Clinical trials: Experimental
Healthy
A Relative Bioavailability Study of 20 mg Famotidine Tablets Under Fasting Condition
The study was conducted as an open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioavailability study comparing famotidine tablets, USP 20 mg manufactured by OHM Laboratories with…
- Trial name
- NCT01079065
- Testing
- Famotidine
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Rhinoplasty
Betadine Effect on Nasal Mucosa Cilia
The goal of the proposed study is to identify PVP-I at 1.25% as an appropriate intranasal topical preparation for patients undergoing rhinoplasty with no effect on the nasal mucosa cilia (NMC) or olfaction using the saccharin…
- Trial name
- NCT04457765
- Testing
- Povidone-Iodine (PVP-I)
- Where
- United States
- Sponsor
- Boston Medical Center
Insulin Resistance
Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome
Sirtuin activators may prove useful in treating age-related diseases and extending lifespan in humans. Resveratrol (RSV), a polyphenol found in red wine, has been shown in vitro to enhance SIRT1 activity.
- Trial name
- RSV (NCT00654667)
- Testing
- Resveratrol
- Where
- United States
- Sponsor
- University of California, San Francisco
Cigarette Smoking
Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers
For the approximately 4.6 million LGBT persons in the U.S., smoking rates among those living in urban areas are roughly twice that of heterosexuals.
- Trial name
- NCT01633567
- Testing
- Culturally Targeted Cessation Program, Non-Targeted Cessation Program
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients
This phase III single arm trial determines whether taking prophylactic letermovir will reduce the likelihood of infection with cytomegalovirus (CMV) in children and adolescents after stem cell transplant compared to estimated…
- Trial name
- NCT05711667
- Testing
- Biospecimen Collection, Letermovir
- Where
- 33 sites in United States
- Volunteers
- 105 people
- Sponsor
- Children's Oncology Group
Acute Coronary Syndromes
Impact of Atorvastatin Versus Rosuvastatin on 25 Hydroxy Vitamin D Levels in Patients With Acute Coronary Syndrome
there will be 2 groups of patients with acute coronary syndrome. The patients will receive one of the 2 study drugs and impact on raising Vitamin D level will be seen after 6 months
- Trial name
- NCT06765265
- Testing
- Rosuvastatin 20 mg/day, Atorvastatin 40 mg
- Where
- Pakistan
- Volunteers
- 152 people
- Sponsor
- King Edward Medical University
Diabetes Mellitus, Type 2
Life-long Tele-monitoring of Patients With Type 2 Diabetes Mellitus in Central Greece
To evaluate whether patients with type 2 diabetes mellitus can be followed by simplified, centralized and large scale tele-monitoring of blood glucose levels and blood pressure, and whether this intervention produces health and…
- Trial name
- RHCluster2GR (NCT01498367)
- Testing
- Telemonitoring of patients with diabetes type 2
- Where
- Greece
- Volunteers
- 154 people
- Sponsor
- Regional Health Authority of Sterea & Thessaly
Sickle Cell Disease, Sickle Cell Anemia in Children
Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease
The goal of this interventional study is to learn about the impact of an intervention for health care providers that teaches individuation and perspective-taking (IPT) skills to enhance patient-centered communication in pediatric…
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia in Children, Sickle Cell Disease (SCD), Sickle Cell
- Trial name
- NCT07540767
- Testing
- Individuation and Perspective-Taking (IPT), pediatric SCD pain management education session
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Connecticut Children's Medical Center
Stroke, Muscle Spasticity
The Movement of Botulinum Toxin Through the Lateral Gastrocnemius Muscle in Humans: An Expanded Examination
Despite the wide-spread use of botulinum toxin (BT) to treat spasticity (increased muscle tone) in central neurological disease, evidence-based guidance on dosing, dilution, and injection technique is limited.
- Trial name
- NCT03367429
- Testing
- Botox
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Weill Medical College of Cornell University
Chronic Obstructive Pulmonary Disease Severe
Cell Therapy Associated With Endobronchial Valve
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases worldwide and is considered a public health problem. The World Health Organization estimates that about 210 million people have COPD.
- Trial name
- CEL&VAL (NCT04018729)
- Testing
- Zephyr Endobronchial Valve, Marrow-derived mesenchymal stromal cell
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Healthy, Obesity
Open Label Randomized Clinical Study to Promote a Healthy Lifestyle in Medical Students
The main medical and social purpose of the project "It's trendy to be healthy!" is the promotion of healthy lifestyles and healthy eating among student youth.
