular Cancer
Sorafenib + mFOLFOX for Hepatocellular Carcinoma
This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational combination of drugs to learn whether the drug combination works in treating a specific cancer.
- Trial name
- NCT01775501
- Testing
- Leucovorin, Fluorouracil, Oxaliplatin
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Diabetes Type 1
Comparison of Insulin's Injection Before or After the Meal in Type 1 Diabetic Patients Treated With Insulin Pump
The current study focuses on terms of use of Insulin Aspart, fast analogue of human insulin and commonly used in the treatment of type 1 diabetes, where it obtained the marketing authorization for this indication.
- Trial name
- BOLUS (NCT02546401)
- Testing
- Insulin Aspart
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Brest
Complex Regional Pain Syndrome
The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome
The aim of this trial is to determine the potential effects and mechanisms of cannabinoid-induced pain relief in complex regional pain syndrome (CRPS).
- Trial name
- NCT06393101
- Testing
- BRC-002
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of California, San Diego
Central Retinal Vein Occlusion
Surgical Stabilizer Assisted RVC With rtPA for CRVO
This phase Ib study investigates the safety and efficacy of performing a retinal vein cannulation with recombinant tissue Plasminogen Activator infusion into a retinal vein with the help of an updated dedicated surgical…
- Trial name
- NCT03417401
- Testing
- Vitrectomy with retinal vein cannulation and intravenous rtPA (Actilyse) infusion up to 1mg., Intravenous Infusion
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cirrhosis
Contrast Enhanced Ultrasound With Lumason in Detecting Liver Cancer in Participants With Cirrhosis
This early phase I trial studies how well contrast enhanced ultrasound with sulfur hexafluoride lipid microspheres (Lumason) works in detecting liver cancer in participants with cirrhosis.
- Trial name
- NCT03407001
- Testing
- Contrast-Enhanced Ultrasound, Sulfur Hexafluoride Lipid Microspheres, Ultrasound
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- M.D. Anderson Cancer Center
Overweight or Obesity
Effect of Akkermansia Muciniphila Akk11 on Metabolic and Gut Health in Overweight and Obese Subjects
To assess the efficacy and safety of the use of probiotics as a food supplement compared to placebo in regulating body metabolism and gut microbiota in overweight or obese subjects.
- Trial name
- NCT06653101
- Testing
- Probiotic
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Vulvovaginal Atrophy
Non-hormonal Medical Device for Treatment of Vulvovaginal Atrophy (VVA) in Post-Menopausal Women
Randomized (1:1), double-blind, sham-controlled, 2-arm parallel study comparing effectiveness and safety of non-hormonal medical device versus sham device to treat VVA in post-menopausal women.
- Trial name
- NCT04887701
- Testing
- Non-hormonal vaginal device therapy
- Where
- 3 sites in Australia
- Volunteers
- 25 people
- Sponsor
- Madorra
Accidental Fall
Merging Attentional Focus and Balance Training to Reduce Fall Risk in Older Adults
Approximately 15 million older adults fall every year in the United States and fall prevention programs have only been moderately successful in arresting fall rates.
- Trial name
- NCT03776201
- Testing
- Balance Training
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of North Carolina, Greensboro
Multiple Sclerosis
Effect of Sensory Integration Therapy on Gait Variability and Quality Of Life in Patients With Multiple Sclerosis
This study aims to evaluate the impact of sensory integration therapy on individuals with multiple sclerosis (MS) by examining its effects on gait variability and overall quality of life.
- Trial name
- NCT07390201
- Testing
- Conventional physical therapy program, Sensory integration therapy
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Cairo University
Cutaneous Squamous Cell Carcinoma, Skin Cancer
A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer
The purpose of the study is to see if the combination of radiation therapy and cemiplimab immunotherapy is an effective treatment for people with locally advanced, unresectable CSCC.
- Conditions
- Cutaneous Squamous Cell Carcinoma, Skin Cancer, Squamous Cell Carcinoma, Locally Advanced Squamous Cell Carcinoma
- Trial name
- NCT05574101
- Testing
- Cemiplimab, Radiotherapy
- Where
- 13 sites in United States
- Volunteers
- 34 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Insomnia, HIV
RCT of CBT for Insomnia With PLWHA
The proposed study will consist of a randomized controlled trial (RCT) comparing a known efficacious treatment for insomnia (CBT-I) to a sleep hygiene (SH) comparison condition.
- Conditions
- Insomnia, HIV, Aids
- Trial name
- NCT02259101
- Testing
- CBT-I Treatment Condition, SH Comparison Condition
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Emory University
Geriatric Sarcopenia
High-Intensity Functional Training on Physical Performance and Mental Health in Elderly With Sarcopenia
Sixty patients with age ranged from 60 to 70 years old with individuals who will be found to have sarcopenia will participate in the study, and will be recruited from nursing home in AL-Abadiyah.
- Trial name
- NCT07399301
- Testing
- High-Intenisity Functional Training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Healthy
Evaluate the Effect of Clarithromycin/Rifampicin on the Pharmacokinetics of DA-8010 in Healthy Adults
This is an open-label, fixed-sequence, phase 1 study to evaluate the effect of clarithromycin/rifampicin on the pharmacokinetics of DA-8010 in healthy adults.
- Trial name
- NCT05991401
- Testing
- DA-8010 5mg, Clarithromycin 500mg, Rifampicin 600mg
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Sports Physical Therapy
Comparative Study on the Effectiveness of Plyometric PU and Swiss Ball PU in Badminton Players
The aim of this study is to find out the comparative effect of plyometric push up and swiss ball push up in the management of throwing distance and accuracy among badminton player.
- Trial name
- NCT06658301
- Testing
- plyometric push up exercises, swiss ball push up exercises
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
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