- Conditions
- Healthy, Obesity, Nutrition, Healthy, Vitamin D Deficiency
- Trial name
- NCT05073029
- Testing
- nutrition program and modification of physical activity, synbiotic (Fructooligosaccharides+Lactobacillus rhamnosus GG ATCC 53103, 4.0х109 colony forming units - CFU), vitamin D3
- Where
- 2 sites in Ukraine
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bogomolets National Medical University
Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia
A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL
This is an open-label, multi-center Phase 1/2 study of oral LOXO-305 (pirtobrutinib) in patients with CLL/SLL and NHL who have failed or are intolerant to standard of care.
- Conditions
- Chronic Lymphocytic Leukemia, Waldenstrom Macroglobulinemia, Mantle Cell Lymphoma, Marginal Zone Lymphoma
- Trial name
- NCT03740529
- Testing
- Pirtobrutinib, Venetoclax, Rituximab
- Where
- 56 sites in United States, Australia and 8 more
- Volunteers
- 803 people
- Sponsor
- Loxo Oncology, Inc.
Fungal Infection
Safety, Pharmacokinetics, Bioavailability, Food Effect, Drug-Drug Interaction Study of APX001 Administered Orally
This is a Phase l double-blind, placebo-controlled, randomized study to investigate the safety, tolerability, pharmacokinetics, bioavailability and food effect of single doses of APX001 administered intravenously and orally…
- Trial name
- NCT02957929
- Testing
- APX001 single IV dose, APX001 single oral dose 1, APX001 single oral dose 2
- Where
- 2 sites in Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Lymphoma, Leukemia
Companion for CAR-T Web App During Chimeric Antigen Receptor T-cell Therapy
The complex logistics and unique toxicities of chimeric antigen receptor T-cell (CAR-T) therapy require intensive patient education and careful monitoring.
- Conditions
- Lymphoma, Leukemia, Plasma Cell Dyscrasia
- Trial name
- NCT05362331
- Testing
- Web Application
- Sponsor
- University of California, San Francisco
Narrative Medicine
Meaning Making While Your Child is in Intensive Care
A quarter of a million children and teenagers are hospitalized annually in Pediatric Intensive Care Units (PICUs) in North America.
- Trial name
- NCT05627531
- Testing
- Narrative Medicine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Akron Children's Hospital
Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
Effect of Zhuli Capsule on Phlegm-heat Syndrome (Tan-re Zheng)
This trial aims to evaluate the clinical control rate of sputum by Zhuli Capsule in the treatment of the Phlegm-heat Syndrome （Tan-re Zheng）in the patients with acute exacerbation of chronic obstructive pulmonary disease or…
- Trial name
- NCT04834531
- Testing
- Zhuli capsule, Standard medical treatment
- Where
- 4 sites in China
- Volunteers
- 324 people
- Sponsor
- Zhong Wang
Fibromyalgia, Obesity
Nutrition and Coping Education for Symptom and Weight Management for Fibromyalgia
Research has shown that weight problems are very common in fibromyalgia. Research also suggests that overweight and obesity may contribute to worsening of fibromyalgia symptoms and biochemical vulnerability associated with…
- Trial name
- NCT00925431
- Testing
- Lifestyle Modification, Supportive education
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Utah
Healthy
A Healthy Female and Male Volunteers Aspirin Study
This is a study to compare the bioavailability of Acetyl Salicylic Acid (ASA) between Esomeprazole and Aspirin after multiple dose administration.
- Trial name
- NCT01448031
- Testing
- Capsule ASA 81mg/esomeprazole 20mg, Acetylsalicylzuur Apotex Cardio
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hyperlipidemias, Dyslipidemias
Study to Investigate Safety, Tolerability, PK and PD Response of SLN360 in Subjects With Elevated Lipoprotein(a)
This study will investigate the safety and tolerability of SLN360 in patients with elevated Lp(a).
- Conditions
- Hyperlipidemias, Dyslipidemias, Elevated Lp(a)
- Trial name
- NCT04606602
- Testing
- SLN360
- Where
- 8 sites in United States, Australia and 2 more
- Volunteers
- 70 people
- Sponsor
- Silence Therapeutics plc
Stroke, Hemiparesis
Constraint-Induced Movement Therapy (CIMT) with Motor Relearning Program (MRP) and Bobath Approach to Augment Functional Motor Recovery of Chronic Hemiparetic Arm
Hemiparesis is a condition characterized by weakness or the inability to move on one side of the body, making it difficult to perform everyday activities like eating or dressing (Iswatun et al., 2022).
- Conditions
- Stroke, Hemiparesis, Hemiparesis After Stroke, Motor Function
- Trial name
- CIMT-MRP (NCT06806553)
- Testing
- Constraint-Induced Movement Therapy (CIMT) With Motor Relearning Program (MRP), Bobath Therapy
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- University of Lahore
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